Rucaparib (phosphate)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.123364
TENM3 teneurin transmembrane protein 3 0.121757
SLIT2 slit homolog 2 (Drosophila) 0.108744
ERBB4 erb-b2 receptor tyrosine kinase 4 0.101425
NPAS3 neuronal PAS domain protein 3 0.0756708
NEBL nebulette 0.0657649
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0571961
ZNF608 zinc finger protein 608 0.0563335
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0556795
EEF2 eukaryotic translation elongation factor 2 0.054617
SMYD3 SET and MYND domain containing 3 0.054575
ATP11A ATPase, class VI, type 11A 0.0541391
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0535773
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0533408
TRIO trio Rho guanine nucleotide exchange factor 0.0515808
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0508504
ADGRG6 adhesion G protein-coupled receptor G6 0.0505517
COL5A2 collagen, type V, alpha 2 0.0483114
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0457779
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0451952
TTC28 tetratricopeptide repeat domain 28 0.0432065
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0412427
FAT1 FAT atypical cadherin 1 0.0403771
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0387705
SRRM2 serine/arginine repetitive matrix 2 0.0383926
PTK2 protein tyrosine kinase 2 0.0374454
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0371544
DENND1A DENN/MADD domain containing 1A 0.0352126
AUTS2 autism susceptibility candidate 2 0.0351846
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0346008
FMNL2 formin-like 2 0.0343225
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0341812
USP9X ubiquitin specific peptidase 9, X-linked 0.0341055
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0339668
SOX5 SRY (sex determining region Y)-box 5 0.0337304
NFIA nuclear factor I/A 0.0331859
ZNF292 zinc finger protein 292 0.032187
PARD3 par-3 family cell polarity regulator 0.0319358
TOX thymocyte selection-associated high mobility group box 0.031932
OSBPL10 oxysterol binding protein-like 10 0.0317168
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0315379
SHROOM3 shroom family member 3 0.0314257
KIAA1958 KIAA1958 0.0312018
PDE4D phosphodiesterase 4D, cAMP-specific 0.0311864
PCBP2 poly(rC) binding protein 2 0.0311238
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0308242
CELF2 CUGBP, Elav-like family member 2 0.0299392
VMP1 vacuole membrane protein 1 0.0297202
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0297118
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0294713
HSPA8 heat shock 70kDa protein 8 0.0294017
KMT2C lysine (K)-specific methyltransferase 2C 0.0289384
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0289143
DST dystonin 0.0287978
PUM1 pumilio RNA-binding family member 1 0.0287812
EXT1 exostosin glycosyltransferase 1 0.0287575
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0285729
SBF2 SET binding factor 2 0.0284194
TRIP12 thyroid hormone receptor interactor 12 0.0282975
ZFAND3 zinc finger, AN1-type domain 3 0.0280521
MACF1 microtubule-actin crosslinking factor 1 0.0274994
ARB2A ARB2 cotranscriptional regulator A 0.0271471
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0270648
CCNY cyclin Y 0.0265773
DIDO1 death inducer-obliterator 1 0.0263325
TBC1D32 TBC1 domain family, member 32 0.0262214
TPD52 tumor protein D52 0.0260989
GPHN gephyrin 0.0257574
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.025118
ARHGAP32 Rho GTPase activating protein 32 0.0250679
MED13 mediator complex subunit 13 0.0250626
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0249425
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0247952
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0245515
MLIP muscular LMNA-interacting protein 0.0243936
QKI QKI, KH domain containing, RNA binding 0.0243669
ADAR adenosine deaminase, RNA-specific 0.0241913
NUP58 nucleoporin 58 0.0240594
GYS1 glycogen synthase 1 (muscle) 0.0240148
GRID2 glutamate receptor, ionotropic, delta 2 0.0239106
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0238732
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0238722
HELZ helicase with zinc finger 0.0238377
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0236243
TBL1X transducin (beta)-like 1X-linked 0.0233963
CHD7 chromodomain helicase DNA binding protein 7 0.0233169
BIRC6 baculoviral IAP repeat containing 6 0.0231113
EFNA5 ephrin-A5 0.0230092
APP amyloid beta (A4) precursor protein 0.0228534
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0225743
WDFY3 WD repeat and FYVE domain containing 3 0.0225419
RABGAP1L RAB GTPase activating protein 1-like 0.0225386
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0223996
SPTBN1 spectrin, beta, non-erythrocytic 1 0.022346
MEMO1 mediator of cell motility 1 0.0222928
GAB2 GRB2-associated binding protein 2 0.0222271
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0222168
ENAH enabled homolog (Drosophila) 0.0221544
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0220924
TAS2R14 taste receptor, type 2, member 14 0.0220409

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0602135
PTMA prothymosin, alpha -0.0595078
RPLP1 ribosomal protein, large, P1 -0.0486699
TMSB10 thymosin beta 10 -0.047077
RPS6 ribosomal protein S6 -0.0392213
RPS19 ribosomal protein S19 -0.0307492
RPL34 ribosomal protein L34 -0.0298336
RPS24 ribosomal protein S24 -0.0276358
RPL31 ribosomal protein L31 -0.0263797
IFI6 interferon, alpha-inducible protein 6 -0.0259358
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0243318
RPL32 ribosomal protein L32 -0.024168
RPL12 ribosomal protein L12 -0.0240544
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0236733
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0236004
RPS3 ribosomal protein S3 -0.0226751
RPL38 ribosomal protein L38 -0.0222225
RPL35A ribosomal protein L35a -0.0214164
RPS13 ribosomal protein S13 -0.0212993
RPS21 ribosomal protein S21 -0.0212504
S100A9 S100 calcium binding protein A9 -0.021018
ACTG1 actin gamma 1 -0.0210071
RPL23 ribosomal protein L23 -0.0208443
FTL ferritin, light polypeptide -0.0204895
B2M beta-2-microglobulin -0.019135
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0184194
EIF1 eukaryotic translation initiation factor 1 -0.0181342
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0176317
RPS23 ribosomal protein S23 -0.0174863
RPS29 ribosomal protein S29 -0.0173223
CBX3 chromobox homolog 3 -0.0171604
RPS12 ribosomal protein S12 -0.0169788
TPT1 tumor protein, translationally-controlled 1 -0.0169413
RPS5 ribosomal protein S5 -0.016894
RPS17 ribosomal protein S17 -0.0167415
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.016616
TUBB tubulin, beta class I -0.0164275
RPL9 ribosomal protein L9 -0.016326
MYL12B myosin, light chain 12B, regulatory -0.0155833
HMGB1 high mobility group box 1 -0.0154665
LDHA lactate dehydrogenase A -0.0154419
RPS8 ribosomal protein S8 -0.0154217
RPS25 ribosomal protein S25 -0.0153741
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0151507
RPS28 ribosomal protein S28 -0.014997
RPLP2 ribosomal protein, large, P2 -0.0149693
VDAC1 voltage-dependent anion channel 1 -0.0146633
RPL18 ribosomal protein L18 -0.0145455
GOLGA4 golgin A4 -0.0145155
RPS11 ribosomal protein S11 -0.014118
RPS14 ribosomal protein S14 -0.0141091
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0137456
GNAS GNAS complex locus -0.0137196
RPLP0 ribosomal protein, large, P0 -0.0137053
RPL35 ribosomal protein L35 -0.0135647
ATP5F1E ATP synthase F1 subunit epsilon -0.0134684
RPS20 ribosomal protein S20 -0.0131238
RPL7A ribosomal protein L7a -0.0130986
RPS15 ribosomal protein S15 -0.0130204
RPL37A ribosomal protein L37a -0.0128786
VIM vimentin -0.0128629
RPL26 ribosomal protein L26 -0.0128373
GABARAPL2 GABA(A) receptor-associated protein-like 2 -0.0127498
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0126233
RPL19 ribosomal protein L19 -0.0125252
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0124091
RPL30 ribosomal protein L30 -0.0122058
RPL7 ribosomal protein L7 -0.0118536
RPS16 ribosomal protein S16 -0.0118288
HMGB2 high mobility group box 2 -0.0117628
ANAPC5 anaphase promoting complex subunit 5 -0.0115067
VKORC1 vitamin K epoxide reductase complex, subunit 1 -0.011506
SOX4 SRY (sex determining region Y)-box 4 -0.0114745
ISG15 ISG15 ubiquitin-like modifier -0.011353
WDR45B WD repeat domain 45B -0.0113418
S100A10 S100 calcium binding protein A10 -0.0112771
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0112492
ZC3H15 zinc finger CCCH-type containing 15 -0.0112012
RNF145 ring finger protein 145 -0.0111573
RUNX1 runt-related transcription factor 1 -0.0111017
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0110443
RPL36 ribosomal protein L36 -0.010893
RPL4 ribosomal protein L4 -0.0106294
RPL36A ribosomal protein L36a -0.0105172
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0104579
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0103554
SOX2 SRY (sex determining region Y)-box 2 -0.0103506
COX7B cytochrome c oxidase subunit VIIb -0.0102825
RPS4X ribosomal protein S4, X-linked -0.0102525
RNF130 ring finger protein 130 -0.0102329
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0101614
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0101277
LMAN1 lectin, mannose-binding, 1 -0.0100909
RPL36AL ribosomal protein L36a-like -0.0100459
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa -0.00995704
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00986903
NDUFA4 NDUFA4, mitochondrial complex associated -0.0096866
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.00964448
CSTB cystatin B (stefin B) -0.00963736
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00960858