| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.41202 |
| FN1 | fibronectin 1 | 0.174724 |
| FAM13A | family with sequence similarity 13, member A | 0.128016 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.116925 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.104367 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0925581 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0870115 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0810918 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0809417 |
| NDRG1 | N-myc downstream regulated 1 | 0.0700841 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0667658 |
| IGF2 | insulin-like growth factor 2 | 0.0661606 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0604812 |
| ZNF292 | zinc finger protein 292 | 0.0587296 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0578389 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0571782 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0570429 |
| ANXA2 | annexin A2 | 0.0563641 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0557436 |
| VEGFA | vascular endothelial growth factor A | 0.053745 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0534059 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0533466 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0531967 |
| ENO1 | enolase 1, (alpha) | 0.0522211 |
| ADM | adrenomedullin | 0.0521545 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0499884 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0497673 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0494542 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0494157 |
| USP3 | ubiquitin specific peptidase 3 | 0.0488806 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0487019 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0468586 |
| RUNX1 | runt-related transcription factor 1 | 0.0467935 |
| FLNB | filamin B, beta | 0.0463923 |
| SPAG9 | sperm associated antigen 9 | 0.0437955 |
| STC1 | stanniocalcin 1 | 0.0434658 |
| RPS6 | ribosomal protein S6 | 0.0434255 |
| SETD5 | SET domain containing 5 | 0.0433703 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0433264 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0431258 |
| RPS8 | ribosomal protein S8 | 0.0428202 |
| PGK1 | phosphoglycerate kinase 1 | 0.0411047 |
| MT2A | metallothionein 2A | 0.0408049 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0407 |
| PTMA | prothymosin, alpha | 0.0404382 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0402963 |
| HELZ | helicase with zinc finger | 0.0395403 |
| ACTG1 | actin gamma 1 | 0.0390545 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0390198 |
| RPS3 | ribosomal protein S3 | 0.0387489 |
| RPL35A | ribosomal protein L35a | 0.0385859 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0381526 |
| NUP58 | nucleoporin 58 | 0.0379655 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0378398 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0369754 |
| RLF | rearranged L-myc fusion | 0.0368103 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0365548 |
| OGA | O-GlcNAcase | 0.0364136 |
| ATP13A3 | ATPase type 13A3 | 0.0362644 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0361822 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0360283 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0359907 |
| CD44 | CD44 molecule (Indian blood group) | 0.0339498 |
| WDR45B | WD repeat domain 45B | 0.0336798 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0336737 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0334553 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0334414 |
| SBF2 | SET binding factor 2 | 0.032979 |
| G0S2 | G0/G1 switch 2 | 0.0328335 |
| CALU | calumenin | 0.032744 |
| RPS12 | ribosomal protein S12 | 0.0322319 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0321938 |
| FOSL1 | FOS-like antigen 1 | 0.0317485 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0312235 |
| RPL37A | ribosomal protein L37a | 0.0312126 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0303993 |
| CD109 | CD109 molecule | 0.0301536 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0299651 |
| HPCAL1 | hippocalcin-like 1 | 0.0293441 |
| SMAD3 | SMAD family member 3 | 0.0288182 |
| RPL12 | ribosomal protein L12 | 0.028545 |
| RPS27A | ribosomal protein S27a | 0.0284021 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.028041 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0279995 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0279805 |
| FAM162A | family with sequence similarity 162, member A | 0.0277727 |
| RNF24 | ring finger protein 24 | 0.0276178 |
| YBX1 | Y box binding protein 1 | 0.0274256 |
| MIMS1 | mitochondrial inner membrane scaffold 1 | 0.0274139 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0272353 |
| ARRDC3 | arrestin domain containing 3 | 0.0271756 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0267873 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.026768 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0267293 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.026644 |
| COL6A1 | collagen, type VI, alpha 1 | 0.026552 |
| RPS19 | ribosomal protein S19 | 0.0265319 |
| JUN | jun proto-oncogene | 0.0265057 |
| GOLGA4 | golgin A4 | 0.02646 |
| SEC24A | SEC24 family member A | 0.0260988 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.116648 |
| TMSB10 | thymosin beta 10 | -0.0790725 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0446786 |
| VCL | vinculin | -0.0439417 |
| HMGA2 | high mobility group AT-hook 2 | -0.0376352 |
| NAV1 | neuron navigator 1 | -0.0324231 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0232759 |
| GLIS3 | GLIS family zinc finger 3 | -0.0225939 |
| EFNA5 | ephrin-A5 | -0.0225657 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0218442 |
| RPLP1 | ribosomal protein, large, P1 | -0.0200418 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0190598 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0186293 |
| EGFR | epidermal growth factor receptor | -0.0182625 |
| EGR1 | early growth response 1 | -0.0181504 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0156236 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0155478 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0155164 |
| RRBP1 | ribosome binding protein 1 | -0.0152988 |
| PALLD | palladin, cytoskeletal associated protein | -0.0150631 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0149513 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0146511 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0142362 |
| CDH13 | cadherin 13 | -0.01385 |
| PRKCA | protein kinase C, alpha | -0.0138211 |
| AEBP2 | AE binding protein 2 | -0.0137734 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0137421 |
| OSMR | oncostatin M receptor | -0.0131586 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0130778 |
| FRMD4A | FERM domain containing 4A | -0.013027 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0129748 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0127495 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0125885 |
| FTL | ferritin, light polypeptide | -0.0124482 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | -0.0123516 |
| CDKL1 | cyclin-dependent kinase-like 1 (CDC2-related kinase) | -0.0123265 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0120803 |
| INTS6 | integrator complex subunit 6 | -0.0119688 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0119116 |
| PRELID2 | PRELI domain containing 2 | -0.0118971 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0118937 |
| RPS24 | ribosomal protein S24 | -0.0117375 |
| PRSS23 | protease, serine, 23 | -0.0114857 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0114495 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0114434 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0114057 |
| MCFD2 | multiple coagulation factor deficiency 2 | -0.0112819 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0112629 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0110798 |
| NABP1 | nucleic acid binding protein 1 | -0.0108695 |
| CLMP | CXADR-like membrane protein | -0.0108154 |
| CLIC4 | chloride intracellular channel 4 | -0.010762 |
| GRAMD1B | GRAM domain containing 1B | -0.0107517 |
| FAM114A1 | family with sequence similarity 114, member A1 | -0.0106596 |
| ASPH | aspartate beta-hydroxylase | -0.0106583 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0103176 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0101622 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0101283 |
| ANKUB1 | ankyrin repeat and ubiquitin domain containing 1 | -0.0100968 |
| CCDC138 | coiled-coil domain containing 138 | -0.0100814 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.00987158 |
| EMP1 | epithelial membrane protein 1 | -0.0097525 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.00970784 |
| RPL4 | ribosomal protein L4 | -0.00965819 |
| RAB31 | RAB31, member RAS oncogene family | -0.00962356 |
| SMYD3 | SET and MYND domain containing 3 | -0.00930315 |
| ACTN4 | actinin, alpha 4 | -0.0092956 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.00927777 |
| CEP350 | centrosomal protein 350kDa | -0.00920284 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.00909063 |
| SHISA5 | shisa family member 5 | -0.00903519 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.00902225 |
| CFAP44 | cilia and flagella associated protein 44 | -0.00887435 |
| ENOSF1 | enolase superfamily member 1 | -0.00875066 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.00872978 |
| HDAC8 | histone deacetylase 8 | -0.00872092 |
| HDLBP | high density lipoprotein binding protein | -0.00869863 |
| ZNF804A | zinc finger protein 804A | -0.00856678 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00853723 |
| LAMA4 | laminin, alpha 4 | -0.00853438 |
| SLC25A51 | solute carrier family 25, member 51 | -0.00833801 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.00827734 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00822651 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | -0.0082259 |
| LASP1 | LIM and SH3 protein 1 | -0.00821732 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.00817109 |
| NINL | ninein-like | -0.00815501 |
| FBXO34 | F-box protein 34 | -0.00813827 |
| KLF12 | Kruppel-like factor 12 | -0.00809266 |
| GOLGB1 | golgin B1 | -0.00808248 |
| TRPC1 | transient receptor potential cation channel, subfamily C, member 1 | -0.00807646 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.00802871 |
| CDK14 | cyclin-dependent kinase 14 | -0.00802756 |
| PCNX4 | pecanex 4 | -0.00793256 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.00785659 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.00782931 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.00781662 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00778417 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00773739 |
| NLGN1 | neuroligin 1 | -0.00771221 |
