| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in A498 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Rucaparib (phosphate)_A498 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.150558 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0966314 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0927934 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0819649 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.0674147 |
| RPS6 | ribosomal protein S6 | 0.0616008 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0584288 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0558129 |
| B2M | beta-2-microglobulin | 0.0547319 |
| FRMD4A | FERM domain containing 4A | 0.0433254 |
| NDRG1 | N-myc downstream regulated 1 | 0.0418605 |
| RPS8 | ribosomal protein S8 | 0.0417841 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0412593 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0399986 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0391463 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0385714 |
| RPL35A | ribosomal protein L35a | 0.0378927 |
| PFN1 | profilin 1 | 0.0363097 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0344927 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0334421 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0327934 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.0319172 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0307405 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0304263 |
| MT2A | metallothionein 2A | 0.0297845 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0294348 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.0292867 |
| VEGFA | vascular endothelial growth factor A | 0.0290577 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0288587 |
| RTN4 | reticulon 4 | 0.0287335 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0281716 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0275973 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0272787 |
| MAP1B | microtubule-associated protein 1B | 0.0268831 |
| POTEF | POTE ankyrin domain family, member F | 0.0266918 |
| ICAM1 | intercellular adhesion molecule 1 | 0.026635 |
| TPM3 | tropomyosin 3 | 0.0263916 |
| ANKRD33B | ankyrin repeat domain 33B | 0.0263476 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0263026 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0262274 |
| ATP13A3 | ATPase type 13A3 | 0.0261945 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0260482 |
| RPL28 | ribosomal protein L28 | 0.025581 |
| MSN | moesin | 0.0253089 |
| DSTN | destrin (actin depolymerizing factor) | 0.0251291 |
| DENND2B | DENN domain containing 2B | 0.0248968 |
| SPAG9 | sperm associated antigen 9 | 0.0248721 |
| HLA-B | major histocompatibility complex, class I, B | 0.0248299 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0247929 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0242766 |
| CD44 | CD44 molecule (Indian blood group) | 0.024129 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0236917 |
| MGST1 | microsomal glutathione S-transferase 1 | 0.0236895 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0231236 |
| FMNL2 | formin-like 2 | 0.0229523 |
| GPC6 | glypican 6 | 0.0225195 |
| RPS2 | ribosomal protein S2 | 0.0222305 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.022026 |
| G0S2 | G0/G1 switch 2 | 0.0218656 |
| CALR | calreticulin | 0.0217657 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0215331 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.0214833 |
| RPL37A | ribosomal protein L37a | 0.0212797 |
| RPS19 | ribosomal protein S19 | 0.0209313 |
| HDGF | hepatoma-derived growth factor | 0.0208374 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0207263 |
| ANXA1 | annexin A1 | 0.0207039 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0204076 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0201687 |
| VIM | vimentin | 0.0199126 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0198021 |
| ANXA2 | annexin A2 | 0.0197625 |
| CTSD | cathepsin D | 0.0197551 |
| ACTG1 | actin gamma 1 | 0.019653 |
| MTDH | metadherin | 0.0195598 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0195469 |
| FLNA | filamin A, alpha | 0.0195008 |
| ADM | adrenomedullin | 0.0193925 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0193015 |
| HLA-A | major histocompatibility complex, class I, A | 0.0190527 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0189566 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | 0.0185544 |
| ADAR | adenosine deaminase, RNA-specific | 0.0185056 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0184728 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | 0.0184352 |
| RPS13 | ribosomal protein S13 | 0.0184261 |
| ANXA5 | annexin A5 | 0.0183973 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0181978 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0179937 |
| USP3 | ubiquitin specific peptidase 3 | 0.0178467 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0178405 |
| RPL12 | ribosomal protein L12 | 0.0178191 |
| CELF1 | CUGBP, Elav-like family member 1 | 0.0175941 |
| TRAM1 | translocation associated membrane protein 1 | 0.0175671 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0174188 |
| CALD1 | caldesmon 1 | 0.0172165 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0171924 |
| RPL8 | ribosomal protein L8 | 0.0169658 |
| PAX8 | paired box 8 | 0.0167839 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0167319 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | -0.122619 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0647813 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0633944 |
| GLIS3 | GLIS family zinc finger 3 | -0.0481747 |
| TXNRD1 | thioredoxin reductase 1 | -0.0345469 |
| VCL | vinculin | -0.0335745 |
| SMAD3 | SMAD family member 3 | -0.0316308 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0262821 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0261422 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.025414 |
| KYNU | kynureninase | -0.0252719 |
| ETV6 | ets variant 6 | -0.0228903 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0200766 |
| TMSB10 | thymosin beta 10 | -0.0199956 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0195133 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0193955 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0193044 |
| PALLD | palladin, cytoskeletal associated protein | -0.0187025 |
| UBC | ubiquitin C | -0.0178674 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0176016 |
| TGFA | transforming growth factor, alpha | -0.0175453 |
| NF1 | neurofibromin 1 | -0.0174744 |
| OSMR | oncostatin M receptor | -0.0172956 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0169651 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0168392 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0159362 |
| LOXL2 | lysyl oxidase-like 2 | -0.0158677 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0156652 |
| TGFB2 | transforming growth factor, beta 2 | -0.0156194 |
| RRBP1 | ribosome binding protein 1 | -0.0155939 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0149506 |
| FAM20C | family with sequence similarity 20, member C | -0.0147462 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.014639 |
| STK17A | serine/threonine kinase 17a | -0.0146171 |
| EHBP1 | EH domain binding protein 1 | -0.0141267 |
| RIC8B | RIC8 guanine nucleotide exchange factor B | -0.0136894 |
| NRP2 | neuropilin 2 | -0.0136689 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0133428 |
| FAM107B | family with sequence similarity 107, member B | -0.0133017 |
| SETX | senataxin | -0.0132891 |
| GOLGA3 | golgin A3 | -0.0129718 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0128983 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.0128329 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0126055 |
| TUT7 | terminal uridylyl transferase 7 | -0.0122367 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | -0.0122025 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0121282 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0120891 |
| TUSC3 | tumor suppressor candidate 3 | -0.0118146 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0117472 |
| CEP350 | centrosomal protein 350kDa | -0.01166 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0114216 |
| GOLGB1 | golgin B1 | -0.0113647 |
| SH3RF1 | SH3 domain containing ring finger 1 | -0.0110938 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0110912 |
| AOPEP | aminopeptidase O (putative) | -0.0110462 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0110321 |
| HDLBP | high density lipoprotein binding protein | -0.0110309 |
| SMYD3 | SET and MYND domain containing 3 | -0.0110183 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0109821 |
| COG5 | component of oligomeric golgi complex 5 | -0.0109809 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0106836 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0106593 |
| FAT1 | FAT atypical cadherin 1 | -0.0105707 |
| FHL2 | four and a half LIM domains 2 | -0.0105182 |
| CDK13 | cyclin-dependent kinase 13 | -0.010499 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0104714 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0104131 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0103832 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.010242 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0101688 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0101471 |
| GLG1 | golgi glycoprotein 1 | -0.0100883 |
| INTS6 | integrator complex subunit 6 | -0.0099149 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | -0.00977485 |
| NUP214 | nucleoporin 214kDa | -0.00965322 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.00963289 |
| SPIDR | scaffolding protein involved in DNA repair | -0.00947601 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.009469 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.00939409 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.00920485 |
| MSR1 | macrophage scavenger receptor 1 | -0.00906329 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.00891348 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0087307 |
| R3HDM1 | R3H domain containing 1 | -0.00870087 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.00865705 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.00859271 |
| TNS3 | tensin 3 | -0.00859171 |
| JUN | jun proto-oncogene | -0.00855585 |
| SLC35F3 | solute carrier family 35, member F3 | -0.00854466 |
| PCBP3 | poly(rC) binding protein 3 | -0.00850415 |
| VMP1 | vacuole membrane protein 1 | -0.00849838 |
| TLE4 | transducin-like enhancer of split 4 | -0.00846701 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.00836192 |
| COL4A2 | collagen, type IV, alpha 2 | -0.00835383 |
| EXOC6B | exocyst complex component 6B | -0.00835095 |
| CA12 | carbonic anhydrase XII | -0.0083286 |
| HMGB2 | high mobility group box 2 | -0.0082935 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.00827487 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.00824892 |
