Rucaparib (phosphate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0877313
CLU clusterin 0.073813
RPS8 ribosomal protein S8 0.0648086
MT2A metallothionein 2A 0.0625938
NDRG1 N-myc downstream regulated 1 0.0624447
ENO1 enolase 1, (alpha) 0.0619388
B2M beta-2-microglobulin 0.0561678
RPS6 ribosomal protein S6 0.0549001
PTMA prothymosin, alpha 0.0523788
FTH1 ferritin, heavy polypeptide 1 0.0516247
IGF2 insulin-like growth factor 2 0.0483747
RPS3 ribosomal protein S3 0.0457293
MTSS1 metastasis suppressor 1 0.0418374
RPS13 ribosomal protein S13 0.0404363
PODXL podocalyxin-like 0.0391099
MEF2A myocyte enhancer factor 2A 0.0388108
RPLP2 ribosomal protein, large, P2 0.0386978
TMSB4X thymosin beta 4, X-linked 0.0383512
RPS12 ribosomal protein S12 0.0371469
RAI14 retinoic acid induced 14 0.0357502
RPS21 ribosomal protein S21 0.0356767
AHNAK AHNAK nucleoprotein 0.0345296
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0340061
TPT1 tumor protein, translationally-controlled 1 0.0318516
RPL11 ribosomal protein L11 0.0318336
HLA-A major histocompatibility complex, class I, A 0.0312642
RPL35A ribosomal protein L35a 0.0312264
PGK1 phosphoglycerate kinase 1 0.0311806
RPL5 ribosomal protein L5 0.0296861
HLA-B major histocompatibility complex, class I, B 0.0296436
GOLGA4 golgin A4 0.0290205
TIMP3 TIMP metallopeptidase inhibitor 3 0.0287245
BHLHE40 basic helix-loop-helix family, member e40 0.028462
RPL8 ribosomal protein L8 0.0283201
RPS19 ribosomal protein S19 0.0283081
RPL12 ribosomal protein L12 0.0282133
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0279517
FLNB filamin B, beta 0.0279202
YBX1 Y box binding protein 1 0.0275954
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0273009
RPL37A ribosomal protein L37a 0.0271759
HLA-E major histocompatibility complex, class I, E 0.0271682
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0263662
TPM3 tropomyosin 3 0.0261428
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0254713
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0249527
POTEF POTE ankyrin domain family, member F 0.0248332
STC1 stanniocalcin 1 0.0246044
IFITM3 interferon induced transmembrane protein 3 0.024299
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0242383
RPL37 ribosomal protein L37 0.0242309
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0241251
EEF2 eukaryotic translation elongation factor 2 0.0239821
NAP1L1 nucleosome assembly protein 1-like 1 0.0236279
CALB1 calbindin 1, 28kDa 0.0235554
RPL23 ribosomal protein L23 0.0235303
RPS27A ribosomal protein S27a 0.0235087
SQSTM1 sequestosome 1 0.0235027
ANXA2 annexin A2 0.0233403
ANXA1 annexin A1 0.0229267
RPL7A ribosomal protein L7a 0.0227396
MT1X metallothionein 1X 0.0223202
S100A9 S100 calcium binding protein A9 0.0222695
RPL36 ribosomal protein L36 0.0219355
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.02172
RACK1 receptor for activated C kinase 1 0.0214218
MYH9 myosin, heavy chain 9, non-muscle 0.0214188
RPL26 ribosomal protein L26 0.0214067
ABI3BP ABI family, member 3 (NESH) binding protein 0.0212351
RPL19 ribosomal protein L19 0.021101
RPL28 ribosomal protein L28 0.020969
S100A2 S100 calcium binding protein A2 0.0208592
S100A10 S100 calcium binding protein A10 0.0207227
CD99 CD99 molecule 0.0206646
RPS29 ribosomal protein S29 0.0203596
PRRC2C proline-rich coiled-coil 2C 0.0203395
RPL34 ribosomal protein L34 0.0202843
TGM2 transglutaminase 2 0.0200602
RPS2 ribosomal protein S2 0.0200481
NAV2 neuron navigator 2 0.0200461
RPS27 ribosomal protein S27 0.019975
CUL4B cullin 4B 0.0196582
ARRDC3 arrestin domain containing 3 0.0195334
TRIO trio Rho guanine nucleotide exchange factor 0.0195249
TTC3 tetratricopeptide repeat domain 3 0.0194779
FLNA filamin A, alpha 0.0194684
RPS25 ribosomal protein S25 0.0191846
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0189264
SRRM2 serine/arginine repetitive matrix 2 0.0186022
CANX calnexin 0.0185794
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.017959
EIF1 eukaryotic translation initiation factor 1 0.0179092
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0178532
VEGFA vascular endothelial growth factor A 0.0178351
HDGF hepatoma-derived growth factor 0.01783
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0178275
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0178081
RPL35 ribosomal protein L35 0.0177831
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0177508
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.017697

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.103102
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0315294
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0289745
OSMR oncostatin M receptor -0.0259056
VCL vinculin -0.0244627
FOXO1 forkhead box O1 -0.0235764
PRELID2 PRELI domain containing 2 -0.0201283
NRG1 neuregulin 1 -0.0192733
SAMD9 sterile alpha motif domain containing 9 -0.018019
PDLIM5 PDZ and LIM domain 5 -0.0167729
PALLD palladin, cytoskeletal associated protein -0.0155888
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0143974
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0139879
DPYD dihydropyrimidine dehydrogenase -0.0137379
BMAL2 basic helix-loop-helix ARNT like 2 -0.0136729
NEK7 NIMA-related kinase 7 -0.01358
DOCK5 dedicator of cytokinesis 5 -0.0131608
RIN2 Ras and Rab interactor 2 -0.0124998
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0122629
AOPEP aminopeptidase O (putative) -0.0122599
NDE1 nudE neurodevelopment protein 1 -0.0117958
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0116606
CEMIP cell migration inducing protein, hyaluronan binding -0.0108101
FOXP1 forkhead box P1 -0.0106201
OSBPL3 oxysterol binding protein-like 3 -0.00983451
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.00969645
MECOM MDS1 and EVI1 complex locus -0.00945444
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.00916052
NRIP1 nuclear receptor interacting protein 1 -0.00858815
CNTNAP3 contactin associated protein-like 3 -0.0084114
C4BPB complement component 4 binding protein, beta -0.00823211
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.00820913
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.00807348
DAAM1 dishevelled associated activator of morphogenesis 1 -0.00793976
BCL2L1 BCL2-like 1 -0.00790468
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 -0.00785323
ARHGAP29 Rho GTPase activating protein 29 -0.007757
RBM39 RNA binding motif protein 39 -0.00755214
EHF ets homologous factor -0.00749008
SMAD3 SMAD family member 3 -0.00741836
NBEA neurobeachin -0.00737423
NIBAN2 niban apoptosis regulator 2 -0.00736695
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.00734393
AFAP1L2 actin filament associated protein 1-like 2 -0.007244
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.00715276
SLC35H1 solute carrier family 35 member H1 -0.00713873
CORO2A coronin, actin binding protein, 2A -0.0070818
IL6ST interleukin 6 signal transducer -0.00697336
RIGI RNA sensor RIG-I -0.00680151
SOX13 SRY (sex determining region Y)-box 13 -0.00675948
SAR1A secretion associated, Ras related GTPase 1A -0.00665975
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.00662526
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.00652026
MAPK10 mitogen-activated protein kinase 10 -0.00651901
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 -0.00649638
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -0.00646152
DENND2C DENN/MADD domain containing 2C -0.00645138
SLC45A4 solute carrier family 45, member 4 -0.00641767
PLXNA2 plexin A2 -0.00638492
RHOJ ras homolog family member J -0.00636567
KIAA0040 KIAA0040 -0.0063338
EFNA5 ephrin-A5 -0.00626734
SETX senataxin -0.00621648
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.00619501
SERINC3 serine incorporator 3 -0.00616719
PRKCH protein kinase C, eta -0.00605671
NLRP1 NLR family, pyrin domain containing 1 -0.00596254
ARF1 ADP-ribosylation factor 1 -0.00586289
LUZP1 leucine zipper protein 1 -0.00585746
EFCAB13 EF-hand calcium binding domain 13 -0.00580358
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.00579003
GM2A GM2 ganglioside activator -0.005756
NCEH1 neutral cholesterol ester hydrolase 1 -0.00566943
IFI44 interferon-induced protein 44 -0.00560616
ZNF217 zinc finger protein 217 -0.00559882
RAB10 RAB10, member RAS oncogene family -0.00550802
IFI16 interferon, gamma-inducible protein 16 -0.00546625
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00541109
ANKRD33B ankyrin repeat domain 33B -0.00537397
MCU mitochondrial calcium uniporter -0.00534223
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.00532197
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.00531485
PARK7 parkinson protein 7 -0.00531323
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0052561
ANKRD28 ankyrin repeat domain 28 -0.00523756
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.0052253
BBS9 Bardet-Biedl syndrome 9 -0.00519732
LMO7 LIM domain 7 -0.00516237
NPC1 Niemann-Pick disease, type C1 -0.00513061
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.00508306
ETNK1 ethanolamine kinase 1 -0.00507642
CDK17 cyclin-dependent kinase 17 -0.00506499
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.00505785
SENP5 SUMO1/sentrin specific peptidase 5 -0.00501634
WNT2B wingless-type MMTV integration site family, member 2B -0.00501119
ABLIM1 actin binding LIM protein 1 -0.0050023
FAM107B family with sequence similarity 107, member B -0.00495348
AMOTL1 angiomotin like 1 -0.00492826
STAT1 signal transducer and activator of transcription 1, 91kDa -0.00491767
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.00489162