Roxadustat_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.221141
NDRG1 N-myc downstream regulated 1 0.14395
FNDC3B fibronectin type III domain containing 3B 0.127152
ASPH aspartate beta-hydroxylase 0.114773
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.11452
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.108476
MYH9 myosin, heavy chain 9, non-muscle 0.10602
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0982311
GRB10 growth factor receptor-bound protein 10 0.0938466
TSC22D2 TSC22 domain family, member 2 0.0902286
PGK1 phosphoglycerate kinase 1 0.0841502
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.083929
PCBP2 poly(rC) binding protein 2 0.0807781
NAMPT nicotinamide phosphoribosyltransferase 0.0787092
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0779994
FXR1 fragile X mental retardation, autosomal homolog 1 0.0759681
AHNAK AHNAK nucleoprotein 0.075279
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0707282
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0697841
DSCAM Down syndrome cell adhesion molecule 0.0685568
UBA6 ubiquitin-like modifier activating enzyme 6 0.0644762
ADAM9 ADAM metallopeptidase domain 9 0.0601245
PTK2 protein tyrosine kinase 2 0.0596375
BHLHE40 basic helix-loop-helix family, member e40 0.058749
TRIO trio Rho guanine nucleotide exchange factor 0.0578932
FAM13A family with sequence similarity 13, member A 0.0565611
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0556481
CCNL1 cyclin L1 0.055608
HSPA8 heat shock 70kDa protein 8 0.054718
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.053441
APP amyloid beta (A4) precursor protein 0.0522539
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0519946
LAMC2 laminin, gamma 2 0.0489217
CDC73 cell division cycle 73 0.0488074
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0483765
PLEC plectin 0.0477796
RBM39 RNA binding motif protein 39 0.0476324
IRF6 interferon regulatory factor 6 0.0475577
RNF145 ring finger protein 145 0.0460899
ENO1 enolase 1, (alpha) 0.0460339
PLAU plasminogen activator, urokinase 0.0459788
RPS3 ribosomal protein S3 0.0456137
HMGB2 high mobility group box 2 0.0452212
RYBP RING1 and YY1 binding protein 0.0450658
SSBP2 single-stranded DNA binding protein 2 0.0447886
PARD3 par-3 family cell polarity regulator 0.04473
RHEB Ras homolog enriched in brain 0.0446841
MARCHF6 membrane associated ring-CH-type finger 6 0.044194
TPM3 tropomyosin 3 0.044157
NCKAP1 NCK-associated protein 1 0.0440959
PKM pyruvate kinase, muscle 0.0438206
ZNF292 zinc finger protein 292 0.0430511
ELL2 elongation factor, RNA polymerase II, 2 0.0430254
AZIN1 antizyme inhibitor 1 0.0429038
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.042175
PPARD peroxisome proliferator-activated receptor delta 0.041638
LAMB3 laminin, beta 3 0.0410682
CALR calreticulin 0.041055
LDHA lactate dehydrogenase A 0.0407769
KMT2E lysine (K)-specific methyltransferase 2E 0.0407265
TFG TRK-fused gene 0.0405552
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0404379
CDK17 cyclin-dependent kinase 17 0.0403917
USP3 ubiquitin specific peptidase 3 0.0403649
ATP13A3 ATPase type 13A3 0.0398266
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0397706
KDM3A lysine (K)-specific demethylase 3A 0.0394324
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0393027
NUP58 nucleoporin 58 0.039255
TRA2B transformer 2 beta homolog (Drosophila) 0.0388975
MSN moesin 0.038847
CPNE8 copine VIII 0.0385807
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0385522
RAD21 RAD21 homolog (S. pombe) 0.0385004
CANX calnexin 0.0378748
ANXA5 annexin A5 0.0375064
FAM162A family with sequence similarity 162, member A 0.0369379
APLP2 amyloid beta (A4) precursor-like protein 2 0.0364685
ECT2 epithelial cell transforming 2 0.0359576
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.035854
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0358354
PAPOLA poly(A) polymerase alpha 0.0356894
CCNG2 cyclin G2 0.0355015
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0353789
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0353611
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0351684
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0339623
QKI QKI, KH domain containing, RNA binding 0.0338642
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0338078
DSPP dentin sialophosphoprotein 0.0334951
TNIP1 TNFAIP3 interacting protein 1 0.0333313
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0333004
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0332551
SPAG9 sperm associated antigen 9 0.0332039
TOP1 topoisomerase (DNA) I 0.0330621
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0329816
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0329662
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0326525
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0324046
CORO1C coronin, actin binding protein, 1C 0.0323753

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.255357
ACTG1 actin gamma 1 -0.11928
FTL ferritin, light polypeptide -0.101768
RPLP1 ribosomal protein, large, P1 -0.0849662
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0696008
RPL34 ribosomal protein L34 -0.0676796
TMSB4X thymosin beta 4, X-linked -0.0644045
RPL8 ribosomal protein L8 -0.0633501
S100A10 S100 calcium binding protein A10 -0.0537885
EIF1 eukaryotic translation initiation factor 1 -0.0497763
RPS23 ribosomal protein S23 -0.0491373
S100A6 S100 calcium binding protein A6 -0.0474975
RPL35A ribosomal protein L35a -0.0464875
FTH1 ferritin, heavy polypeptide 1 -0.0449623
ALCAM activated leukocyte cell adhesion molecule -0.0432714
EFNA5 ephrin-A5 -0.0398968
PTMA prothymosin, alpha -0.0384523
IFI27 interferon, alpha-inducible protein 27 -0.0373375
EXT1 exostosin glycosyltransferase 1 -0.03711
FBXO32 F-box protein 32 -0.0370909
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0370121
CCND1 cyclin D1 -0.0330088
RPS8 ribosomal protein S8 -0.0319301
LOC112694756 uncharaterized LOC112694756 -0.0306754
RPS15 ribosomal protein S15 -0.0293284
GOLGA4 golgin A4 -0.0286615
SAMD4A sterile alpha motif domain containing 4A -0.0279564
TMSB10 thymosin beta 10 -0.0270857
MYO1E myosin IE -0.0266432
RPL32 ribosomal protein L32 -0.0262179
S100A9 S100 calcium binding protein A9 -0.0259899
TPT1 tumor protein, translationally-controlled 1 -0.0259127
CSTB cystatin B (stefin B) -0.0256123
TMEM165 transmembrane protein 165 -0.0248906
RPS29 ribosomal protein S29 -0.024537
PLSCR1 phospholipid scramblase 1 -0.0237406
TXNIP thioredoxin interacting protein -0.0235973
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0230666
GOLGB1 golgin B1 -0.0228845
GNAS GNAS complex locus -0.0228797
AREG amphiregulin -0.0226735
MDK midkine (neurite growth-promoting factor 2) -0.0226105
MAP1B microtubule-associated protein 1B -0.0225276
TPM4 tropomyosin 4 -0.0225238
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0223758
HSPB1 heat shock 27kDa protein 1 -0.0220871
RPL28 ribosomal protein L28 -0.0219406
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0218917
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0214741
RPS6 ribosomal protein S6 -0.0214457
RPS5 ribosomal protein S5 -0.0213326
ZBTB20 zinc finger and BTB domain containing 20 -0.021314
ASTN2 astrotactin 2 -0.0211954
RPS19 ribosomal protein S19 -0.0210904
IFITM3 interferon induced transmembrane protein 3 -0.0206706
EGFR epidermal growth factor receptor -0.0205658
RRBP1 ribosome binding protein 1 -0.0202301
RPS13 ribosomal protein S13 -0.0201496
HMGA1 high mobility group AT-hook 1 -0.0199231
BLZF1 basic leucine zipper nuclear factor 1 -0.0198616
RPS10 ribosomal protein S10 -0.0198158
MACC1 metastasis associated in colon cancer 1 -0.0197382
HMGB1 high mobility group box 1 -0.0196405
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0192931
TTC3 tetratricopeptide repeat domain 3 -0.0192398
RPLP0 ribosomal protein, large, P0 -0.019127
NF1 neurofibromin 1 -0.0189981
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.0184031
CCNI cyclin I -0.0183951
NIPBL Nipped-B homolog (Drosophila) -0.0183621
ERBIN erbb2 interacting protein -0.0182554
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0182187
RPS21 ribosomal protein S21 -0.0179932
KRT19 keratin 19, type I -0.0179784
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0179751
RASAL2 RAS protein activator like 2 -0.0179542
SOX4 SRY (sex determining region Y)-box 4 -0.0177777
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0177371
SVIL supervillin -0.0176603
LY6E lymphocyte antigen 6 complex, locus E -0.0173311
MX2 MX dynamin-like GTPase 2 -0.017299
TUBB4B tubulin, beta 4B class IVb -0.0170572
ETV6 ets variant 6 -0.0170024
GOLPH3L golgi phosphoprotein 3-like -0.0167893
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0167085
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0166366
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0166009
IGFBP3 insulin-like growth factor binding protein 3 -0.0165033
BPTF bromodomain PHD finger transcription factor -0.0164921
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0164495
TBCA tubulin folding cofactor A -0.0164358
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0163793
IFI16 interferon, gamma-inducible protein 16 -0.0163158
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0162314
NRP1 neuropilin 1 -0.0161894
YY1 YY1 transcription factor -0.0160605
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0160428
ANKRD17 ankyrin repeat domain 17 -0.015914
CEP350 centrosomal protein 350kDa -0.0156035
SNX6 sorting nexin 6 -0.0155409