| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in BT-474 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Rucaparib (phosphate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL19 | ribosomal protein L19 | 0.170585 |
| RPL23 | ribosomal protein L23 | 0.104035 |
| MT2A | metallothionein 2A | 0.0720463 |
| ERBB2 | erb-b2 receptor tyrosine kinase 2 | 0.0614346 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.057972 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0551063 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0533654 |
| SHROOM3 | shroom family member 3 | 0.0507816 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0459527 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0439266 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0420374 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0382667 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0360661 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0359904 |
| CREB5 | cAMP responsive element binding protein 5 | 0.034552 |
| ACTG1 | actin gamma 1 | 0.0343471 |
| ANXA2 | annexin A2 | 0.0326166 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0312997 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.031088 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0308093 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0301928 |
| RPS3 | ribosomal protein S3 | 0.0300095 |
| VEGFA | vascular endothelial growth factor A | 0.028351 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0275378 |
| ATXN1 | ataxin 1 | 0.0274725 |
| SRCIN1 | SRC kinase signaling inhibitor 1 | 0.0274147 |
| EGFR | epidermal growth factor receptor | 0.0272142 |
| RPL37A | ribosomal protein L37a | 0.0270674 |
| CEP250 | centrosomal protein 250kDa | 0.0265119 |
| MSI2 | musashi RNA-binding protein 2 | 0.0264832 |
| NEBL | nebulette | 0.0263017 |
| EHMT1 | euchromatic histone-lysine N-methyltransferase 1 | 0.0254542 |
| ITGB6 | integrin, beta 6 | 0.0253451 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0252076 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.025048 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0250053 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.024591 |
| RPS29 | ribosomal protein S29 | 0.0244686 |
| ATP8B1 | ATPase, aminophospholipid transporter, class I, type 8B, member 1 | 0.0241081 |
| YAP1 | Yes-associated protein 1 | 0.0237675 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0236385 |
| KIAA1217 | KIAA1217 | 0.023389 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.023157 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0231322 |
| RPL35A | ribosomal protein L35a | 0.0226871 |
| HLA-C | major histocompatibility complex, class I, C | 0.0225081 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0224719 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0221624 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0221583 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | 0.021989 |
| TFRC | transferrin receptor | 0.0214206 |
| RPLP0 | ribosomal protein, large, P0 | 0.0213784 |
| NCOA6 | nuclear receptor coactivator 6 | 0.0210495 |
| SLC22A23 | solute carrier family 22, member 23 | 0.020978 |
| TMEM45B | transmembrane protein 45B | 0.0209764 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0207827 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0207697 |
| PTK2 | protein tyrosine kinase 2 | 0.0206881 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0206543 |
| KRT7 | keratin 7, type II | 0.0206267 |
| POTEF | POTE ankyrin domain family, member F | 0.0206005 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0203329 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0203279 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.020327 |
| DTNA | dystrobrevin, alpha | 0.0202134 |
| RPL30 | ribosomal protein L30 | 0.0200613 |
| GATAD2B | GATA zinc finger domain containing 2B | 0.0200547 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0199562 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0195996 |
| SGMS1 | sphingomyelin synthase 1 | 0.0194942 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | 0.0194942 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0194507 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0193604 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0193439 |
| ATG7 | autophagy related 7 | 0.0192199 |
| MCL1 | myeloid cell leukemia 1 | 0.0191723 |
| RUNX1 | runt-related transcription factor 1 | 0.0190451 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0187644 |
| RPL11 | ribosomal protein L11 | 0.0186846 |
| RPL37 | ribosomal protein L37 | 0.0185903 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0185309 |
| KLF6 | Kruppel-like factor 6 | 0.0181379 |
| GRB7 | growth factor receptor-bound protein 7 | 0.0178946 |
| S100A14 | S100 calcium binding protein A14 | 0.0178886 |
| RPL38 | ribosomal protein L38 | 0.0177761 |
| PLEC | plectin | 0.0176905 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0173626 |
| CUL3 | cullin 3 | 0.0171629 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0171264 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0171191 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0169693 |
| LARP4B | La ribonucleoprotein domain family, member 4B | 0.0166565 |
| ENAH | enabled homolog (Drosophila) | 0.0166324 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0165946 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0165589 |
| RPS13 | ribosomal protein S13 | 0.0165331 |
| CSNK1D | casein kinase 1, delta | 0.0164732 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0164189 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.0161616 |
| RPS19 | ribosomal protein S19 | 0.0161124 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.073389 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0664314 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0432129 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0397918 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0396488 |
| UBC | ubiquitin C | -0.0366578 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0279903 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.0263986 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.025471 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0242547 |
| PTMA | prothymosin, alpha | -0.0241242 |
| ASPH | aspartate beta-hydroxylase | -0.0240679 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0237979 |
| PGK1 | phosphoglycerate kinase 1 | -0.0235371 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0224905 |
| RARRES1 | retinoic acid receptor responder (tazarotene induced) 1 | -0.0202938 |
| SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | -0.0200003 |
| MYO6 | myosin VI | -0.0197638 |
| SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | -0.0194392 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0187228 |
| YPEL2 | yippee-like 2 (Drosophila) | -0.0179137 |
| DUSP16 | dual specificity phosphatase 16 | -0.0177022 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0176235 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0172185 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0169447 |
| CFB | complement factor B | -0.0166578 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.016389 |
| ZNF609 | zinc finger protein 609 | -0.0162964 |
| LMO7 | LIM domain 7 | -0.0160031 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0159702 |
| TMEM123 | transmembrane protein 123 | -0.015528 |
| TES | testin LIM domain protein | -0.0154239 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0151812 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | -0.0151802 |
| RPS27A | ribosomal protein S27a | -0.0151264 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0150967 |
| S100A6 | S100 calcium binding protein A6 | -0.0150958 |
| MYO1D | myosin ID | -0.0150921 |
| PATL1 | protein associated with topoisomerase II homolog 1 (yeast) | -0.0146872 |
| GOLGA4 | golgin A4 | -0.0146577 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0146121 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.014469 |
| SLFN5 | schlafen family member 5 | -0.0143439 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0143292 |
| TNS3 | tensin 3 | -0.0142291 |
| CDC50A | cell division cycle 50 P4-ATPase accessory subunit A | -0.014047 |
| JUN | jun proto-oncogene | -0.0140246 |
| VIM | vimentin | -0.0139662 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | -0.0136953 |
| MAP4 | microtubule-associated protein 4 | -0.0136307 |
| FDPS | farnesyl diphosphate synthase | -0.013575 |
| MORF4L2 | mortality factor 4 like 2 | -0.0134678 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0128661 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.012745 |
| RAD21 | RAD21 homolog (S. pombe) | -0.012684 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0125295 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0125209 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0124778 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0124147 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0123328 |
| PTPN2 | protein tyrosine phosphatase, non-receptor type 2 | -0.0122211 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0121565 |
| GPC5 | glypican 5 | -0.0121372 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0120928 |
| DICER1 | dicer 1, ribonuclease type III | -0.0120061 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0119889 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | -0.0119847 |
| TIPRL | TOR signaling pathway regulator | -0.0119253 |
| NUMB | numb homolog (Drosophila) | -0.0119071 |
| DENND5A | DENN/MADD domain containing 5A | -0.0118344 |
| DIAPH1 | diaphanous-related formin 1 | -0.0117925 |
| AUTS2 | autism susceptibility candidate 2 | -0.0115513 |
| TRAM1 | translocation associated membrane protein 1 | -0.0114405 |
| TPM1 | tropomyosin 1 (alpha) | -0.0113609 |
| VEZF1 | vascular endothelial zinc finger 1 | -0.0112253 |
| ANKRD36C | ankyrin repeat domain 36C | -0.0112117 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0111987 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | -0.0111308 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0111287 |
| RPS24 | ribosomal protein S24 | -0.0111036 |
| RBPMS | RNA binding protein with multiple splicing | -0.0110716 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.011055 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0110335 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0109984 |
| CLOCK | clock circadian regulator | -0.0109315 |
| YBX1 | Y box binding protein 1 | -0.0108437 |
| CANX | calnexin | -0.0107915 |
| INSR | insulin receptor | -0.0107388 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | -0.0107333 |
| OGA | O-GlcNAcase | -0.010704 |
| CCDC47 | coiled-coil domain containing 47 | -0.0106967 |
| CCNI | cyclin I | -0.0106914 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.010664 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0106094 |
| RBM27 | RNA binding motif protein 27 | -0.0105576 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0105473 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | -0.010536 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0104266 |
| CLIC4 | chloride intracellular channel 4 | -0.0103916 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0103579 |
