| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.120542 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.106678 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0654645 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0642155 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0398505 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0359614 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0350364 |
| RPL35A | ribosomal protein L35a | 0.0346507 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0342056 |
| FAM13A | family with sequence similarity 13, member A | 0.0331391 |
| EFNA5 | ephrin-A5 | 0.0306934 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0305408 |
| MT2A | metallothionein 2A | 0.0302641 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0296399 |
| STC1 | stanniocalcin 1 | 0.0292883 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0272156 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0264232 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0262492 |
| SPAG9 | sperm associated antigen 9 | 0.0259789 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.025256 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0242892 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.024138 |
| RPS8 | ribosomal protein S8 | 0.0233387 |
| PYGL | phosphorylase, glycogen, liver | 0.0232075 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0228458 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0227512 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | 0.0221725 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0220134 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.0217355 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0206048 |
| ZNF292 | zinc finger protein 292 | 0.0203063 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0189509 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0189312 |
| NDRG1 | N-myc downstream regulated 1 | 0.018746 |
| STC2 | stanniocalcin 2 | 0.0183499 |
| RPS2 | ribosomal protein S2 | 0.0175629 |
| HELZ | helicase with zinc finger | 0.0172224 |
| USP3 | ubiquitin specific peptidase 3 | 0.0169862 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.016773 |
| TMSB4X | thymosin beta 4, X-linked | 0.0164287 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0162875 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0162443 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.016027 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0157195 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0156919 |
| HLA-A | major histocompatibility complex, class I, A | 0.0155279 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0154173 |
| NUP58 | nucleoporin 58 | 0.0151915 |
| RPL36 | ribosomal protein L36 | 0.0150822 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0149459 |
| B2M | beta-2-microglobulin | 0.0144827 |
| ARRDC3 | arrestin domain containing 3 | 0.0144547 |
| TPD52 | tumor protein D52 | 0.0144065 |
| SRGN | serglycin | 0.0140798 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0140166 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0139927 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0136993 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0136055 |
| RPL13A | ribosomal protein L13a | 0.0134999 |
| HLA-B | major histocompatibility complex, class I, B | 0.0134848 |
| SLC16A6 | solute carrier family 16, member 6 | 0.0134538 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0133869 |
| RPL6 | ribosomal protein L6 | 0.0129408 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0129375 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0128288 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.012349 |
| ANXA2 | annexin A2 | 0.0123279 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0122014 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0121001 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0120958 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0119662 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0119265 |
| WDFY2 | WD repeat and FYVE domain containing 2 | 0.0118518 |
| FOSL1 | FOS-like antigen 1 | 0.0117565 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.011716 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | 0.0115711 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0115365 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0115138 |
| CLU | clusterin | 0.0113053 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0109619 |
| RPL37A | ribosomal protein L37a | 0.0109528 |
| RPL35 | ribosomal protein L35 | 0.0109423 |
| USP37 | ubiquitin specific peptidase 37 | 0.0107805 |
| WDR45B | WD repeat domain 45B | 0.0107627 |
| HLA-C | major histocompatibility complex, class I, C | 0.0107321 |
| RPL12 | ribosomal protein L12 | 0.0106854 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0105701 |
| SFXN1 | sideroflexin 1 | 0.0105281 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0104599 |
| RPS6 | ribosomal protein S6 | 0.0103687 |
| CRLF2 | cytokine receptor-like factor 2 | 0.0103645 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0103143 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0102517 |
| ANXA1 | annexin A1 | 0.010154 |
| RUNX1 | runt-related transcription factor 1 | 0.0101398 |
| RPLP0 | ribosomal protein, large, P0 | 0.0100171 |
| ANGPTL4 | angiopoietin-like 4 | 0.00988038 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.00986592 |
| MT1X | metallothionein 1X | 0.00985882 |
| COL4A6 | collagen, type IV, alpha 6 | 0.00949581 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.113616 |
| TMSB10 | thymosin beta 10 | -0.106424 |
| UBC | ubiquitin C | -0.080587 |
| ASPH | aspartate beta-hydroxylase | -0.071568 |
| TXNRD1 | thioredoxin reductase 1 | -0.066605 |
| GRAMD1B | GRAM domain containing 1B | -0.0576033 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0521752 |
| RPS27A | ribosomal protein S27a | -0.0495852 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0489477 |
| PCBP2 | poly(rC) binding protein 2 | -0.0462525 |
| RPL31 | ribosomal protein L31 | -0.0447578 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0446551 |
| MCL1 | myeloid cell leukemia 1 | -0.0444843 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.044101 |
| COL5A2 | collagen, type V, alpha 2 | -0.0426503 |
| VCL | vinculin | -0.0377236 |
| FTL | ferritin, light polypeptide | -0.0371154 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0369031 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0365679 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0364909 |
| PDE10A | phosphodiesterase 10A | -0.0360257 |
| GDA | guanine deaminase | -0.035396 |
| LDHA | lactate dehydrogenase A | -0.0353224 |
| RPLP1 | ribosomal protein, large, P1 | -0.0350571 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0343761 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0341186 |
| RPS24 | ribosomal protein S24 | -0.0327695 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0316667 |
| PTMA | prothymosin, alpha | -0.0314376 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0308704 |
| PKM | pyruvate kinase, muscle | -0.0299824 |
| KYNU | kynureninase | -0.0293524 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.0280598 |
| RPL4 | ribosomal protein L4 | -0.0276837 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0274112 |
| TNPO1 | transportin 1 | -0.0268609 |
| ENO1 | enolase 1, (alpha) | -0.0265525 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0247507 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.0244019 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0242128 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0236809 |
| AHNAK | AHNAK nucleoprotein | -0.0232268 |
| DST | dystonin | -0.0231921 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0231136 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0228626 |
| EZR | ezrin | -0.0218421 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.021761 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.021159 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0211154 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0208667 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0206009 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0204085 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0197345 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | -0.0195937 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0194418 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0192283 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0191526 |
| VMP1 | vacuole membrane protein 1 | -0.0187547 |
| INTS6 | integrator complex subunit 6 | -0.0185186 |
| TBXT | T-box transcription factor T | -0.0184809 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.018367 |
| MYOF | myoferlin | -0.0182716 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0181352 |
| PALLD | palladin, cytoskeletal associated protein | -0.0180345 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0178988 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.017821 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0178037 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0177781 |
| POTEF | POTE ankyrin domain family, member F | -0.0176499 |
| SET | SET nuclear proto-oncogene | -0.0175389 |
| APP | amyloid beta (A4) precursor protein | -0.0175029 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0170513 |
| RPL23 | ribosomal protein L23 | -0.0164961 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0164857 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0160874 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0159329 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0157783 |
| ACTN4 | actinin, alpha 4 | -0.0152977 |
| PTEN | phosphatase and tensin homolog | -0.0152569 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0152429 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.01524 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0150936 |
| RPS4X | ribosomal protein S4, X-linked | -0.0150084 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.014979 |
| RPS5 | ribosomal protein S5 | -0.0147932 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0146701 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0144995 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0144772 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0144154 |
| ZNF638 | zinc finger protein 638 | -0.0143934 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.014382 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0143038 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0142823 |
| RPL36A | ribosomal protein L36a | -0.0140867 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | -0.0139511 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0139143 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0137483 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0136979 |
| TPM4 | tropomyosin 4 | -0.0136372 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0136334 |
