| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.168709 |
| PGK1 | phosphoglycerate kinase 1 | 0.113723 |
| ASPH | aspartate beta-hydroxylase | 0.110148 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.102977 |
| PCBP3 | poly(rC) binding protein 3 | 0.0938987 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0933777 |
| PDE10A | phosphodiesterase 10A | 0.0917864 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0857175 |
| EFNA5 | ephrin-A5 | 0.0821209 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0740361 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0732448 |
| MYOF | myoferlin | 0.0723687 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0719921 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0710136 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0697711 |
| FN1 | fibronectin 1 | 0.0682013 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0654767 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0651662 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0640517 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0638635 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0631265 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0613879 |
| COL5A2 | collagen, type V, alpha 2 | 0.0602467 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0565159 |
| OGA | O-GlcNAcase | 0.0546659 |
| CD109 | CD109 molecule | 0.0546433 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0544576 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0541873 |
| PYGL | phosphorylase, glycogen, liver | 0.0541493 |
| AHNAK | AHNAK nucleoprotein | 0.0531906 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0524361 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0503439 |
| NEK7 | NIMA-related kinase 7 | 0.0489085 |
| ENO1 | enolase 1, (alpha) | 0.0483894 |
| CDH13 | cadherin 13 | 0.048238 |
| GDA | guanine deaminase | 0.0473431 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0469145 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0456889 |
| TBXT | T-box transcription factor T | 0.0452175 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0451698 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0438373 |
| SPAG9 | sperm associated antigen 9 | 0.0435744 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.043317 |
| PCBP2 | poly(rC) binding protein 2 | 0.0426466 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0412949 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0412361 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0385731 |
| LDHA | lactate dehydrogenase A | 0.0383061 |
| FAM13A | family with sequence similarity 13, member A | 0.0372583 |
| PRKD3 | protein kinase D3 | 0.037256 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0367064 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0364899 |
| NRCAM | neuronal cell adhesion molecule | 0.0362611 |
| FLNB | filamin B, beta | 0.0362353 |
| ZNF292 | zinc finger protein 292 | 0.0354753 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0354026 |
| NBAS | neuroblastoma amplified sequence | 0.0339172 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0338571 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0337951 |
| RBM39 | RNA binding motif protein 39 | 0.033777 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.03334 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0332511 |
| PRELID2 | PRELI domain containing 2 | 0.0331428 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0325958 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.032445 |
| GRAMD1B | GRAM domain containing 1B | 0.0323493 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0322279 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | 0.0308279 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.030528 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.030401 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0300325 |
| DST | dystonin | 0.0292497 |
| APP | amyloid beta (A4) precursor protein | 0.0290299 |
| DNER | delta/notch-like EGF repeat containing | 0.0289808 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0289216 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0289116 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0288948 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0284181 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0281553 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0279991 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0279837 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0276831 |
| FMNL2 | formin-like 2 | 0.0276743 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0276422 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0273612 |
| HELZ | helicase with zinc finger | 0.0272155 |
| USP34 | ubiquitin specific peptidase 34 | 0.0270152 |
| RPL4 | ribosomal protein L4 | 0.0267607 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0263281 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0263173 |
| EZR | ezrin | 0.0262033 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0261297 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0259054 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0258894 |
| CUL3 | cullin 3 | 0.0253151 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0251891 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0251444 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0250955 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.02491 |
| CTBP2 | C-terminal binding protein 2 | 0.0248719 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.132158 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.128677 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0983429 |
| VIM | vimentin | -0.0465521 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0330565 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.032503 |
| FTL | ferritin, light polypeptide | -0.0311311 |
| EGR1 | early growth response 1 | -0.0300888 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0298837 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0281486 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0264503 |
| RPS23 | ribosomal protein S23 | -0.0259451 |
| RPS6 | ribosomal protein S6 | -0.0258767 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0257778 |
| RPLP1 | ribosomal protein, large, P1 | -0.0239141 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0213559 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0208635 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0208217 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0204655 |
| PTMA | prothymosin, alpha | -0.0189166 |
| S100A6 | S100 calcium binding protein A6 | -0.017593 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0174695 |
| ASTN2 | astrotactin 2 | -0.0165488 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0159236 |
| TBCA | tubulin folding cofactor A | -0.015441 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0153952 |
| BPTF | bromodomain PHD finger transcription factor | -0.0150758 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.015014 |
| TMSB10 | thymosin beta 10 | -0.013632 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0129244 |
| PFN1 | profilin 1 | -0.012752 |
| RPS8 | ribosomal protein S8 | -0.0126762 |
| RANBP17 | RAN binding protein 17 | -0.0126238 |
| SYAP1 | synapse associated protein 1 | -0.0124412 |
| SRGN | serglycin | -0.0124303 |
| NCKAP5 | NCK-associated protein 5 | -0.0124149 |
| MYPN | myopalladin | -0.0123836 |
| RTN1 | reticulon 1 | -0.0122243 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0122098 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0119719 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0119466 |
| TPM4 | tropomyosin 4 | -0.0118403 |
| PAPPA2 | pappalysin 2 | -0.0117586 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.011606 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0115194 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0115073 |
| CD44 | CD44 molecule (Indian blood group) | -0.0115071 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0114921 |
| RPL34 | ribosomal protein L34 | -0.0113818 |
| RPL8 | ribosomal protein L8 | -0.0113242 |
| B2M | beta-2-microglobulin | -0.0111087 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0110074 |
| RPL35A | ribosomal protein L35a | -0.0108807 |
| TMSB4X | thymosin beta 4, X-linked | -0.0107556 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0106249 |
| RPL39 | ribosomal protein L39 | -0.0105856 |
| MAP1B | microtubule-associated protein 1B | -0.0104833 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0103172 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0100956 |
| VMP1 | vacuole membrane protein 1 | -0.0100735 |
| ACTG1 | actin gamma 1 | -0.00992132 |
| HLA-A | major histocompatibility complex, class I, A | -0.00968589 |
| NFX1 | nuclear transcription factor, X-box binding 1 | -0.00964779 |
| NABP1 | nucleic acid binding protein 1 | -0.00964433 |
| PCNX4 | pecanex 4 | -0.00964172 |
| MYADM | myeloid-associated differentiation marker | -0.00953364 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0095021 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.00947581 |
| RPL28 | ribosomal protein L28 | -0.00943601 |
| RPL11 | ribosomal protein L11 | -0.00941639 |
| TXNIP | thioredoxin interacting protein | -0.00940274 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.00914918 |
| NTN4 | netrin 4 | -0.00914391 |
| S100A10 | S100 calcium binding protein A10 | -0.00912351 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.00909335 |
| RPS14 | ribosomal protein S14 | -0.00902888 |
| RPS2 | ribosomal protein S2 | -0.00900201 |
| RPLP0 | ribosomal protein, large, P0 | -0.00896552 |
| NUCB2 | nucleobindin 2 | -0.00893732 |
| GLCCI1 | glucocorticoid induced 1 | -0.00881062 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00880026 |
| EHBP1 | EH domain binding protein 1 | -0.00878255 |
| LMAN1 | lectin, mannose-binding, 1 | -0.00875965 |
| CCNI | cyclin I | -0.00869567 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.00868489 |
| DDX56 | DEAD (Asp-Glu-Ala-Asp) box helicase 56 | -0.00866686 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.00856282 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.00852389 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.00849027 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.00847893 |
| AGR2 | anterior gradient 2 | -0.00847163 |
| STEAP1B | STEAP family member 1B | -0.00819087 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.00818944 |
| BSG | basigin (Ok blood group) | -0.00817297 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.00796648 |
| PHF14 | PHD finger protein 14 | -0.00790579 |
| AHI1 | Abelson helper integration site 1 | -0.00784124 |
| R3HDM2 | R3H domain containing 2 | -0.00784124 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.00783466 |
| MT2A | metallothionein 2A | -0.00782245 |
