| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.084775 |
| PTMA | prothymosin, alpha | 0.0686175 |
| RPL23 | ribosomal protein L23 | 0.0476644 |
| EFNA5 | ephrin-A5 | 0.0471958 |
| FN1 | fibronectin 1 | 0.046949 |
| RPL37A | ribosomal protein L37a | 0.0416303 |
| MUC16 | mucin 16, cell surface associated | 0.0410076 |
| RPS3 | ribosomal protein S3 | 0.0409372 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0398649 |
| MT2A | metallothionein 2A | 0.0397222 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0386648 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0379613 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0378055 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0367788 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0365615 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0365305 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0363685 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0352297 |
| RPS12 | ribosomal protein S12 | 0.0349151 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.034458 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0340252 |
| AHNAK | AHNAK nucleoprotein | 0.0339777 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0339677 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.0326332 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0319721 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0319099 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0314967 |
| MYO6 | myosin VI | 0.0307481 |
| PCBP2 | poly(rC) binding protein 2 | 0.0305785 |
| PDE10A | phosphodiesterase 10A | 0.0302195 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.029463 |
| CD2AP | CD2-associated protein | 0.0288878 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0286915 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0284042 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0275882 |
| H3-3B | H3.3 histone B | 0.0273912 |
| RPL35A | ribosomal protein L35a | 0.027388 |
| FAT1 | FAT atypical cadherin 1 | 0.0273617 |
| TMSB10 | thymosin beta 10 | 0.0269725 |
| ZNF638 | zinc finger protein 638 | 0.0268593 |
| CDCP1 | CUB domain containing protein 1 | 0.0267445 |
| LOC112694756 | uncharaterized LOC112694756 | 0.026714 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0259397 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0258969 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0258537 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0254927 |
| RPS20 | ribosomal protein S20 | 0.0253098 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0252207 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0252015 |
| RCOR1 | REST corepressor 1 | 0.0246977 |
| MT1X | metallothionein 1X | 0.0244177 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0243825 |
| CLTC | clathrin, heavy chain (Hc) | 0.0243815 |
| RPS16 | ribosomal protein S16 | 0.0243499 |
| NPTN | neuroplastin | 0.0241232 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0241171 |
| ACTN4 | actinin, alpha 4 | 0.023868 |
| RPS8 | ribosomal protein S8 | 0.0238356 |
| BCKDHB | branched chain keto acid dehydrogenase E1, beta polypeptide | 0.0237249 |
| SMAD3 | SMAD family member 3 | 0.0236804 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0236568 |
| H1-0 | H1.0 linker histone | 0.0236333 |
| LOX | lysyl oxidase | 0.0234532 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0233815 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0233557 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.0232997 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.023016 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.022945 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0228869 |
| WDFY3 | WD repeat and FYVE domain containing 3 | 0.0225548 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0225278 |
| ATF6 | activating transcription factor 6 | 0.022409 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0219878 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.021981 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0217144 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0216585 |
| CDK13 | cyclin-dependent kinase 13 | 0.0212077 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0210951 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0210362 |
| MYOF | myoferlin | 0.0209995 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0208889 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0208693 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0208047 |
| MAP1B | microtubule-associated protein 1B | 0.0207421 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0207412 |
| ATOSA | atos homolog A | 0.020737 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0203731 |
| RPL7A | ribosomal protein L7a | 0.0201357 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0198769 |
| KIAA1328 | KIAA1328 | 0.0198452 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0197895 |
| RYBP | RING1 and YY1 binding protein | 0.0197393 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0197257 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0196336 |
| EPHA2 | EPH receptor A2 | 0.0196221 |
| FLNB | filamin B, beta | 0.0195616 |
| SNX25 | sorting nexin 25 | 0.0194934 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0194817 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0194099 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0193987 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.123607 |
| SPAG9 | sperm associated antigen 9 | -0.0822781 |
| LSAMP | limbic system-associated membrane protein | -0.0710265 |
| LAMB3 | laminin, beta 3 | -0.0628275 |
| EGR1 | early growth response 1 | -0.0516428 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0513923 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0512482 |
| KYNU | kynureninase | -0.049401 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0474855 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0455834 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0449707 |
| KRT17 | keratin 17, type I | -0.0441132 |
| ANXA2 | annexin A2 | -0.0439992 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0438872 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0437347 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0427025 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0426439 |
| RAB10 | RAB10, member RAS oncogene family | -0.0420513 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.041579 |
| KLHL24 | kelch-like family member 24 | -0.0405353 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0394349 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0386195 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0367764 |
| GPC6 | glypican 6 | -0.0367415 |
| CUX1 | cut-like homeobox 1 | -0.0361619 |
| USP3 | ubiquitin specific peptidase 3 | -0.0360959 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.036022 |
| FMNL2 | formin-like 2 | -0.0356978 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0355777 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0351898 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0349722 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0349145 |
| JUN | jun proto-oncogene | -0.034858 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0348354 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0342457 |
| AK1 | adenylate kinase 1 | -0.0341755 |
| CYRIB | CYFIP related Rac1 interactor B | -0.033893 |
| MORF4L2 | mortality factor 4 like 2 | -0.0338686 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0338078 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0335501 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0330681 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0329473 |
| PARD3 | par-3 family cell polarity regulator | -0.032817 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0326088 |
| SH3D19 | SH3 domain containing 19 | -0.0325467 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0324899 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0319539 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0317069 |
| SETX | senataxin | -0.0315314 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0310785 |
| ZXDC | ZXD family zinc finger C | -0.0309658 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0306986 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0306854 |
| TNPO1 | transportin 1 | -0.0306305 |
| DST | dystonin | -0.0301793 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0300629 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0298983 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0298693 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0296177 |
| QKI | QKI, KH domain containing, RNA binding | -0.0293484 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0293356 |
| AFF1 | AF4/FMR2 family, member 1 | -0.029276 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.028666 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0282314 |
| RIGI | RNA sensor RIG-I | -0.0282078 |
| SMYD3 | SET and MYND domain containing 3 | -0.0279671 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.0278498 |
| RTN4 | reticulon 4 | -0.0276391 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0275924 |
| MYO1E | myosin IE | -0.0273835 |
| SBF2 | SET binding factor 2 | -0.0273589 |
| SRP54 | signal recognition particle 54kDa | -0.027157 |
| FRYL | FRY-like | -0.0270795 |
| NBAS | neuroblastoma amplified sequence | -0.0270443 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0266205 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0265892 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0264061 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0264005 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0262559 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0260898 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.025884 |
| FOXP1 | forkhead box P1 | -0.025774 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0256831 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0255664 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0255216 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0253711 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0252721 |
| RNF145 | ring finger protein 145 | -0.0252454 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0251256 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.02499 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.024784 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0246865 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0246735 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0246134 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0245384 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0244258 |
| MSN | moesin | -0.0243319 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0242956 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | -0.0241412 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0241093 |
