| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.181868 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.18017 |
| FAT1 | FAT atypical cadherin 1 | 0.108582 |
| PGK1 | phosphoglycerate kinase 1 | 0.1053 |
| LMO7 | LIM domain 7 | 0.0928671 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0888309 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0885046 |
| FLNB | filamin B, beta | 0.0884602 |
| MED13L | mediator complex subunit 13-like | 0.0771482 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0768884 |
| AHNAK | AHNAK nucleoprotein | 0.0752418 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0747654 |
| RBM39 | RNA binding motif protein 39 | 0.0712735 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0706673 |
| KRT8 | keratin 8, type II | 0.0679761 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0675443 |
| RNF145 | ring finger protein 145 | 0.0673994 |
| ITGA6 | integrin, alpha 6 | 0.0646132 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0641935 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0621117 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.061957 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0616778 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0616114 |
| FAM13A | family with sequence similarity 13, member A | 0.0613863 |
| RREB1 | ras responsive element binding protein 1 | 0.0611987 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0610936 |
| MYO5B | myosin VB | 0.0590845 |
| TFG | TRK-fused gene | 0.058487 |
| ZNF292 | zinc finger protein 292 | 0.0577452 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0575681 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0557454 |
| PARD3 | par-3 family cell polarity regulator | 0.0555194 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0547276 |
| CCNY | cyclin Y | 0.0542992 |
| EREG | epiregulin | 0.0541878 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.053935 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0538224 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.053692 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0528886 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0520761 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0519521 |
| TXNIP | thioredoxin interacting protein | 0.0519017 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0505004 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0488666 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0476891 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0474257 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0473178 |
| PCBP2 | poly(rC) binding protein 2 | 0.0468538 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0468191 |
| ANXA2 | annexin A2 | 0.0466196 |
| WDR45B | WD repeat domain 45B | 0.0456859 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0455265 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0440778 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0433497 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0432328 |
| NUP58 | nucleoporin 58 | 0.0430526 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0429557 |
| ENO1 | enolase 1, (alpha) | 0.0424274 |
| RAB1A | RAB1A, member RAS oncogene family | 0.04219 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.041929 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.041668 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0415696 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0414915 |
| RLF | rearranged L-myc fusion | 0.0411698 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0401685 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0390883 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0389596 |
| YME1L1 | YME1-like 1 ATPase | 0.0387772 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.038694 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0386777 |
| SPAG9 | sperm associated antigen 9 | 0.0386736 |
| B2M | beta-2-microglobulin | 0.0380212 |
| LRRC1 | leucine rich repeat containing 1 | 0.0380044 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0379223 |
| DSPP | dentin sialophosphoprotein | 0.0378922 |
| NCKAP1 | NCK-associated protein 1 | 0.0378573 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0377393 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0375282 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0375054 |
| OGA | O-GlcNAcase | 0.0372763 |
| HELZ | helicase with zinc finger | 0.0369968 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0366818 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0365295 |
| USP3 | ubiquitin specific peptidase 3 | 0.0364916 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0363965 |
| APP | amyloid beta (A4) precursor protein | 0.0360107 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0359801 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0358517 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0354532 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0353074 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0348086 |
| FNBP1L | formin binding protein 1-like | 0.0346034 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0345205 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.034463 |
| COPA | coatomer protein complex, subunit alpha | 0.0344622 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0340599 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0340077 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.033966 |
| VEGFA | vascular endothelial growth factor A | 0.0338176 |
| CALR | calreticulin | 0.0335306 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.19148 |
| PTMA | prothymosin, alpha | -0.110109 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0788472 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0718645 |
| NPSR1 | neuropeptide S receptor 1 | -0.0655994 |
| RPLP1 | ribosomal protein, large, P1 | -0.0627112 |
| FTL | ferritin, light polypeptide | -0.0452972 |
| RPS6 | ribosomal protein S6 | -0.0448584 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0393705 |
| RPS8 | ribosomal protein S8 | -0.0379619 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0369979 |
| RPL34 | ribosomal protein L34 | -0.0356957 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0346681 |
| RPS23 | ribosomal protein S23 | -0.0344823 |
| RPLP0 | ribosomal protein, large, P0 | -0.0341425 |
| HMGB1 | high mobility group box 1 | -0.0340423 |
| ACTG1 | actin gamma 1 | -0.0339617 |
| RPL35A | ribosomal protein L35a | -0.0335482 |
| RPL8 | ribosomal protein L8 | -0.0331798 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0285638 |
| AGR2 | anterior gradient 2 | -0.0274033 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0271616 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0270391 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0261325 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0252638 |
| RPS14 | ribosomal protein S14 | -0.0242945 |
| CADPS | Ca++-dependent secretion activator | -0.0241672 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0240152 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0230057 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.02236 |
| CCND1 | cyclin D1 | -0.0218531 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0206676 |
| EPCAM | epithelial cell adhesion molecule | -0.0201159 |
| RPL11 | ribosomal protein L11 | -0.0195352 |
| DEK | DEK proto-oncogene | -0.0192093 |
| RPL32 | ribosomal protein L32 | -0.0190186 |
| CENPF | centromere protein F, 350/400kDa | -0.0186823 |
| KIF5B | kinesin family member 5B | -0.0186079 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0182423 |
| FRMD5 | FERM domain containing 5 | -0.0181181 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0180319 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.017942 |
| GOLGB1 | golgin B1 | -0.017743 |
| HMGA1 | high mobility group AT-hook 1 | -0.017643 |
| PKP4 | plakophilin 4 | -0.0175496 |
| BPTF | bromodomain PHD finger transcription factor | -0.0175009 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0174866 |
| RPS15 | ribosomal protein S15 | -0.0173023 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0172168 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0170637 |
| RRBP1 | ribosome binding protein 1 | -0.0168888 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0166608 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.0163373 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0162827 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0162307 |
| MT2A | metallothionein 2A | -0.0157363 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0157309 |
| PHF14 | PHD finger protein 14 | -0.0156529 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0155275 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0149712 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0149016 |
| ASTN2 | astrotactin 2 | -0.0147309 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | -0.0147139 |
| RPS27 | ribosomal protein S27 | -0.0144587 |
| RPL28 | ribosomal protein L28 | -0.0144539 |
| TNS4 | tensin 4 | -0.0143736 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0143727 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0143657 |
| TBCA | tubulin folding cofactor A | -0.0141816 |
| MYL12B | myosin, light chain 12B, regulatory | -0.013984 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0139355 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0139122 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0138237 |
| EPHB2 | EPH receptor B2 | -0.0137996 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0136534 |
| UBXN4 | UBX domain protein 4 | -0.0136127 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0136117 |
| GPHN | gephyrin | -0.0136081 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0135706 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0135537 |
| RPS2 | ribosomal protein S2 | -0.0135524 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0135281 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0133981 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0133778 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0133371 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0132422 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0132338 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0132325 |
| RPS25 | ribosomal protein S25 | -0.0132287 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0132246 |
| S100A10 | S100 calcium binding protein A10 | -0.0131435 |
| RPS21 | ribosomal protein S21 | -0.0128334 |
| RPL19 | ribosomal protein L19 | -0.01279 |
| ZNF106 | zinc finger protein 106 | -0.0127726 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0126699 |
| RPS29 | ribosomal protein S29 | -0.0126287 |
| MECOM | MDS1 and EVI1 complex locus | -0.0126116 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.0125111 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0124024 |
| RESF1 | retroelement silencing factor 1 | -0.0123678 |
