| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Rucaparib (phosphate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0924149 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0872061 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0837909 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0755036 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0693179 |
| FAM13A | family with sequence similarity 13, member A | 0.067575 |
| MT2A | metallothionein 2A | 0.0619331 |
| RNF145 | ring finger protein 145 | 0.0556642 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0555553 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0524472 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0496852 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0481702 |
| ANXA2 | annexin A2 | 0.0468675 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.046598 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0446963 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0440679 |
| AHNAK | AHNAK nucleoprotein | 0.0412368 |
| TOP1 | topoisomerase (DNA) I | 0.0407087 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0404706 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0389836 |
| H1-0 | H1.0 linker histone | 0.0389693 |
| LMO7 | LIM domain 7 | 0.0386749 |
| CES1 | carboxylesterase 1 | 0.0359946 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0359817 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0324538 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0312547 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0305295 |
| DNER | delta/notch-like EGF repeat containing | 0.0302227 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0299578 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0293121 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0292045 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0290836 |
| SCEL | sciellin | 0.0289504 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0284646 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.027925 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0278912 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0273071 |
| WASF2 | WAS protein family, member 2 | 0.02666 |
| ATP13A3 | ATPase type 13A3 | 0.0258878 |
| SMAD3 | SMAD family member 3 | 0.0247018 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0241304 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0240267 |
| ANXA1 | annexin A1 | 0.0239297 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0231707 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0225846 |
| FRY | furry homolog (Drosophila) | 0.0225799 |
| TPD52 | tumor protein D52 | 0.0224817 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0219952 |
| DSPP | dentin sialophosphoprotein | 0.0218239 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0215106 |
| YAP1 | Yes-associated protein 1 | 0.0213037 |
| MT1X | metallothionein 1X | 0.0210659 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0210646 |
| HELZ | helicase with zinc finger | 0.0208766 |
| PLEC | plectin | 0.0205405 |
| SBF2 | SET binding factor 2 | 0.0203651 |
| KCMF1 | potassium channel modulatory factor 1 | 0.020153 |
| MCL1 | myeloid cell leukemia 1 | 0.0200803 |
| ACTG1 | actin gamma 1 | 0.0200355 |
| LAMB3 | laminin, beta 3 | 0.0196324 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0195655 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0193 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0188139 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0186669 |
| POTEF | POTE ankyrin domain family, member F | 0.0184007 |
| TMEM165 | transmembrane protein 165 | 0.0183078 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0181308 |
| RREB1 | ras responsive element binding protein 1 | 0.0180236 |
| NCKAP1 | NCK-associated protein 1 | 0.0175452 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0174582 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0174433 |
| FLNB | filamin B, beta | 0.0169267 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0164267 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0160838 |
| EFNA5 | ephrin-A5 | 0.0158271 |
| PER1 | period circadian clock 1 | 0.0157506 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0154944 |
| SCNN1G | sodium channel, non voltage gated 1 gamma subunit | 0.0152528 |
| ATP11A | ATPase, class VI, type 11A | 0.0148693 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0148445 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0147795 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0147399 |
| USP3 | ubiquitin specific peptidase 3 | 0.0146695 |
| METTL9 | methyltransferase like 9 | 0.0146544 |
| S100P | S100 calcium binding protein P | 0.0144999 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0144654 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0144255 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0142899 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0142884 |
| TPM3 | tropomyosin 3 | 0.0142628 |
| RUNX1 | runt-related transcription factor 1 | 0.014158 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0137635 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0135284 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0134493 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0133807 |
| FNBP1L | formin binding protein 1-like | 0.0132229 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0130963 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0126827 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0126499 |
| DENND3 | DENN/MADD domain containing 3 | 0.0124086 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.127739 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0614243 |
| ASPH | aspartate beta-hydroxylase | -0.0579514 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0525501 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.045237 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0339525 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0312759 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0306564 |
| NDRG1 | N-myc downstream regulated 1 | -0.0252712 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0245278 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0242815 |
| MAP7 | microtubule-associated protein 7 | -0.0236541 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0234168 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0231632 |
| GOLGB1 | golgin B1 | -0.0226779 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0225827 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0209378 |
| STC1 | stanniocalcin 1 | -0.0205159 |
| KIAA1217 | KIAA1217 | -0.0204385 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0203876 |
| LAMC2 | laminin, gamma 2 | -0.0202728 |
| JMJD1C | jumonji domain containing 1C | -0.0201522 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0200646 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0195856 |
| VCL | vinculin | -0.018617 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0179886 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0179855 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0178006 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0174781 |
| EGFR | epidermal growth factor receptor | -0.0170138 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.016979 |
| SP100 | SP100 nuclear antigen | -0.0169077 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0166522 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0164819 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0164403 |
| RAD51B | RAD51 paralog B | -0.0164287 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0161403 |
| NGLY1 | N-glycanase 1 | -0.0157766 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0156681 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0156555 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0156424 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0155745 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0154 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0152161 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0148369 |
| GOLGA4 | golgin A4 | -0.014724 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0144601 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.014193 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0141859 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0137876 |
| GPC6 | glypican 6 | -0.0137686 |
| PRKCE | protein kinase C, epsilon | -0.0136679 |
| RPLP1 | ribosomal protein, large, P1 | -0.0135507 |
| PAPOLA | poly(A) polymerase alpha | -0.0135312 |
| PRELID2 | PRELI domain containing 2 | -0.0132708 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.0132347 |
| TMF1 | TATA element modulatory factor 1 | -0.0127665 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | -0.012638 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0124478 |
| RNF213 | ring finger protein 213 | -0.0124272 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0123944 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0123674 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0122682 |
| FAAH2 | fatty acid amide hydrolase 2 | -0.0122432 |
| CPE | carboxypeptidase E | -0.0122134 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0121521 |
| IER3 | immediate early response 3 | -0.0120948 |
| USP53 | ubiquitin specific peptidase 53 | -0.0120788 |
| PKM | pyruvate kinase, muscle | -0.0120621 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0120296 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0115151 |
| FTL | ferritin, light polypeptide | -0.0114837 |
| SENP5 | SUMO1/sentrin specific peptidase 5 | -0.0114571 |
| RPS2 | ribosomal protein S2 | -0.0111517 |
| CEP350 | centrosomal protein 350kDa | -0.0111209 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0109593 |
| GPHN | gephyrin | -0.0109197 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0109184 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0107527 |
| TUFT1 | tuftelin 1 | -0.010694 |
| PMP22 | peripheral myelin protein 22 | -0.0106886 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0106744 |
| B2M | beta-2-microglobulin | -0.0106442 |
| FRMD4B | FERM domain containing 4B | -0.00997099 |
| CLTC | clathrin, heavy chain (Hc) | -0.00989798 |
| PLSCR1 | phospholipid scramblase 1 | -0.00981722 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.00977609 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.00964955 |
| RAB27B | RAB27B, member RAS oncogene family | -0.00957898 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00955321 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.00953723 |
| MYO9A | myosin IXA | -0.00952877 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00951482 |
| AHR | aryl hydrocarbon receptor | -0.00949186 |
| BPTF | bromodomain PHD finger transcription factor | -0.00947162 |
| FNIP1 | folliculin interacting protein 1 | -0.00914647 |
| RIGI | RNA sensor RIG-I | -0.00912144 |
| HOMER1 | homer scaffolding protein 1 | -0.00905056 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.00901027 |
| PTEN | phosphatase and tensin homolog | -0.00900112 |
