| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Rucaparib (phosphate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.168125 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.156034 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.1304 |
| NDRG1 | N-myc downstream regulated 1 | 0.128049 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0950043 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0689532 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0683354 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0674191 |
| FAM13A | family with sequence similarity 13, member A | 0.0664703 |
| KYNU | kynureninase | 0.063943 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0603787 |
| FN1 | fibronectin 1 | 0.0575799 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0552472 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0548503 |
| SLTM | SAFB-like, transcription modulator | 0.0547356 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0509663 |
| RUNX1 | runt-related transcription factor 1 | 0.0494865 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0480689 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0471983 |
| ANXA2 | annexin A2 | 0.0461859 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0460684 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0442623 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0437312 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0433575 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0412826 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0389433 |
| CDC73 | cell division cycle 73 | 0.0375778 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0320067 |
| STC1 | stanniocalcin 1 | 0.0310267 |
| ADM | adrenomedullin | 0.0303621 |
| PDE8A | phosphodiesterase 8A | 0.0300488 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0300369 |
| DTNA | dystrobrevin, alpha | 0.0299779 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0295612 |
| INHBA | inhibin, beta A | 0.0292784 |
| MCL1 | myeloid cell leukemia 1 | 0.0287665 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0284551 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0282653 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0282646 |
| PDE10A | phosphodiesterase 10A | 0.0281382 |
| MYO1E | myosin IE | 0.0278848 |
| PYGL | phosphorylase, glycogen, liver | 0.0276889 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0276413 |
| AHNAK | AHNAK nucleoprotein | 0.0274928 |
| CCNY | cyclin Y | 0.0266932 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0266645 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0266346 |
| ATP11A | ATPase, class VI, type 11A | 0.0263052 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0262823 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0261803 |
| KIF5B | kinesin family member 5B | 0.0257438 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0256195 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.025618 |
| LAMA4 | laminin, alpha 4 | 0.0251213 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0251207 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0249804 |
| ABHD17C | abhydrolase domain containing 17C | 0.0248429 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0247824 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0240874 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0237529 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0237062 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.023705 |
| LDHA | lactate dehydrogenase A | 0.0236526 |
| LAMB3 | laminin, beta 3 | 0.0231427 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0229568 |
| TJP1 | tight junction protein 1 | 0.0227267 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0225721 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0221219 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0220985 |
| ANKRD37 | ankyrin repeat domain 37 | 0.02207 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0219567 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0218884 |
| ARRDC3 | arrestin domain containing 3 | 0.0218795 |
| RNF145 | ring finger protein 145 | 0.0216327 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0215647 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0215595 |
| AFDN | afadin, adherens junction formation factor | 0.0215135 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0214155 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0210317 |
| XRN2 | 5'-3' exoribonuclease 2 | 0.0207393 |
| KRT17 | keratin 17, type I | 0.0207126 |
| RHOA | ras homolog family member A | 0.0206541 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0205954 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0203793 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.020379 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.020035 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0197091 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0193739 |
| ABI1 | abl-interactor 1 | 0.0191569 |
| SNX9 | sorting nexin 9 | 0.0190611 |
| MYO5B | myosin VB | 0.0184643 |
| COPA | coatomer protein complex, subunit alpha | 0.0183436 |
| CMIP | c-Maf inducing protein | 0.0181025 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0179182 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0179143 |
| DIAPH2 | diaphanous-related formin 2 | 0.0177888 |
| ABLIM1 | actin binding LIM protein 1 | 0.0177839 |
| SETD5 | SET domain containing 5 | 0.0175885 |
| VMP1 | vacuole membrane protein 1 | 0.0172181 |
| EGR1 | early growth response 1 | 0.0169336 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0838569 |
| VIM | vimentin | -0.0785746 |
| AK1 | adenylate kinase 1 | -0.071931 |
| B2M | beta-2-microglobulin | -0.0642866 |
| PRKCA | protein kinase C, alpha | -0.0642146 |
| MT2A | metallothionein 2A | -0.0596953 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0589763 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0549809 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0530678 |
| TXNRD1 | thioredoxin reductase 1 | -0.0492249 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0478818 |
| FTL | ferritin, light polypeptide | -0.0467298 |
| HLA-B | major histocompatibility complex, class I, B | -0.0462311 |
| JMJD1C | jumonji domain containing 1C | -0.044966 |
| RIGI | RNA sensor RIG-I | -0.0447517 |
| APP | amyloid beta (A4) precursor protein | -0.043263 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0425694 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0418483 |
| CALU | calumenin | -0.040991 |
| PTMA | prothymosin, alpha | -0.0409662 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0407157 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0404164 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | -0.0396187 |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 | -0.0380342 |
| S100A10 | S100 calcium binding protein A10 | -0.037662 |
| RPS11 | ribosomal protein S11 | -0.0373624 |
| TPI1 | triosephosphate isomerase 1 | -0.037017 |
| RPL19 | ribosomal protein L19 | -0.0368714 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0367445 |
| ZNF638 | zinc finger protein 638 | -0.0366134 |
| KRT19 | keratin 19, type I | -0.0355885 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0354993 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0354066 |
| SMYD3 | SET and MYND domain containing 3 | -0.0347644 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0345048 |
| BRD2 | bromodomain containing 2 | -0.0340022 |
| RPS21 | ribosomal protein S21 | -0.0338545 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0338386 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0337657 |
| METTL15 | methyltransferase like 15 | -0.0336317 |
| GNAS | GNAS complex locus | -0.0335125 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.03331 |
| MAP4 | microtubule-associated protein 4 | -0.0330245 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0328292 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0327832 |
| SFTPA2 | surfactant protein A2 | -0.0323902 |
| SP100 | SP100 nuclear antigen | -0.0323759 |
| RPS3 | ribosomal protein S3 | -0.0322361 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.032225 |
| EFNA5 | ephrin-A5 | -0.0316501 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0313615 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0312394 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0308943 |
| RPLP1 | ribosomal protein, large, P1 | -0.0306976 |
| RPS19 | ribosomal protein S19 | -0.0304126 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0303816 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0303349 |
| KIF13A | kinesin family member 13A | -0.0302463 |
| RPL11 | ribosomal protein L11 | -0.0302286 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0302096 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0301302 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0298692 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0298266 |
| EXOC4 | exocyst complex component 4 | -0.0296589 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0296466 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.029461 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.029445 |
| FOXO3 | forkhead box O3 | -0.029302 |
| CD44 | CD44 molecule (Indian blood group) | -0.0292367 |
| LIMA1 | LIM domain and actin binding 1 | -0.0287495 |
| ENO1 | enolase 1, (alpha) | -0.0287293 |
| NME7 | NME/NM23 family member 7 | -0.028411 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0283257 |
| THOC2 | THO complex 2 | -0.0277501 |
| LOXL2 | lysyl oxidase-like 2 | -0.0276205 |
| RPS25 | ribosomal protein S25 | -0.0273062 |
| TMEM165 | transmembrane protein 165 | -0.027295 |
| EHBP1 | EH domain binding protein 1 | -0.0269241 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0265805 |
| RNF149 | ring finger protein 149 | -0.0263691 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0263461 |
| SRP54 | signal recognition particle 54kDa | -0.026252 |
| RPL38 | ribosomal protein L38 | -0.0256059 |
| SEPTIN2 | septin 2 | -0.0252113 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0251222 |
| AFAP1 | actin filament associated protein 1 | -0.0250904 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0249453 |
| NF1 | neurofibromin 1 | -0.0249437 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0249348 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0248757 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0248516 |
| NUMB | numb homolog (Drosophila) | -0.0246827 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0246746 |
| UBE2O | ubiquitin-conjugating enzyme E2O | -0.024645 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.0245182 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0241029 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0241018 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0239414 |
| RSF1 | remodeling and spacing factor 1 | -0.0234952 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0228667 |
