| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.217218 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.206946 |
| FNDC3B | fibronectin type III domain containing 3B | 0.155206 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.150731 |
| ENO1 | enolase 1, (alpha) | 0.124383 |
| FN1 | fibronectin 1 | 0.122662 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0983028 |
| AFDN | afadin, adherens junction formation factor | 0.0728248 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0689077 |
| PGK1 | phosphoglycerate kinase 1 | 0.067528 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0655563 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0640879 |
| TF | transferrin | 0.0628266 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0618756 |
| NDRG1 | N-myc downstream regulated 1 | 0.0599346 |
| DTNA | dystrobrevin, alpha | 0.0575977 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0564562 |
| LDHA | lactate dehydrogenase A | 0.0535569 |
| INSIG2 | insulin induced gene 2 | 0.0534947 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0524191 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0512965 |
| SDC4 | syndecan 4 | 0.0509584 |
| DSPP | dentin sialophosphoprotein | 0.0509215 |
| APOB | apolipoprotein B | 0.050643 |
| PCBP2 | poly(rC) binding protein 2 | 0.0475973 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0473266 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0468874 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0468142 |
| FLNB | filamin B, beta | 0.0467041 |
| ZNF292 | zinc finger protein 292 | 0.0449527 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0448042 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.044463 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0437574 |
| HELZ | helicase with zinc finger | 0.0420262 |
| RBM39 | RNA binding motif protein 39 | 0.0413479 |
| VEGFA | vascular endothelial growth factor A | 0.0395695 |
| FMNL2 | formin-like 2 | 0.0394889 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0390665 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0387929 |
| NGLY1 | N-glycanase 1 | 0.0385798 |
| RPL3 | ribosomal protein L3 | 0.0384313 |
| PEG3 | paternally expressed 3 | 0.0382066 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0381947 |
| WDR45B | WD repeat domain 45B | 0.03785 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0376432 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0372084 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0366629 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0365719 |
| TNS1 | tensin 1 | 0.0359366 |
| GRK3 | G protein-coupled receptor kinase 3 | 0.0355275 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0350813 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0346064 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0341493 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0340522 |
| NUP58 | nucleoporin 58 | 0.0332665 |
| WWC2 | WW and C2 domain containing 2 | 0.0331592 |
| RUNX1 | runt-related transcription factor 1 | 0.032889 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0327776 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0326219 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0324493 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0321616 |
| NBAS | neuroblastoma amplified sequence | 0.031861 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0316972 |
| QKI | QKI, KH domain containing, RNA binding | 0.0315097 |
| PRELID2 | PRELI domain containing 2 | 0.031418 |
| MSI2 | musashi RNA-binding protein 2 | 0.0311388 |
| MYO1B | myosin IB | 0.0306966 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0304929 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0303816 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0292739 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.028369 |
| KIF1B | kinesin family member 1B | 0.0277611 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0277494 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0275915 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0275229 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0274663 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0271637 |
| AHNAK | AHNAK nucleoprotein | 0.0270307 |
| RPL4 | ribosomal protein L4 | 0.0270125 |
| MTSS1 | metastasis suppressor 1 | 0.0267109 |
| SEC24A | SEC24 family member A | 0.0266489 |
| ARFGEF3 | ARFGEF family member 3 | 0.0266174 |
| RLF | rearranged L-myc fusion | 0.0264921 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.026381 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0260401 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0256417 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0255913 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0254924 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0252881 |
| ARRDC3 | arrestin domain containing 3 | 0.0252578 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0251732 |
| TBC1D22A | TBC1 domain family, member 22A | 0.024911 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0248826 |
| BBX | bobby sox homolog (Drosophila) | 0.0247394 |
| RYBP | RING1 and YY1 binding protein | 0.0247358 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0247146 |
| YEATS2 | YEATS domain containing 2 | 0.0245374 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0243474 |
| TOP1 | topoisomerase (DNA) I | 0.0240942 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0230867 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.335179 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0659619 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.049012 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0431318 |
| EHBP1 | EH domain binding protein 1 | -0.0383914 |
| PTCHD4 | patched domain containing 4 | -0.0377593 |
| C3 | complement component 3 | -0.0353495 |
| VCL | vinculin | -0.0331984 |
| EGR1 | early growth response 1 | -0.02973 |
| GPC6 | glypican 6 | -0.0281586 |
| ITGAV | integrin, alpha V | -0.0265125 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0251838 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0239949 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0239279 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0228264 |
| RPS6 | ribosomal protein S6 | -0.0225926 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0222716 |
| RPS8 | ribosomal protein S8 | -0.0219682 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.021839 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0218195 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0218063 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0217425 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0215684 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0213475 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0208662 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0196935 |
| FOXP1 | forkhead box P1 | -0.0196808 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.019284 |
| ITGA1 | integrin, alpha 1 | -0.0191016 |
| RPL34 | ribosomal protein L34 | -0.0188991 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0186722 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0182332 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0180862 |
| RIGI | RNA sensor RIG-I | -0.0180834 |
| BPTF | bromodomain PHD finger transcription factor | -0.0177011 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0176588 |
| ZNF644 | zinc finger protein 644 | -0.0175821 |
| APOA2 | apolipoprotein A-II | -0.0174148 |
| ACTN4 | actinin, alpha 4 | -0.0171944 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0169112 |
| RPLP1 | ribosomal protein, large, P1 | -0.0166822 |
| BCL2L1 | BCL2-like 1 | -0.0166318 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0162775 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0162641 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0160166 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0159345 |
| MT2A | metallothionein 2A | -0.0158348 |
| KIF21A | kinesin family member 21A | -0.0153061 |
| FILIP1L | filamin A interacting protein 1-like | -0.0153001 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0150828 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.0148115 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0147227 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0143596 |
| GNAS | GNAS complex locus | -0.0142865 |
| RRBP1 | ribosome binding protein 1 | -0.0141214 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0140676 |
| TPM1 | tropomyosin 1 (alpha) | -0.0140303 |
| HNMT | histamine N-methyltransferase | -0.0138742 |
| RPS24 | ribosomal protein S24 | -0.0138506 |
| SCN9A | sodium channel, voltage gated, type IX alpha subunit | -0.0138502 |
| AHR | aryl hydrocarbon receptor | -0.0137007 |
| CTDSPL | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like | -0.0135334 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0132166 |
| RPL37 | ribosomal protein L37 | -0.0131186 |
| SYNJ2 | synaptojanin 2 | -0.0130553 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0129506 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0129318 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0127851 |
| CCN2 | cellular communication network factor 2 | -0.0127476 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0125616 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0123369 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.01222 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.01213 |
| VMP1 | vacuole membrane protein 1 | -0.012102 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.01203 |
| RPS19 | ribosomal protein S19 | -0.0117906 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0117775 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.011632 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0116273 |
| SYN3 | synapsin III | -0.0115284 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0115065 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0114332 |
| FAM135A | family with sequence similarity 135, member A | -0.0113225 |
| PELO | pelota homolog (Drosophila) | -0.0112618 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0112288 |
| DST | dystonin | -0.0109916 |
| GOLGB1 | golgin B1 | -0.0109857 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0109588 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0109442 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0108651 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0108354 |
| AOPEP | aminopeptidase O (putative) | -0.0107889 |
| RPS25 | ribosomal protein S25 | -0.0106181 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0106074 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0105646 |
| THBS1 | thrombospondin 1 | -0.0105616 |
| DSTN | destrin (actin depolymerizing factor) | -0.01046 |
| COBLL1 | cordon-bleu WH2 repeat protein-like 1 | -0.0104337 |
| ACYP2 | acylphosphatase 2, muscle type | -0.01033 |
| RPL31 | ribosomal protein L31 | -0.0101621 |
