| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.106417 |
| RAD51B | RAD51 paralog B | 0.100428 |
| PCBP2 | poly(rC) binding protein 2 | 0.0899682 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0871593 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0709303 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0633407 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0607886 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0519437 |
| OGA | O-GlcNAcase | 0.0513502 |
| PRELID2 | PRELI domain containing 2 | 0.0465469 |
| PGK1 | phosphoglycerate kinase 1 | 0.0460905 |
| MCL1 | myeloid cell leukemia 1 | 0.0452112 |
| CCNL1 | cyclin L1 | 0.0436165 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0427889 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0426086 |
| RBM39 | RNA binding motif protein 39 | 0.0414996 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.041357 |
| AHNAK | AHNAK nucleoprotein | 0.0405245 |
| NUP58 | nucleoporin 58 | 0.0398169 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0396116 |
| PTK2 | protein tyrosine kinase 2 | 0.0395072 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0384982 |
| HELZ | helicase with zinc finger | 0.0383572 |
| RLF | rearranged L-myc fusion | 0.0383291 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0381964 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0381305 |
| ENO1 | enolase 1, (alpha) | 0.0380168 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0379675 |
| PFKP | phosphofructokinase, platelet | 0.0374856 |
| BRD2 | bromodomain containing 2 | 0.0367432 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.036276 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0361468 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0360106 |
| BBX | bobby sox homolog (Drosophila) | 0.0354518 |
| EXOC4 | exocyst complex component 4 | 0.0351047 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0344534 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0342179 |
| ZNF292 | zinc finger protein 292 | 0.0340476 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0336476 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0334424 |
| ZNF638 | zinc finger protein 638 | 0.033178 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0328654 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0328418 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0326478 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0321299 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0320516 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0319997 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0315521 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0312314 |
| RUNX1 | runt-related transcription factor 1 | 0.0311007 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0310616 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0310071 |
| PER1 | period circadian clock 1 | 0.0309592 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0307918 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.030495 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0300832 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0300558 |
| PYGL | phosphorylase, glycogen, liver | 0.0298898 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0298877 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0298521 |
| LRRC23 | leucine rich repeat containing 23 | 0.0290884 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0289145 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0286518 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0285265 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0284432 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0281547 |
| YBX3 | Y box binding protein 3 | 0.0281341 |
| IQGAP3 | IQ motif containing GTPase activating protein 3 | 0.0280352 |
| RPL3 | ribosomal protein L3 | 0.0279268 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0278039 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0276549 |
| CUL3 | cullin 3 | 0.0275163 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0274477 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0272322 |
| MED13L | mediator complex subunit 13-like | 0.0271592 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0269236 |
| COPA | coatomer protein complex, subunit alpha | 0.0268946 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0268208 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0264597 |
| ACTN1 | actinin, alpha 1 | 0.0262996 |
| YAP1 | Yes-associated protein 1 | 0.0262092 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0262008 |
| TFG | TRK-fused gene | 0.0260428 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.025525 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.025232 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0250487 |
| FMNL2 | formin-like 2 | 0.0249346 |
| CEP192 | centrosomal protein 192kDa | 0.0246874 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0246795 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0245156 |
| PARD3 | par-3 family cell polarity regulator | 0.0244384 |
| PKM | pyruvate kinase, muscle | 0.0244106 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0243746 |
| MAT2A | methionine adenosyltransferase II, alpha | 0.0243505 |
| SMAD3 | SMAD family member 3 | 0.0242276 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0239061 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0238072 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0236495 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0235064 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0233569 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.243787 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0815391 |
| VIM | vimentin | -0.0772852 |
| ACTG1 | actin gamma 1 | -0.0407467 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0357609 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0350224 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0336211 |
| RPS8 | ribosomal protein S8 | -0.0331065 |
| RPLP1 | ribosomal protein, large, P1 | -0.0328745 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0326103 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0320933 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0319596 |
| OSMR | oncostatin M receptor | -0.0310118 |
| GNAS | GNAS complex locus | -0.0302821 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0301999 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0286122 |
| RPS21 | ribosomal protein S21 | -0.0283144 |
| RPL8 | ribosomal protein L8 | -0.027579 |
| TXNRD1 | thioredoxin reductase 1 | -0.0274279 |
| SRP72 | signal recognition particle 72kDa | -0.0273985 |
| TMSB10 | thymosin beta 10 | -0.0271482 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0270346 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.025965 |
| RPL34 | ribosomal protein L34 | -0.0250689 |
| RPL35A | ribosomal protein L35a | -0.0245079 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.024306 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0240837 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0238199 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0236822 |
| RPS27 | ribosomal protein S27 | -0.023396 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0228116 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0224867 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0223992 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0215048 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0206907 |
| RPL11 | ribosomal protein L11 | -0.020609 |
| RPLP0 | ribosomal protein, large, P0 | -0.0203989 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0197672 |
| DEK | DEK proto-oncogene | -0.0195188 |
| RPS15 | ribosomal protein S15 | -0.0194968 |
| GLO1 | glyoxalase I | -0.0193124 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.019248 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0192336 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0192115 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0190715 |
| CBX3 | chromobox homolog 3 | -0.0187279 |
| MT2A | metallothionein 2A | -0.0185284 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0183083 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0178956 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0178306 |
| RPL38 | ribosomal protein L38 | -0.0176504 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0175417 |
| ZCRB1 | zinc finger CCHC-type and RNA binding motif 1 | -0.0175023 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0174346 |
| S100A11 | S100 calcium binding protein A11 | -0.0174124 |
| CCT3 | chaperonin containing TCP1, subunit 3 (gamma) | -0.0173288 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.0171285 |
| IGF2 | insulin-like growth factor 2 | -0.0169703 |
| PTMA | prothymosin, alpha | -0.0169415 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0168689 |
| RPL36A | ribosomal protein L36a | -0.0166663 |
| PFN1 | profilin 1 | -0.0164635 |
| RPS4X | ribosomal protein S4, X-linked | -0.0164612 |
| TPM4 | tropomyosin 4 | -0.0163751 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0158177 |
| UBB | ubiquitin B | -0.0157123 |
| RPL12 | ribosomal protein L12 | -0.0156493 |
| S100A6 | S100 calcium binding protein A6 | -0.0156407 |
| KLF6 | Kruppel-like factor 6 | -0.0154173 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0153547 |
| PRDX1 | peroxiredoxin 1 | -0.0153419 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0153334 |
| GOLGB1 | golgin B1 | -0.0150354 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0150281 |
| TRIM56 | tripartite motif containing 56 | -0.0148963 |
| RACK1 | receptor for activated C kinase 1 | -0.0147456 |
| GSTP1 | glutathione S-transferase pi 1 | -0.0145374 |
| CCND1 | cyclin D1 | -0.0144457 |
| RASAL2 | RAS protein activator like 2 | -0.0144234 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0143508 |
| EGFR | epidermal growth factor receptor | -0.014329 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0142333 |
| HLA-B | major histocompatibility complex, class I, B | -0.01409 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0140255 |
| CDK12 | cyclin-dependent kinase 12 | -0.0138507 |
| RPS27A | ribosomal protein S27a | -0.0138482 |
| EGR1 | early growth response 1 | -0.0137883 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0137829 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0136163 |
| PPM1G | protein phosphatase, Mg2+/Mn2+ dependent, 1G | -0.0135643 |
| RPL6 | ribosomal protein L6 | -0.0134603 |
| RPL26 | ribosomal protein L26 | -0.0132205 |
| REST | RE1-silencing transcription factor | -0.0131537 |
| RPS24 | ribosomal protein S24 | -0.0129996 |
| RPS2 | ribosomal protein S2 | -0.0129925 |
| DST | dystonin | -0.0129486 |
| GPATCH8 | G patch domain containing 8 | -0.0129186 |
| FUS | FUS RNA binding protein | -0.0128138 |
| METTL21A | methyltransferase like 21A | -0.0127786 |
| BMP5 | bone morphogenetic protein 5 | -0.0127578 |
