| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EEF2 | eukaryotic translation elongation factor 2 | 0.0690951 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0555986 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0527233 |
| TPM3 | tropomyosin 3 | 0.0510347 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0479081 |
| COPA | coatomer protein complex, subunit alpha | 0.0455346 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0451808 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0445208 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0413539 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0383036 |
| PCBP2 | poly(rC) binding protein 2 | 0.0359512 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0317757 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0308578 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.0305677 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.029885 |
| CCNL1 | cyclin L1 | 0.0295613 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0292764 |
| UBAP2L | ubiquitin associated protein 2-like | 0.028926 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.028825 |
| BRD2 | bromodomain containing 2 | 0.02879 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0269753 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0269564 |
| TFG | TRK-fused gene | 0.0267495 |
| SPAG9 | sperm associated antigen 9 | 0.0266903 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0261007 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0253908 |
| UBC | ubiquitin C | 0.0248007 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0245605 |
| HELZ | helicase with zinc finger | 0.0241441 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0240415 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0239942 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0227661 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0226374 |
| SRP54 | signal recognition particle 54kDa | 0.0224619 |
| NOTCH2 | notch 2 | 0.021995 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0218759 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0217812 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0213765 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.021317 |
| NCKAP1 | NCK-associated protein 1 | 0.0205593 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0205377 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0204407 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0203411 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0203341 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0202732 |
| RLF | rearranged L-myc fusion | 0.0200971 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0198043 |
| NUP58 | nucleoporin 58 | 0.0194367 |
| TLN1 | talin 1 | 0.0194349 |
| COG5 | component of oligomeric golgi complex 5 | 0.0192229 |
| CEP192 | centrosomal protein 192kDa | 0.0191085 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0188615 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0187996 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0186311 |
| NUP153 | nucleoporin 153kDa | 0.0185443 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0183701 |
| ANLN | anillin, actin binding protein | 0.018172 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0181283 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0179954 |
| ADAR | adenosine deaminase, RNA-specific | 0.0179182 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0178925 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0178859 |
| JMJD1C | jumonji domain containing 1C | 0.0178252 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0176333 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0175659 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0175109 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0173943 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0173715 |
| CEP135 | centrosomal protein 135kDa | 0.0171092 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0170542 |
| PTPN11 | protein tyrosine phosphatase, non-receptor type 11 | 0.0170332 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0169161 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0169058 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0167027 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0166771 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0166189 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0165942 |
| RPL3 | ribosomal protein L3 | 0.0165416 |
| CANX | calnexin | 0.0165111 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0164358 |
| FNIP1 | folliculin interacting protein 1 | 0.01642 |
| OGA | O-GlcNAcase | 0.0163838 |
| CRY1 | cryptochrome circadian clock 1 | 0.0163672 |
| NBAS | neuroblastoma amplified sequence | 0.0162998 |
| SUCO | SUN domain containing ossification factor | 0.016086 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.016026 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0160205 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0158928 |
| GOLGA4 | golgin A4 | 0.01582 |
| WDR43 | WD repeat domain 43 | 0.0157577 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0156868 |
| TBK1 | TANK-binding kinase 1 | 0.0156765 |
| FLNA | filamin A, alpha | 0.0155158 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0154722 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0154632 |
| ATP13A3 | ATPase type 13A3 | 0.0154587 |
| YBX1 | Y box binding protein 1 | 0.0152843 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0152676 |
| MSN | moesin | 0.0151829 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0151417 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0747696 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0627388 |
| PTMA | prothymosin, alpha | -0.0604672 |
| RPS3 | ribosomal protein S3 | -0.0563209 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.053674 |
| VIM | vimentin | -0.0534294 |
| RPL35A | ribosomal protein L35a | -0.0525004 |
| GRAMD1B | GRAM domain containing 1B | -0.0522112 |
| RPL37 | ribosomal protein L37 | -0.0516885 |
| RPS8 | ribosomal protein S8 | -0.0491163 |
| MT2A | metallothionein 2A | -0.0480174 |
| ACTG1 | actin gamma 1 | -0.0439103 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0434172 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0429285 |
| RPS21 | ribosomal protein S21 | -0.0423142 |
| RPL26 | ribosomal protein L26 | -0.0420948 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0403943 |
| RPL23 | ribosomal protein L23 | -0.0400931 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0390261 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0379688 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0373486 |
| RPS29 | ribosomal protein S29 | -0.0364911 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0362522 |
| RPL34 | ribosomal protein L34 | -0.0351179 |
| RPS19 | ribosomal protein S19 | -0.0342807 |
| RPL37A | ribosomal protein L37a | -0.0331127 |
| RPL12 | ribosomal protein L12 | -0.0321676 |
| RPS12 | ribosomal protein S12 | -0.0320063 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0301886 |
| TPI1 | triosephosphate isomerase 1 | -0.0301439 |
| RPLP2 | ribosomal protein, large, P2 | -0.0291131 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0286407 |
| RPL9 | ribosomal protein L9 | -0.0285849 |
| RPS27A | ribosomal protein S27a | -0.0284761 |
| RPS27 | ribosomal protein S27 | -0.0284438 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0278532 |
| RAD51B | RAD51 paralog B | -0.0277631 |
| RPL38 | ribosomal protein L38 | -0.0275865 |
| OSMR | oncostatin M receptor | -0.0270049 |
| RPL8 | ribosomal protein L8 | -0.0269532 |
| RPL32 | ribosomal protein L32 | -0.0263066 |
| GNAS | GNAS complex locus | -0.0260332 |
| RPL19 | ribosomal protein L19 | -0.0255423 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0254629 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.025227 |
| EGFR | epidermal growth factor receptor | -0.0246937 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0246223 |
| YBX3 | Y box binding protein 3 | -0.0246209 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0245407 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0243525 |
| HMGA2 | high mobility group AT-hook 2 | -0.0242962 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0240555 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.023932 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0232692 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0232663 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0232415 |
| RPS6 | ribosomal protein S6 | -0.0230503 |
| RPLP1 | ribosomal protein, large, P1 | -0.021989 |
| S100A6 | S100 calcium binding protein A6 | -0.0217173 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0216821 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0215411 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0214421 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0211304 |
| RPS25 | ribosomal protein S25 | -0.0210305 |
| ATP11A | ATPase, class VI, type 11A | -0.020795 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0207911 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.020656 |
| RPL11 | ribosomal protein L11 | -0.0205505 |
| RPL36 | ribosomal protein L36 | -0.0205215 |
| RPS10 | ribosomal protein S10 | -0.0204883 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0203878 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0202355 |
| RPS15 | ribosomal protein S15 | -0.0202265 |
| RPL36A | ribosomal protein L36a | -0.020111 |
| WWOX | WW domain containing oxidoreductase | -0.0196784 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0195098 |
| RPL27 | ribosomal protein L27 | -0.0190339 |
| RPS24 | ribosomal protein S24 | -0.0187973 |
| PDE10A | phosphodiesterase 10A | -0.0186049 |
| RPL31 | ribosomal protein L31 | -0.0184538 |
| RPL5 | ribosomal protein L5 | -0.0181483 |
| RPL30 | ribosomal protein L30 | -0.0181389 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0179855 |
| DENND5B | DENN/MADD domain containing 5B | -0.017775 |
| HLA-B | major histocompatibility complex, class I, B | -0.0177167 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0176863 |
| FTL | ferritin, light polypeptide | -0.0175033 |
| PFN1 | profilin 1 | -0.0173986 |
| SMAD3 | SMAD family member 3 | -0.0172714 |
| TRIM56 | tripartite motif containing 56 | -0.0171884 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0171407 |
| CAVIN1 | caveolae associated protein 1 | -0.0169721 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.016844 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0167683 |
| ATG7 | autophagy related 7 | -0.0165453 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.016388 |
| S100A10 | S100 calcium binding protein A10 | -0.0163809 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0163718 |
| RPL35 | ribosomal protein L35 | -0.0163254 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0162368 |
