Rucaparib (phosphate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.173839
FN1 fibronectin 1 0.149278
APOB apolipoprotein B 0.148857
C3 complement component 3 0.125545
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.113412
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0768517
ELL2 elongation factor, RNA polymerase II, 2 0.0487761
DSPP dentin sialophosphoprotein 0.0487439
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0463022
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0447835
NKD1 naked cuticle homolog 1 (Drosophila) 0.0433483
FBF1 Fas (TNFRSF6) binding factor 1 0.0430644
LRMDA leucine rich melanocyte differentiation associated 0.0419457
EEF2 eukaryotic translation elongation factor 2 0.0401397
SAMD4A sterile alpha motif domain containing 4A 0.0388435
FNDC3B fibronectin type III domain containing 3B 0.0368022
EHBP1 EH domain binding protein 1 0.0344709
FAT1 FAT atypical cadherin 1 0.0344159
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0335262
TRIO trio Rho guanine nucleotide exchange factor 0.0331983
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0330673
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0323996
VEGFA vascular endothelial growth factor A 0.031977
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0317097
GPC6 glypican 6 0.0311794
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0305357
ERRFI1 ERBB receptor feedback inhibitor 1 0.029664
RUNX1 runt-related transcription factor 1 0.0293561
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0290229
AFDN afadin, adherens junction formation factor 0.0285297
AKAP12 A kinase (PRKA) anchor protein 12 0.0283233
JMJD1C jumonji domain containing 1C 0.027743
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0270422
MYH9 myosin, heavy chain 9, non-muscle 0.0263361
MAML2 mastermind-like 2 (Drosophila) 0.0262383
ENO1 enolase 1, (alpha) 0.0259868
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0252588
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0246001
ATXN1 ataxin 1 0.0238122
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0235059
ARHGAP9 Rho GTPase activating protein 9 0.0231613
AHNAK AHNAK nucleoprotein 0.0230957
IGF1R insulin-like growth factor 1 receptor 0.021866
ZMIZ1 zinc finger, MIZ-type containing 1 0.0215241
A2M alpha-2-macroglobulin 0.0213505
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0212866
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0209862
DST dystonin 0.0207425
KIF5B kinesin family member 5B 0.0200754
BHLHE40 basic helix-loop-helix family, member e40 0.0199857
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0199822
NAP1L1 nucleosome assembly protein 1-like 1 0.0198337
PTPRM protein tyrosine phosphatase, receptor type, M 0.0197543
SOS1 son of sevenless homolog 1 (Drosophila) 0.0194244
ANKRD11 ankyrin repeat domain 11 0.019067
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0190232
NPAS2 neuronal PAS domain protein 2 0.0190178
SMAD3 SMAD family member 3 0.0184392
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0184358
EPAS1 endothelial PAS domain protein 1 0.0183065
ABTB3 ankyrin repeat and BTB domain containing 3 0.0179873
IFRD1 interferon-related developmental regulator 1 0.0177587
JAK1 Janus kinase 1 0.0177209
DENND4A DENN/MADD domain containing 4A 0.0176664
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0176494
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0175541
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0170438
TBC1D22A TBC1 domain family, member 22A 0.016534
DSCAM Down syndrome cell adhesion molecule 0.016479
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0163618
RPL3 ribosomal protein L3 0.0161851
CNKSR3 CNKSR family member 3 0.0160877
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0160043
FTH1 ferritin, heavy polypeptide 1 0.0160018
MRTFA myocardin related transcription factor A 0.0156584
MALRD1 MAM and LDL receptor class A domain containing 1 0.015647
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0154549
SESTD1 SEC14 and spectrin domains 1 0.0154244
KRT8 keratin 8, type II 0.0153742
LCOR ligand dependent nuclear receptor corepressor 0.0152928
MACF1 microtubule-actin crosslinking factor 1 0.0152163
PKP4 plakophilin 4 0.0151545
PAWR PRKC, apoptosis, WT1, regulator 0.015129
GPC3 glypican 3 0.0150869
TNS3 tensin 3 0.014995
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0148115
ABI1 abl-interactor 1 0.0147086
SDC4 syndecan 4 0.0145747
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0144908
LPP LIM domain containing preferred translocation partner in lipoma 0.0144394
PTCHD4 patched domain containing 4 0.0139737
GSE1 Gse1 coiled-coil protein 0.0138689
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0138053
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0137575
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0136364
NRIP1 nuclear receptor interacting protein 1 0.0134051
UBASH3B ubiquitin associated and SH3 domain containing B 0.013373
EPS8 epidermal growth factor receptor pathway substrate 8 0.0132667
PTK2 protein tyrosine kinase 2 0.0131732
FLNB filamin B, beta 0.0131235

decreased expression

Symbol Name Standardized Value
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.174013
MT2A metallothionein 2A -0.0719325
TIMP1 TIMP metallopeptidase inhibitor 1 -0.055891
FTL ferritin, light polypeptide -0.0516653
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0422306
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0387375
TMSB10 thymosin beta 10 -0.0304389
PLIN2 perilipin 2 -0.0228066
HMGA1 high mobility group AT-hook 1 -0.0221485
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.019076
MARCKS myristoylated alanine-rich protein kinase C substrate -0.018458
APOA2 apolipoprotein A-II -0.0177967
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0162564
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0160234
RPS5 ribosomal protein S5 -0.0158358
LDHA lactate dehydrogenase A -0.0149218
RPLP1 ribosomal protein, large, P1 -0.0141789
NDRG1 N-myc downstream regulated 1 -0.0141004
RPLP0 ribosomal protein, large, P0 -0.0137404
RPL32 ribosomal protein L32 -0.0135849
RPS6 ribosomal protein S6 -0.0135176
APOE apolipoprotein E -0.0134372
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0132019
CPE carboxypeptidase E -0.0127985
FAM162A family with sequence similarity 162, member A -0.0127785
ZMYND8 zinc finger, MYND-type containing 8 -0.0126943
MT1X metallothionein 1X -0.0123557
APOA1 apolipoprotein A-I -0.0120137
PTMA prothymosin, alpha -0.0119984
RPS19 ribosomal protein S19 -0.0117689
PERP PERP, TP53 apoptosis effector -0.011501
CYB5R3 cytochrome b5 reductase 3 -0.0113734
RPLP2 ribosomal protein, large, P2 -0.0112891
LYZ lysozyme -0.0112343
TSC22D2 TSC22 domain family, member 2 -0.0112179
PKM pyruvate kinase, muscle -0.0111046
RPS23 ribosomal protein S23 -0.0109391
IFITM1 interferon induced transmembrane protein 1 -0.0108808
SEC62 SEC62 homolog (S. cerevisiae) -0.0105996
IFI6 interferon, alpha-inducible protein 6 -0.01041
TRAM1 translocation associated membrane protein 1 -0.0103595
RPS14 ribosomal protein S14 -0.0103268
GNAS GNAS complex locus -0.0102801
IFITM3 interferon induced transmembrane protein 3 -0.0101253
RPS24 ribosomal protein S24 -0.0100097
GOLGA4 golgin A4 -0.00994824
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.00992205
RPL31 ribosomal protein L31 -0.00966692
GLRX glutaredoxin (thioltransferase) -0.00953124
TPT1 tumor protein, translationally-controlled 1 -0.00948425
CST3 cystatin C -0.00947681
EIF5B eukaryotic translation initiation factor 5B -0.00919869
VIM vimentin -0.00910829
WSB1 WD repeat and SOCS box containing 1 -0.00908628
RPL8 ribosomal protein L8 -0.00882947
INSIG2 insulin induced gene 2 -0.00877053
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.00870012
VDAC1 voltage-dependent anion channel 1 -0.00868403
UGP2 UDP-glucose pyrophosphorylase 2 -0.00865555
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.00857059
THOC2 THO complex 2 -0.00851188
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.00844442
RBM25 RNA binding motif protein 25 -0.00838747
KTN1 kinectin 1 (kinesin receptor) -0.00835304
TENM1 teneurin transmembrane protein 1 -0.00831328
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein -0.00824592
SMAD5 SMAD family member 5 -0.00823344
RPL9 ribosomal protein L9 -0.00813825
GK glycerol kinase -0.00812734
KIF21A kinesin family member 21A -0.00808593
ZFP36L1 ZFP36 ring finger protein-like 1 -0.00808565
TERF2IP telomeric repeat binding factor 2, interacting protein -0.00807128
BTG1 B-cell translocation gene 1, anti-proliferative -0.0079554
SMC3 structural maintenance of chromosomes 3 -0.00792409
PCBP2 poly(rC) binding protein 2 -0.00777631
PDE8A phosphodiesterase 8A -0.00763756
ISG15 ISG15 ubiquitin-like modifier -0.00763158
RPL34 ribosomal protein L34 -0.0076024
CKAP4 cytoskeleton-associated protein 4 -0.0076013
RDX radixin -0.00747397
ZNF638 zinc finger protein 638 -0.00739433
MCFD2 multiple coagulation factor deficiency 2 -0.00737221
BIRC3 baculoviral IAP repeat containing 3 -0.00736617
CTSD cathepsin D -0.00730057
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.00728515
EPSTI1 epithelial stromal interaction 1 (breast) -0.00725757
PDIA3 protein disulfide isomerase family A, member 3 -0.00721499
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.00720241
RPS13 ribosomal protein S13 -0.00718964
HILPDA hypoxia inducible lipid droplet-associated -0.0071708
XPO1 exportin 1 -0.00707859
CCDC88A coiled-coil domain containing 88A -0.00707659
GLG1 golgi glycoprotein 1 -0.00707086
SEPTIN7 septin 7 -0.00706133
OAZ1 ornithine decarboxylase antizyme 1 -0.00704013
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.00701745
RPL39 ribosomal protein L39 -0.00698657
SRSF11 serine/arginine-rich splicing factor 11 -0.00698415
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.00697511
CNOT8 CCR4-NOT transcription complex, subunit 8 -0.00697477