| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Roxadustat perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Roxadustat_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.15479 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.152275 |
| FN1 | fibronectin 1 | 0.112532 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0885753 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0805211 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0763642 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0710059 |
| AHR | aryl hydrocarbon receptor | 0.0644822 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0588938 |
| CD109 | CD109 molecule | 0.058634 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0574245 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0563745 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0563633 |
| CANX | calnexin | 0.0559883 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0546268 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0543185 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0539456 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0538191 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0527783 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0497283 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0458143 |
| SPAG9 | sperm associated antigen 9 | 0.0448927 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0448466 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0444018 |
| SUCO | SUN domain containing ossification factor | 0.0442643 |
| RBM39 | RNA binding motif protein 39 | 0.0442087 |
| FAT1 | FAT atypical cadherin 1 | 0.0434436 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0427308 |
| NDRG1 | N-myc downstream regulated 1 | 0.042006 |
| FAM13A | family with sequence similarity 13, member A | 0.0413837 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0412699 |
| SMOX | spermine oxidase | 0.0410082 |
| ENO1 | enolase 1, (alpha) | 0.0395374 |
| SFTPA2 | surfactant protein A2 | 0.0392092 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0383655 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0382722 |
| CDC73 | cell division cycle 73 | 0.038133 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0368481 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0365592 |
| ZNF292 | zinc finger protein 292 | 0.0364436 |
| OGA | O-GlcNAcase | 0.0361059 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0360857 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0358354 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0356857 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0350343 |
| ITGA1 | integrin, alpha 1 | 0.03494 |
| TPR | translocated promoter region, nuclear basket protein | 0.0339203 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0338093 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0337214 |
| AFDN | afadin, adherens junction formation factor | 0.0333713 |
| PTK2 | protein tyrosine kinase 2 | 0.0331971 |
| SMAD3 | SMAD family member 3 | 0.032843 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0328092 |
| PCBP2 | poly(rC) binding protein 2 | 0.0327417 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0317818 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0317457 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0317145 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0315012 |
| RUNX2 | runt-related transcription factor 2 | 0.0311423 |
| PGK1 | phosphoglycerate kinase 1 | 0.0309379 |
| HELZ | helicase with zinc finger | 0.030572 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0301075 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0294562 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0293059 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0291802 |
| RNF145 | ring finger protein 145 | 0.0289467 |
| PRELID2 | PRELI domain containing 2 | 0.0288029 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0287501 |
| RPS12 | ribosomal protein S12 | 0.0287338 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0287078 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0286545 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0282704 |
| CALR | calreticulin | 0.0281916 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0279035 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0278808 |
| COPA | coatomer protein complex, subunit alpha | 0.0275913 |
| TFG | TRK-fused gene | 0.0275471 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0274555 |
| ZC3H11A | zinc finger CCCH-type containing 11A | 0.0273528 |
| CLTC | clathrin, heavy chain (Hc) | 0.0269963 |
| AHNAK | AHNAK nucleoprotein | 0.0266374 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0263467 |
| PRPF8 | pre-mRNA processing factor 8 | 0.0262924 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0262841 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0261791 |
| HMGA2 | high mobility group AT-hook 2 | 0.0260993 |
| RLF | rearranged L-myc fusion | 0.0259124 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0259032 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0258712 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0257093 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.025534 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0252827 |
| RTN4 | reticulon 4 | 0.0251942 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0251783 |
| XPO1 | exportin 1 | 0.0251081 |
| SFXN1 | sideroflexin 1 | 0.0249558 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0248934 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0247745 |
| APP | amyloid beta (A4) precursor protein | 0.0247585 |
| PLIN2 | perilipin 2 | 0.0247584 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.146244 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0350021 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.032076 |
| ACTG1 | actin gamma 1 | -0.0306449 |
| INTS6 | integrator complex subunit 6 | -0.029817 |
| HLA-B | major histocompatibility complex, class I, B | -0.028059 |
| RPS23 | ribosomal protein S23 | -0.0209358 |
| S100A10 | S100 calcium binding protein A10 | -0.0203619 |
| RPL35A | ribosomal protein L35a | -0.0200729 |
| EGR1 | early growth response 1 | -0.0199793 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0198235 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0194071 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | -0.0193674 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0191943 |
| RPLP1 | ribosomal protein, large, P1 | -0.0182674 |
| LRRC23 | leucine rich repeat containing 23 | -0.0171011 |
| PTMA | prothymosin, alpha | -0.016505 |
| RPS29 | ribosomal protein S29 | -0.0159613 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0156481 |
| HMGB1 | high mobility group box 1 | -0.0153915 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0150155 |
| TBCA | tubulin folding cofactor A | -0.0149677 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0145976 |
| HMGA1 | high mobility group AT-hook 1 | -0.0142338 |
| RPS15 | ribosomal protein S15 | -0.0142153 |
| KRT81 | keratin 81, type II | -0.0130577 |
| RPL34 | ribosomal protein L34 | -0.0130527 |
| RPS11 | ribosomal protein S11 | -0.012785 |
| RPL8 | ribosomal protein L8 | -0.0125002 |
| VCL | vinculin | -0.0123152 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0122972 |
| FTL | ferritin, light polypeptide | -0.0121069 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0120188 |
| RPS6 | ribosomal protein S6 | -0.0116822 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0116177 |
| BPTF | bromodomain PHD finger transcription factor | -0.0115228 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0114397 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.01115 |
| SMIM14 | small integral membrane protein 14 | -0.0110074 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0110058 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0109618 |
| CUX1 | cut-like homeobox 1 | -0.0108732 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0105092 |
| ASTN2 | astrotactin 2 | -0.0105062 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0104644 |
| GNAS | GNAS complex locus | -0.0103451 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0101574 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0101406 |
| POU2F2 | POU class 2 homeobox 2 | -0.0101394 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0101065 |
| RPL38 | ribosomal protein L38 | -0.0100651 |
| AGR2 | anterior gradient 2 | -0.0100522 |
| NABP1 | nucleic acid binding protein 1 | -0.00998716 |
| NPAS1 | neuronal PAS domain protein 1 | -0.00990742 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.00985119 |
| IGF2 | insulin-like growth factor 2 | -0.00983999 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.00977493 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.00960926 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0095533 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.00951185 |
| SP100 | SP100 nuclear antigen | -0.00944751 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.00939405 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.00936377 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.00919622 |
| ORAI2 | ORAI calcium release-activated calcium modulator 2 | -0.00908003 |
| FAM177A1 | family with sequence similarity 177, member A1 | -0.00904848 |
| RAN | RAN, member RAS oncogene family | -0.00891665 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.00881731 |
| CCND1 | cyclin D1 | -0.0086176 |
| ATP6V1G1 | ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 | -0.00855646 |
| SELENOK | selenoprotein K | -0.00841302 |
| TUBB4B | tubulin, beta 4B class IVb | -0.00837542 |
| CDH13 | cadherin 13 | -0.00834419 |
| POTEF | POTE ankyrin domain family, member F | -0.00828396 |
| AEBP2 | AE binding protein 2 | -0.00827876 |
| ERI2 | ERI1 exoribonuclease family member 2 | -0.00825989 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.00825952 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.00811714 |
| KRT19 | keratin 19, type I | -0.00795956 |
| CCDC138 | coiled-coil domain containing 138 | -0.00792618 |
| HSPA1A | heat shock 70kDa protein 1A | -0.00790983 |
| SERF2 | small EDRK-rich factor 2 | -0.00771208 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00767086 |
| PALLD | palladin, cytoskeletal associated protein | -0.00764845 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0076096 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00759772 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.00750726 |
| NOP56 | NOP56 ribonucleoprotein | -0.00742066 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.00740809 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00729485 |
| UBE2M | ubiquitin-conjugating enzyme E2M | -0.00727142 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00720575 |
| DGKI | diacylglycerol kinase, iota | -0.00718737 |
| RPS24 | ribosomal protein S24 | -0.0071622 |
| TTC23L | tetratricopeptide repeat domain 23-like | -0.00715703 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.00714462 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00711438 |
| NAV1 | neuron navigator 1 | -0.00711339 |
| RPL9 | ribosomal protein L9 | -0.00706184 |
| FRMD4A | FERM domain containing 4A | -0.00706041 |
