Roxadustat_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.138161
FNDC3B fibronectin type III domain containing 3B 0.130792
PCBP2 poly(rC) binding protein 2 0.116043
GRB10 growth factor receptor-bound protein 10 0.102587
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0947801
SDK1 sidekick cell adhesion molecule 1 0.0942527
FAM13A family with sequence similarity 13, member A 0.0842585
RICTOR RPTOR independent companion of MTOR, complex 2 0.0815998
KDM3A lysine (K)-specific demethylase 3A 0.0805082
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0740464
PDE4D phosphodiesterase 4D, cAMP-specific 0.0711276
ATP13A3 ATPase type 13A3 0.0708564
UBA6 ubiquitin-like modifier activating enzyme 6 0.0674025
ELL2 elongation factor, RNA polymerase II, 2 0.0647121
SOD2 superoxide dismutase 2, mitochondrial 0.0617182
KDM2A lysine (K)-specific demethylase 2A 0.0564396
NDRG1 N-myc downstream regulated 1 0.0552396
TRIO trio Rho guanine nucleotide exchange factor 0.0539475
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0508582
SMAD3 SMAD family member 3 0.0502364
RBM39 RNA binding motif protein 39 0.0501338
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0490584
ZNF292 zinc finger protein 292 0.0480115
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0470369
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0469824
NAV2 neuron navigator 2 0.0461882
PRELID2 PRELI domain containing 2 0.0456791
PGK1 phosphoglycerate kinase 1 0.045627
ENO1 enolase 1, (alpha) 0.0450979
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0450031
KMT2C lysine (K)-specific methyltransferase 2C 0.0435759
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.042438
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0417848
HELZ helicase with zinc finger 0.0417632
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0406345
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.040292
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.040271
NBAS neuroblastoma amplified sequence 0.0398146
PIAS2 protein inhibitor of activated STAT, 2 0.0392627
AHNAK AHNAK nucleoprotein 0.0390655
RAB8B RAB8B, member RAS oncogene family 0.0390052
FN1 fibronectin 1 0.0385713
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0382756
MYH9 myosin, heavy chain 9, non-muscle 0.038145
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0377876
LOX lysyl oxidase 0.0372847
USP34 ubiquitin specific peptidase 34 0.0360621
SIK3 SIK family kinase 3 0.0359761
FLNB filamin B, beta 0.0357615
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0354575
RUNX1 runt-related transcription factor 1 0.03529
PTK2 protein tyrosine kinase 2 0.035056
USP3 ubiquitin specific peptidase 3 0.0349984
ANKRD11 ankyrin repeat domain 11 0.0349513
ZFAND3 zinc finger, AN1-type domain 3 0.0341215
PFKP phosphofructokinase, platelet 0.0336775
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0335976
MYO1B myosin IB 0.0333817
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0333798
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0333523
APP amyloid beta (A4) precursor protein 0.032979
OGA O-GlcNAcase 0.0328885
GPC6 glypican 6 0.0327755
UGCG UDP-glucose ceramide glucosyltransferase 0.0315628
AKAP13 A kinase (PRKA) anchor protein 13 0.0311248
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0305582
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0295053
RIOK3 RIO kinase 3 0.0290241
WAC WW domain containing adaptor with coiled-coil 0.0289652
ESYT2 extended synaptotagmin-like protein 2 0.0286161
MAP2K1 mitogen-activated protein kinase kinase 1 0.0285056
CD109 CD109 molecule 0.0284408
RNF145 ring finger protein 145 0.0281696
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0281164
PICALM phosphatidylinositol binding clathrin assembly protein 0.0279935
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0278846
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0276195
RLF rearranged L-myc fusion 0.0275744
HOOK2 hook microtubule-tethering protein 2 0.0275727
NGLY1 N-glycanase 1 0.0274505
ADAM17 ADAM metallopeptidase domain 17 0.0273941
SETD5 SET domain containing 5 0.0270805
SPRED2 sprouty-related, EVH1 domain containing 2 0.0266928
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0266224
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0264713
PARD3 par-3 family cell polarity regulator 0.0264261
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0262884
CDC73 cell division cycle 73 0.0262728
CORO1C coronin, actin binding protein, 1C 0.0262284
BIRC6 baculoviral IAP repeat containing 6 0.0261636
STRN3 striatin, calmodulin binding protein 3 0.026071
JARID2 jumonji, AT rich interactive domain 2 0.0259369
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0255395
CHD1L chromodomain helicase DNA binding protein 1-like 0.025472
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0254354
SPAG9 sperm associated antigen 9 0.0253709
ASPH aspartate beta-hydroxylase 0.0252651
ENO2 enolase 2 (gamma, neuronal) 0.0251023
TOP1 topoisomerase (DNA) I 0.0248999
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0247407

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0993895
VIM vimentin -0.0872884
RPLP1 ribosomal protein, large, P1 -0.062354
FTL ferritin, light polypeptide -0.061549
IGFBP3 insulin-like growth factor binding protein 3 -0.0483805
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0462559
FTH1 ferritin, heavy polypeptide 1 -0.0435274
EIF1 eukaryotic translation initiation factor 1 -0.0366597
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0349529
TMSB10 thymosin beta 10 -0.0337459
NRG1 neuregulin 1 -0.0326686
RPL34 ribosomal protein L34 -0.0298125
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.029536
RPLP0 ribosomal protein, large, P0 -0.0284809
RPL35A ribosomal protein L35a -0.0282708
RPS6 ribosomal protein S6 -0.0279261
C15ORF48 chromosome 15 open reading frame 48 -0.0277492
RPS19 ribosomal protein S19 -0.0262073
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0261593
IER3 immediate early response 3 -0.0259168
TMSB4X thymosin beta 4, X-linked -0.0257121
KYNU kynureninase -0.025601
RPS8 ribosomal protein S8 -0.0242458
BTG1 B-cell translocation gene 1, anti-proliferative -0.0242147
ZBTB20 zinc finger and BTB domain containing 20 -0.0240247
RPL32 ribosomal protein L32 -0.0232139
EGR1 early growth response 1 -0.022614
RPS29 ribosomal protein S29 -0.0225731
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0222473
MT2A metallothionein 2A -0.022136
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0218355
GNAS GNAS complex locus -0.0216466
RPS21 ribosomal protein S21 -0.0213746
RPL28 ribosomal protein L28 -0.0211979
AKAP9 A kinase (PRKA) anchor protein 9 -0.0209623
RPL36 ribosomal protein L36 -0.0209104
SOS1 son of sevenless homolog 1 (Drosophila) -0.0205799
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0200878
TFPI2 tissue factor pathway inhibitor 2 -0.0200362
S100A6 S100 calcium binding protein A6 -0.0197919
GOLGB1 golgin B1 -0.0196748
EHBP1 EH domain binding protein 1 -0.0194803
RAI14 retinoic acid induced 14 -0.0192949
RPS27 ribosomal protein S27 -0.0191882
TPT1 tumor protein, translationally-controlled 1 -0.0189283
ANKRD28 ankyrin repeat domain 28 -0.018412
RPL31 ribosomal protein L31 -0.0181078
RPL37 ribosomal protein L37 -0.0180778
PTMA prothymosin, alpha -0.0180678
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0179417
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0174863
B2M beta-2-microglobulin -0.0170991
RPLP2 ribosomal protein, large, P2 -0.0169148
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0168096
RPL8 ribosomal protein L8 -0.0167924
ATM ATM serine/threonine kinase -0.0167065
MYO9A myosin IXA -0.016611
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0165595
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0164152
RSU1 Ras suppressor protein 1 -0.0164012
RPL38 ribosomal protein L38 -0.016299
MX2 MX dynamin-like GTPase 2 -0.0162489
RPL11 ribosomal protein L11 -0.0162161
SLFN5 schlafen family member 5 -0.015781
RHOBTB3 Rho-related BTB domain containing 3 -0.0156947
DPYD dihydropyrimidine dehydrogenase -0.01547
STC1 stanniocalcin 1 -0.01537
RPS13 ribosomal protein S13 -0.0152704
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 -0.0151347
RPS25 ribosomal protein S25 -0.0151112
RPS24 ribosomal protein S24 -0.0150159
BLZF1 basic leucine zipper nuclear factor 1 -0.014967
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0149373
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0148389
BPTF bromodomain PHD finger transcription factor -0.0147514
RPL23 ribosomal protein L23 -0.0147124
LOC102724023 ES1 protein homolog, mitochondrial -0.0147023
NCOA7 nuclear receptor coactivator 7 -0.0143406
ACTG1 actin gamma 1 -0.0142539
RPL19 ribosomal protein L19 -0.0142013
ANKHD1 ankyrin repeat and KH domain containing 1 -0.014199
AHI1 Abelson helper integration site 1 -0.0141371
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0139794
GOLGA3 golgin A3 -0.0138697
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.013867
RPL12 ribosomal protein L12 -0.013648
ATG7 autophagy related 7 -0.0136194
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0135648
RPS23 ribosomal protein S23 -0.0134668
MON2 MON2 homolog (S. cerevisiae) -0.0132036
FOS FBJ murine osteosarcoma viral oncogene homolog -0.013141
S100A9 S100 calcium binding protein A9 -0.0129387
ZC3H12C zinc finger CCCH-type containing 12C -0.0129383
RPL37A ribosomal protein L37a -0.012884
ARF1 ADP-ribosylation factor 1 -0.0127243
RPS14 ribosomal protein S14 -0.0127195
PRH1 proline-rich protein HaeIII subfamily 1 -0.0126698
RACK1 receptor for activated C kinase 1 -0.0125385
SLC38A1 solute carrier family 38, member 1 -0.012506
RAB1A RAB1A, member RAS oncogene family -0.0124164