| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in A549 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.154637 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.149864 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.118067 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.113481 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0953774 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0742867 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0734221 |
| SMAD3 | SMAD family member 3 | 0.071536 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.069189 |
| ANXA2 | annexin A2 | 0.0679239 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0619539 |
| SPAG9 | sperm associated antigen 9 | 0.0584415 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0580841 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0580536 |
| USP3 | ubiquitin specific peptidase 3 | 0.0574719 |
| AHNAK | AHNAK nucleoprotein | 0.0550832 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0516476 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0504232 |
| NAV2 | neuron navigator 2 | 0.0465347 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0454171 |
| FLNB | filamin B, beta | 0.0440458 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0435252 |
| NDRG1 | N-myc downstream regulated 1 | 0.042375 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0421067 |
| UBC | ubiquitin C | 0.0411231 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0408938 |
| FMNL2 | formin-like 2 | 0.0404951 |
| HELZ | helicase with zinc finger | 0.0401804 |
| NBAS | neuroblastoma amplified sequence | 0.0391987 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0388637 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0385181 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0382343 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0373876 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0372804 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0371787 |
| RASA2 | RAS p21 protein activator 2 | 0.0369805 |
| MYOF | myoferlin | 0.0365818 |
| OGA | O-GlcNAcase | 0.0361603 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0348756 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0338997 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0337926 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0337559 |
| SBF2 | SET binding factor 2 | 0.0335865 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0332365 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0326502 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.032119 |
| WDR43 | WD repeat domain 43 | 0.0320767 |
| CD44 | CD44 molecule (Indian blood group) | 0.0320561 |
| NUP58 | nucleoporin 58 | 0.0316312 |
| FLNA | filamin A, alpha | 0.0312651 |
| RTN4 | reticulon 4 | 0.0311305 |
| OLA1 | Obg-like ATPase 1 | 0.0310053 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0298339 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0292584 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0290133 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0286027 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0285666 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0284647 |
| PLEC | plectin | 0.0282629 |
| FAM107B | family with sequence similarity 107, member B | 0.0282423 |
| UBA2 | ubiquitin-like modifier activating enzyme 2 | 0.0281988 |
| BCL2L1 | BCL2-like 1 | 0.0279114 |
| PTK2 | protein tyrosine kinase 2 | 0.0277083 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.026374 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.0263295 |
| DENND4A | DENN/MADD domain containing 4A | 0.0261016 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0257056 |
| ACTG1 | actin gamma 1 | 0.0257049 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0256577 |
| ATP13A3 | ATPase type 13A3 | 0.0254491 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0254301 |
| KCTD9 | potassium channel tetramerization domain containing 9 | 0.0252355 |
| TPD52 | tumor protein D52 | 0.025136 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.025114 |
| POTEF | POTE ankyrin domain family, member F | 0.0246574 |
| APP | amyloid beta (A4) precursor protein | 0.0243608 |
| KIRREL3 | kin of IRRE like 3 (Drosophila) | 0.0241998 |
| ZFAND6 | zinc finger, AN1-type domain 6 | 0.024148 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0241265 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0236328 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.023606 |
| KLF6 | Kruppel-like factor 6 | 0.0235652 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0235494 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0234815 |
| ECPAS | Ecm29 proteasome adaptor and scaffold | 0.0234713 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0233828 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0233523 |
| RAB8B | RAB8B, member RAS oncogene family | 0.023197 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0231532 |
| SETD5 | SET domain containing 5 | 0.0229378 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0229052 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0228952 |
| RPL28 | ribosomal protein L28 | 0.0227664 |
| PARD3 | par-3 family cell polarity regulator | 0.0226374 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0225799 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0225184 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0223213 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0222842 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0221816 |
| JAK1 | Janus kinase 1 | 0.0219408 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0593415 |
| TMSB10 | thymosin beta 10 | -0.0542342 |
| EGFR | epidermal growth factor receptor | -0.0516539 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0491173 |
| RPS19 | ribosomal protein S19 | -0.0488443 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0451584 |
| MT2A | metallothionein 2A | -0.0409155 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0391749 |
| VCL | vinculin | -0.0354334 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0345147 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.032132 |
| RPS6 | ribosomal protein S6 | -0.0315416 |
| RPL35A | ribosomal protein L35a | -0.0297059 |
| RPS29 | ribosomal protein S29 | -0.0274278 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0273791 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0273008 |
| RPS23 | ribosomal protein S23 | -0.0269937 |
| GOLGB1 | golgin B1 | -0.0249264 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0249001 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0239887 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.023808 |
| RPL23 | ribosomal protein L23 | -0.0232784 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0220022 |
| RRBP1 | ribosome binding protein 1 | -0.0218795 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0217925 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0212805 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0212203 |
| RIGI | RNA sensor RIG-I | -0.0208407 |
| EGR1 | early growth response 1 | -0.0207236 |
| NRG1 | neuregulin 1 | -0.0206825 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0203471 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0201305 |
| IER3 | immediate early response 3 | -0.0199824 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0198944 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0192614 |
| PTMA | prothymosin, alpha | -0.0191903 |
| KYNU | kynureninase | -0.0185592 |
| SP100 | SP100 nuclear antigen | -0.0184552 |
| OSMR | oncostatin M receptor | -0.0182557 |
| AADAC | arylacetamide deacetylase | -0.0182073 |
| EFNA5 | ephrin-A5 | -0.0180627 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0180584 |
| TPM1 | tropomyosin 1 (alpha) | -0.0179372 |
| DUSP16 | dual specificity phosphatase 16 | -0.0169433 |
| INTS6 | integrator complex subunit 6 | -0.0167413 |
| RPS3 | ribosomal protein S3 | -0.016613 |
| ST6GAL2 | ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 | -0.0163773 |
| RPS27 | ribosomal protein S27 | -0.0161812 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0152018 |
| RPS16 | ribosomal protein S16 | -0.0148317 |
| RPLP2 | ribosomal protein, large, P2 | -0.0148067 |
| S100A11 | S100 calcium binding protein A11 | -0.0147587 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0145862 |
| HDLBP | high density lipoprotein binding protein | -0.014272 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0142242 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0141753 |
| CCDC88A | coiled-coil domain containing 88A | -0.0140075 |
| HLA-B | major histocompatibility complex, class I, B | -0.0139593 |
| RPL34 | ribosomal protein L34 | -0.013907 |
| RPS11 | ribosomal protein S11 | -0.0137364 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0137255 |
| RHCG | Rh family, C glycoprotein | -0.0136456 |
| LOXL2 | lysyl oxidase-like 2 | -0.0130562 |
| RPS5 | ribosomal protein S5 | -0.0128169 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0128137 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0127404 |
| RPS17 | ribosomal protein S17 | -0.0125012 |
| RPS10 | ribosomal protein S10 | -0.012447 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0124423 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.012411 |
| PDGFA | platelet-derived growth factor alpha polypeptide | -0.0124033 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0123759 |
| EXOC4 | exocyst complex component 4 | -0.0123752 |
| RPL38 | ribosomal protein L38 | -0.012362 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0121625 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0121333 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0121324 |
| CDK13 | cyclin-dependent kinase 13 | -0.0121 |
| RPL36A | ribosomal protein L36a | -0.012058 |
| HMGA2 | high mobility group AT-hook 2 | -0.0119474 |
| BPTF | bromodomain PHD finger transcription factor | -0.0118927 |
| RPLP1 | ribosomal protein, large, P1 | -0.0118652 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0118499 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0118105 |
| CLIC4 | chloride intracellular channel 4 | -0.0117213 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0116538 |
| TBCA | tubulin folding cofactor A | -0.0113618 |
| CMIP | c-Maf inducing protein | -0.0112216 |
| RPS25 | ribosomal protein S25 | -0.0111603 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.0109603 |
| LMO7 | LIM domain 7 | -0.0109348 |
| ZFHX3 | zinc finger homeobox 3 | -0.0108985 |
| RPL12 | ribosomal protein L12 | -0.0108951 |
| LAMC2 | laminin, gamma 2 | -0.0105112 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0104914 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0104815 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0104399 |
| RPL32 | ribosomal protein L32 | -0.0104247 |
| CP | ceruloplasmin (ferroxidase) | -0.0104206 |
| SLC25A51 | solute carrier family 25, member 51 | -0.0103707 |
