| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.137207 |
| TPM3 | tropomyosin 3 | 0.0713705 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0698837 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0644753 |
| WDR43 | WD repeat domain 43 | 0.0570332 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0566541 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0556721 |
| IGF2 | insulin-like growth factor 2 | 0.0518412 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0498293 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0473431 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0468632 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0459604 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0454752 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0442037 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.042568 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0418387 |
| TPD52 | tumor protein D52 | 0.0403379 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0392915 |
| RTN4 | reticulon 4 | 0.0389339 |
| ZNF292 | zinc finger protein 292 | 0.0359465 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0339223 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0327094 |
| PTK2 | protein tyrosine kinase 2 | 0.0325179 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0324271 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0319319 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0317437 |
| CCNL1 | cyclin L1 | 0.0312017 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0310697 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0303079 |
| ACTG1 | actin gamma 1 | 0.0302574 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0294689 |
| HDGF | hepatoma-derived growth factor | 0.0294096 |
| SPAG9 | sperm associated antigen 9 | 0.0288318 |
| RPS12 | ribosomal protein S12 | 0.0285346 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0282211 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0276429 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0275312 |
| USP3 | ubiquitin specific peptidase 3 | 0.026853 |
| APP | amyloid beta (A4) precursor protein | 0.0266338 |
| POTEF | POTE ankyrin domain family, member F | 0.0264404 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0263336 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0263114 |
| YBX1 | Y box binding protein 1 | 0.0262584 |
| ENO1 | enolase 1, (alpha) | 0.0256988 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0256477 |
| RASAL2 | RAS protein activator like 2 | 0.0255396 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0254359 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.025435 |
| FLNA | filamin A, alpha | 0.0254156 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0253759 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0252354 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0250988 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.024677 |
| JAK1 | Janus kinase 1 | 0.0244668 |
| BRD2 | bromodomain containing 2 | 0.0241229 |
| RBM39 | RNA binding motif protein 39 | 0.0239914 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0239378 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0238651 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0236884 |
| RPS2 | ribosomal protein S2 | 0.0234841 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0233341 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.02326 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0231067 |
| KIF5B | kinesin family member 5B | 0.0230294 |
| FGB | fibrinogen beta chain | 0.023008 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0228745 |
| NUP58 | nucleoporin 58 | 0.0224728 |
| RPL3 | ribosomal protein L3 | 0.0224546 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.022453 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0222264 |
| PCBP2 | poly(rC) binding protein 2 | 0.0220614 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0219992 |
| NCKAP1 | NCK-associated protein 1 | 0.0216939 |
| FAM168A | family with sequence similarity 168, member A | 0.0216678 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0214358 |
| NUP153 | nucleoporin 153kDa | 0.0211941 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0210413 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0210398 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0209348 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0208674 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0208642 |
| HLA-A | major histocompatibility complex, class I, A | 0.0206566 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.020624 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.020522 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0204796 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0204327 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0204241 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0204166 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | 0.0202153 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0201761 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0200101 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0200018 |
| BRD4 | bromodomain containing 4 | 0.0199717 |
| SF1 | splicing factor 1 | 0.0199217 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0198865 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0194086 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0193051 |
| DENND4A | DENN/MADD domain containing 4A | 0.019104 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0190356 |
| YTHDC1 | YTH domain containing 1 | 0.018771 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.133506 |
| TMSB10 | thymosin beta 10 | -0.13244 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0806628 |
| VIM | vimentin | -0.0733834 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0518806 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0516329 |
| MT2A | metallothionein 2A | -0.051489 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0410434 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0387671 |
| S100A10 | S100 calcium binding protein A10 | -0.0349164 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0345409 |
| IER3 | immediate early response 3 | -0.0340817 |
| RPLP1 | ribosomal protein, large, P1 | -0.0318183 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0263844 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0252195 |
| S100A6 | S100 calcium binding protein A6 | -0.0243271 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0243112 |
| GRAMD1B | GRAM domain containing 1B | -0.0227269 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0214472 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0205352 |
| OSMR | oncostatin M receptor | -0.0200795 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0199606 |
| RPS24 | ribosomal protein S24 | -0.0198268 |
| BICC1 | BicC family RNA binding protein 1 | -0.0189909 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0189167 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0177566 |
| PYGL | phosphorylase, glycogen, liver | -0.0175056 |
| TXNRD1 | thioredoxin reductase 1 | -0.0172498 |
| SVIL | supervillin | -0.0168853 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.016556 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0159603 |
| PTMA | prothymosin, alpha | -0.0156854 |
| RPL31 | ribosomal protein L31 | -0.0154957 |
| RPL23 | ribosomal protein L23 | -0.015071 |
| RPL19 | ribosomal protein L19 | -0.0140654 |
| TPM4 | tropomyosin 4 | -0.0139567 |
| PARK7 | parkinson protein 7 | -0.0138149 |
| LDHA | lactate dehydrogenase A | -0.0137115 |
| SERF2 | small EDRK-rich factor 2 | -0.0136464 |
| FAM107B | family with sequence similarity 107, member B | -0.0136108 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0133891 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0130427 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0123231 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0122952 |
| RPS23 | ribosomal protein S23 | -0.0122443 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0121909 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.012048 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0120458 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0115424 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0114801 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0110664 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0108582 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0107692 |
| RPL34 | ribosomal protein L34 | -0.0106678 |
| ASTN2 | astrotactin 2 | -0.0106644 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0102061 |
| H1-0 | H1.0 linker histone | -0.0101803 |
| VCL | vinculin | -0.0101598 |
| BMP5 | bone morphogenetic protein 5 | -0.0101083 |
| RPL35A | ribosomal protein L35a | -0.0100573 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.00993278 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.00987006 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.00980682 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.00971666 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.00965428 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.00961342 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.00939667 |
| KYNU | kynureninase | -0.00930205 |
| HMGA2 | high mobility group AT-hook 2 | -0.00928713 |
| NCOA7 | nuclear receptor coactivator 7 | -0.00923472 |
| CMIP | c-Maf inducing protein | -0.00921431 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.00920569 |
| EFNA5 | ephrin-A5 | -0.00897837 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.00892687 |
| RPS5 | ribosomal protein S5 | -0.00888558 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.00884272 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.008775 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.00871776 |
| RPS15 | ribosomal protein S15 | -0.00870188 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.00860558 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | -0.00856698 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.00849204 |
| RPS21 | ribosomal protein S21 | -0.00838329 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.00832856 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.00829491 |
| BPTF | bromodomain PHD finger transcription factor | -0.00827952 |
| RPL36A | ribosomal protein L36a | -0.00823741 |
| CCDC68 | coiled-coil domain containing 68 | -0.00823619 |
| PGK1 | phosphoglycerate kinase 1 | -0.00823138 |
| TUBB | tubulin, beta class I | -0.00819095 |
| EHBP1 | EH domain binding protein 1 | -0.0080943 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.00804891 |
| CAVIN1 | caveolae associated protein 1 | -0.00794057 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00792692 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.00786312 |
| NAV3 | neuron navigator 3 | -0.00782686 |
| PRSS23 | protease, serine, 23 | -0.00782627 |
| CUX1 | cut-like homeobox 1 | -0.00773857 |
| GSTP1 | glutathione S-transferase pi 1 | -0.00770632 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.00758875 |
