| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.158866 |
| PTMA | prothymosin, alpha | 0.142191 |
| TMSB10 | thymosin beta 10 | 0.106469 |
| PGK1 | phosphoglycerate kinase 1 | 0.100871 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0936036 |
| AHNAK | AHNAK nucleoprotein | 0.0853329 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0734547 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0663863 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0655835 |
| FMNL2 | formin-like 2 | 0.0653493 |
| SPAG9 | sperm associated antigen 9 | 0.0632101 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0619037 |
| APP | amyloid beta (A4) precursor protein | 0.0611847 |
| OGA | O-GlcNAcase | 0.0609892 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0606581 |
| POTEF | POTE ankyrin domain family, member F | 0.0578798 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0564988 |
| CAPRIN2 | caprin family member 2 | 0.0557331 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0540712 |
| DST | dystonin | 0.0528295 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0520921 |
| RAI1 | retinoic acid induced 1 | 0.0517039 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0506301 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0495086 |
| RPS3 | ribosomal protein S3 | 0.049216 |
| XPO1 | exportin 1 | 0.047983 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0478615 |
| ZNF292 | zinc finger protein 292 | 0.0466338 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0456336 |
| MT2A | metallothionein 2A | 0.044247 |
| EZR | ezrin | 0.0440911 |
| PCBP2 | poly(rC) binding protein 2 | 0.0439657 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0436164 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0427974 |
| SRPK2 | SRSF protein kinase 2 | 0.0420052 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0417267 |
| RPL35A | ribosomal protein L35a | 0.0413389 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.041002 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.040436 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0402461 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0401276 |
| RBM39 | RNA binding motif protein 39 | 0.0392461 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0391798 |
| CCNL1 | cyclin L1 | 0.0383003 |
| RPS6 | ribosomal protein S6 | 0.0372059 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0368892 |
| HELZ | helicase with zinc finger | 0.0366213 |
| FLNB | filamin B, beta | 0.0365908 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0362732 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.036079 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.03601 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0359674 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0351496 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.035113 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0346384 |
| RPL37A | ribosomal protein L37a | 0.034308 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0342663 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0338675 |
| RPL27 | ribosomal protein L27 | 0.0335828 |
| DSCAM | Down syndrome cell adhesion molecule | 0.033437 |
| FNIP1 | folliculin interacting protein 1 | 0.0327635 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0326181 |
| NUP58 | nucleoporin 58 | 0.0325008 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0322928 |
| RPL18 | ribosomal protein L18 | 0.0322382 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0319625 |
| FTL | ferritin, light polypeptide | 0.0318385 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0317273 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0313856 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0311142 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0310269 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0309159 |
| TOP1 | topoisomerase (DNA) I | 0.0308279 |
| ANLN | anillin, actin binding protein | 0.0305128 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0305018 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0300643 |
| WAC | WW domain containing adaptor with coiled-coil | 0.030024 |
| MATR3 | matrin 3 | 0.0299847 |
| TPI1 | triosephosphate isomerase 1 | 0.0298912 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0298112 |
| RPL5 | ribosomal protein L5 | 0.0297067 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0296716 |
| RPLP2 | ribosomal protein, large, P2 | 0.0293671 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0291997 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.029152 |
| ECT2 | epithelial cell transforming 2 | 0.0289327 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0287534 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0287072 |
| RPL36 | ribosomal protein L36 | 0.0285661 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0285442 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0283466 |
| ENO1 | enolase 1, (alpha) | 0.0280541 |
| PER1 | period circadian clock 1 | 0.0280115 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0278987 |
| UBE2G1 | ubiquitin-conjugating enzyme E2G 1 | 0.0278577 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0278452 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0278083 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0278033 |
| TXNIP | thioredoxin interacting protein | 0.027482 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0274458 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.193928 |
| VIM | vimentin | -0.15923 |
| TP63 | tumor protein p63 | -0.150626 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.132594 |
| TXNRD1 | thioredoxin reductase 1 | -0.102791 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0984458 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0865135 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0725222 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0700807 |
| TMSB4X | thymosin beta 4, X-linked | -0.0693358 |
| CD44 | CD44 molecule (Indian blood group) | -0.0540656 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0512753 |
| CADM2 | cell adhesion molecule 2 | -0.0480808 |
| UBC | ubiquitin C | -0.047504 |
| DPYD | dihydropyrimidine dehydrogenase | -0.043738 |
| EHBP1 | EH domain binding protein 1 | -0.0430003 |
| RIGI | RNA sensor RIG-I | -0.0402007 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0393581 |
| PDE10A | phosphodiesterase 10A | -0.0350209 |
| SP100 | SP100 nuclear antigen | -0.0347613 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0345551 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0327741 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0325228 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0322193 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0317664 |
| HDAC9 | histone deacetylase 9 | -0.0303793 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.028962 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0287609 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | -0.0283208 |
| TNS3 | tensin 3 | -0.0280879 |
| BPTF | bromodomain PHD finger transcription factor | -0.0279994 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0267172 |
| PLSCR1 | phospholipid scramblase 1 | -0.0266359 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0262786 |
| MT1E | metallothionein 1E | -0.026274 |
| DPH6 | diphthamine biosynthesis 6 | -0.025784 |
| MT1X | metallothionein 1X | -0.0252336 |
| JUN | jun proto-oncogene | -0.0252003 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0251299 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0244825 |
| VMP1 | vacuole membrane protein 1 | -0.0243893 |
| NEK10 | NIMA-related kinase 10 | -0.0242467 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0241068 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0240754 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0237754 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0230443 |
| DNER | delta/notch-like EGF repeat containing | -0.0229951 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0225569 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0223943 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0221466 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0216771 |
| EMP1 | epithelial membrane protein 1 | -0.0216727 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.021627 |
| INTS6 | integrator complex subunit 6 | -0.0214285 |
| HLA-B | major histocompatibility complex, class I, B | -0.0213206 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0212744 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0207472 |
| DNTTIP1 | deoxynucleotidyltransferase, terminal, interacting protein 1 | -0.020721 |
| CMIP | c-Maf inducing protein | -0.0202296 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.020147 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0198095 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0197032 |
| OSMR | oncostatin M receptor | -0.0194673 |
| MYO9A | myosin IXA | -0.0194124 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0189888 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0187844 |
| TRIM56 | tripartite motif containing 56 | -0.0187102 |
| AEBP2 | AE binding protein 2 | -0.0186474 |
| ZNF638 | zinc finger protein 638 | -0.0184486 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0183839 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0183062 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0179836 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0176878 |
| HMGB1 | high mobility group box 1 | -0.0176405 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0175413 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0175142 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0174879 |
| ATM | ATM serine/threonine kinase | -0.0172075 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0171292 |
| RPS27A | ribosomal protein S27a | -0.0167907 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0167018 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0166587 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0165144 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0165025 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0164102 |
| ERCC1 | excision repair cross-complementation group 1 | -0.016318 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.016225 |
| STK17A | serine/threonine kinase 17a | -0.0160891 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.016041 |
| ATG7 | autophagy related 7 | -0.0160128 |
| RGS4 | regulator of G-protein signaling 4 | -0.0157658 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0157218 |
| AHI1 | Abelson helper integration site 1 | -0.0156531 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0154284 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0154012 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0152934 |
| HDAC8 | histone deacetylase 8 | -0.0152025 |
| COMMD10 | COMM domain containing 10 | -0.0150308 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0150215 |
| GOLGB1 | golgin B1 | -0.0148546 |
