| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.267333 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.180919 |
| ATP13A3 | ATPase type 13A3 | 0.137487 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.132538 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.108565 |
| B2M | beta-2-microglobulin | 0.0707786 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0644865 |
| ADM | adrenomedullin | 0.0637739 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0636153 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0603544 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0599789 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0590629 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0581287 |
| NUP58 | nucleoporin 58 | 0.0574184 |
| FLNB | filamin B, beta | 0.0557329 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0511889 |
| CCNL1 | cyclin L1 | 0.0511644 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0503925 |
| CANX | calnexin | 0.0481664 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0463742 |
| CALR | calreticulin | 0.0457963 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0450578 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0447847 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.043621 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0435645 |
| TPD52 | tumor protein D52 | 0.0434794 |
| SPAG9 | sperm associated antigen 9 | 0.0428017 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0418487 |
| NUP153 | nucleoporin 153kDa | 0.0404078 |
| ANKRD10 | ankyrin repeat domain 10 | 0.0399844 |
| USP3 | ubiquitin specific peptidase 3 | 0.0386896 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.0382833 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0379296 |
| TPM3 | tropomyosin 3 | 0.0377568 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0377152 |
| HLA-B | major histocompatibility complex, class I, B | 0.0373977 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.037233 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.037213 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0370909 |
| PGK1 | phosphoglycerate kinase 1 | 0.0361184 |
| ZNF841 | zinc finger protein 841 | 0.0359978 |
| AHNAK | AHNAK nucleoprotein | 0.0354469 |
| TSC22D2 | TSC22 domain family, member 2 | 0.034846 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0346565 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0342605 |
| RLF | rearranged L-myc fusion | 0.0342202 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0341478 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0338228 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0335301 |
| PDS5B | PDS5 cohesin associated factor B | 0.0330288 |
| HLA-A | major histocompatibility complex, class I, A | 0.032967 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0323392 |
| FAR1 | fatty acyl CoA reductase 1 | 0.0321157 |
| ZNF292 | zinc finger protein 292 | 0.0321116 |
| TXNRD1 | thioredoxin reductase 1 | 0.0320707 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0319159 |
| GOLGA4 | golgin A4 | 0.031741 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0316226 |
| NOP58 | NOP58 ribonucleoprotein | 0.0314391 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0314129 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0309689 |
| TFG | TRK-fused gene | 0.0305901 |
| UBC | ubiquitin C | 0.0304474 |
| HLA-E | major histocompatibility complex, class I, E | 0.0304298 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.030078 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0295464 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.029406 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0286312 |
| TGFB2 | transforming growth factor, beta 2 | 0.028617 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0284504 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.028222 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0279974 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.027894 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0278046 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0277647 |
| RBM39 | RNA binding motif protein 39 | 0.0276548 |
| FOSL1 | FOS-like antigen 1 | 0.0276375 |
| DENND4C | DENN/MADD domain containing 4C | 0.0275546 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.027365 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0270815 |
| JUN | jun proto-oncogene | 0.026969 |
| PTK2 | protein tyrosine kinase 2 | 0.0268774 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0267893 |
| ANXA1 | annexin A1 | 0.0267644 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0267482 |
| SMAD3 | SMAD family member 3 | 0.0266261 |
| SUCO | SUN domain containing ossification factor | 0.0265369 |
| RTN4 | reticulon 4 | 0.0265313 |
| PLIN2 | perilipin 2 | 0.0263483 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0263378 |
| ARRDC3 | arrestin domain containing 3 | 0.0262869 |
| VEGFA | vascular endothelial growth factor A | 0.026279 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0262506 |
| ECT2 | epithelial cell transforming 2 | 0.0261487 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0260172 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.025548 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0248893 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0246299 |
| DENND5A | DENN/MADD domain containing 5A | 0.0245627 |
| RHEB | Ras homolog enriched in brain | 0.0241548 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | -0.171684 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0790285 |
| INTS6 | integrator complex subunit 6 | -0.0581242 |
| PHACTR1 | phosphatase and actin regulator 1 | -0.0526919 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0525495 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0372061 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0369634 |
| TLE4 | transducin-like enhancer of split 4 | -0.0353641 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.033061 |
| TMSB10 | thymosin beta 10 | -0.0322798 |
| VIM | vimentin | -0.0311423 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0295586 |
| ASPH | aspartate beta-hydroxylase | -0.0292783 |
| SMYD3 | SET and MYND domain containing 3 | -0.0289162 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0287653 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0277585 |
| PRELID2 | PRELI domain containing 2 | -0.0273751 |
| FHIT | fragile histidine triad | -0.0260888 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0256641 |
| EGFR | epidermal growth factor receptor | -0.025509 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0254144 |
| PLSCR1 | phospholipid scramblase 1 | -0.0252663 |
| ZNF804A | zinc finger protein 804A | -0.0245972 |
| VCL | vinculin | -0.0244353 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0238469 |
| DST | dystonin | -0.0236992 |
| NABP1 | nucleic acid binding protein 1 | -0.0235761 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | -0.0232269 |
| DIAPH3 | diaphanous-related formin 3 | -0.0230073 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0226894 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0223699 |
| ZNF432 | zinc finger protein 432 | -0.0222048 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0214417 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0207838 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0206097 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0204629 |
| TENM3 | teneurin transmembrane protein 3 | -0.0201378 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0200755 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0199526 |
| E2F3 | E2F transcription factor 3 | -0.0199115 |
| EFNA5 | ephrin-A5 | -0.0193891 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0186081 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0184663 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.0184308 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0177248 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0173994 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0173123 |
| RAD51B | RAD51 paralog B | -0.0171762 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0169944 |
| RIGI | RNA sensor RIG-I | -0.0168416 |
| LYPD6B | LY6/PLAUR domain containing 6B | -0.0167737 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0167495 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0164788 |
| PCLO | piccolo presynaptic cytomatrix protein | -0.0164388 |
| KALRN | kalirin, RhoGEF kinase | -0.0163091 |
| GLIS3 | GLIS family zinc finger 3 | -0.0162184 |
| CAST | calpastatin | -0.0161433 |
| ACTG1 | actin gamma 1 | -0.0161131 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0161101 |
| KLF12 | Kruppel-like factor 12 | -0.0156079 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0154699 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0151679 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0151396 |
| CMIP | c-Maf inducing protein | -0.0150486 |
| RPLP1 | ribosomal protein, large, P1 | -0.0150291 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0149187 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.014785 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0146623 |
| CCND1 | cyclin D1 | -0.0145957 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0144872 |
| CSTF3 | cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa | -0.0144698 |
| FER | fer (fps/fes related) tyrosine kinase | -0.0143565 |
| RRBP1 | ribosome binding protein 1 | -0.0141578 |
| AEBP2 | AE binding protein 2 | -0.0141136 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0139146 |
| EXOC4 | exocyst complex component 4 | -0.0138827 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0137448 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0136314 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0136239 |
| ZXDC | ZXD family zinc finger C | -0.0136189 |
| PARD3B | par-3 family cell polarity regulator beta | -0.0135886 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0135761 |
| WWOX | WW domain containing oxidoreductase | -0.0135564 |
| CUX1 | cut-like homeobox 1 | -0.0134319 |
| LRRC23 | leucine rich repeat containing 23 | -0.013396 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0133613 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.01334 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0132869 |
| RGS7 | regulator of G-protein signaling 7 | -0.0132482 |
| NAV1 | neuron navigator 1 | -0.0128816 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0128628 |
| FOXN3 | forkhead box N3 | -0.0127803 |
| FOXP1 | forkhead box P1 | -0.01269 |
| ZNF407 | zinc finger protein 407 | -0.0126805 |
| HDAC9 | histone deacetylase 9 | -0.0126017 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0125949 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -0.0124834 |
| RASAL2 | RAS protein activator like 2 | -0.0124624 |
| ZNF93 | zinc finger protein 93 | -0.0124388 |
| PCNX4 | pecanex 4 | -0.0121688 |
