| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Roxadustat_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.0818273 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0664165 |
| FN1 | fibronectin 1 | 0.064952 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0526702 |
| RBM39 | RNA binding motif protein 39 | 0.0505985 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0468123 |
| DST | dystonin | 0.0468086 |
| PCBP2 | poly(rC) binding protein 2 | 0.0457685 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0448016 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0444818 |
| PKM | pyruvate kinase, muscle | 0.0442937 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0438117 |
| AHNAK | AHNAK nucleoprotein | 0.0425589 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0425489 |
| FMNL2 | formin-like 2 | 0.0408543 |
| FRMD6 | FERM domain containing 6 | 0.0406217 |
| PTMA | prothymosin, alpha | 0.0406108 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0390815 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0386243 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.03741 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0372333 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0364497 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0358121 |
| PGK1 | phosphoglycerate kinase 1 | 0.035811 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0355454 |
| CD44 | CD44 molecule (Indian blood group) | 0.0347458 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0346908 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0338629 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.0335895 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0335865 |
| RASA3 | RAS p21 protein activator 3 | 0.0333077 |
| CLMP | CXADR-like membrane protein | 0.0332261 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0323271 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.031753 |
| APP | amyloid beta (A4) precursor protein | 0.0309959 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0307414 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0305628 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.030049 |
| SETX | senataxin | 0.0297593 |
| RPS16 | ribosomal protein S16 | 0.029515 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0294338 |
| WAC | WW domain containing adaptor with coiled-coil | 0.029208 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.029151 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0291338 |
| SLMAP | sarcolemma associated protein | 0.0286865 |
| ACTG1 | actin gamma 1 | 0.0285115 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0283592 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0283452 |
| ADM | adrenomedullin | 0.0283442 |
| RPL27 | ribosomal protein L27 | 0.0283176 |
| EIF5AL1 | eukaryotic translation initiation factor 5A-like 1 | 0.0280276 |
| PLCB4 | phospholipase C, beta 4 | 0.0278859 |
| WWOX | WW domain containing oxidoreductase | 0.0278712 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.02781 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.027609 |
| MED13L | mediator complex subunit 13-like | 0.0275889 |
| RPS19 | ribosomal protein S19 | 0.0275455 |
| MYO9B | myosin IXB | 0.0273524 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.0273205 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0271984 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0271895 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0267586 |
| RPL37A | ribosomal protein L37a | 0.0266851 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0264075 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0262034 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.026097 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0258871 |
| CAVIN1 | caveolae associated protein 1 | 0.0258521 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | 0.0258498 |
| TPI1 | triosephosphate isomerase 1 | 0.0255438 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0254315 |
| RPS6 | ribosomal protein S6 | 0.0250828 |
| RPL28 | ribosomal protein L28 | 0.025074 |
| C12ORF75 | chromosome 12 open reading frame 75 | 0.0249963 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.0249763 |
| FBXO32 | F-box protein 32 | 0.0249744 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | 0.0247018 |
| RPL7 | ribosomal protein L7 | 0.024675 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0246119 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.024511 |
| SLC25A26 | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | 0.0243057 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0241055 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0240854 |
| VGF | VGF nerve growth factor inducible | 0.0239228 |
| IL1R1 | interleukin 1 receptor, type I | 0.0238707 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0238304 |
| FEM1C | fem-1 homolog c (C. elegans) | 0.023825 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0236911 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0236587 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | 0.0236496 |
| TNRC6A | trinucleotide repeat containing 6A | 0.0235915 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0234938 |
| IL6 | interleukin 6 | 0.0234622 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0234163 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0232079 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.023152 |
| SMAD3 | SMAD family member 3 | 0.0231471 |
| GRAMD1B | GRAM domain containing 1B | 0.0230233 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.022863 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0228408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.19609 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.187348 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.183212 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.114725 |
| HLA-B | major histocompatibility complex, class I, B | -0.10832 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0853436 |
| B2M | beta-2-microglobulin | -0.0794516 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0761001 |
| CALU | calumenin | -0.0714285 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.071089 |
| CANX | calnexin | -0.0619249 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0593759 |
| ANXA2 | annexin A2 | -0.055821 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.054001 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0519513 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0478878 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.045789 |
| GOLGA4 | golgin A4 | -0.0455762 |
| HLA-C | major histocompatibility complex, class I, C | -0.0455221 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0448809 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0436066 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0432008 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0417439 |
| HMGA2 | high mobility group AT-hook 2 | -0.0416465 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0416091 |
| CLIC4 | chloride intracellular channel 4 | -0.0412119 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0403261 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0400584 |
| CCDC88A | coiled-coil domain containing 88A | -0.0397951 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0395912 |
| WASF2 | WAS protein family, member 2 | -0.0395494 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0394114 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0390589 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0387984 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0386086 |
| TMEM165 | transmembrane protein 165 | -0.0385308 |
| CDK13 | cyclin-dependent kinase 13 | -0.0380713 |
| LOXL2 | lysyl oxidase-like 2 | -0.0380051 |
| MT2A | metallothionein 2A | -0.0378952 |
| GLG1 | golgi glycoprotein 1 | -0.0377793 |
| HIP1 | huntingtin interacting protein 1 | -0.0366615 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0361977 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0361394 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0357811 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0357376 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0354601 |
| EHBP1 | EH domain binding protein 1 | -0.0348126 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0347172 |
| ZNF395 | zinc finger protein 395 | -0.0344478 |
| ATP13A3 | ATPase type 13A3 | -0.0343417 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0341739 |
| CDH13 | cadherin 13 | -0.0332527 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 | -0.0327124 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0325799 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0325573 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0325136 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0324936 |
| TMSB4X | thymosin beta 4, X-linked | -0.0323955 |
| ASPH | aspartate beta-hydroxylase | -0.0323173 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0321446 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0316718 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0314156 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0310407 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0307002 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0306488 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0305588 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.030548 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0305425 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0302201 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0301096 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0299306 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0296476 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0294247 |
| MT1X | metallothionein 1X | -0.0289283 |
| STC1 | stanniocalcin 1 | -0.0287677 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.02865 |
| EMP1 | epithelial membrane protein 1 | -0.0282978 |
| RPL27A | ribosomal protein L27a | -0.0281713 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0278725 |
| SEC24A | SEC24 family member A | -0.0278649 |
| GPR173 | G protein-coupled receptor 173 | -0.027733 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0276223 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0274387 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0273397 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0272099 |
| NAV2 | neuron navigator 2 | -0.027149 |
| PDIA5 | protein disulfide isomerase family A, member 5 | -0.0265882 |
| HDLBP | high density lipoprotein binding protein | -0.0265067 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0264155 |
| PRELID2 | PRELI domain containing 2 | -0.0264133 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0263603 |
| S100A10 | S100 calcium binding protein A10 | -0.025864 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.025852 |
| COG5 | component of oligomeric golgi complex 5 | -0.0258276 |
| SEPTIN2 | septin 2 | -0.0257713 |
| NRXN3 | neurexin 3 | -0.0254365 |
| RYK | receptor-like tyrosine kinase | -0.0252882 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.025269 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0251412 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0249588 |
