| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.10046 |
| YAP1 | Yes-associated protein 1 | 0.0741618 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.072475 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0700352 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0657872 |
| AREG | amphiregulin | 0.0635368 |
| RTN4 | reticulon 4 | 0.0578591 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0566227 |
| PCBP2 | poly(rC) binding protein 2 | 0.0562254 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0558824 |
| CCN2 | cellular communication network factor 2 | 0.0546926 |
| RRM2 | ribonucleotide reductase M2 | 0.0536015 |
| NLGN1 | neuroligin 1 | 0.0514817 |
| POTEF | POTE ankyrin domain family, member F | 0.0508739 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0506093 |
| JMJD1C | jumonji domain containing 1C | 0.0489864 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0460215 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0458622 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0455382 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0451986 |
| VMP1 | vacuole membrane protein 1 | 0.0440024 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0436454 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.042893 |
| YBX1 | Y box binding protein 1 | 0.0421309 |
| CCNL1 | cyclin L1 | 0.0420822 |
| PDGFC | platelet derived growth factor C | 0.0420164 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0419731 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0419174 |
| TPM3 | tropomyosin 3 | 0.0416109 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0411764 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0408946 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0381786 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0377486 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0372137 |
| ASPH | aspartate beta-hydroxylase | 0.0371998 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0368845 |
| CPOX | coproporphyrinogen oxidase | 0.0365353 |
| ACTG1 | actin gamma 1 | 0.0360189 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0350306 |
| EPHA6 | EPH receptor A6 | 0.0349805 |
| TUBA1B | tubulin, alpha 1b | 0.0346403 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0343775 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0336741 |
| TBK1 | TANK-binding kinase 1 | 0.0330888 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.033018 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0329298 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0327725 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0326111 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0323931 |
| WWOX | WW domain containing oxidoreductase | 0.0319675 |
| MGAT4C | MGAT4 family, member C | 0.0317841 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.031288 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0309086 |
| TMEM41B | transmembrane protein 41B | 0.0306914 |
| NHSL1 | NHS-like 1 | 0.0306352 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0302743 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0300033 |
| HLA-A | major histocompatibility complex, class I, A | 0.0285051 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0275947 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0274151 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0270633 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0268625 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | 0.0266453 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0264401 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0263976 |
| USP34 | ubiquitin specific peptidase 34 | 0.0261563 |
| PCDH9 | protocadherin 9 | 0.025831 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0257475 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0256646 |
| ARRDC3 | arrestin domain containing 3 | 0.0250739 |
| EGR1 | early growth response 1 | 0.0249419 |
| BRD2 | bromodomain containing 2 | 0.0247807 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0247758 |
| FAT1 | FAT atypical cadherin 1 | 0.0247573 |
| EPHA5 | EPH receptor A5 | 0.0245405 |
| KCMF1 | potassium channel modulatory factor 1 | 0.024395 |
| ATP11A | ATPase, class VI, type 11A | 0.0243764 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0243481 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.024323 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0242214 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0242135 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0240357 |
| PTMS | parathymosin | 0.0239823 |
| TPI1 | triosephosphate isomerase 1 | 0.0236538 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0234495 |
| CEP192 | centrosomal protein 192kDa | 0.0226633 |
| RBM25 | RNA binding motif protein 25 | 0.022553 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0220765 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0218171 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0215073 |
| FLNA | filamin A, alpha | 0.0214981 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0213906 |
| ENO1 | enolase 1, (alpha) | 0.0213095 |
| DIAPH3 | diaphanous-related formin 3 | 0.0211019 |
| PRELID2 | PRELI domain containing 2 | 0.0208972 |
| HMGA1 | high mobility group AT-hook 1 | 0.0207433 |
| RBM39 | RNA binding motif protein 39 | 0.0206895 |
| IPO7 | importin 7 | 0.0206562 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0206097 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0205813 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0565871 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.0512266 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0469715 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0453078 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0426808 |
| CLDN1 | claudin 1 | -0.0426483 |
| RASAL2 | RAS protein activator like 2 | -0.042003 |
| MMP12 | matrix metallopeptidase 12 | -0.0415107 |
| ZNF804A | zinc finger protein 804A | -0.0403694 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0396033 |
| SNCA | synuclein, alpha (non A4 component of amyloid precursor) | -0.0374424 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.036797 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0364824 |
| RPS3 | ribosomal protein S3 | -0.0277094 |
| EGFR | epidermal growth factor receptor | -0.0270609 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0267843 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0263636 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0245368 |
| CMIP | c-Maf inducing protein | -0.0244464 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0242764 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0233607 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0225597 |
| CAVIN1 | caveolae associated protein 1 | -0.0225029 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0222679 |
| LMO7 | LIM domain 7 | -0.0221353 |
| PCDH7 | protocadherin 7 | -0.0219398 |
| RAI14 | retinoic acid induced 14 | -0.0217143 |
| CDK6 | cyclin-dependent kinase 6 | -0.0215625 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0211436 |
| NIPSNAP2 | nipsnap homolog 2 | -0.0210175 |
| NEBL | nebulette | -0.0210161 |
| RPS27A | ribosomal protein S27a | -0.0207145 |
| DST | dystonin | -0.0204208 |
| RPL12 | ribosomal protein L12 | -0.0202072 |
| RPS16 | ribosomal protein S16 | -0.0201701 |
| TSPAN5 | tetraspanin 5 | -0.0199998 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0198272 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0197542 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0197027 |
| EHBP1 | EH domain binding protein 1 | -0.0193295 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.019305 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0190538 |
| MAP1B | microtubule-associated protein 1B | -0.0188608 |
| RPL35A | ribosomal protein L35a | -0.0188374 |
| RPL38 | ribosomal protein L38 | -0.0187146 |
| MAP4 | microtubule-associated protein 4 | -0.0181096 |
| NSD1 | nuclear receptor binding SET domain protein 1 | -0.0176907 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | -0.0171764 |
| H1-0 | H1.0 linker histone | -0.0169771 |
| S100A6 | S100 calcium binding protein A6 | -0.0166725 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0162787 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0161819 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0161295 |
| FSTL5 | follistatin-like 5 | -0.0160787 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0159241 |
| RPL37A | ribosomal protein L37a | -0.0158632 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0153677 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0152644 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -0.0148164 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0146402 |
| PARK7 | parkinson protein 7 | -0.0142648 |
| RPL34 | ribosomal protein L34 | -0.0141034 |
| ASTN2 | astrotactin 2 | -0.0140237 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0138864 |
| RPS19 | ribosomal protein S19 | -0.0136794 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0136428 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0135707 |
| RPS29 | ribosomal protein S29 | -0.0135592 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0134975 |
| MTAP | methylthioadenosine phosphorylase | -0.0134844 |
| SPIDR | scaffolding protein involved in DNA repair | -0.0132579 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0131283 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0131033 |
| RPL36A | ribosomal protein L36a | -0.0130904 |
| AHNAK | AHNAK nucleoprotein | -0.0129627 |
| RPL13A | ribosomal protein L13a | -0.0128764 |
| RPL18 | ribosomal protein L18 | -0.0127916 |
| SYT1 | synaptotagmin I | -0.012697 |
| RPL36 | ribosomal protein L36 | -0.0125714 |
| RPS8 | ribosomal protein S8 | -0.0124882 |
| WASF2 | WAS protein family, member 2 | -0.0124256 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0124235 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0123764 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0122999 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0121842 |
| TMEM131 | transmembrane protein 131 | -0.012124 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0120419 |
| IPMK | inositol polyphosphate multikinase | -0.0119775 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | -0.0119462 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.011934 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0119022 |
| THOC2 | THO complex 2 | -0.0118491 |
| FAM162A | family with sequence similarity 162, member A | -0.0118105 |
| RNF216 | ring finger protein 216 | -0.0116699 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | -0.0115749 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0115319 |
| SEPTIN10 | septin 10 | -0.0114418 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0113805 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0113628 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0113541 |
