| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL5A2 | collagen, type V, alpha 2 | 0.249275 |
| COL11A1 | collagen, type XI, alpha 1 | 0.199992 |
| ITGAV | integrin, alpha V | 0.130968 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.11422 |
| COL3A1 | collagen, type III, alpha 1 | 0.107147 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.105167 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0982626 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0912404 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0905069 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0832133 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0777441 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0689507 |
| PGK1 | phosphoglycerate kinase 1 | 0.0649055 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0620399 |
| AHNAK | AHNAK nucleoprotein | 0.0602326 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0598208 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0562592 |
| LDHA | lactate dehydrogenase A | 0.0555859 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0543519 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0541898 |
| THBS1 | thrombospondin 1 | 0.0526981 |
| FNDC3B | fibronectin type III domain containing 3B | 0.05161 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0491705 |
| SMYD3 | SET and MYND domain containing 3 | 0.0466783 |
| PCDH9 | protocadherin 9 | 0.0462391 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0461524 |
| USP25 | ubiquitin specific peptidase 25 | 0.045817 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0452405 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0448927 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0445373 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0442908 |
| NTM | neurotrimin | 0.0431482 |
| FN1 | fibronectin 1 | 0.0422502 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0419039 |
| ENO1 | enolase 1, (alpha) | 0.0404866 |
| CALR | calreticulin | 0.038701 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0369801 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0369345 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0369068 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0365585 |
| CLTC | clathrin, heavy chain (Hc) | 0.0355984 |
| RAI1 | retinoic acid induced 1 | 0.0354665 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0347601 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0346267 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.033901 |
| UPP1 | uridine phosphorylase 1 | 0.0336835 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0336655 |
| KIF5B | kinesin family member 5B | 0.0336002 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.0329926 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.032492 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | 0.0319594 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.0319069 |
| NEBL | nebulette | 0.0313394 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0312981 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.0301918 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0300874 |
| ZNF292 | zinc finger protein 292 | 0.029723 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0296605 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0295834 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0295466 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0294428 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0291761 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0291256 |
| UBQLN1 | ubiquilin 1 | 0.0288689 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0284123 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.0282287 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0270926 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0269812 |
| ZNF608 | zinc finger protein 608 | 0.0269336 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0267932 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0267764 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0267578 |
| RPL7A | ribosomal protein L7a | 0.0267555 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0266743 |
| POU3F2 | POU class 3 homeobox 2 | 0.0266229 |
| RPS24 | ribosomal protein S24 | 0.0265943 |
| RPL5 | ribosomal protein L5 | 0.0264435 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0263777 |
| SUN1 | Sad1 and UNC84 domain containing 1 | 0.0262552 |
| PTK2 | protein tyrosine kinase 2 | 0.0262243 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.026222 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0260638 |
| HDAC9 | histone deacetylase 9 | 0.0259134 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0257705 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0257612 |
| ARCN1 | archain 1 | 0.025672 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0254688 |
| TMSB10 | thymosin beta 10 | 0.0254667 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | 0.0254307 |
| TENM3 | teneurin transmembrane protein 3 | 0.0253839 |
| CALU | calumenin | 0.0251656 |
| SEC24B | SEC24 family member B | 0.0251493 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | 0.0251384 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0250087 |
| ZNF451 | zinc finger protein 451 | 0.0246756 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.024604 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0245595 |
| NDRG1 | N-myc downstream regulated 1 | 0.0245342 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0244644 |
| RPL12 | ribosomal protein L12 | 0.024354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FBXO11 | F-box protein 11 | -0.0748749 |
| PFN1 | profilin 1 | -0.0677175 |
| SRP54 | signal recognition particle 54kDa | -0.0659399 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.0643236 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0529924 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0467905 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0465153 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0464282 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0461159 |
| LYST | lysosomal trafficking regulator | -0.044862 |
| PEG10 | paternally expressed 10 | -0.0446576 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0443369 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0443235 |
| PHIP | pleckstrin homology domain interacting protein | -0.0436711 |
| RPL35A | ribosomal protein L35a | -0.0402987 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0396912 |
| RTN4 | reticulon 4 | -0.0380158 |
| HMGB1 | high mobility group box 1 | -0.0368726 |
| ENAH | enabled homolog (Drosophila) | -0.0351306 |
| MTF2 | metal response element binding transcription factor 2 | -0.0347504 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0341656 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.033264 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0331681 |
| ARL13B | ADP-ribosylation factor-like 13B | -0.0328371 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0328275 |
| GLG1 | golgi glycoprotein 1 | -0.0326105 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.0323977 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0323728 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.0319773 |
| MED13L | mediator complex subunit 13-like | -0.031623 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | -0.0310428 |
| SRPK2 | SRSF protein kinase 2 | -0.0297454 |
| KIF1B | kinesin family member 1B | -0.0295247 |
| BRDT | bromodomain, testis-specific | -0.0290432 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0287996 |
| MKI67 | marker of proliferation Ki-67 | -0.028694 |
| KIF2A | kinesin heavy chain member 2A | -0.0285937 |
| GNAS | GNAS complex locus | -0.0283174 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0278791 |
| FNIP1 | folliculin interacting protein 1 | -0.0274476 |
| RBM20 | RNA binding motif protein 20 | -0.0271365 |
| IWS1 | IWS1 homolog (S. cerevisiae) | -0.0265785 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0263835 |
| NUP58 | nucleoporin 58 | -0.0263624 |
| FSCN1 | fascin actin-bundling protein 1 | -0.0261953 |
| GAB2 | GRB2-associated binding protein 2 | -0.0257211 |
| RPL23 | ribosomal protein L23 | -0.0257046 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0256311 |
| YBX1 | Y box binding protein 1 | -0.0254908 |
| YY1 | YY1 transcription factor | -0.025433 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.0245108 |
| EVI5 | ecotropic viral integration site 5 | -0.0244784 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0244142 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0241662 |
| RPS8 | ribosomal protein S8 | -0.0241239 |
| MARK2 | MAP/microtubule affinity-regulating kinase 2 | -0.0240713 |
| FAM168B | family with sequence similarity 168, member B | -0.024068 |
| ANXA2 | annexin A2 | -0.0238281 |
| TLK2 | tousled-like kinase 2 | -0.0238036 |
| DENND4A | DENN/MADD domain containing 4A | -0.0236584 |
| SNX6 | sorting nexin 6 | -0.0232382 |
| PNPLA8 | patatin-like phospholipase domain containing 8 | -0.0231629 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | -0.0231431 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0230525 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0229587 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0227612 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0227015 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0225864 |
| PUM1 | pumilio RNA-binding family member 1 | -0.0225419 |
| WASF2 | WAS protein family, member 2 | -0.0223246 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0222197 |
| RAD51B | RAD51 paralog B | -0.0221781 |
| TARS1 | threonyl-tRNA synthetase 1 | -0.0221209 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0219503 |
| PRKD1 | protein kinase D1 | -0.0219036 |
| MED4 | mediator complex subunit 4 | -0.0218904 |
| VMP1 | vacuole membrane protein 1 | -0.0217385 |
| CUX1 | cut-like homeobox 1 | -0.0217338 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0217267 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.0217013 |
| PDS5B | PDS5 cohesin associated factor B | -0.0216782 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0215802 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | -0.0214559 |
| TAOK1 | TAO kinase 1 | -0.0213483 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0212688 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0212425 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0211757 |
| UBB | ubiquitin B | -0.0211087 |
| EIF2A | eukaryotic translation initiation factor 2A, 65kDa | -0.0208619 |
| RDX | radixin | -0.0208581 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0207881 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0207587 |
| RPL28 | ribosomal protein L28 | -0.0207502 |
| SLC39A10 | solute carrier family 39 (zinc transporter), member 10 | -0.0206973 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0206511 |
| RASAL2 | RAS protein activator like 2 | -0.0206159 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0205648 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0205396 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0205361 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0204267 |
