| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.177283 |
| NDRG1 | N-myc downstream regulated 1 | 0.166985 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.114942 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0777224 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.07769 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0675116 |
| SLTM | SAFB-like, transcription modulator | 0.060567 |
| PGK1 | phosphoglycerate kinase 1 | 0.0592171 |
| MCL1 | myeloid cell leukemia 1 | 0.0577012 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0547561 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0520925 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0518485 |
| LAMC2 | laminin, gamma 2 | 0.0501963 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0501917 |
| FAM13A | family with sequence similarity 13, member A | 0.0495427 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0492924 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0477873 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0471884 |
| SMAD3 | SMAD family member 3 | 0.046298 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0447595 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0447348 |
| PKM | pyruvate kinase, muscle | 0.0444697 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0439262 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0438743 |
| ATP13A3 | ATPase type 13A3 | 0.042955 |
| AHNAK | AHNAK nucleoprotein | 0.0426681 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0419209 |
| PCBP2 | poly(rC) binding protein 2 | 0.041578 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0409837 |
| RUNX1 | runt-related transcription factor 1 | 0.039698 |
| ENO1 | enolase 1, (alpha) | 0.0390447 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0386622 |
| RPS3 | ribosomal protein S3 | 0.0376692 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0372767 |
| ANXA5 | annexin A5 | 0.0365113 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0363616 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.036178 |
| TMSB10 | thymosin beta 10 | 0.0328452 |
| NPTN | neuroplastin | 0.0325996 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0325248 |
| ASPH | aspartate beta-hydroxylase | 0.0321139 |
| MYOF | myoferlin | 0.0320576 |
| TPD52 | tumor protein D52 | 0.032001 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0312986 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0309757 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0308949 |
| LAMB3 | laminin, beta 3 | 0.0303259 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0296048 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0288161 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0287469 |
| LAMA4 | laminin, alpha 4 | 0.0286686 |
| ARRDC3 | arrestin domain containing 3 | 0.0278883 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0278114 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0277342 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0268581 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0268395 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0267461 |
| HELZ | helicase with zinc finger | 0.0267237 |
| NGLY1 | N-glycanase 1 | 0.0265646 |
| ANXA2 | annexin A2 | 0.0261047 |
| UVRAG | UV radiation resistance associated | 0.0258106 |
| DTNA | dystrobrevin, alpha | 0.0257684 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0254588 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0247579 |
| NCKAP1 | NCK-associated protein 1 | 0.0243496 |
| APP | amyloid beta (A4) precursor protein | 0.0242914 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0241788 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.024129 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0240735 |
| SNX9 | sorting nexin 9 | 0.0237257 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0236718 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0236077 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0235284 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0235047 |
| FLNB | filamin B, beta | 0.0231412 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0229643 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0224914 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0223975 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0222094 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0220818 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0220704 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0217058 |
| LMO7 | LIM domain 7 | 0.0215706 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0215593 |
| RASA2 | RAS p21 protein activator 2 | 0.0214746 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0213051 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0212279 |
| GPC6 | glypican 6 | 0.0210361 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0209311 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0208012 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0206646 |
| CDCP1 | CUB domain containing protein 1 | 0.0205236 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0201759 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0201547 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0199569 |
| SEC61G | Sec61 gamma subunit | 0.0198112 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0197507 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0194931 |
| RNF145 | ring finger protein 145 | 0.0194819 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0193743 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.154965 |
| TXNRD1 | thioredoxin reductase 1 | -0.0931803 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0639642 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0443308 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0344275 |
| RPLP1 | ribosomal protein, large, P1 | -0.0271135 |
| RPLP0 | ribosomal protein, large, P0 | -0.0249436 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0242887 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0239948 |
| GOLGB1 | golgin B1 | -0.0239572 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0238458 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0223643 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0218552 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0200605 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0190324 |
| FTL | ferritin, light polypeptide | -0.0188666 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0182971 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0179645 |
| RPL8 | ribosomal protein L8 | -0.0165578 |
| SEC24D | SEC24 family member D | -0.0160126 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0157295 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0152225 |
| S100A10 | S100 calcium binding protein A10 | -0.0151 |
| TKT | transketolase | -0.0149799 |
| GNAS | GNAS complex locus | -0.0146545 |
| ABLIM1 | actin binding LIM protein 1 | -0.0144806 |
| H1-0 | H1.0 linker histone | -0.0143782 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.0139304 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0137965 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0137673 |
| RPL34 | ribosomal protein L34 | -0.013633 |
| CANX | calnexin | -0.0134849 |
| CCNI | cyclin I | -0.0131966 |
| AGR2 | anterior gradient 2 | -0.0131414 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0131285 |
| MGST1 | microsomal glutathione S-transferase 1 | -0.0130454 |
| SMIM14 | small integral membrane protein 14 | -0.0129477 |
| RPS6 | ribosomal protein S6 | -0.0127611 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0127404 |
| HDLBP | high density lipoprotein binding protein | -0.0126909 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0124578 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0124297 |
| PTMA | prothymosin, alpha | -0.0122442 |
| SRP72 | signal recognition particle 72kDa | -0.0120584 |
| FRMD4B | FERM domain containing 4B | -0.0119308 |
| NDE1 | nudE neurodevelopment protein 1 | -0.0117883 |
| MT1X | metallothionein 1X | -0.0116936 |
| EMP1 | epithelial membrane protein 1 | -0.0115056 |
| RPS24 | ribosomal protein S24 | -0.011476 |
| ARF1 | ADP-ribosylation factor 1 | -0.0112783 |
| UBE4A | ubiquitination factor E4A | -0.0111513 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0110238 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.01094 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0108487 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0107843 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0107725 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0102829 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0102046 |
| RPS8 | ribosomal protein S8 | -0.0100005 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0098928 |
| WASF2 | WAS protein family, member 2 | -0.00982067 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0097269 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.00969971 |
| PATJ | PATJ crumbs cell polarity complex component | -0.00964681 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.00963051 |
| LOC112694756 | uncharaterized LOC112694756 | -0.00958895 |
| MGAT4C | MGAT4 family, member C | -0.00927752 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.00924923 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.00924007 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00923579 |
| TRIM56 | tripartite motif containing 56 | -0.00919764 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.00915755 |
| ARCN1 | archain 1 | -0.00913976 |
| ALG11 | ALG11, alpha-1,2-mannosyltransferase | -0.00913588 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.00892142 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00886637 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.00886069 |
| CCDC186 | coiled-coil domain containing 186 | -0.00875773 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0087 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.00863174 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.00859139 |
| RPS23 | ribosomal protein S23 | -0.00850893 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.00847137 |
| NCOA7 | nuclear receptor coactivator 7 | -0.00842902 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0083911 |
| HLA-B | major histocompatibility complex, class I, B | -0.00832015 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.00816803 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.00816713 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.00812671 |
| ECD | ecdysoneless homolog (Drosophila) | -0.00809926 |
| CPE | carboxypeptidase E | -0.00802827 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00800238 |
| RAB1A | RAB1A, member RAS oncogene family | -0.00789684 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.00786514 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.00783406 |
| IER3 | immediate early response 3 | -0.00781242 |
| RBBP6 | retinoblastoma binding protein 6 | -0.00777491 |
| CST3 | cystatin C | -0.00760297 |
| YME1L1 | YME1-like 1 ATPase | -0.00759679 |
| MLEC | malectin | -0.00751384 |
