Roxadustat_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 0.112931
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.108008
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.102504
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0943086
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0930014
APP amyloid beta (A4) precursor protein 0.0923019
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0871815
TRIO trio Rho guanine nucleotide exchange factor 0.0868441
AHNAK AHNAK nucleoprotein 0.0795286
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0750738
TXNRD1 thioredoxin reductase 1 0.0743652
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0729267
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0717416
PCBP2 poly(rC) binding protein 2 0.0659805
WDR43 WD repeat domain 43 0.0646881
TPD52 tumor protein D52 0.063649
PAWR PRKC, apoptosis, WT1, regulator 0.0597462
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0595171
PARD3 par-3 family cell polarity regulator 0.0558305
KDM3A lysine (K)-specific demethylase 3A 0.0555518
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0552889
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0552135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0546058
RPL4 ribosomal protein L4 0.0543539
TPM3 tropomyosin 3 0.0531179
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0530572
LPP LIM domain containing preferred translocation partner in lipoma 0.0523262
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0511794
ECT2 epithelial cell transforming 2 0.0505197
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0500246
UBASH3B ubiquitin associated and SH3 domain containing B 0.0498842
PUM1 pumilio RNA-binding family member 1 0.048063
RBM39 RNA binding motif protein 39 0.0467336
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0456907
ZFAND3 zinc finger, AN1-type domain 3 0.0453337
FMNL2 formin-like 2 0.0446388
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0431699
CHN1 chimerin 1 0.0429749
EEF2 eukaryotic translation elongation factor 2 0.0424606
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0423722
ZNF292 zinc finger protein 292 0.0422851
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0415122
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0408085
PM20D1 peptidase M20 domain containing 1 0.0404019
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0403356
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0403306
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0400486
EIF4A1 eukaryotic translation initiation factor 4A1 0.0399752
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0398845
MACF1 microtubule-actin crosslinking factor 1 0.0398683
XPO1 exportin 1 0.0395419
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0393537
HSPA8 heat shock 70kDa protein 8 0.0387914
ERRFI1 ERBB receptor feedback inhibitor 1 0.0385873
RPS3 ribosomal protein S3 0.0385867
ENO1 enolase 1, (alpha) 0.0385187
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0383038
EWSR1 EWS RNA-binding protein 1 0.0382541
ADAM9 ADAM metallopeptidase domain 9 0.037973
EIF4A2 eukaryotic translation initiation factor 4A2 0.0377292
KIF5B kinesin family member 5B 0.0376746
YBX1 Y box binding protein 1 0.0374496
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0370634
PFKP phosphofructokinase, platelet 0.0370144
SLC38A2 solute carrier family 38, member 2 0.0366142
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0364865
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0363619
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0360715
MYH9 myosin, heavy chain 9, non-muscle 0.036028
NUP58 nucleoporin 58 0.0359709
CSDE1 cold shock domain containing E1, RNA-binding 0.0359482
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0357887
HYOU1 hypoxia up-regulated 1 0.035621
ANLN anillin, actin binding protein 0.0355556
USP3 ubiquitin specific peptidase 3 0.0351775
CANX calnexin 0.0350994
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0350066
YME1L1 YME1-like 1 ATPase 0.0349735
PKM pyruvate kinase, muscle 0.034868
RPL3 ribosomal protein L3 0.0347977
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0345712
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0344719
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0338079
MARCHF6 membrane associated ring-CH-type finger 6 0.0336831
FXR1 fragile X mental retardation, autosomal homolog 1 0.033546
CCNY cyclin Y 0.0334864
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0327669
NCKAP1 NCK-associated protein 1 0.0325272
FNBP1L formin binding protein 1-like 0.0321799
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0320456
RPS12 ribosomal protein S12 0.0316545
CASC3 cancer susceptibility candidate 3 0.0316306
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0314053
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0313919
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0312726
PTK2 protein tyrosine kinase 2 0.0310566
YTHDC1 YTH domain containing 1 0.0308447
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) 0.0306576
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0306382
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0305731

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.280943
MT2A metallothionein 2A -0.150506
FTL ferritin, light polypeptide -0.104795
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.102865
FTH1 ferritin, heavy polypeptide 1 -0.0996528
PDE4D phosphodiesterase 4D, cAMP-specific -0.0847941
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0761861
IGFBP3 insulin-like growth factor binding protein 3 -0.0593572
S100A6 S100 calcium binding protein A6 -0.0538244
IGF2 insulin-like growth factor 2 -0.0528836
THSD4 thrombospondin, type I, domain containing 4 -0.0504098
EIF1 eukaryotic translation initiation factor 1 -0.0497753
ACTG1 actin gamma 1 -0.0436828
RPLP1 ribosomal protein, large, P1 -0.0407709
STC1 stanniocalcin 1 -0.039926
KYNU kynureninase -0.0374985
C15ORF48 chromosome 15 open reading frame 48 -0.0361967
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0360242
EGR1 early growth response 1 -0.0345159
HLA-B major histocompatibility complex, class I, B -0.0307559
GLIS3 GLIS family zinc finger 3 -0.0287052
RPS15 ribosomal protein S15 -0.0262113
PYGL phosphorylase, glycogen, liver -0.0258623
HMGB1 high mobility group box 1 -0.025665
NRG1 neuregulin 1 -0.0250869
CCL5 chemokine (C-C motif) ligand 5 -0.0249318
PFN1 profilin 1 -0.0248682
ARHGAP26 Rho GTPase activating protein 26 -0.0227796
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.022728
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0212857
OSMR oncostatin M receptor -0.0209865
BASP1 brain abundant, membrane attached signal protein 1 -0.0209808
CDK13 cyclin-dependent kinase 13 -0.0208901
MARCKS myristoylated alanine-rich protein kinase C substrate -0.020624
RPS29 ribosomal protein S29 -0.0205225
NNMT nicotinamide N-methyltransferase -0.0203174
TRIP11 thyroid hormone receptor interactor 11 -0.0194065
MT1X metallothionein 1X -0.0194014
RPS5 ribosomal protein S5 -0.0193937
IER3 immediate early response 3 -0.019319
S100A10 S100 calcium binding protein A10 -0.0191226
LRP10 low density lipoprotein receptor-related protein 10 -0.0190323
TM4SF1 transmembrane 4 L six family member 1 -0.0189576
ZBTB20 zinc finger and BTB domain containing 20 -0.0189266
NUMB numb homolog (Drosophila) -0.0186381
SOS1 son of sevenless homolog 1 (Drosophila) -0.018319
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0180855
ASTN2 astrotactin 2 -0.017956
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0179539
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0178982
TBCA tubulin folding cofactor A -0.0178316
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0177393
NBEAL1 neurobeachin-like 1 -0.0177008
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.017654
RPL35A ribosomal protein L35a -0.0170321
SRGN serglycin -0.0169497
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0164483
RPS23 ribosomal protein S23 -0.0164177
ALCAM activated leukocyte cell adhesion molecule -0.016378
RPS20 ribosomal protein S20 -0.0162578
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.016004
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0159847
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0159671
RPL8 ribosomal protein L8 -0.0158523
FAM177A1 family with sequence similarity 177, member A1 -0.015836
MYO1E myosin IE -0.0157462
CREBBP CREB binding protein -0.0153614
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0152254
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0152234
RPL34 ribosomal protein L34 -0.0151292
ZNF609 zinc finger protein 609 -0.0150431
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0150295
LOC102724023 ES1 protein homolog, mitochondrial -0.0148386
ATG7 autophagy related 7 -0.0145756
BTG1 B-cell translocation gene 1, anti-proliferative -0.0143278
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0142748
GPHN gephyrin -0.0142139
UBXN4 UBX domain protein 4 -0.0141822
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0141594
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0141102
VIM vimentin -0.014084
RPL28 ribosomal protein L28 -0.0140467
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0138816
HMGA2 high mobility group AT-hook 2 -0.0138578
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0138436
PRKD1 protein kinase D1 -0.0137479
MAML3 mastermind-like 3 (Drosophila) -0.0136215
LAMC2 laminin, gamma 2 -0.0135689
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0134483
MAP7 microtubule-associated protein 7 -0.0134001
MTHFD2L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like -0.013386
DST dystonin -0.0133514
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0132537
S100A11 S100 calcium binding protein A11 -0.0132235
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0131342
EHBP1 EH domain binding protein 1 -0.0130869
ANGPTL4 angiopoietin-like 4 -0.0129404
B2M beta-2-microglobulin -0.0129239
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.0128754
FOXP1 forkhead box P1 -0.0128245