Rucaparib (phosphate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.109017
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.10309
CD44 CD44 molecule (Indian blood group) 0.0894946
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0850258
VEGFA vascular endothelial growth factor A 0.0806213
COL6A3 collagen, type VI, alpha 3 0.0665293
MYH9 myosin, heavy chain 9, non-muscle 0.0647516
FTH1 ferritin, heavy polypeptide 1 0.0646727
RPS8 ribosomal protein S8 0.0626327
TRIO trio Rho guanine nucleotide exchange factor 0.0625945
AHNAK AHNAK nucleoprotein 0.0515852
ENO1 enolase 1, (alpha) 0.0498903
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0486382
COL1A1 collagen, type I, alpha 1 0.0469731
ACTG1 actin gamma 1 0.0413164
FN1 fibronectin 1 0.0412603
EXT1 exostosin glycosyltransferase 1 0.0373055
TMSB4X thymosin beta 4, X-linked 0.0368317
FNDC3B fibronectin type III domain containing 3B 0.0344309
CXCL8 chemokine (C-X-C motif) ligand 8 0.0331031
ALCAM activated leukocyte cell adhesion molecule 0.0316626
CDH13 cadherin 13 0.0315996
RPL35A ribosomal protein L35a 0.0313253
ANXA2 annexin A2 0.0308363
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.030755
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0307296
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0304539
EEF2 eukaryotic translation elongation factor 2 0.0303176
LGALS1 lectin, galactoside-binding, soluble, 1 0.0295579
HLA-B major histocompatibility complex, class I, B 0.0287336
FLNA filamin A, alpha 0.0287075
RPL11 ribosomal protein L11 0.0280504
NAV2 neuron navigator 2 0.0276839
RPS6 ribosomal protein S6 0.0272712
PTMA prothymosin, alpha 0.0266843
CALR calreticulin 0.0265748
HLA-A major histocompatibility complex, class I, A 0.0262402
CALU calumenin 0.0262049
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0261458
SMAD3 SMAD family member 3 0.0260605
RACK1 receptor for activated C kinase 1 0.0249137
RPL26 ribosomal protein L26 0.0249067
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0247239
BHLHE40 basic helix-loop-helix family, member e40 0.0244874
VIM vimentin 0.0242627
ARRDC3 arrestin domain containing 3 0.0241087
B2M beta-2-microglobulin 0.0240626
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0230437
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0226841
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0222081
PLEC plectin 0.0219313
YBX1 Y box binding protein 1 0.0219059
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0218806
RPS12 ribosomal protein S12 0.0218771
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0217431
LPP LIM domain containing preferred translocation partner in lipoma 0.021661
RPL28 ribosomal protein L28 0.02163
RPL23 ribosomal protein L23 0.0215681
S100A9 S100 calcium binding protein A9 0.0214752
RPS3 ribosomal protein S3 0.0212619
MT1X metallothionein 1X 0.0211921
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0211133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.020987
RPL19 ribosomal protein L19 0.0208038
RPL12 ribosomal protein L12 0.0208028
RPL37A ribosomal protein L37a 0.0201174
RPL5 ribosomal protein L5 0.0197782
RPN1 ribophorin I 0.0194803
RPL7 ribosomal protein L7 0.0194066
MTSS1 metastasis suppressor 1 0.018932
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0187408
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0186555
PRELID2 PRELI domain containing 2 0.0185573
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0185552
NAV1 neuron navigator 1 0.0185127
SQSTM1 sequestosome 1 0.0184006
RPL8 ribosomal protein L8 0.0181071
NAP1L1 nucleosome assembly protein 1-like 1 0.0180464
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0177377
RPL13A ribosomal protein L13a 0.0177072
RUNX1 runt-related transcription factor 1 0.0175281
RPS2 ribosomal protein S2 0.0172105
RPS19 ribosomal protein S19 0.0172045
RPLP2 ribosomal protein, large, P2 0.017204
STC1 stanniocalcin 1 0.0170281
NAMPT nicotinamide phosphoribosyltransferase 0.016791
HSPA8 heat shock 70kDa protein 8 0.016626
TM4SF1 transmembrane 4 L six family member 1 0.0162379
RPL36 ribosomal protein L36 0.0161567
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0161251
RPL30 ribosomal protein L30 0.0159594
CANX calnexin 0.0157061
LOXL2 lysyl oxidase-like 2 0.015689
LOC112694756 uncharaterized LOC112694756 0.0156813
SPAG9 sperm associated antigen 9 0.0156602
RPLP0 ribosomal protein, large, P0 0.015613
CSF1 colony stimulating factor 1 (macrophage) 0.0155901
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0155588
RPS27A ribosomal protein S27a 0.0155406
RASA2 RAS p21 protein activator 2 0.0154947

decreased expression

Symbol Name Standardized Value
COL1A2 collagen, type I, alpha 2 -0.0406249
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0281737
LOX lysyl oxidase -0.025673
TMSB10 thymosin beta 10 -0.0145779
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0144094
FBN1 fibrillin 1 -0.0140829
F3 coagulation factor III (thromboplastin, tissue factor) -0.0140034
TRAM1 translocation associated membrane protein 1 -0.0132564
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0128698
EGR1 early growth response 1 -0.012464
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0115755
PSD3 pleckstrin and Sec7 domain containing 3 -0.0110311
COPA coatomer protein complex, subunit alpha -0.0102475
SQLE squalene epoxidase -0.00957788
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00946877
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.00916499
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.00898484
TAPBP TAP binding protein (tapasin) -0.00862416
DPYD dihydropyrimidine dehydrogenase -0.00851895
ENO2 enolase 2 (gamma, neuronal) -0.00809708
COL6A1 collagen, type VI, alpha 1 -0.00793921
TMEM165 transmembrane protein 165 -0.00788545
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0078818
CYB5R3 cytochrome b5 reductase 3 -0.00777743
MYADM myeloid-associated differentiation marker -0.00767444
HYOU1 hypoxia up-regulated 1 -0.00764799
ATM ATM serine/threonine kinase -0.00752444
CA12 carbonic anhydrase XII -0.00726886
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.00724932
SRP54 signal recognition particle 54kDa -0.00714108
IL6 interleukin 6 -0.00711433
SEC24A SEC24 family member A -0.0069843
MRPS6 mitochondrial ribosomal protein S6 -0.00686329
WASF2 WAS protein family, member 2 -0.00674887
IGFBP3 insulin-like growth factor binding protein 3 -0.00674044
KCTD9 potassium channel tetramerization domain containing 9 -0.00664176
TPM4 tropomyosin 4 -0.00658705
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.00645223
ADAM9 ADAM metallopeptidase domain 9 -0.00620345
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.00619796
SPDYA speedy/RINGO cell cycle regulator family member A -0.00581736
SYVN1 synovial apoptosis inhibitor 1, synoviolin -0.0056669
TAOK1 TAO kinase 1 -0.00563245
GARS1 glycyl-tRNA synthetase 1 -0.00538123
SLC38A2 solute carrier family 38, member 2 -0.00530068
LDHA lactate dehydrogenase A -0.00529032
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00517918
SKIC3 SKI3 subunit of superkiller complex -0.00512881
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.00509147
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.00508627
HMCN1 hemicentin 1 -0.00501669
TMEM41B transmembrane protein 41B -0.00493681
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.00493463
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -0.00487071
GJA1 gap junction protein, alpha 1, 43kDa -0.00485548
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.00485204
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.00481543
CLMP CXADR-like membrane protein -0.00481184
CALCOCO2 calcium binding and coiled-coil domain 2 -0.0048017
NGLY1 N-glycanase 1 -0.00476681
EHD2 EH-domain containing 2 -0.00475295
TNPO1 transportin 1 -0.00472198
NPEPPS aminopeptidase puromycin sensitive -0.00471444
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.00468605
POSTN periostin, osteoblast specific factor -0.0046271
TES testin LIM domain protein -0.00461138
AGO3 argonaute RISC catalytic component 3 -0.00454861
BLTP2 bridge-like lipid transfer protein family member 2 -0.00454294
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.00453873
SERINC3 serine incorporator 3 -0.00453086
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 -0.00452073
RAB5A RAB5A, member RAS oncogene family -0.00445173
SULF1 sulfatase 1 -0.00441026
NKTR natural killer cell triggering receptor -0.00438802
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -0.00435068
LMAN1 lectin, mannose-binding, 1 -0.00434707
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.00432398
RIC1 RAB6A GEF complex partner 1 -0.00427743
UGDH UDP-glucose 6-dehydrogenase -0.00425368
ZCCHC7 zinc finger, CCHC domain containing 7 -0.00418671
GLG1 golgi glycoprotein 1 -0.00418167
SRPRA SRP receptor subunit alpha -0.00416368
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.00415804
RNF11 ring finger protein 11 -0.00415262
EVI5 ecotropic viral integration site 5 -0.00414804
FAM162A family with sequence similarity 162, member A -0.00413588
ALKBH5 AlkB family member 5, RNA demethylase -0.00409455
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0040733
RNF145 ring finger protein 145 -0.00405786
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 -0.00405621
APAF1 apoptotic peptidase activating factor 1 -0.00401319
USP37 ubiquitin specific peptidase 37 -0.00401084
TMEM67 transmembrane protein 67 -0.00400831
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.00387513
PTGIS prostaglandin I2 (prostacyclin) synthase -0.00385207
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.00382076
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0038033
AHI1 Abelson helper integration site 1 -0.00379356
VIRMA vir like m6A methyltransferase associated -0.00378142
SERP1 stress-associated endoplasmic reticulum protein 1 -0.00376456