| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in HEC-1-A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AHNAK | AHNAK nucleoprotein | 0.0782875 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0681791 |
| APP | amyloid beta (A4) precursor protein | 0.0654742 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0546808 |
| SMAD3 | SMAD family member 3 | 0.0461255 |
| ITGB8 | integrin, beta 8 | 0.0406866 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0390613 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0375035 |
| FLNA | filamin A, alpha | 0.0344856 |
| PLEC | plectin | 0.034448 |
| SNX9 | sorting nexin 9 | 0.0333102 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0332324 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0321286 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0320087 |
| ANXA2 | annexin A2 | 0.0302087 |
| TMSB4X | thymosin beta 4, X-linked | 0.0299661 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0296567 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0296269 |
| TXNRD1 | thioredoxin reductase 1 | 0.0280929 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0279674 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0274216 |
| H1-0 | H1.0 linker histone | 0.0273407 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0264171 |
| TJP1 | tight junction protein 1 | 0.0257435 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0255802 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0254537 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0252358 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0252021 |
| EPB41L2 | erythrocyte membrane protein band 4.1-like 2 | 0.0250914 |
| VCL | vinculin | 0.0249895 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | 0.0248378 |
| EZR | ezrin | 0.0246378 |
| WWC1 | WW and C2 domain containing 1 | 0.0237283 |
| AFDN | afadin, adherens junction formation factor | 0.023583 |
| MYO1D | myosin ID | 0.0233544 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0218694 |
| NCKAP1 | NCK-associated protein 1 | 0.021867 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0216394 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0212659 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0210577 |
| FAT1 | FAT atypical cadherin 1 | 0.0209796 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0209309 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0207734 |
| NF1 | neurofibromin 1 | 0.0201798 |
| CCNL1 | cyclin L1 | 0.0200352 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0197963 |
| PAX8 | paired box 8 | 0.0190631 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0189848 |
| RNF213 | ring finger protein 213 | 0.0189753 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0187724 |
| MYO6 | myosin VI | 0.0187515 |
| SLTM | SAFB-like, transcription modulator | 0.0185078 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0183425 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0180857 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0178208 |
| SPAG9 | sperm associated antigen 9 | 0.0172909 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0172496 |
| TEX10 | testis expressed 10 | 0.0172466 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0172262 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0170742 |
| ATP13A3 | ATPase type 13A3 | 0.017057 |
| RANBP2 | RAN binding protein 2 | 0.0169631 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.016917 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0168921 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0168304 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0168273 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0167939 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0167398 |
| ANLN | anillin, actin binding protein | 0.0167126 |
| PRELID2 | PRELI domain containing 2 | 0.0166243 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0165757 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.01657 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0165689 |
| ANXA11 | annexin A11 | 0.0165216 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0164348 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0162978 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0162742 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0159633 |
| ANO6 | anoctamin 6 | 0.0159566 |
| KLC1 | kinesin light chain 1 | 0.0157771 |
| ENO1 | enolase 1, (alpha) | 0.0156671 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0156602 |
| ATP11B | ATPase, class VI, type 11B | 0.0156294 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0155623 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0155027 |
| SBF2 | SET binding factor 2 | 0.015479 |
| TFRC | transferrin receptor | 0.0154259 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0153289 |
| EGR1 | early growth response 1 | 0.0152521 |
| LAMC2 | laminin, gamma 2 | 0.0150983 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0150445 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0149418 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0148752 |
| SINHCAF | SIN3-HDAC complex associated factor | 0.0148256 |
| RPL4 | ribosomal protein L4 | 0.0147332 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0146596 |
| IPO7 | importin 7 | 0.0145731 |
| SEPTIN9 | septin 9 | 0.0145691 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0145563 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0145354 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.093043 |
| MT2A | metallothionein 2A | -0.0678125 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0587355 |
| PTMA | prothymosin, alpha | -0.0545196 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0526977 |
| RPL35A | ribosomal protein L35a | -0.051449 |
| RPS6 | ribosomal protein S6 | -0.0483173 |
| ACTG1 | actin gamma 1 | -0.0440116 |
| HMGA1 | high mobility group AT-hook 1 | -0.0428591 |
| RPS8 | ribosomal protein S8 | -0.041707 |
| RPL12 | ribosomal protein L12 | -0.0385468 |
| RPL23 | ribosomal protein L23 | -0.0384122 |
| FTL | ferritin, light polypeptide | -0.0335405 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0331277 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0293699 |
| S100A9 | S100 calcium binding protein A9 | -0.0290363 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0277711 |
| TMSB10 | thymosin beta 10 | -0.0274842 |
| RPS12 | ribosomal protein S12 | -0.0261312 |
| RPS19 | ribosomal protein S19 | -0.025145 |
| TPM4 | tropomyosin 4 | -0.0250854 |
| GOLGA4 | golgin A4 | -0.0246533 |
| RPS29 | ribosomal protein S29 | -0.0214044 |
| RPL26 | ribosomal protein L26 | -0.0202416 |
| VCAN | versican | -0.0201292 |
| RPL8 | ribosomal protein L8 | -0.0198698 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0194012 |
| RPS14 | ribosomal protein S14 | -0.019311 |
| KRT7 | keratin 7, type II | -0.0192908 |
| RPL7A | ribosomal protein L7a | -0.0192007 |
| RAD51B | RAD51 paralog B | -0.018939 |
| S100A6 | S100 calcium binding protein A6 | -0.0188746 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0185895 |
| RPS23 | ribosomal protein S23 | -0.0184282 |
| LDHA | lactate dehydrogenase A | -0.0184239 |
| WWOX | WW domain containing oxidoreductase | -0.0183763 |
| PFN1 | profilin 1 | -0.0183358 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.018096 |
| S100A10 | S100 calcium binding protein A10 | -0.0180194 |
| RPL37A | ribosomal protein L37a | -0.0177081 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0175623 |
| UPP1 | uridine phosphorylase 1 | -0.0172018 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0171418 |
| FHIT | fragile histidine triad | -0.0171413 |
| ASPH | aspartate beta-hydroxylase | -0.0171145 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0167781 |
| RPL32 | ribosomal protein L32 | -0.0164816 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0163632 |
| RPS25 | ribosomal protein S25 | -0.0163414 |
| RPL9 | ribosomal protein L9 | -0.0159002 |
| RPS13 | ribosomal protein S13 | -0.0158395 |
| RPL34 | ribosomal protein L34 | -0.0157885 |
| CALR | calreticulin | -0.015582 |
| RPS27 | ribosomal protein S27 | -0.0155419 |
| HDGF | hepatoma-derived growth factor | -0.0150802 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0150739 |
| RPLP2 | ribosomal protein, large, P2 | -0.0147601 |
| RPL37 | ribosomal protein L37 | -0.0146604 |
| RPL35 | ribosomal protein L35 | -0.0146268 |
| POTEF | POTE ankyrin domain family, member F | -0.0144292 |
| PERP | PERP, TP53 apoptosis effector | -0.0141877 |
| INTS6 | integrator complex subunit 6 | -0.0135997 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0134966 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0133681 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0132425 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0131941 |
| RRBP1 | ribosome binding protein 1 | -0.0131721 |
| RPS3 | ribosomal protein S3 | -0.0130742 |
| RPL18 | ribosomal protein L18 | -0.0129479 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.012921 |
| RPS15 | ribosomal protein S15 | -0.0127498 |
| RPS17 | ribosomal protein S17 | -0.0126238 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0124253 |
| RPL15 | ribosomal protein L15 | -0.0123902 |
| RPS10 | ribosomal protein S10 | -0.0123844 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0122976 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.012164 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0121104 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0120694 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0119837 |
| KRT19 | keratin 19, type I | -0.0118076 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0117942 |
| RPL36 | ribosomal protein L36 | -0.0116873 |
| BPTF | bromodomain PHD finger transcription factor | -0.011653 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.011578 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.011446 |
| TUBA1B | tubulin, alpha 1b | -0.01123 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.0111747 |
| INSIG2 | insulin induced gene 2 | -0.0110253 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0110108 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0107136 |
| S100A14 | S100 calcium binding protein A14 | -0.0107054 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0106892 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0106719 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0106428 |
| MTDH | metadherin | -0.0106162 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0105873 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0105387 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0104113 |
| ZNF395 | zinc finger protein 395 | -0.0103564 |
