Rucaparib (phosphate)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.191879
AHNAK AHNAK nucleoprotein 0.172878
NDRG1 N-myc downstream regulated 1 0.130078
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.102651
FAT1 FAT atypical cadherin 1 0.0987854
EEF2 eukaryotic translation elongation factor 2 0.0902722
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0818907
ERRFI1 ERBB receptor feedback inhibitor 1 0.0764838
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0657606
MYH9 myosin, heavy chain 9, non-muscle 0.0633939
TBC1D22A TBC1 domain family, member 22A 0.0610572
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0596689
GOLGA4 golgin A4 0.0570494
ENO1 enolase 1, (alpha) 0.0566294
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0564313
CANX calnexin 0.0554102
NUP58 nucleoporin 58 0.0546129
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0543026
UBA6 ubiquitin-like modifier activating enzyme 6 0.0514253
VEGFA vascular endothelial growth factor A 0.0512829
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0501058
HOOK2 hook microtubule-tethering protein 2 0.0496829
ANKRD11 ankyrin repeat domain 11 0.0467115
FTH1 ferritin, heavy polypeptide 1 0.0465987
RNMT RNA (guanine-7-) methyltransferase 0.0462028
PABPC1 poly(A) binding protein, cytoplasmic 1 0.045278
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0450196
PDIA4 protein disulfide isomerase family A, member 4 0.0448157
CSDE1 cold shock domain containing E1, RNA-binding 0.0419247
ZNF638 zinc finger protein 638 0.0415034
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0408196
YEATS2 YEATS domain containing 2 0.0407972
SRRM2 serine/arginine repetitive matrix 2 0.040741
FLNA filamin A, alpha 0.0394236
RUNX1 runt-related transcription factor 1 0.0391535
SBF2 SET binding factor 2 0.0391448
TTC3 tetratricopeptide repeat domain 3 0.0386276
NBAS neuroblastoma amplified sequence 0.0382007
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0379086
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.037516
TXNRD1 thioredoxin reductase 1 0.0374758
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.03732
BIRC6 baculoviral IAP repeat containing 6 0.0368006
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.036493
ZNF292 zinc finger protein 292 0.0363603
TMF1 TATA element modulatory factor 1 0.0360653
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0360215
TPM3 tropomyosin 3 0.0359141
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0358945
CSNK1A1 casein kinase 1, alpha 1 0.0357604
COPA coatomer protein complex, subunit alpha 0.0341314
ZCCHC7 zinc finger, CCHC domain containing 7 0.0338614
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0332686
HELZ helicase with zinc finger 0.0330527
KMT2C lysine (K)-specific methyltransferase 2C 0.0330174
RLF rearranged L-myc fusion 0.0329371
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0325407
TRA2A transformer 2 alpha homolog (Drosophila) 0.0325237
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0316463
DDIT4 DNA-damage-inducible transcript 4 0.0313946
TRIP12 thyroid hormone receptor interactor 12 0.0312502
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0311316
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0305509
SETD5 SET domain containing 5 0.0304155
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0301299
HSPA8 heat shock 70kDa protein 8 0.0300617
PCBP2 poly(rC) binding protein 2 0.0300472
GARS1 glycyl-tRNA synthetase 1 0.0299251
RPL3 ribosomal protein L3 0.0297499
KIF5B kinesin family member 5B 0.0297046
SAMD4A sterile alpha motif domain containing 4A 0.0296081
CNOT1 CCR4-NOT transcription complex, subunit 1 0.029517
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0293823
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0293078
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0291743
MAP2K1 mitogen-activated protein kinase kinase 1 0.0291536
OGA O-GlcNAcase 0.0290068
COG5 component of oligomeric golgi complex 5 0.02894
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0287438
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0286357
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0285768
KDM2A lysine (K)-specific demethylase 2A 0.0284833
WDFY3 WD repeat and FYVE domain containing 3 0.0283542
ATXN1 ataxin 1 0.0283457
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0282444
APLP2 amyloid beta (A4) precursor-like protein 2 0.0282074
LOC112694756 uncharaterized LOC112694756 0.0281268
TOP2A topoisomerase (DNA) II alpha 170kDa 0.02807
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0271987
RAB7A RAB7A, member RAS oncogene family 0.0270581
RCOR1 REST corepressor 1 0.0269829
BHLHE40 basic helix-loop-helix family, member e40 0.026982
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0269319
PMM2 phosphomannomutase 2 0.0268639
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0263451
OLA1 Obg-like ATPase 1 0.0263227
BRD2 bromodomain containing 2 0.0263224
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0262461
LPP LIM domain containing preferred translocation partner in lipoma 0.0261396
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0259452

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.101429
TMSB10 thymosin beta 10 -0.0704918
FTL ferritin, light polypeptide -0.0559816
TPT1 tumor protein, translationally-controlled 1 -0.0423431
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0382751
RPS24 ribosomal protein S24 -0.0362538
RPLP1 ribosomal protein, large, P1 -0.0354814
RPS19 ribosomal protein S19 -0.0345678
RPL31 ribosomal protein L31 -0.0318227
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0313014
RPL12 ribosomal protein L12 -0.0296331
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0293452
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0292768
RPL35A ribosomal protein L35a -0.0278221
RPS25 ribosomal protein S25 -0.0268849
LMNA lamin A/C -0.0255106
RPS6 ribosomal protein S6 -0.0251765
S100A9 S100 calcium binding protein A9 -0.0249685
RPL34 ribosomal protein L34 -0.0243987
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0219002
S100A10 S100 calcium binding protein A10 -0.021099
EIF1 eukaryotic translation initiation factor 1 -0.0210622
RPL26 ribosomal protein L26 -0.0209695
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0207063
RPS21 ribosomal protein S21 -0.0201619
SPDYA speedy/RINGO cell cycle regulator family member A -0.0201471
RPL23 ribosomal protein L23 -0.0198579
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0191687
KRT19 keratin 19, type I -0.0186164
RPL32 ribosomal protein L32 -0.018411
UGDH UDP-glucose 6-dehydrogenase -0.0177553
RPL11 ribosomal protein L11 -0.0175422
MT2A metallothionein 2A -0.0175391
HMGB1 high mobility group box 1 -0.0174619
INTS6 integrator complex subunit 6 -0.0173453
EPCAM epithelial cell adhesion molecule -0.0172524
CCND1 cyclin D1 -0.0166581
RPL36AL ribosomal protein L36a-like -0.016423
PRDX2 peroxiredoxin 2 -0.0163697
MYL12B myosin, light chain 12B, regulatory -0.0163422
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0161354
RPS16 ribosomal protein S16 -0.0158711
RPS5 ribosomal protein S5 -0.0157399
ZBTB20 zinc finger and BTB domain containing 20 -0.0154721
RPLP2 ribosomal protein, large, P2 -0.0153568
TUBB tubulin, beta class I -0.015354
CBX3 chromobox homolog 3 -0.0152944
GCC2 GRIP and coiled-coil domain containing 2 -0.015036
SEPTIN7 septin 7 -0.0150158
TBCA tubulin folding cofactor A -0.0150065
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0149537
ZMYND8 zinc finger, MYND-type containing 8 -0.014573
TKT transketolase -0.0144987
PERP PERP, TP53 apoptosis effector -0.0144754
RPL38 ribosomal protein L38 -0.0143573
RPS23 ribosomal protein S23 -0.014349
RPS20 ribosomal protein S20 -0.0138898
RPS13 ribosomal protein S13 -0.0138683
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0138513
RPL30 ribosomal protein L30 -0.0138032
RPL36 ribosomal protein L36 -0.0135639
DCAF6 DDB1 and CUL4 associated factor 6 -0.0135075
RPL36A ribosomal protein L36a -0.0134804
RPS29 ribosomal protein S29 -0.0133957
RPLP0 ribosomal protein, large, P0 -0.0133537
HSPB1 heat shock 27kDa protein 1 -0.0133104
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0132651
GNAS GNAS complex locus -0.0132169
SERF2 small EDRK-rich factor 2 -0.0130487
TUBA1B tubulin, alpha 1b -0.0129826
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.012843
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0128195
RBBP6 retinoblastoma binding protein 6 -0.0127292
PDLIM5 PDZ and LIM domain 5 -0.0126764
NFIA nuclear factor I/A -0.012666
NOL7 nucleolar protein 7, 27kDa -0.0126436
RPS27 ribosomal protein S27 -0.0126332
EGR1 early growth response 1 -0.0126137
FAM133B family with sequence similarity 133, member B -0.0124884
STAT1 signal transducer and activator of transcription 1, 91kDa -0.012395
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0123931
TPM4 tropomyosin 4 -0.0123802
LRRC23 leucine rich repeat containing 23 -0.0123575
RPL8 ribosomal protein L8 -0.0122572
VCL vinculin -0.0121509
RPS15 ribosomal protein S15 -0.0120053
SSB Sjogren syndrome antigen B (autoantigen La) -0.0119933
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -0.0119079
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0119066
RPL27 ribosomal protein L27 -0.0118238
IER3 immediate early response 3 -0.0118203
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0118164
CEBPZOS CEBPZ opposite strand -0.0117254
SIK3 SIK family kinase 3 -0.0115465
PURA purine-rich element binding protein A -0.0114429
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0113809
NT5C2 5'-nucleotidase, cytosolic II -0.0112235
ZNF652 zinc finger protein 652 -0.0110825
TNRC6B trinucleotide repeat containing 6B -0.0108734
NUCB2 nucleobindin 2 -0.0108588