| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/91276 |
| Similar Terms | |
| Downloads & Tools |
199 proteins with high or low expression in Roxatidine relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.52 |
| ENO1 | enolase 1, (alpha) | 0.42 |
| TBX3 | T-box 3 | 0.37 |
| ARHGAP28 | Rho GTPase activating protein 28 | 0.37 |
| C12ORF57 | chromosome 12 open reading frame 57 | 0.35 |
| RFNG | RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase | 0.34 |
| EPN3 | epsin 3 | 0.32 |
| TMEM175 | transmembrane protein 175 | 0.32 |
| ATXN7L3B | ataxin 7-like 3B | 0.31 |
| F13A1 | coagulation factor XIII, A1 polypeptide | 0.3 |
| BTBD11 | BTB (POZ) domain containing 11 | 0.3 |
| MAGEA12 | melanoma antigen family A12 | 0.3 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.28 |
| GSE1 | Gse1 coiled-coil protein | 0.28 |
| PEX12 | peroxisomal biogenesis factor 12 | 0.28 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | 0.27 |
| LMBR1 | limb development membrane protein 1 | 0.27 |
| IFFO2 | intermediate filament family orphan 2 | 0.27 |
| SOX7 | SRY (sex determining region Y)-box 7 | 0.27 |
| KLHL29 | kelch-like family member 29 | 0.26 |
| TTC9C | tetratricopeptide repeat domain 9C | 0.26 |
| ZNF576 | zinc finger protein 576 | 0.25 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.25 |
| SDC1 | syndecan 1 | 0.25 |
| FGFR1OP2 | FGFR1 oncogene partner 2 | 0.25 |
| PANK1 | pantothenate kinase 1 | 0.24 |
| HOXB9 | homeobox B9 | 0.24 |
| NFE2L3 | nuclear factor, erythroid 2-like 3 | 0.24 |
| TMEM259 | transmembrane protein 259 | 0.24 |
| EVL | Enah/Vasp-like | 0.23 |
| DUSP22 | dual specificity phosphatase 22 | 0.23 |
| TMEM64 | transmembrane protein 64 | 0.23 |
| ZNF276 | zinc finger protein 276 | 0.23 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.22 |
| BMT2 | base methyltransferase of 25S rRNA 2 homolog | 0.22 |
| PLEKHJ1 | pleckstrin homology domain containing, family J member 1 | 0.22 |
| PPP2CA | protein phosphatase 2, catalytic subunit, alpha isozyme | 0.22 |
| MRNIP | MRN complex interacting protein | 0.22 |
| PLEKHG2 | pleckstrin homology domain containing, family G (with RhoGef domain) member 2 | 0.21 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | 0.21 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.21 |
| RNF187 | ring finger protein 187 | 0.21 |
| ZNF101 | zinc finger protein 101 | 0.21 |
| CCDC9B | coiled-coil domain containing 9B | 0.21 |
| CUTA | cutA divalent cation tolerance homolog (E. coli) | 0.21 |
| B2M | beta-2-microglobulin | 0.21 |
| MYCBP | MYC binding protein | 0.21 |
| DESI2 | desumoylating isopeptidase 2 | 0.21 |
| IL17RB | interleukin 17 receptor B | 0.2 |
| ATP9A | ATPase, class II, type 9A | 0.2 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | 0.2 |
| TCTEX1D2 | Tctex1 domain containing 2 | 0.2 |
| XIRP1 | xin actin binding repeat containing 1 | 0.2 |
| LTN1 | listerin E3 ubiquitin protein ligase 1 | 0.2 |
| FAM234A | family with sequence similarity 234 member A | 0.2 |
| USP1 | ubiquitin specific peptidase 1 | 0.2 |
| SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor | 0.2 |
| SFI1 | Sfi1 homolog, spindle assembly associated (yeast) | 0.2 |
| MSH5 | mutS homolog 5 | 0.2 |
| STMN2 | stathmin 2 | 0.2 |
| COMMD6 | COMM domain containing 6 | 0.19 |
| NADK | NAD kinase | 0.19 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | 0.19 |
| SELENOW | selenoprotein W | 0.19 |
| TRHDE | thyrotropin-releasing hormone degrading enzyme | 0.19 |
| PER2 | period circadian clock 2 | 0.19 |
| CEP112 | centrosomal protein 112kDa | 0.19 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.19 |
| PDCD7 | programmed cell death 7 | 0.19 |
| PSMG4 | proteasome (prosome, macropain) assembly chaperone 4 | 0.19 |
| MBOAT1 | membrane bound O-acyltransferase domain containing 1 | 0.19 |
| KBTBD6 | kelch repeat and BTB (POZ) domain containing 6 | 0.19 |
| DAPK2 | death-associated protein kinase 2 | 0.18 |
| SVIP | small VCP/p97-interacting protein | 0.18 |
| TULP4 | tubby like protein 4 | 0.18 |
| TMEM129 | transmembrane protein 129, E3 ubiquitin protein ligase | 0.18 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 0.18 |
| REEP3 | receptor accessory protein 3 | 0.18 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.18 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.18 |
| RCBTB1 | regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 | 0.18 |
| EVA1C | eva-1 homolog C (C. elegans) | 0.17 |
| CIPC | CLOCK-interacting pacemaker | 0.17 |
| FBXO31 | F-box protein 31 | 0.17 |
| MTPN | myotrophin | 0.17 |
| CRTC3 | CREB regulated transcription coactivator 3 | 0.17 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.17 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.17 |
| MAGEA2 | melanoma antigen family A2 | 0.17 |
| KPTN | kaptin (actin binding protein) | 0.17 |
| ZNF239 | zinc finger protein 239 | 0.17 |
| HAPLN3 | hyaluronan and proteoglycan link protein 3 | 0.17 |
| TPM2 | tropomyosin 2 (beta) | 0.17 |
| SGCE | sarcoglycan, epsilon | 0.17 |
| FAT4 | FAT atypical cadherin 4 | 0.17 |
| IFT38 | intraflagellar transport 38 | 0.17 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.17 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | 0.17 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.17 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ALPK3 | alpha-kinase 3 | -1.41 |
| NALCN | sodium leak channel, non selective | -1.3 |
| SEPTIN4 | septin 4 | -1.25 |
| SLC26A11 | solute carrier family 26 (anion exchanger), member 11 | -0.9 |
| CASZ1 | castor zinc finger 1 | -0.85 |
| CHRD | chordin | -0.85 |
| EPHA4 | EPH receptor A4 | -0.69 |
| VIM | vimentin | -0.61 |
| SMC1B | structural maintenance of chromosomes 1B | -0.59 |
| CROCC2 | ciliary rootlet coiled-coil, rootletin family member 2 | -0.57 |
| SF1 | splicing factor 1 | -0.55 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | -0.54 |
| IFNGR1 | interferon gamma receptor 1 | -0.54 |
| PCDHGA10 | protocadherin gamma subfamily A, 10 | -0.53 |
| SH2B3 | SH2B adaptor protein 3 | -0.51 |
| BRD7 | bromodomain containing 7 | -0.49 |
| CAV2 | caveolin 2 | -0.49 |
| RGL3 | ral guanine nucleotide dissociation stimulator-like 3 | -0.48 |
| PIP | prolactin-induced protein | -0.48 |
| TEN1 | TEN1 CST complex subunit | -0.48 |
| SH2B2 | SH2B adaptor protein 2 | -0.48 |
| HINFP | histone H4 transcription factor | -0.48 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | -0.47 |
| CKM | creatine kinase, muscle | -0.47 |
| MRPS18C | mitochondrial ribosomal protein S18C | -0.46 |
| SUMO1 | small ubiquitin-like modifier 1 | -0.46 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | -0.46 |
| RNPEPL1 | arginyl aminopeptidase (aminopeptidase B)-like 1 | -0.46 |
| SMAP1 | small ArfGAP 1 | -0.44 |
| ZBED8L | ZBED8 like | -0.43 |
| KCTD21 | potassium channel tetramerization domain containing 21 | -0.43 |
| ARHGEF35 | Rho guanine nucleotide exchange factor (GEF) 35 | -0.43 |
| VASN | vasorin | -0.42 |
| MTMR8 | myotubularin related protein 8 | -0.42 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | -0.42 |
| LRRC8B | leucine rich repeat containing 8 family, member B | -0.41 |
| PDE9A | phosphodiesterase 9A | -0.4 |
| SET | SET nuclear proto-oncogene | -0.4 |
| COL13A1 | collagen, type XIII, alpha 1 | -0.38 |
| GIN1 | gypsy retrotransposon integrase 1 | -0.38 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | -0.37 |
| SLC30A6 | solute carrier family 30 (zinc transporter), member 6 | -0.37 |
| KMT5B | lysine methyltransferase 5B | -0.36 |
| ZNF219 | zinc finger protein 219 | -0.36 |
| SPEG | SPEG complex locus | -0.36 |
| RNF4 | ring finger protein 4 | -0.36 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.36 |
| PCTP | phosphatidylcholine transfer protein | -0.35 |
| MFSD6 | major facilitator superfamily domain containing 6 | -0.35 |
| MYO15B | myosin XVB | -0.35 |
| NGFR | nerve growth factor receptor | -0.35 |
| ZMYM6 | zinc finger, MYM-type 6 | -0.34 |
| RPL26 | ribosomal protein L26 | -0.34 |
| STARD3NL | STARD3 N-terminal like | -0.34 |
| FN1 | fibronectin 1 | -0.34 |
| ADAMTS7 | ADAM metallopeptidase with thrombospondin type 1 motif, 7 | -0.32 |
| LINGO1 | leucine rich repeat and Ig domain containing 1 | -0.32 |
| GLRX | glutaredoxin (thioltransferase) | -0.32 |
| FGF19 | fibroblast growth factor 19 | -0.32 |
| ZNF658 | zinc finger protein 658 | -0.32 |
| BSN | bassoon presynaptic cytomatrix protein | -0.32 |
| KLK7 | kallikrein-related peptidase 7 | -0.31 |
| NOTCH3 | notch 3 | -0.31 |
| ABCD4 | ATP-binding cassette, sub-family D (ALD), member 4 | -0.31 |
| KIAA0232 | KIAA0232 | -0.3 |
| JAGN1 | jagunal homolog 1 (Drosophila) | -0.3 |
| ABCD1 | ATP-binding cassette, sub-family D (ALD), member 1 | -0.3 |
| PSMC1 | proteasome (prosome, macropain) 26S subunit, ATPase, 1 | -0.3 |
| TNNC2 | troponin C type 2 (fast) | -0.3 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -0.29 |
| AMACR | alpha-methylacyl-CoA racemase | -0.29 |
| LMF1 | lipase maturation factor 1 | -0.29 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.29 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.29 |
| ZFAT | zinc finger and AT hook domain containing | -0.29 |
| AUNIP | aurora kinase A and ninein interacting protein | -0.29 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.28 |
| PLPP6 | phospholipid phosphatase 6 | -0.28 |
| GK5 | glycerol kinase 5 (putative) | -0.28 |
| ZDHHC9 | zinc finger, DHHC-type containing 9 | -0.28 |
| HELQ | helicase, POLQ-like | -0.28 |
| ZNF280B | zinc finger protein 280B | -0.28 |
| SLC39A7 | solute carrier family 39 (zinc transporter), member 7 | -0.27 |
| KLF13 | Kruppel-like factor 13 | -0.27 |
| MATR3 | matrin 3 | -0.27 |
| SLC45A4 | solute carrier family 45, member 4 | -0.27 |
| ATP6V0A1 | ATPase, H+ transporting, lysosomal V0 subunit a1 | -0.27 |
| GJC1 | gap junction protein, gamma 1, 45kDa | -0.27 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.27 |
| SERINC5 | serine incorporator 5 | -0.26 |
| TMEM102 | transmembrane protein 102 | -0.26 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.26 |
| TTC30A | tetratricopeptide repeat domain 30A | -0.26 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.26 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 | -0.26 |
| CYBRD1 | cytochrome b reductase 1 | -0.26 |
| CEP57 | centrosomal protein 57kDa | -0.26 |
| MYH7B | myosin, heavy chain 7B, cardiac muscle, beta | -0.26 |
| ATG4D | autophagy related 4D, cysteine peptidase | -0.26 |
| OPA3 | optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) | -0.26 |
