| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| THSD4 | thrombospondin, type I, domain containing 4 | 0.17028 |
| MSI2 | musashi RNA-binding protein 2 | 0.126348 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.125876 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.107214 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0901784 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0840271 |
| CALB1 | calbindin 1, 28kDa | 0.0772365 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0755093 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.071339 |
| AHNAK | AHNAK nucleoprotein | 0.0581777 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0573507 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0539874 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0511628 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.050632 |
| CANX | calnexin | 0.0501732 |
| RPL35A | ribosomal protein L35a | 0.0484802 |
| DENND1A | DENN/MADD domain containing 1A | 0.0468964 |
| RPS8 | ribosomal protein S8 | 0.0466233 |
| FLNB | filamin B, beta | 0.0456757 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0449726 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0441713 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0440615 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0427959 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0420916 |
| CTBP2 | C-terminal binding protein 2 | 0.0399463 |
| RPLP0 | ribosomal protein, large, P0 | 0.0398813 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0391821 |
| SLMAP | sarcolemma associated protein | 0.0390919 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.038635 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0386075 |
| MYO5B | myosin VB | 0.0382653 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0374739 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0368624 |
| RPL23 | ribosomal protein L23 | 0.0366287 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0358365 |
| USP3 | ubiquitin specific peptidase 3 | 0.0356708 |
| RPS3 | ribosomal protein S3 | 0.0356535 |
| RPL12 | ribosomal protein L12 | 0.0350075 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0349833 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0349323 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | 0.0347901 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0342624 |
| RPL34 | ribosomal protein L34 | 0.0335101 |
| COBL | cordon-bleu WH2 repeat protein | 0.033227 |
| AOPEP | aminopeptidase O (putative) | 0.032495 |
| LAMB3 | laminin, beta 3 | 0.0322162 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.032199 |
| ENO1 | enolase 1, (alpha) | 0.0315749 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0311364 |
| FAT1 | FAT atypical cadherin 1 | 0.0309225 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.030794 |
| RPL13A | ribosomal protein L13a | 0.0307299 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0302949 |
| LIN54 | lin-54 DREAM MuvB core complex component | 0.0302395 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.030179 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0299946 |
| NPSR1 | neuropeptide S receptor 1 | 0.0296726 |
| ANXA2 | annexin A2 | 0.0296075 |
| KRT18 | keratin 18, type I | 0.0295731 |
| AFDN | afadin, adherens junction formation factor | 0.0295696 |
| PYGB | phosphorylase, glycogen; brain | 0.029194 |
| DNM2 | dynamin 2 | 0.0290943 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0287998 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0287997 |
| DSPP | dentin sialophosphoprotein | 0.0283557 |
| SLTM | SAFB-like, transcription modulator | 0.0282066 |
| RREB1 | ras responsive element binding protein 1 | 0.0281781 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0276766 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0276525 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0276382 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0275648 |
| MLEC | malectin | 0.0273636 |
| PTK2 | protein tyrosine kinase 2 | 0.0272099 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.027101 |
| KIAA1671 | KIAA1671 | 0.0270404 |
| KRT8 | keratin 8, type II | 0.0270237 |
| SBF2 | SET binding factor 2 | 0.0270094 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0267101 |
| CALU | calumenin | 0.0266491 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0263555 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0262694 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0262215 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0256781 |
| RPS27A | ribosomal protein S27a | 0.0251974 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0249751 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0248303 |
| NAP1L4 | nucleosome assembly protein 1-like 4 | 0.0246728 |
| STK39 | serine threonine kinase 39 | 0.0245497 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0242125 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0239357 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | 0.0239064 |
| RAB3GAP1 | RAB3 GTPase activating protein subunit 1 (catalytic) | 0.0238884 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0232683 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0230557 |
| MYOF | myoferlin | 0.0226227 |
| TC2N | tandem C2 domains, nuclear | 0.0225975 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0224179 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0223875 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0223267 |
| MED13L | mediator complex subunit 13-like | 0.0222644 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.1358 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.123972 |
| MYO1E | myosin IE | -0.0855617 |
| LMO7 | LIM domain 7 | -0.0827872 |
| PRSS3 | protease, serine, 3 | -0.0663172 |
| RPLP1 | ribosomal protein, large, P1 | -0.0662325 |
| TXNRD1 | thioredoxin reductase 1 | -0.0661766 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0656511 |
| PKP2 | plakophilin 2 | -0.0600424 |
| VCL | vinculin | -0.0582586 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0547461 |
| FHL2 | four and a half LIM domains 2 | -0.0542621 |
| RPS2 | ribosomal protein S2 | -0.0505236 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.0477274 |
| WWC1 | WW and C2 domain containing 1 | -0.0437119 |
| TMEM45B | transmembrane protein 45B | -0.0419158 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0395909 |
| MUC13 | mucin 13, cell surface associated | -0.0395348 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0370075 |
| TSPAN8 | tetraspanin 8 | -0.0369537 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.036254 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0350352 |
| RNF145 | ring finger protein 145 | -0.0347399 |
| RPL31 | ribosomal protein L31 | -0.0329297 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0322061 |
| PLEKHG1 | pleckstrin homology domain containing, family G (with RhoGef domain) member 1 | -0.0321815 |
| MKI67 | marker of proliferation Ki-67 | -0.0312569 |
| ATXN1 | ataxin 1 | -0.0305614 |
| ASPH | aspartate beta-hydroxylase | -0.0304769 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0302129 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0292047 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.0291191 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0283976 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0274918 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0267782 |
| SEPTIN10 | septin 10 | -0.0262802 |
| PTEN | phosphatase and tensin homolog | -0.026272 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0251495 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0251084 |
| RIGI | RNA sensor RIG-I | -0.024904 |
| CCPG1 | cell cycle progression 1 | -0.0248452 |
| IL6ST | interleukin 6 signal transducer | -0.0247632 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0246396 |
| MX1 | MX dynamin-like GTPase 1 | -0.024079 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0240536 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0239822 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0232094 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0227883 |
| CCSER1 | coiled-coil serine-rich protein 1 | -0.0222597 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0219358 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0218354 |
| MX2 | MX dynamin-like GTPase 2 | -0.0214726 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0212926 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0210571 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0207594 |
| IFNGR1 | interferon gamma receptor 1 | -0.0203913 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0202106 |
| BOD1L1 | biorientation of chromosomes in cell division 1-like 1 | -0.0200509 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0199154 |
| DPYD | dihydropyrimidine dehydrogenase | -0.01968 |
| FOXP1 | forkhead box P1 | -0.0196166 |
| RPL4 | ribosomal protein L4 | -0.0194988 |
| ABHD17C | abhydrolase domain containing 17C | -0.0194855 |
| UBXN4 | UBX domain protein 4 | -0.0193327 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0193059 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.019102 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0190393 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0190352 |
| XPC | xeroderma pigmentosum, complementation group C | -0.019024 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0188713 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0188411 |
| TRIM56 | tripartite motif containing 56 | -0.0187379 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0186382 |
| DUSP4 | dual specificity phosphatase 4 | -0.0184867 |
| GOLM2 | golgi membrane protein 2 | -0.0179822 |
| EGR1 | early growth response 1 | -0.0179429 |
| RPL21 | ribosomal protein L21 | -0.0179364 |
| LIMA1 | LIM domain and actin binding 1 | -0.0179171 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0178947 |
| CENPF | centromere protein F, 350/400kDa | -0.0175147 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0172625 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0171255 |
| UGT1A6 | UDP glucuronosyltransferase 1 family, polypeptide A6 | -0.0169721 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0168964 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0167941 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.016688 |
| PLSCR1 | phospholipid scramblase 1 | -0.0165685 |
| AHCYL2 | adenosylhomocysteinase-like 2 | -0.016532 |
| TSPAN3 | tetraspanin 3 | -0.0165199 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.016367 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0163295 |
| ITGA6 | integrin, alpha 6 | -0.0162819 |
| TNRC18 | trinucleotide repeat containing 18 | -0.0162178 |
| HLA-B | major histocompatibility complex, class I, B | -0.0160678 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0158301 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0157292 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0156272 |
| NOSTRIN | nitric oxide synthase trafficking | -0.0155931 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | -0.0155134 |
| MYO1D | myosin ID | -0.0155 |
