Roxadustat_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.295264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.108695
VIM vimentin 0.0963876
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0888344
EFNA5 ephrin-A5 0.0785675
RPS6 ribosomal protein S6 0.0709196
TRIO trio Rho guanine nucleotide exchange factor 0.0676116
PTK2 protein tyrosine kinase 2 0.0650099
GPC6 glypican 6 0.0643365
NALF1 NALCN channel auxiliary factor 1 0.0617278
PDE10A phosphodiesterase 10A 0.0611867
PTPRG protein tyrosine phosphatase, receptor type, G 0.0603698
MARCHF6 membrane associated ring-CH-type finger 6 0.0601645
TMSB10 thymosin beta 10 0.0595127
PTMA prothymosin, alpha 0.0590634
DTNA dystrobrevin, alpha 0.0587067
MT2A metallothionein 2A 0.0564971
PDE4D phosphodiesterase 4D, cAMP-specific 0.0555985
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0542283
NAV3 neuron navigator 3 0.0530031
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0501637
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0492942
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0492514
ELL2 elongation factor, RNA polymerase II, 2 0.0486104
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0478779
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.044957
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0438029
ZNF292 zinc finger protein 292 0.0435803
NUP58 nucleoporin 58 0.0432511
STC1 stanniocalcin 1 0.042919
KDM3A lysine (K)-specific demethylase 3A 0.0417317
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0413154
EXT1 exostosin glycosyltransferase 1 0.041217
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0401798
SPAG9 sperm associated antigen 9 0.0393541
SAMD4A sterile alpha motif domain containing 4A 0.0380113
OGA O-GlcNAcase 0.0360286
AKAP12 A kinase (PRKA) anchor protein 12 0.0357469
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0351766
FNDC3B fibronectin type III domain containing 3B 0.0347323
CERS6 ceramide synthase 6 0.033686
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0333682
LPP LIM domain containing preferred translocation partner in lipoma 0.0318362
NDRG1 N-myc downstream regulated 1 0.0317179
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0313969
RTN4 reticulon 4 0.0309767
SRPK2 SRSF protein kinase 2 0.0300938
RORA RAR-related orphan receptor A 0.0297098
CUL3 cullin 3 0.0296714
USP34 ubiquitin specific peptidase 34 0.028866
RPS12 ribosomal protein S12 0.028797
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0286485
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.028549
PUM2 pumilio RNA-binding family member 2 0.0285297
SBF2 SET binding factor 2 0.0282194
LDHA lactate dehydrogenase A 0.0277778
NAMPT nicotinamide phosphoribosyltransferase 0.0261862
PSD3 pleckstrin and Sec7 domain containing 3 0.0261445
KMT2C lysine (K)-specific methyltransferase 2C 0.0260066
RPL23 ribosomal protein L23 0.0258669
DST dystonin 0.025721
PRRC2C proline-rich coiled-coil 2C 0.0251817
ANXA2 annexin A2 0.0248274
RPL31 ribosomal protein L31 0.02445
SEC31A SEC31 homolog A (S. cerevisiae) 0.0241953
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0238425
WAC WW domain containing adaptor with coiled-coil 0.0237433
PKM pyruvate kinase, muscle 0.0230106
FLNB filamin B, beta 0.0212217
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0205685
NPAS2 neuronal PAS domain protein 2 0.0204034
RPS3 ribosomal protein S3 0.0197347
ENO1 enolase 1, (alpha) 0.0192452
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0190634
RPL26 ribosomal protein L26 0.0186855
AFF4 AF4/FMR2 family, member 4 0.0185499
DSCAM Down syndrome cell adhesion molecule 0.0179359
WSB1 WD repeat and SOCS box containing 1 0.017878
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.017738
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0176694
UBA6 ubiquitin-like modifier activating enzyme 6 0.0175566
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0167519
ZCCHC7 zinc finger, CCHC domain containing 7 0.016328
IGFBP3 insulin-like growth factor binding protein 3 0.0161135
RPL37A ribosomal protein L37a 0.0160217
YEATS2 YEATS domain containing 2 0.0157364
KTN1 kinectin 1 (kinesin receptor) 0.0146144
RACK1 receptor for activated C kinase 1 0.0142361
NAP1L1 nucleosome assembly protein 1-like 1 0.0137831
FMNL2 formin-like 2 0.0137325
MYOF myoferlin 0.0136131
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.013539
CANX calnexin 0.0134001
RBM39 RNA binding motif protein 39 0.0128903
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0123274
MATR3 matrin 3 0.011313
GOLGA4 golgin A4 0.0108209
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0107449
ACTG1 actin gamma 1 0.0105187
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00999522

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.196649
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.147204
NKD1 naked cuticle homolog 1 (Drosophila) -0.13497
MAML2 mastermind-like 2 (Drosophila) -0.08975
EGR1 early growth response 1 -0.0822705
NAV2 neuron navigator 2 -0.0791676
SNX9 sorting nexin 9 -0.0785727
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0784762
INTS6 integrator complex subunit 6 -0.0770331
FNIP1 folliculin interacting protein 1 -0.0747253
CARD16 caspase recruitment domain family, member 16 -0.072217
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0719442
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0685961
TBC1D22A TBC1 domain family, member 22A -0.0680578
ZBTB20 zinc finger and BTB domain containing 20 -0.0623521
PTPRM protein tyrosine phosphatase, receptor type, M -0.0623012
RABGAP1L RAB GTPase activating protein 1-like -0.0621161
TENM3 teneurin transmembrane protein 3 -0.0607718
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0591699
SYT1 synaptotagmin I -0.0588819
PRKCA protein kinase C, alpha -0.0566577
CMIP c-Maf inducing protein -0.0561497
GMDS GDP-mannose 4,6-dehydratase -0.0561465
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0544284
SLC38A2 solute carrier family 38, member 2 -0.0517776
ITGA6 integrin, alpha 6 -0.0514851
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0486998
SP100 SP100 nuclear antigen -0.0474543
JMJD1C jumonji domain containing 1C -0.0466847
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.046403
ARHGAP32 Rho GTPase activating protein 32 -0.046351
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0459459
ANKRD28 ankyrin repeat domain 28 -0.0458087
HDLBP high density lipoprotein binding protein -0.0446984
AKAP9 A kinase (PRKA) anchor protein 9 -0.0432612
MBD5 methyl-CpG binding domain protein 5 -0.04173
FRMD5 FERM domain containing 5 -0.0396212
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0391199
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.038286
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0376163
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0373486
CNKSR3 CNKSR family member 3 -0.0362682
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0352731
DLG1 discs, large homolog 1 (Drosophila) -0.0352137
EZR ezrin -0.0351198
LMO7 LIM domain 7 -0.0342082
RPS8 ribosomal protein S8 -0.0341411
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0339272
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.032765
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0326569
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0309069
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0306813
STK24 serine/threonine kinase 24 -0.0298547
NPC1 Niemann-Pick disease, type C1 -0.029456
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0290592
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0289004
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0288363
VCL vinculin -0.0286417
SQSTM1 sequestosome 1 -0.0281813
MYO1E myosin IE -0.0280434
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0280022
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0267758
NF1 neurofibromin 1 -0.0264474
MYO5B myosin VB -0.0261658
RPL12 ribosomal protein L12 -0.0254971
SOD2 superoxide dismutase 2, mitochondrial -0.0252563
KDM4C lysine (K)-specific demethylase 4C -0.0248804
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0247919
SRRM2 serine/arginine repetitive matrix 2 -0.0247382
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0234903
JARID2 jumonji, AT rich interactive domain 2 -0.0227096
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0225073
FOXP1 forkhead box P1 -0.0213077
KAT6B K(lysine) acetyltransferase 6B -0.0212942
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0197176
EGFR epidermal growth factor receptor -0.0191473
WASF2 WAS protein family, member 2 -0.0181525
NCOR2 nuclear receptor corepressor 2 -0.0181236
OSBPL8 oxysterol binding protein-like 8 -0.0180698
PDLIM5 PDZ and LIM domain 5 -0.0179681
TAS2R14 taste receptor, type 2, member 14 -0.0175642
PRKG1 protein kinase, cGMP-dependent, type I -0.0174251
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0173423
AHNAK AHNAK nucleoprotein -0.0173271
CALU calumenin -0.0167395
RBM25 RNA binding motif protein 25 -0.0166158
ZNF638 zinc finger protein 638 -0.0163384
FAM107B family with sequence similarity 107, member B -0.0151869
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0149333
LAMB3 laminin, beta 3 -0.0148335
CDK6 cyclin-dependent kinase 6 -0.0148269
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.014568
PCBP2 poly(rC) binding protein 2 -0.0140711
FTL ferritin, light polypeptide -0.0136539
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0136529
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0135761
ANKRD12 ankyrin repeat domain 12 -0.013541
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0134715
CDC73 cell division cycle 73 -0.0133472
MBNL1 muscleblind-like splicing regulator 1 -0.0125853