Rucaparib (phosphate)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

186 genes differentially expressed following the Rucaparib (phosphate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.0768322
HELZ helicase with zinc finger 0.0690109
USP3 ubiquitin specific peptidase 3 0.0680394
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0658943
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0644224
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0638768
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0606404
KPNB1 karyopherin (importin) beta 1 0.0584618
JARID2 jumonji, AT rich interactive domain 2 0.0557812
RPL13A ribosomal protein L13a 0.0548118
NAP1L1 nucleosome assembly protein 1-like 1 0.0525508
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0503815
PTPRM protein tyrosine phosphatase, receptor type, M 0.0500694
PGK1 phosphoglycerate kinase 1 0.0482004
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0451898
RPL11 ribosomal protein L11 0.0450392
AREG amphiregulin 0.0441294
RPL35A ribosomal protein L35a 0.0440097
ANKRD11 ankyrin repeat domain 11 0.0437891
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.043788
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0437469
RBM39 RNA binding motif protein 39 0.043241
KMT2E lysine (K)-specific methyltransferase 2E 0.0426451
ZNF292 zinc finger protein 292 0.0406235
BHLHE40 basic helix-loop-helix family, member e40 0.0403978
ZNF654 zinc finger protein 654 0.0402924
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0402692
ELL2 elongation factor, RNA polymerase II, 2 0.0393889
BTBD9 BTB (POZ) domain containing 9 0.0388548
MRTFA myocardin related transcription factor A 0.0382222
H3-3B H3.3 histone B 0.0368758
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0367678
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0364929
ZFAND3 zinc finger, AN1-type domain 3 0.0362158
RPS27 ribosomal protein S27 0.0342209
PKM pyruvate kinase, muscle 0.0331042
MT2A metallothionein 2A 0.0324616
MYL12B myosin, light chain 12B, regulatory 0.0324053
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 0.0318386
SMC4 structural maintenance of chromosomes 4 0.0304442
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0298265
SETD5 SET domain containing 5 0.029036
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0288063
VMP1 vacuole membrane protein 1 0.0281919
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0279066
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0278164
NAMPT nicotinamide phosphoribosyltransferase 0.0270598
S100A9 S100 calcium binding protein A9 0.0253536
USP34 ubiquitin specific peptidase 34 0.0252398
RICTOR RPTOR independent companion of MTOR, complex 2 0.0244312
SPAG9 sperm associated antigen 9 0.023408
ERRFI1 ERBB receptor feedback inhibitor 1 0.0233032
RPL5 ribosomal protein L5 0.0228331
IGFBP3 insulin-like growth factor binding protein 3 0.0227866
RLF rearranged L-myc fusion 0.022405
FLNB filamin B, beta 0.0215249
RNF145 ring finger protein 145 0.0207909
IQGAP1 IQ motif containing GTPase activating protein 1 0.0202555
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0201071
RNMT RNA (guanine-7-) methyltransferase 0.0195681
NUP153 nucleoporin 153kDa 0.0193866
SNX9 sorting nexin 9 0.0185302
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0182872
PDIA6 protein disulfide isomerase family A, member 6 0.0179644
NKD1 naked cuticle homolog 1 (Drosophila) 0.0174807
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0169009
RPL26 ribosomal protein L26 0.0160203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0159516
SBF2 SET binding factor 2 0.0156877
RTN4 reticulon 4 0.0156569
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0154113
NPC1 Niemann-Pick disease, type C1 0.0147774
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0138607
ZMYM2 zinc finger, MYM-type 2 0.013551
IER3 immediate early response 3 0.0132762
ZNF148 zinc finger protein 148 0.01141
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0113711
CCNI cyclin I 0.0112747
ACTG1 actin gamma 1 0.0112011
ANKRD12 ankyrin repeat domain 12 0.0103594
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0101537
TAS2R14 taste receptor, type 2, member 14 0.00999623
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.00989064
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.00955699
NUMB numb homolog (Drosophila) 0.00952633
PTK2 protein tyrosine kinase 2 0.0093212
TRIO trio Rho guanine nucleotide exchange factor 0.00923604
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.00860551
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.00806037
RPS12 ribosomal protein S12 0.00593045
COG5 component of oligomeric golgi complex 5 0.0058555
AHNAK AHNAK nucleoprotein 0.00563526
KTN1 kinectin 1 (kinesin receptor) 0.00506012
DST dystonin 0.00479277
FBXO11 F-box protein 11 0.00416041
CXCL8 chemokine (C-X-C motif) ligand 8 0.0038596
ANXA2 annexin A2 0.00260212
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.00239991
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00203684
IGF2 insulin-like growth factor 2 0.0018142

decreased expression

Symbol Name Standardized Value
MYO1E myosin IE -0.140122
TMSB10 thymosin beta 10 -0.113629
HMGA2 high mobility group AT-hook 2 -0.0987659
MYOF myoferlin -0.0938684
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0926956
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0896852
ALCAM activated leukocyte cell adhesion molecule -0.0864543
LAMA4 laminin, alpha 4 -0.0816709
PRKCA protein kinase C, alpha -0.0806822
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0804749
EXT1 exostosin glycosyltransferase 1 -0.0791053
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0767321
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0719141
COL5A1 collagen, type V, alpha 1 -0.0667627
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.063695
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0635006
RAD51B RAD51 paralog B -0.0623624
PARD3 par-3 family cell polarity regulator -0.0616078
EFNA5 ephrin-A5 -0.0599311
PTMA prothymosin, alpha -0.059519
TPM4 tropomyosin 4 -0.0594855
MYO6 myosin VI -0.0590815
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0583343
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0577729
RPS13 ribosomal protein S13 -0.0525776
MACF1 microtubule-actin crosslinking factor 1 -0.052403
VCL vinculin -0.0513132
FHIT fragile histidine triad -0.0499283
TTC3 tetratricopeptide repeat domain 3 -0.0488526
RPL23 ribosomal protein L23 -0.0481051
ZBTB20 zinc finger and BTB domain containing 20 -0.0448848
EGR1 early growth response 1 -0.0442511
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0434055
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0431566
RPS19 ribosomal protein S19 -0.042901
TPT1 tumor protein, translationally-controlled 1 -0.0416863
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0413857
NDRG1 N-myc downstream regulated 1 -0.0405925
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0390441
EGFR epidermal growth factor receptor -0.0373513
CANX calnexin -0.0369283
RPL34 ribosomal protein L34 -0.0367161
LDHA lactate dehydrogenase A -0.0363394
MCL1 myeloid cell leukemia 1 -0.0353687
RPS6 ribosomal protein S6 -0.0350852
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0349625
SLTM SAFB-like, transcription modulator -0.0345191
RUNX1 runt-related transcription factor 1 -0.0327912
NALF1 NALCN channel auxiliary factor 1 -0.0314232
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0310448
RPL15 ribosomal protein L15 -0.030072
GOLGA4 golgin A4 -0.0299082
RPS8 ribosomal protein S8 -0.0298454
SAMD4A sterile alpha motif domain containing 4A -0.0292936
LAMB3 laminin, beta 3 -0.0274691
PSD3 pleckstrin and Sec7 domain containing 3 -0.0269597
PDE10A phosphodiesterase 10A -0.0263629
ASPH aspartate beta-hydroxylase -0.0257277
RPS25 ribosomal protein S25 -0.0251888
CDH13 cadherin 13 -0.0247228
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0240961
STC1 stanniocalcin 1 -0.0239403
PRRC2C proline-rich coiled-coil 2C -0.0231296
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0230462
SMYD3 SET and MYND domain containing 3 -0.0225629
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0213326
FNDC3B fibronectin type III domain containing 3B -0.0210345
CD44 CD44 molecule (Indian blood group) -0.0202639
PDE4D phosphodiesterase 4D, cAMP-specific -0.0189077
VIM vimentin -0.0188598
GPC6 glypican 6 -0.0150364
FTL ferritin, light polypeptide -0.014702
RPS3 ribosomal protein S3 -0.0102837
DIAPH2 diaphanous-related formin 2 -0.00960354
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.00923228
GLG1 golgi glycoprotein 1 -0.00906208
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.00792034
NAV2 neuron navigator 2 -0.00547617
ENO1 enolase 1, (alpha) -0.00543637
YBX3 Y box binding protein 3 -0.00442976
DSCAM Down syndrome cell adhesion molecule -0.00439134
TOP1 topoisomerase (DNA) I -0.00370801
RPL12 ribosomal protein L12 -0.00356328
RPLP1 ribosomal protein, large, P1 -0.00206552
RPL37A ribosomal protein L37a -0.00165223
B2M beta-2-microglobulin -1.79161E-5