| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.112782 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.107327 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0913256 |
| NDRG1 | N-myc downstream regulated 1 | 0.0876516 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0768882 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0748619 |
| POTEF | POTE ankyrin domain family, member F | 0.0656924 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0622585 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0599181 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0593137 |
| ANXA2 | annexin A2 | 0.0572138 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0569545 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.055621 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0543591 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0531494 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.051577 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.0495473 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0489827 |
| TOP1 | topoisomerase (DNA) I | 0.0484747 |
| ASPH | aspartate beta-hydroxylase | 0.0480804 |
| G0S2 | G0/G1 switch 2 | 0.0467048 |
| MAL2 | mal, T-cell differentiation protein 2 (gene/pseudogene) | 0.0466247 |
| RNF145 | ring finger protein 145 | 0.0454664 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0436628 |
| UBC | ubiquitin C | 0.0432562 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0428177 |
| CCNL1 | cyclin L1 | 0.0419037 |
| TFG | TRK-fused gene | 0.0408143 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0407459 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0400612 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0389551 |
| VEGFA | vascular endothelial growth factor A | 0.0386917 |
| FAM13A | family with sequence similarity 13, member A | 0.0383555 |
| ZNF292 | zinc finger protein 292 | 0.0379501 |
| USP3 | ubiquitin specific peptidase 3 | 0.037495 |
| MSN | moesin | 0.0371579 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0371206 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0366697 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0366463 |
| MYO6 | myosin VI | 0.0365712 |
| LAMB3 | laminin, beta 3 | 0.036188 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0359635 |
| PTK2 | protein tyrosine kinase 2 | 0.0356752 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0355038 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0353527 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.035165 |
| ARRDC3 | arrestin domain containing 3 | 0.0349892 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0347873 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.033045 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0330174 |
| NUP58 | nucleoporin 58 | 0.0329499 |
| YTHDC1 | YTH domain containing 1 | 0.0327416 |
| DHX15 | DEAH (Asp-Glu-Ala-His) box helicase 15 | 0.0326692 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0324913 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0323826 |
| AHNAK | AHNAK nucleoprotein | 0.0320988 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0320683 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0318821 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0318813 |
| MT2A | metallothionein 2A | 0.0316245 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0313543 |
| AREG | amphiregulin | 0.0310961 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0308701 |
| TPM3 | tropomyosin 3 | 0.0307627 |
| PCBP2 | poly(rC) binding protein 2 | 0.030702 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0304218 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0297909 |
| SLMAP | sarcolemma associated protein | 0.0297859 |
| RASA2 | RAS p21 protein activator 2 | 0.0296199 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0293018 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.0292836 |
| CALR | calreticulin | 0.0292199 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0291059 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0286975 |
| NCKAP1 | NCK-associated protein 1 | 0.0284401 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box helicase 9 | 0.0282785 |
| PGK1 | phosphoglycerate kinase 1 | 0.0280059 |
| MXD1 | MAX dimerization protein 1 | 0.0276169 |
| RTN4 | reticulon 4 | 0.0274439 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0271971 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0271468 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0267075 |
| CTSB | cathepsin B | 0.0264352 |
| ATP13A3 | ATPase type 13A3 | 0.026406 |
| PLEC | plectin | 0.0262681 |
| SPAG9 | sperm associated antigen 9 | 0.0261477 |
| CDK17 | cyclin-dependent kinase 17 | 0.0260189 |
| CDC73 | cell division cycle 73 | 0.0259264 |
| RLF | rearranged L-myc fusion | 0.0258395 |
| QKI | QKI, KH domain containing, RNA binding | 0.0257417 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0256421 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.025438 |
| IRF6 | interferon regulatory factor 6 | 0.0253758 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0253669 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0250474 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0249916 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0248759 |
| RIOK3 | RIO kinase 3 | 0.0247316 |
| COPA | coatomer protein complex, subunit alpha | 0.0246965 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0245247 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.0798426 |
| TMSB10 | thymosin beta 10 | -0.0794759 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0761641 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0684509 |
| FBXO32 | F-box protein 32 | -0.0578586 |
| RPLP1 | ribosomal protein, large, P1 | -0.0522397 |
| PTMA | prothymosin, alpha | -0.0486736 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.043142 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0424253 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0394366 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.033709 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0332368 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0317614 |
| EFNA5 | ephrin-A5 | -0.0305165 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0300671 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0288205 |
| PALLD | palladin, cytoskeletal associated protein | -0.0280081 |
| VCL | vinculin | -0.0277427 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0277153 |
| FBXO34 | F-box protein 34 | -0.0269685 |
| RPL34 | ribosomal protein L34 | -0.0261783 |
| GOLGB1 | golgin B1 | -0.0251583 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0241785 |
| MYO1E | myosin IE | -0.0240415 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0238812 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0235344 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0230407 |
| VIM | vimentin | -0.0223416 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0223345 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0222529 |
| RPS24 | ribosomal protein S24 | -0.0217561 |
| CEP350 | centrosomal protein 350kDa | -0.0217036 |
| ACTG1 | actin gamma 1 | -0.0212289 |
| TPM4 | tropomyosin 4 | -0.0211768 |
| PGBD5 | piggyBac transposable element derived 5 | -0.0208689 |
| FNIP1 | folliculin interacting protein 1 | -0.0204272 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.0196975 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0190239 |
| RPS23 | ribosomal protein S23 | -0.0186616 |
| RPS6 | ribosomal protein S6 | -0.0186205 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0185518 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | -0.0184876 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0182571 |
| RPS20 | ribosomal protein S20 | -0.017899 |
| MX2 | MX dynamin-like GTPase 2 | -0.0177803 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.017691 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0175774 |
| ETV6 | ets variant 6 | -0.0175198 |
| RPL9 | ribosomal protein L9 | -0.0175186 |
| RPL30 | ribosomal protein L30 | -0.0171589 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0169673 |
| RPL35A | ribosomal protein L35a | -0.016947 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0168602 |
| RPS19 | ribosomal protein S19 | -0.0165821 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0165282 |
| RIGI | RNA sensor RIG-I | -0.0159487 |
| RPL23 | ribosomal protein L23 | -0.0158876 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0157496 |
| S100A10 | S100 calcium binding protein A10 | -0.0154326 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0153454 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0152429 |
| SMYD3 | SET and MYND domain containing 3 | -0.015029 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0148234 |
| RRBP1 | ribosome binding protein 1 | -0.0146848 |
| RPL31 | ribosomal protein L31 | -0.0142272 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.014185 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0139034 |
| RPS29 | ribosomal protein S29 | -0.0136188 |
| SP100 | SP100 nuclear antigen | -0.0134167 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0131231 |
| RPL12 | ribosomal protein L12 | -0.0130078 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0128384 |
| RPL4 | ribosomal protein L4 | -0.0128059 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0126318 |
| LMNA | lamin A/C | -0.0124131 |
| CSTB | cystatin B (stefin B) | -0.0123722 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0123315 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0121746 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0121396 |
| RAB10 | RAB10, member RAS oncogene family | -0.0120836 |
| FAF2 | Fas associated factor family member 2 | -0.0119322 |
| RPL36A | ribosomal protein L36a | -0.0118371 |
| CDK13 | cyclin-dependent kinase 13 | -0.0118346 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0118038 |
| TBCA | tubulin folding cofactor A | -0.011569 |
| CUX1 | cut-like homeobox 1 | -0.011386 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.011334 |
| RAD51B | RAD51 paralog B | -0.0113311 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0112342 |
| RBM47 | RNA binding motif protein 47 | -0.0111903 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0110591 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0110547 |
| GPATCH8 | G patch domain containing 8 | -0.011029 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0110224 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0110194 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0109468 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.010891 |
| RPL32 | ribosomal protein L32 | -0.0108244 |
| PRKCA | protein kinase C, alpha | -0.0107092 |
| HDLBP | high density lipoprotein binding protein | -0.0106691 |
