| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | 0.180767 |
| ZNF292 | zinc finger protein 292 | 0.0986501 |
| ECT2 | epithelial cell transforming 2 | 0.0878098 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0855748 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.075066 |
| PRELID2 | PRELI domain containing 2 | 0.070605 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.069069 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.066999 |
| PGK1 | phosphoglycerate kinase 1 | 0.0642362 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0614201 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0584636 |
| PDGFC | platelet derived growth factor C | 0.0534038 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0513404 |
| NCKAP1 | NCK-associated protein 1 | 0.0467531 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0464915 |
| CDC73 | cell division cycle 73 | 0.046228 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0451295 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0439089 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0418489 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0402898 |
| NBAS | neuroblastoma amplified sequence | 0.0398766 |
| FAT1 | FAT atypical cadherin 1 | 0.0394858 |
| HELZ | helicase with zinc finger | 0.0391449 |
| ENO1 | enolase 1, (alpha) | 0.0391281 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0383676 |
| CNOT6L | CCR4-NOT transcription complex, subunit 6-like | 0.0376985 |
| QKI | QKI, KH domain containing, RNA binding | 0.03738 |
| NUP58 | nucleoporin 58 | 0.036476 |
| RPL3 | ribosomal protein L3 | 0.035935 |
| RYBP | RING1 and YY1 binding protein | 0.0356007 |
| RHEB | Ras homolog enriched in brain | 0.0345757 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0343472 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0343197 |
| CORO1C | coronin, actin binding protein, 1C | 0.0340113 |
| YAP1 | Yes-associated protein 1 | 0.0335404 |
| CASC3 | cancer susceptibility candidate 3 | 0.0330861 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0326674 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0323006 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0319088 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0317534 |
| FAM168A | family with sequence similarity 168, member A | 0.0312942 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.030773 |
| TFG | TRK-fused gene | 0.0304134 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0300282 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0297502 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0293731 |
| EZR | ezrin | 0.0292141 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0291716 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0290408 |
| RCOR1 | REST corepressor 1 | 0.0288763 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | 0.0286168 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0279284 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.027815 |
| BMP10 | bone morphogenetic protein 10 | 0.0275872 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0273582 |
| DSCAM | Down syndrome cell adhesion molecule | 0.027345 |
| RPL4 | ribosomal protein L4 | 0.0265648 |
| EWSR1 | EWS RNA-binding protein 1 | 0.0258276 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0257467 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.025637 |
| ANLN | anillin, actin binding protein | 0.0255492 |
| MACROD2 | MACRO domain containing 2 | 0.0255435 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0255206 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0254614 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0252484 |
| CRY1 | cryptochrome circadian clock 1 | 0.0251546 |
| PER1 | period circadian clock 1 | 0.0248133 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0247559 |
| CABIN1 | calcineurin binding protein 1 | 0.0246924 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0244234 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0243508 |
| VCL | vinculin | 0.0239722 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0237509 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0237476 |
| UBC | ubiquitin C | 0.0237359 |
| CENPF | centromere protein F, 350/400kDa | 0.0235655 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0233101 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0231081 |
| VGLL4 | vestigial-like family member 4 | 0.0227852 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0222969 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | 0.0220216 |
| PCBP2 | poly(rC) binding protein 2 | 0.0218777 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.021774 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.021755 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 0.0217453 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.0216367 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0215764 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0213391 |
| TENT4A | terminal nucleotidyltransferase 4A | 0.0211798 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0211724 |
| XPO6 | exportin 6 | 0.0211525 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.021008 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0209014 |
| CYTH3 | cytohesin 3 | 0.0208656 |
| TUFT1 | tuftelin 1 | 0.0207752 |
| RBM39 | RNA binding motif protein 39 | 0.0206676 |
| ATOSA | atos homolog A | 0.02066 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0202214 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0200875 |
| OGA | O-GlcNAcase | 0.0197601 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.186643 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.184685 |
| TMSB4X | thymosin beta 4, X-linked | -0.119256 |
| NBEA | neurobeachin | -0.0787311 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0739122 |
| S100A6 | S100 calcium binding protein A6 | -0.0721663 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0720759 |
| ACTG1 | actin gamma 1 | -0.069393 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.0679028 |
| FOXP1 | forkhead box P1 | -0.0636262 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0617428 |
| RPS6 | ribosomal protein S6 | -0.0606876 |
| PFN1 | profilin 1 | -0.0526931 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0523761 |
| RPL11 | ribosomal protein L11 | -0.0506153 |
| RPS8 | ribosomal protein S8 | -0.0502289 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0485163 |
| TXNRD1 | thioredoxin reductase 1 | -0.0474841 |
| GOLGA4 | golgin A4 | -0.0468141 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0460937 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0443847 |
| PKM | pyruvate kinase, muscle | -0.0443562 |
| RPLP1 | ribosomal protein, large, P1 | -0.0438418 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.043584 |
| RPLP0 | ribosomal protein, large, P0 | -0.0421258 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0409338 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0398432 |
| EFNA5 | ephrin-A5 | -0.0397366 |
| RPS19 | ribosomal protein S19 | -0.0383961 |
| AHI1 | Abelson helper integration site 1 | -0.0380262 |
| RPS23 | ribosomal protein S23 | -0.0372958 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0368893 |
| ANKRD17 | ankyrin repeat domain 17 | -0.035951 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0358455 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0351931 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0345754 |
| GPHN | gephyrin | -0.0344112 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0338307 |
| PHF14 | PHD finger protein 14 | -0.0336085 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0330695 |
| GNAS | GNAS complex locus | -0.0329168 |
| HMGA1 | high mobility group AT-hook 1 | -0.0328767 |
| RPL8 | ribosomal protein L8 | -0.032006 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.031677 |
| EGFR | epidermal growth factor receptor | -0.0316489 |
| DPYD | dihydropyrimidine dehydrogenase | -0.031299 |
| S100A4 | S100 calcium binding protein A4 | -0.0307606 |
| RPL35A | ribosomal protein L35a | -0.0303383 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0302853 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0301522 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0300793 |
| SBF2 | SET binding factor 2 | -0.0299942 |
| RPL26 | ribosomal protein L26 | -0.0293459 |
| BPTF | bromodomain PHD finger transcription factor | -0.0292034 |
| ANK2 | ankyrin 2, neuronal | -0.0290649 |
| RPL27A | ribosomal protein L27a | -0.0285003 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0280975 |
| MT2A | metallothionein 2A | -0.0277979 |
| PRDX2 | peroxiredoxin 2 | -0.0272286 |
| NFIA | nuclear factor I/A | -0.0270469 |
| RACK1 | receptor for activated C kinase 1 | -0.0267386 |
| RPL34 | ribosomal protein L34 | -0.0262804 |
| EXOC6B | exocyst complex component 6B | -0.0262785 |
| S100A10 | S100 calcium binding protein A10 | -0.0262521 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0262248 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0261923 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0260682 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0258986 |
| RPL9 | ribosomal protein L9 | -0.0258746 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0258139 |
| TCF12 | transcription factor 12 | -0.0257962 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0253542 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0251526 |
| RPL19 | ribosomal protein L19 | -0.0251303 |
| FTL | ferritin, light polypeptide | -0.0247176 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0246374 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0245584 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0243206 |
| TRERF1 | transcriptional regulating factor 1 | -0.0241288 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0241048 |
| DUSP4 | dual specificity phosphatase 4 | -0.0239792 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0239539 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0238709 |
| DUSP6 | dual specificity phosphatase 6 | -0.0236464 |
| LDHA | lactate dehydrogenase A | -0.0236233 |
| NF1 | neurofibromin 1 | -0.023399 |
| DOCK3 | dedicator of cytokinesis 3 | -0.0229717 |
| MTDH | metadherin | -0.0229239 |
| RPLP2 | ribosomal protein, large, P2 | -0.0229069 |
| RPS27A | ribosomal protein S27a | -0.0228885 |
| RPS21 | ribosomal protein S21 | -0.0226855 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0225778 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0225031 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0224533 |
| PTEN | phosphatase and tensin homolog | -0.0221853 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0219229 |
| RPS25 | ribosomal protein S25 | -0.0217715 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0217574 |
| OSMR | oncostatin M receptor | -0.021749 |
| RPL12 | ribosomal protein L12 | -0.0217341 |
