| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | 0.197558 |
| NDRG1 | N-myc downstream regulated 1 | 0.178034 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.148525 |
| PODXL | podocalyxin-like | 0.12173 |
| AHNAK | AHNAK nucleoprotein | 0.109314 |
| PGK1 | phosphoglycerate kinase 1 | 0.107389 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0954106 |
| EZR | ezrin | 0.0912658 |
| POTEF | POTE ankyrin domain family, member F | 0.0911296 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0758378 |
| FOXO1 | forkhead box O1 | 0.0754071 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0742341 |
| PLEC | plectin | 0.0674389 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.067002 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0623851 |
| CD44 | CD44 molecule (Indian blood group) | 0.0608331 |
| MEF2A | myocyte enhancer factor 2A | 0.0590564 |
| SULF1 | sulfatase 1 | 0.0580635 |
| ITGA6 | integrin, alpha 6 | 0.0574193 |
| BCL2L1 | BCL2-like 1 | 0.0560517 |
| ANLN | anillin, actin binding protein | 0.054348 |
| RBM39 | RNA binding motif protein 39 | 0.0531429 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.052788 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0501967 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0480041 |
| MSN | moesin | 0.0469006 |
| MYO10 | myosin X | 0.0462818 |
| ACTN4 | actinin, alpha 4 | 0.0446896 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0445004 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0444628 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0438817 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | 0.0434567 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.043439 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0432323 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0429804 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0426461 |
| LDHA | lactate dehydrogenase A | 0.0423924 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0421 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0418993 |
| FOSL1 | FOS-like antigen 1 | 0.0418939 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0415747 |
| ENO1 | enolase 1, (alpha) | 0.0404989 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0398958 |
| EMP1 | epithelial membrane protein 1 | 0.039203 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0381151 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0374941 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0373911 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0371057 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0368609 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0362868 |
| ATP13A3 | ATPase type 13A3 | 0.0361951 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0353249 |
| HSPG2 | heparan sulfate proteoglycan 2 | 0.0351258 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0347865 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0347854 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0346679 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0345582 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0345421 |
| HERC3 | HECT and RLD domain containing E3 ubiquitin protein ligase 3 | 0.0345363 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0338059 |
| EFHD2 | EF-hand domain family, member D2 | 0.0337348 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.033544 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0335199 |
| CENPF | centromere protein F, 350/400kDa | 0.033218 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0327966 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | 0.0327506 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0327416 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0327063 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0327042 |
| SLK | STE20-like kinase | 0.0325271 |
| LMO7 | LIM domain 7 | 0.0324066 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0322559 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | 0.0320055 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0319206 |
| NEK7 | NIMA-related kinase 7 | 0.031506 |
| OGA | O-GlcNAcase | 0.0310514 |
| NAV2 | neuron navigator 2 | 0.0309489 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0308842 |
| EPHA2 | EPH receptor A2 | 0.0308656 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0308604 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0307556 |
| PKM | pyruvate kinase, muscle | 0.0307342 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0303621 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0303266 |
| PLS3 | plastin 3 | 0.0301575 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0301364 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0296147 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0295301 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0295133 |
| LNPEP | leucyl/cystinyl aminopeptidase | 0.0294934 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0293662 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0290794 |
| MYOF | myoferlin | 0.029057 |
| ANXA11 | annexin A11 | 0.028857 |
| CUL4B | cullin 4B | 0.0288295 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0288179 |
| MED13L | mediator complex subunit 13-like | 0.0285101 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.028483 |
| LAMA5 | laminin, alpha 5 | 0.0282559 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0282022 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.118102 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0780672 |
| TMSB4X | thymosin beta 4, X-linked | -0.0762346 |
| INTS6 | integrator complex subunit 6 | -0.0713609 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0509448 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0507847 |
| UBC | ubiquitin C | -0.045218 |
| STC1 | stanniocalcin 1 | -0.0448287 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0437395 |
| RPS8 | ribosomal protein S8 | -0.0424251 |
| HLA-E | major histocompatibility complex, class I, E | -0.0421701 |
| CNTNAP3 | contactin associated protein-like 3 | -0.0403157 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0383756 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0374858 |
| HM13 | histocompatibility (minor) 13 | -0.0354586 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0340974 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0324556 |
| RPS27A | ribosomal protein S27a | -0.0275944 |
| CDK13 | cyclin-dependent kinase 13 | -0.0274553 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0265114 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0264071 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0259012 |
| RPL39 | ribosomal protein L39 | -0.0258138 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0256064 |
| MYO9A | myosin IXA | -0.0255305 |
| CANX | calnexin | -0.0249916 |
| ARF1 | ADP-ribosylation factor 1 | -0.0239681 |
| RPL8 | ribosomal protein L8 | -0.0230823 |
| ATM | ATM serine/threonine kinase | -0.0228468 |
| HMGA2 | high mobility group AT-hook 2 | -0.0224223 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0223446 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0220252 |
| RPL30 | ribosomal protein L30 | -0.0218095 |
| RPLP1 | ribosomal protein, large, P1 | -0.021796 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0210075 |
| THBD | thrombomodulin | -0.0207953 |
| AGO3 | argonaute RISC catalytic component 3 | -0.0199718 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0194902 |
| FOXP1 | forkhead box P1 | -0.01944 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0192282 |
| EXOC4 | exocyst complex component 4 | -0.0190505 |
| RPL34 | ribosomal protein L34 | -0.0188172 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.018714 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0186322 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0184665 |
| RPS12 | ribosomal protein S12 | -0.0183354 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0182674 |
| HDAC9 | histone deacetylase 9 | -0.0181869 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0180654 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0179223 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0178365 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0176665 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0175701 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0174172 |
| ATG7 | autophagy related 7 | -0.0173225 |
| RPL12 | ribosomal protein L12 | -0.0172645 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0168799 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0166554 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0165015 |
| CTBP2 | C-terminal binding protein 2 | -0.016433 |
| GOLGB1 | golgin B1 | -0.0163944 |
| MECOM | MDS1 and EVI1 complex locus | -0.0163366 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.016291 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0162092 |
| PALLD | palladin, cytoskeletal associated protein | -0.0158731 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0157782 |
| RPLP0 | ribosomal protein, large, P0 | -0.0156807 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0156803 |
| DOK5 | docking protein 5 | -0.0156521 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0155987 |
| GNAS | GNAS complex locus | -0.0152434 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0150537 |
| RPS23 | ribosomal protein S23 | -0.0149572 |
| OSMR | oncostatin M receptor | -0.0148888 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0148616 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0148504 |
| RRBP1 | ribosome binding protein 1 | -0.0148245 |
| ZRANB2 | zinc finger, RAN-binding domain containing 2 | -0.0148009 |
| SQSTM1 | sequestosome 1 | -0.0146678 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0144691 |
| JAK1 | Janus kinase 1 | -0.014458 |
| RPL23 | ribosomal protein L23 | -0.0144372 |
| HDAC8 | histone deacetylase 8 | -0.0144184 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0143503 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0143499 |
| RACK1 | receptor for activated C kinase 1 | -0.014289 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.014233 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0142 |
| S100A10 | S100 calcium binding protein A10 | -0.0141287 |
| HIP1 | huntingtin interacting protein 1 | -0.0140944 |
| MTAP | methylthioadenosine phosphorylase | -0.0140884 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0140599 |
| KRT17 | keratin 17, type I | -0.014007 |
| PGM3 | phosphoglucomutase 3 | -0.0138903 |
| EFNA5 | ephrin-A5 | -0.0136994 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0136874 |
| EHBP1 | EH domain binding protein 1 | -0.0135635 |
| RPS25 | ribosomal protein S25 | -0.0135443 |
| RPL27A | ribosomal protein L27a | -0.0134024 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.013379 |
