Rucaparib (phosphate)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Rucaparib (phosphate)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANXA2 annexin A2 0.0916581
GMDS GDP-mannose 4,6-dehydratase 0.0887087
EXT1 exostosin glycosyltransferase 1 0.0870528
B2M beta-2-microglobulin 0.0840587
ARHGAP26 Rho GTPase activating protein 26 0.0787988
FNDC3B fibronectin type III domain containing 3B 0.0772009
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0761841
SQSTM1 sequestosome 1 0.0651601
MACC1 metastasis associated in colon cancer 1 0.0649243
EZR ezrin 0.0633856
MBNL2 muscleblind-like splicing regulator 2 0.0585816
NDRG1 N-myc downstream regulated 1 0.055035
LMO7 LIM domain 7 0.0543009
TPT1 tumor protein, translationally-controlled 1 0.0527103
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0498964
RUNX1 runt-related transcription factor 1 0.0487512
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0483719
PRKCA protein kinase C, alpha 0.0479545
HLA-B major histocompatibility complex, class I, B 0.0467651
CCNL1 cyclin L1 0.0465986
FTH1 ferritin, heavy polypeptide 1 0.0462876
SEC31A SEC31 homolog A (S. cerevisiae) 0.046264
RAB7A RAB7A, member RAS oncogene family 0.0452378
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0438335
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.043715
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0433719
RNF213 ring finger protein 213 0.0433523
AHNAK AHNAK nucleoprotein 0.0427274
TRIO trio Rho guanine nucleotide exchange factor 0.0426815
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0415746
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0406884
ITGA6 integrin, alpha 6 0.0406808
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0398042
EGR1 early growth response 1 0.0390378
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0388307
LPP LIM domain containing preferred translocation partner in lipoma 0.0379506
SPATA13 spermatogenesis associated 13 0.0377465
EPS8 epidermal growth factor receptor pathway substrate 8 0.0373003
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0372547
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0370221
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0367122
AREG amphiregulin 0.0364298
HLA-C major histocompatibility complex, class I, C 0.0362072
FNIP1 folliculin interacting protein 1 0.0356987
IRF1 interferon regulatory factor 1 0.0356728
ZMYND8 zinc finger, MYND-type containing 8 0.035164
MSI2 musashi RNA-binding protein 2 0.0351632
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0349115
AKAP13 A kinase (PRKA) anchor protein 13 0.0347251
BTBD9 BTB (POZ) domain containing 9 0.0343766
CANX calnexin 0.0341109
LYZ lysozyme 0.0337158
UBC ubiquitin C 0.0337071
IFI6 interferon, alpha-inducible protein 6 0.033599
JUN jun proto-oncogene 0.0333288
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0332155
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0330064
RRBP1 ribosome binding protein 1 0.0326122
ENO1 enolase 1, (alpha) 0.0324214
CALR calreticulin 0.0317042
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0314136
TSC22D1 TSC22 domain family, member 1 0.0312764
PDIA3 protein disulfide isomerase family A, member 3 0.0311056
H1-0 H1.0 linker histone 0.0310926
PTMA prothymosin, alpha 0.0310637
CALU calumenin 0.0307608
MXD1 MAX dimerization protein 1 0.0306317
GCLC glutamate-cysteine ligase, catalytic subunit 0.0304423
KLF6 Kruppel-like factor 6 0.0296028
GOLGA4 golgin A4 0.0292924
FNDC3A fibronectin type III domain containing 3A 0.0292125
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0291633
TBC1D22A TBC1 domain family, member 22A 0.0291053
INTS6 integrator complex subunit 6 0.029015
CXCL8 chemokine (C-X-C motif) ligand 8 0.0288239
SPAG9 sperm associated antigen 9 0.028818
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0285962
NAMPT nicotinamide phosphoribosyltransferase 0.0285021
FAT1 FAT atypical cadherin 1 0.0282265
IGFBP3 insulin-like growth factor binding protein 3 0.0282125
SSH2 slingshot protein phosphatase 2 0.0281503
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.028084
SAMD4A sterile alpha motif domain containing 4A 0.0279541
LOC112694756 uncharaterized LOC112694756 0.027628
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0275753
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0273007
MORF4L2 mortality factor 4 like 2 0.0272446
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0269524
EPHB2 EPH receptor B2 0.0269412
ATP11A ATPase, class VI, type 11A 0.0267332
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0262897
ERBIN erbb2 interacting protein 0.0259497
ZBTB20 zinc finger and BTB domain containing 20 0.0258559
ZNRF3 zinc and ring finger 3 0.0256344
ZNF292 zinc finger protein 292 0.0254132
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0249249
STS steroid sulfatase (microsomal), isozyme S 0.0248664
RAB1A RAB1A, member RAS oncogene family 0.0248559
RPL35A ribosomal protein L35a 0.0243536
UBAC2 UBA domain containing 2 0.024267

decreased expression

Symbol Name Standardized Value
IFNGR1 interferon gamma receptor 1 -0.0335732
NRIP1 nuclear receptor interacting protein 1 -0.0297462
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0273649
RNF43 ring finger protein 43 -0.0266892
NCKAP5 NCK-associated protein 5 -0.0198311
IL20RA interleukin 20 receptor, alpha -0.0186212
PHF3 PHD finger protein 3 -0.0158444
CHD1 chromodomain helicase DNA binding protein 1 -0.0158099
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0157144
MAP2K6 mitogen-activated protein kinase kinase 6 -0.0151026
STK24 serine/threonine kinase 24 -0.0143381
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0141605
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0140142
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0138004
EPCAM epithelial cell adhesion molecule -0.0137948
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0134712
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0123714
BPTF bromodomain PHD finger transcription factor -0.0117368
TSHZ1 teashirt zinc finger homeobox 1 -0.0117236
SH3GLB1 SH3-domain GRB2-like endophilin B1 -0.0115555
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0114382
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0114118
ARGLU1 arginine and glutamate rich 1 -0.0109756
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0104915
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0101807
MED13L mediator complex subunit 13-like -0.0101439
CAPRIN1 cell cycle associated protein 1 -0.00987093
ZMYM2 zinc finger, MYM-type 2 -0.00968677
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.00902601
ZNF608 zinc finger protein 608 -0.0089914
BICRAL BICRA like chromatin remodeling complex associated protein -0.00892915
RPS2 ribosomal protein S2 -0.0089031
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.00886492
SDCCAG8 serologically defined colon cancer antigen 8 -0.00881637
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -0.00880324
YAP1 Yes-associated protein 1 -0.00879746
CLYBL citrate lyase beta like -0.00871769
PROS1 protein S (alpha) -0.00860815
SMYD3 SET and MYND domain containing 3 -0.00851965
FAAH2 fatty acid amide hydrolase 2 -0.00831829
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0082468
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.00807457
THOC2 THO complex 2 -0.00803691
PHC3 polyhomeotic homolog 3 (Drosophila) -0.00801857
CCDC171 coiled-coil domain containing 171 -0.00800937
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.00792589
GPATCH8 G patch domain containing 8 -0.00784594
RPL21 ribosomal protein L21 -0.00781882
GAPVD1 GTPase activating protein and VPS9 domains 1 -0.00776916
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.00769807
YIPF4 Yip1 domain family, member 4 -0.00767247
FBXL20 F-box and leucine-rich repeat protein 20 -0.00760607
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.00760033
WWC1 WW and C2 domain containing 1 -0.0075808
THUMPD2 THUMP domain containing 2 -0.00755136
TRAM1 translocation associated membrane protein 1 -0.0075109
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.00750347
GBP2 guanylate binding protein 2, interferon-inducible -0.00743723
MATR3 matrin 3 -0.00734909
HGD homogentisate 1,2-dioxygenase -0.00730566
RBM25 RNA binding motif protein 25 -0.00730022
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1 -0.00728254
IL4R interleukin 4 receptor -0.00727954
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.00724507
RNF111 ring finger protein 111 -0.00722646
ANTXR2 anthrax toxin receptor 2 -0.00716945
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.00715293
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.00711799
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 -0.00709077
AGO3 argonaute RISC catalytic component 3 -0.00704533
SERINC1 serine incorporator 1 -0.00702295
CCDC122 coiled-coil domain containing 122 -0.00698758
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.00697232
KRIT1 KRIT1, ankyrin repeat containing -0.00689946
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.00686891
SACK1B scaffolding CK1 anchoring protein B -0.00683425
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -0.00680321
JMY junction mediating and regulatory protein, p53 cofactor -0.00679729
SETD2 SET domain containing 2 -0.0067767
RNASE7 ribonuclease, RNase A family, 7 -0.00667842
SPOPL speckle-type POZ protein-like -0.00664923
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.00663796
ARID4A AT rich interactive domain 4A (RBP1-like) -0.00659549
DCP2 decapping mRNA 2 -0.00658675
ZDHHC17 zinc finger, DHHC-type containing 17 -0.00657081
HIPK3 homeodomain interacting protein kinase 3 -0.00654281
PNPLA7 patatin-like phospholipase domain containing 7 -0.0065367
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.00653015
STRN striatin, calmodulin binding protein -0.00652811
AKAP11 A kinase (PRKA) anchor protein 11 -0.00652219
KAT6B K(lysine) acetyltransferase 6B -0.00650328
MAP2K4 mitogen-activated protein kinase kinase 4 -0.0064947
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.00648289
ITSN2 intersectin 2 -0.00641299
STEAP2 STEAP family member 2, metalloreductase -0.00641259
MTA3 metastasis associated 1 family, member 3 -0.00641146
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 -0.00641093
ATP5F1C ATP synthase F1 subunit gamma -0.00640768
TOX3 TOX high mobility group box family member 3 -0.00640529
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.00638718