| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.218617 |
| AHNAK | AHNAK nucleoprotein | 0.121456 |
| NDRG1 | N-myc downstream regulated 1 | 0.0947105 |
| ANLN | anillin, actin binding protein | 0.0882604 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0876281 |
| DSCAM | Down syndrome cell adhesion molecule | 0.086742 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0818579 |
| PGK1 | phosphoglycerate kinase 1 | 0.0730467 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0730356 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.067461 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.0663441 |
| FAM13A | family with sequence similarity 13, member A | 0.0649691 |
| PCBP2 | poly(rC) binding protein 2 | 0.0644062 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0621843 |
| ZNF292 | zinc finger protein 292 | 0.0602286 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0600182 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.059702 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0581961 |
| DSPP | dentin sialophosphoprotein | 0.0572723 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0542865 |
| ITGA6 | integrin, alpha 6 | 0.0530095 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0527496 |
| HYOU1 | hypoxia up-regulated 1 | 0.0518634 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0517014 |
| FAT1 | FAT atypical cadherin 1 | 0.0506872 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.050351 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.049441 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0492014 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0490165 |
| RBM39 | RNA binding motif protein 39 | 0.0481144 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0472591 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.046916 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0463862 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0462558 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0462496 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0460474 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0455299 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0449167 |
| HELZ | helicase with zinc finger | 0.0434148 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0429251 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0426431 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0425967 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0419073 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0415672 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0410862 |
| OGA | O-GlcNAcase | 0.0408908 |
| ESRP1 | epithelial splicing regulatory protein 1 | 0.0407304 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0402255 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0399913 |
| ANXA1 | annexin A1 | 0.0391709 |
| XPO1 | exportin 1 | 0.0384442 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0372953 |
| ANXA11 | annexin A11 | 0.0370869 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0370166 |
| PLEC | plectin | 0.036665 |
| ARF4 | ADP-ribosylation factor 4 | 0.0365278 |
| CCNY | cyclin Y | 0.0362842 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0362781 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0358677 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0352091 |
| YEATS2 | YEATS domain containing 2 | 0.0351629 |
| FNIP1 | folliculin interacting protein 1 | 0.0351053 |
| VEGFA | vascular endothelial growth factor A | 0.0350199 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0350155 |
| SPAG9 | sperm associated antigen 9 | 0.0347314 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.034325 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0342958 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0337952 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0336853 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0333886 |
| NUP58 | nucleoporin 58 | 0.0330904 |
| SNX9 | sorting nexin 9 | 0.0325291 |
| EZR | ezrin | 0.0324519 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | 0.0323939 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0320587 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0317467 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0316796 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0316772 |
| APP | amyloid beta (A4) precursor protein | 0.0315446 |
| WDR45B | WD repeat domain 45B | 0.0314136 |
| CDK19 | cyclin-dependent kinase 19 | 0.0313534 |
| PRELID2 | PRELI domain containing 2 | 0.0312549 |
| GOLGA4 | golgin A4 | 0.0309594 |
| SUN1 | Sad1 and UNC84 domain containing 1 | 0.030671 |
| H1-0 | H1.0 linker histone | 0.030513 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0304855 |
| CCNL1 | cyclin L1 | 0.0304758 |
| KRT8 | keratin 8, type II | 0.0303415 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0297937 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0294301 |
| TMEM123 | transmembrane protein 123 | 0.0293185 |
| SNX13 | sorting nexin 13 | 0.0291361 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0285123 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0285071 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0283399 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0282336 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0281962 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0279859 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0278244 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0277773 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NPSR1 | neuropeptide S receptor 1 | -0.123738 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0855212 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0726721 |
| AGR2 | anterior gradient 2 | -0.0706729 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0644468 |
| PTMA | prothymosin, alpha | -0.0626987 |
| RPS6 | ribosomal protein S6 | -0.0549992 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0536399 |
| RPL35A | ribosomal protein L35a | -0.0529897 |
| RPLP1 | ribosomal protein, large, P1 | -0.0456046 |
| S100A6 | S100 calcium binding protein A6 | -0.0413867 |
| RPS25 | ribosomal protein S25 | -0.040314 |
| RPS8 | ribosomal protein S8 | -0.0394148 |
| S100A10 | S100 calcium binding protein A10 | -0.0385348 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0361409 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0350849 |
| RPL34 | ribosomal protein L34 | -0.0346092 |
| ACTG1 | actin gamma 1 | -0.0312649 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.030505 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0284937 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0279484 |
| HMGB1 | high mobility group box 1 | -0.0278934 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0275095 |
| POF1B | premature ovarian failure, 1B | -0.0270642 |
| RPL11 | ribosomal protein L11 | -0.027015 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0265326 |
| SP100 | SP100 nuclear antigen | -0.0255408 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0254883 |
| RPL39 | ribosomal protein L39 | -0.0251788 |
| HLA-B | major histocompatibility complex, class I, B | -0.0251457 |
| RPL38 | ribosomal protein L38 | -0.0250347 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0245228 |
| LCN2 | lipocalin 2 | -0.0243471 |
| RPS24 | ribosomal protein S24 | -0.0232253 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0229762 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0227117 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0225445 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0222377 |
| PLSCR1 | phospholipid scramblase 1 | -0.0220341 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0219402 |
| GALNT5 | polypeptide N-acetylgalactosaminyltransferase 5 | -0.0215084 |
| RPL23 | ribosomal protein L23 | -0.021414 |
| RPS27A | ribosomal protein S27a | -0.0210512 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0210391 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0209153 |
| TMSB4X | thymosin beta 4, X-linked | -0.0208872 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0208519 |
| MYO1E | myosin IE | -0.0207181 |
| BPTF | bromodomain PHD finger transcription factor | -0.0203859 |
| IER3 | immediate early response 3 | -0.0203688 |
| RRBP1 | ribosome binding protein 1 | -0.0203241 |
| WWOX | WW domain containing oxidoreductase | -0.0203154 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0201508 |
| CCND1 | cyclin D1 | -0.0200541 |
| RPLP0 | ribosomal protein, large, P0 | -0.0198201 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.019777 |
| CDK6 | cyclin-dependent kinase 6 | -0.0196788 |
| EHBP1 | EH domain binding protein 1 | -0.0195508 |
| GNAS | GNAS complex locus | -0.0195078 |
| PRSS3 | protease, serine, 3 | -0.0191399 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0189517 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.018884 |
| EPCAM | epithelial cell adhesion molecule | -0.0188612 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0187869 |
| CBX3 | chromobox homolog 3 | -0.0185236 |
| INTS6 | integrator complex subunit 6 | -0.0183742 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0183652 |
| DEK | DEK proto-oncogene | -0.0183364 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0182582 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0181591 |
| ARF1 | ADP-ribosylation factor 1 | -0.0179648 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0179417 |
| MYO1D | myosin ID | -0.0171811 |
| RPL9 | ribosomal protein L9 | -0.0171227 |
| SH3D19 | SH3 domain containing 19 | -0.0170462 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0169918 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0168894 |
| ATM | ATM serine/threonine kinase | -0.0168722 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0167738 |
| RPS10 | ribosomal protein S10 | -0.0166184 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0165679 |
| MTAP | methylthioadenosine phosphorylase | -0.016522 |
| TCF12 | transcription factor 12 | -0.0164983 |
| PHF14 | PHD finger protein 14 | -0.0164936 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0164794 |
| RPS21 | ribosomal protein S21 | -0.0164668 |
| S100A9 | S100 calcium binding protein A9 | -0.0163594 |
| RPL8 | ribosomal protein L8 | -0.0163475 |
| COMMD10 | COMM domain containing 10 | -0.016339 |
| XAF1 | XIAP associated factor 1 | -0.0161277 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0159848 |
| RPS23 | ribosomal protein S23 | -0.0159406 |
| VCL | vinculin | -0.0159142 |
| RPL26 | ribosomal protein L26 | -0.0158446 |
| GPX2 | glutathione peroxidase 2 | -0.0157658 |
| CDK12 | cyclin-dependent kinase 12 | -0.0157362 |
| RIGI | RNA sensor RIG-I | -0.0156537 |
| TRIM56 | tripartite motif containing 56 | -0.0155611 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0155378 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0154482 |
