| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in AsPC-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | 0.163107 |
| LAMB3 | laminin, beta 3 | 0.0922073 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0810864 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0797885 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0766831 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0618076 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0606433 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0541583 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.049741 |
| EFNA5 | ephrin-A5 | 0.0442995 |
| NDRG1 | N-myc downstream regulated 1 | 0.0435629 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0422894 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.0405262 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0399248 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0389679 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0389618 |
| TPM3 | tropomyosin 3 | 0.037628 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0372473 |
| AHNAK | AHNAK nucleoprotein | 0.0363447 |
| PARD3 | par-3 family cell polarity regulator | 0.0337702 |
| MCL1 | myeloid cell leukemia 1 | 0.0337038 |
| FMNL2 | formin-like 2 | 0.0333798 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0333328 |
| MXD1 | MAX dimerization protein 1 | 0.0326351 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.031942 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0312426 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0309159 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0303427 |
| HMGA2 | high mobility group AT-hook 2 | 0.0303228 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0285552 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.0281654 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0278439 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0273027 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0266237 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0259778 |
| SLMAP | sarcolemma associated protein | 0.0257955 |
| SACK1A | scaffolding CK1 anchoring protein A | 0.0257867 |
| FOSL1 | FOS-like antigen 1 | 0.0255048 |
| CLMP | CXADR-like membrane protein | 0.0252912 |
| RCOR1 | REST corepressor 1 | 0.0251144 |
| KIRREL1 | kirre like nephrin family adhesion molecule 1 | 0.025073 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0249691 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0248884 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0245056 |
| MSN | moesin | 0.0244082 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0243077 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0242547 |
| SERTAD2 | SERTA domain containing 2 | 0.0241827 |
| PLEC | plectin | 0.0233068 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0229621 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0226198 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0226124 |
| RPL37A | ribosomal protein L37a | 0.0224689 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0218231 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0215144 |
| RPS3 | ribosomal protein S3 | 0.0213077 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0211734 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0211552 |
| RPS12 | ribosomal protein S12 | 0.0211107 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0209403 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0209347 |
| CAPRIN2 | caprin family member 2 | 0.0208431 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0207135 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0206629 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0206092 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.020094 |
| ATP13A3 | ATPase type 13A3 | 0.0200072 |
| DSPP | dentin sialophosphoprotein | 0.0198588 |
| UPP1 | uridine phosphorylase 1 | 0.0194735 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0193114 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0192454 |
| RASAL2 | RAS protein activator like 2 | 0.0191005 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0190973 |
| LAMC2 | laminin, gamma 2 | 0.0190154 |
| RTN4 | reticulon 4 | 0.018664 |
| RPS8 | ribosomal protein S8 | 0.0186477 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0183279 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0176491 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0174209 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0172266 |
| MYO5B | myosin VB | 0.0168677 |
| FAM13A | family with sequence similarity 13, member A | 0.0168437 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.016771 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.016643 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0164702 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0163458 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.016305 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0161381 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0161172 |
| SBF2 | SET binding factor 2 | 0.0160955 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0160243 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0159634 |
| PARD6B | par-6 family cell polarity regulator beta | 0.0156739 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0156348 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0154841 |
| TGM2 | transglutaminase 2 | 0.015391 |
| TRRAP | transformation/transcription domain-associated protein | 0.0153252 |
| OSMR | oncostatin M receptor | 0.015293 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0152624 |
| EPHA2 | EPH receptor A2 | 0.015238 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.182901 |
| VIM | vimentin | -0.12038 |
| PTMA | prothymosin, alpha | -0.0731804 |
| EMP1 | epithelial membrane protein 1 | -0.05989 |
| S100A10 | S100 calcium binding protein A10 | -0.0552297 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0550838 |
| LMO7 | LIM domain 7 | -0.0487331 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0463393 |
| ARPC1A | actin related protein 2/3 complex, subunit 1A, 41kDa | -0.0459447 |
| HMGA1 | high mobility group AT-hook 1 | -0.0420625 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0392065 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | -0.038403 |
| EZR | ezrin | -0.038069 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0373455 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0367567 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0349491 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0344913 |
| TXNRD1 | thioredoxin reductase 1 | -0.0332275 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0325243 |
| VCAN | versican | -0.0316629 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0304424 |
| SQSTM1 | sequestosome 1 | -0.0286885 |
| UBC | ubiquitin C | -0.0285289 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0284 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0274491 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0265387 |
| RPLP1 | ribosomal protein, large, P1 | -0.0264157 |
| RRBP1 | ribosome binding protein 1 | -0.0254792 |
| RPS24 | ribosomal protein S24 | -0.024378 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0243125 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0239453 |
| MYOF | myoferlin | -0.0239421 |
| LDHA | lactate dehydrogenase A | -0.0234808 |
| S100A4 | S100 calcium binding protein A4 | -0.0233323 |
| HDLBP | high density lipoprotein binding protein | -0.0232992 |
| PGK1 | phosphoglycerate kinase 1 | -0.0231786 |
| FTL | ferritin, light polypeptide | -0.0231103 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0220117 |
| ARHGAP42 | Rho GTPase activating protein 42 | -0.0219944 |
| RBM39 | RNA binding motif protein 39 | -0.0216708 |
| LAMA4 | laminin, alpha 4 | -0.0210262 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0205849 |
| TAOK3 | TAO kinase 3 | -0.0199958 |
| GOLGA4 | golgin A4 | -0.0199805 |
| TXNIP | thioredoxin interacting protein | -0.0194829 |
| UBE2I | ubiquitin-conjugating enzyme E2I | -0.0194062 |
| S100A6 | S100 calcium binding protein A6 | -0.0193769 |
| FAM107B | family with sequence similarity 107, member B | -0.0192957 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0187492 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0187404 |
| PERP | PERP, TP53 apoptosis effector | -0.0186236 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0185858 |
| RPL31 | ribosomal protein L31 | -0.018282 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0182706 |
| LMNA | lamin A/C | -0.0181228 |
| VCL | vinculin | -0.0180688 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0178087 |
| ARF1 | ADP-ribosylation factor 1 | -0.0177859 |
| KRT19 | keratin 19, type I | -0.017749 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0177304 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0176646 |
| GOLGB1 | golgin B1 | -0.0173301 |
| KRT18 | keratin 18, type I | -0.0172615 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0170229 |
| IER3 | immediate early response 3 | -0.0170012 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0166563 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | -0.0166213 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0164857 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0161333 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0160553 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0155915 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.015497 |
| RPS20 | ribosomal protein S20 | -0.0154611 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0153327 |
| GNAS | GNAS complex locus | -0.014985 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0148972 |
| SP100 | SP100 nuclear antigen | -0.0148207 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0147818 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0147811 |
| COL17A1 | collagen, type XVII, alpha 1 | -0.0147276 |
| NOP58 | NOP58 ribonucleoprotein | -0.0146502 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.014484 |
| NT5C3A | 5'-nucleotidase, cytosolic IIIA | -0.014294 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | -0.0142024 |
| HBP1 | HMG-box transcription factor 1 | -0.0141365 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0139017 |
| DSTN | destrin (actin depolymerizing factor) | -0.0138623 |
| NPR2 | natriuretic peptide receptor 2 | -0.0135832 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0135523 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0134598 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0133641 |
| APAF1 | apoptotic peptidase activating factor 1 | -0.0132818 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0129386 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0129055 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0128336 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0128308 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0128297 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0128029 |
| RBM25 | RNA binding motif protein 25 | -0.0127994 |
| SEPTIN7 | septin 7 | -0.0126825 |
