Roxadustat_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Roxadustat perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Roxadustat_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.215575
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.167616
PGK1 phosphoglycerate kinase 1 0.135674
NAV2 neuron navigator 2 0.108903
MYH9 myosin, heavy chain 9, non-muscle 0.100652
TRIO trio Rho guanine nucleotide exchange factor 0.0902618
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0820327
FNDC3B fibronectin type III domain containing 3B 0.0818434
AHNAK AHNAK nucleoprotein 0.0750423
AKAP12 A kinase (PRKA) anchor protein 12 0.0735782
ARRDC3 arrestin domain containing 3 0.0715246
CADM1 cell adhesion molecule 1 0.0712208
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0704165
LDHA lactate dehydrogenase A 0.0695942
FRMD4A FERM domain containing 4A 0.0628886
NAMPT nicotinamide phosphoribosyltransferase 0.0626107
ENO1 enolase 1, (alpha) 0.0576142
ADM adrenomedullin 0.0565668
ELL2 elongation factor, RNA polymerase II, 2 0.0564821
NDRG1 N-myc downstream regulated 1 0.0547082
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0527909
UGCG UDP-glucose ceramide glucosyltransferase 0.0517839
KDM3A lysine (K)-specific demethylase 3A 0.0510759
UBC ubiquitin C 0.0507114
FN1 fibronectin 1 0.0497236
FMNL2 formin-like 2 0.0468998
PLIN2 perilipin 2 0.043365
MYOF myoferlin 0.043117
ATP13A3 ATPase type 13A3 0.0413459
PDE10A phosphodiesterase 10A 0.0395939
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0394651
PRELID2 PRELI domain containing 2 0.0393655
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0392833
LOXL2 lysyl oxidase-like 2 0.0385484
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0370593
SMAD3 SMAD family member 3 0.0365837
ERRFI1 ERBB receptor feedback inhibitor 1 0.0365694
ICAM1 intercellular adhesion molecule 1 0.0338236
MXI1 MAX interactor 1, dimerization protein 0.033757
DST dystonin 0.0336761
ANLN anillin, actin binding protein 0.033527
HELZ helicase with zinc finger 0.0333944
ANXA2 annexin A2 0.032972
RB1CC1 RB1-inducible coiled-coil 1 0.0329719
EIF4A1 eukaryotic translation initiation factor 4A1 0.0328589
ZFP36L1 ZFP36 ring finger protein-like 1 0.0325259
APP amyloid beta (A4) precursor protein 0.0324521
RAI1 retinoic acid induced 1 0.0321391
WDR45B WD repeat domain 45B 0.0319696
KTN1 kinectin 1 (kinesin receptor) 0.0319593
WTAP Wilms tumor 1 associated protein 0.0312793
SQSTM1 sequestosome 1 0.0309358
MKI67 marker of proliferation Ki-67 0.0307575
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0304765
PCBP2 poly(rC) binding protein 2 0.0301229
RUNX1 runt-related transcription factor 1 0.0297339
HLA-B major histocompatibility complex, class I, B 0.0296395
CD109 CD109 molecule 0.0291385
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0290243
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0290241
OGA O-GlcNAcase 0.0284804
EIF1 eukaryotic translation initiation factor 1 0.0274756
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0272494
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.027192
TNS3 tensin 3 0.0266445
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0264309
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0264017
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0263398
EEF2 eukaryotic translation elongation factor 2 0.0260905
AMPD3 adenosine monophosphate deaminase 3 0.0260215
ESYT2 extended synaptotagmin-like protein 2 0.0258344
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0256266
FLNB filamin B, beta 0.0254094
SNX9 sorting nexin 9 0.0252157
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0251752
HLA-E major histocompatibility complex, class I, E 0.0250688
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0250002
NGLY1 N-glycanase 1 0.0246664
ARFGEF3 ARFGEF family member 3 0.024606
PKM pyruvate kinase, muscle 0.0245922
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0243595
FOXO3 forkhead box O3 0.0242309
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0239334
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0237671
FLOT1 flotillin 1 0.0236964
LOX lysyl oxidase 0.0236392
FRMPD4 FERM and PDZ domain containing 4 0.0234415
STC1 stanniocalcin 1 0.0234397
KIF13A kinesin family member 13A 0.0234397
B2M beta-2-microglobulin 0.0234035
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0232924
SEPTIN9 septin 9 0.0231637
COL1A2 collagen, type I, alpha 2 0.0231268
PFKP phosphofructokinase, platelet 0.0230044
KLF6 Kruppel-like factor 6 0.02265
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0226485
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0225626
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0224697
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0222972
CENPF centromere protein F, 350/400kDa 0.0221181

decreased expression

Symbol Name Standardized Value
GLIS3 GLIS family zinc finger 3 -0.0507329
BICC1 BicC family RNA binding protein 1 -0.042579
RPS12 ribosomal protein S12 -0.0389793
RPS3 ribosomal protein S3 -0.0334729
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0309995
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0306363
RPL37A ribosomal protein L37a -0.028947
TMSB4X thymosin beta 4, X-linked -0.0282703
IGFBP3 insulin-like growth factor binding protein 3 -0.0263188
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0257138
ZBTB20 zinc finger and BTB domain containing 20 -0.0254611
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0237676
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0234061
VCL vinculin -0.0219978
SOX5 SRY (sex determining region Y)-box 5 -0.021758
RPS8 ribosomal protein S8 -0.0199704
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0199129
VEGFA vascular endothelial growth factor A -0.0196842
KYNU kynureninase -0.0188385
DPYD dihydropyrimidine dehydrogenase -0.0184156
RAI14 retinoic acid induced 14 -0.0179333
NF1 neurofibromin 1 -0.0179082
EHBP1 EH domain binding protein 1 -0.0178019
RPL36A ribosomal protein L36a -0.0177842
CTSD cathepsin D -0.0174861
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0173978
RPS16 ribosomal protein S16 -0.0159594
CD44 CD44 molecule (Indian blood group) -0.0157946
FTH1 ferritin, heavy polypeptide 1 -0.0156687
EEF1G eukaryotic translation elongation factor 1 gamma -0.0153453
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.015258
RPL5 ribosomal protein L5 -0.0152519
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0151048
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0147533
MAGED1 melanoma antigen family D1 -0.0143358
HDAC8 histone deacetylase 8 -0.0140403
ANKRD28 ankyrin repeat domain 28 -0.0139259
RPLP2 ribosomal protein, large, P2 -0.0139163
CDK13 cyclin-dependent kinase 13 -0.0136307
TPT1 tumor protein, translationally-controlled 1 -0.0134872
TGFBI transforming growth factor, beta-induced, 68kDa -0.0133786
TRIM55 tripartite motif containing 55 -0.0133684
VCAN versican -0.0130444
CNTN6 contactin 6 -0.0130358
NRP1 neuropilin 1 -0.0128082
ATG7 autophagy related 7 -0.0127177
EGR1 early growth response 1 -0.0123903
SEC23IP SEC23 interacting protein -0.0122764
IGFBP7 insulin-like growth factor binding protein 7 -0.0119109
ZMYND8 zinc finger, MYND-type containing 8 -0.0114909
NABP1 nucleic acid binding protein 1 -0.0113087
AHI1 Abelson helper integration site 1 -0.0110585
TCEAL9 transcription elongation factor A like 9 -0.0110206
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0110142
TNRC6B trinucleotide repeat containing 6B -0.0108831
SRGN serglycin -0.0107646
SLC38A2 solute carrier family 38, member 2 -0.0104242
SPIDR scaffolding protein involved in DNA repair -0.0102591
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0102252
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0101225
PRKG1 protein kinase, cGMP-dependent, type I -0.0101176
RPL36 ribosomal protein L36 -0.0100728
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.010058
PTPRK protein tyrosine phosphatase, receptor type, K -0.0099401
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00993027
SAMD3 sterile alpha motif domain containing 3 -0.00980476
EFCAB13 EF-hand calcium binding domain 13 -0.00980114
TMSB10 thymosin beta 10 -0.00959491
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00957861
TRIP12 thyroid hormone receptor interactor 12 -0.00946003
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00942439
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.00939634
RPL31 ribosomal protein L31 -0.00938792
CLMP CXADR-like membrane protein -0.00938045
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00932598
HMGA2 high mobility group AT-hook 2 -0.00931849
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 -0.00927612
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.00927238
MBD5 methyl-CpG binding domain protein 5 -0.00920589
RPL35A ribosomal protein L35a -0.00919196
SENP5 SUMO1/sentrin specific peptidase 5 -0.00913925
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.00906875
TPM1 tropomyosin 1 (alpha) -0.00903089
ZC3H12B zinc finger CCCH-type containing 12B -0.00892567
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.00891542
WASF1 WAS protein family, member 1 -0.00882669
FBXL2 F-box and leucine-rich repeat protein 2 -0.00880166
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -0.0087995
USP15 ubiquitin specific peptidase 15 -0.00878891
GLIPR1 GLI pathogenesis-related 1 -0.00878099
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.00868325
RPL27 ribosomal protein L27 -0.0086596
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.00865776
TOX2 TOX high mobility group box family member 2 -0.00862197
FAM114A1 family with sequence similarity 114, member A1 -0.00861743
DNAAF9 dynein axonemal assembly factor 9 -0.00861661
TTC17 tetratricopeptide repeat domain 17 -0.00860542
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.00855496
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.008551
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.00848455