Rucaparib (phosphate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PBX3 pre-B-cell leukemia homeobox 3 0.0387911
FLNB filamin B, beta 0.034922
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.034794
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0343338
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0323748
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0311901
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0289426
SRRM2 serine/arginine repetitive matrix 2 0.0258301
EEF2 eukaryotic translation elongation factor 2 0.025491
RAD51B RAD51 paralog B 0.0248256
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.024591
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0239332
EXOC4 exocyst complex component 4 0.0239316
ECPAS Ecm29 proteasome adaptor and scaffold 0.0233296
NAV2 neuron navigator 2 0.0228143
MACF1 microtubule-actin crosslinking factor 1 0.0219764
HLA-A major histocompatibility complex, class I, A 0.021848
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0214396
BIRC6 baculoviral IAP repeat containing 6 0.0204421
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0204024
UBA6 ubiquitin-like modifier activating enzyme 6 0.020307
MCL1 myeloid cell leukemia 1 0.0200732
WDFY2 WD repeat and FYVE domain containing 2 0.0197486
LPP LIM domain containing preferred translocation partner in lipoma 0.0196288
NCKAP1 NCK-associated protein 1 0.0193744
ANK2 ankyrin 2, neuronal 0.0193472
PTK2 protein tyrosine kinase 2 0.0192551
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0192508
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0191138
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0188325
COG5 component of oligomeric golgi complex 5 0.0182736
DST dystonin 0.0182122
JMJD1C jumonji domain containing 1C 0.0175908
AFF1 AF4/FMR2 family, member 1 0.0175461
FHIT fragile histidine triad 0.01752
AHNAK AHNAK nucleoprotein 0.0175126
TRIP12 thyroid hormone receptor interactor 12 0.0172701
ZEB1 zinc finger E-box binding homeobox 1 0.0172541
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0171156
PTBP2 polypyrimidine tract binding protein 2 0.016933
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0167187
CKAP5 cytoskeleton associated protein 5 0.0165909
ANTXR2 anthrax toxin receptor 2 0.0164801
TAC4 tachykinin 4 (hemokinin) 0.0164273
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0163637
ELL2 elongation factor, RNA polymerase II, 2 0.0162924
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0162691
RASA2 RAS p21 protein activator 2 0.0162225
FAM91A1 family with sequence similarity 91, member A1 0.0161623
MYH9 myosin, heavy chain 9, non-muscle 0.0156291
YEATS2 YEATS domain containing 2 0.0156108
YAP1 Yes-associated protein 1 0.0155399
TPM3 tropomyosin 3 0.0149443
CORO1C coronin, actin binding protein, 1C 0.0147888
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0147869
MCTP1 multiple C2 domains, transmembrane 1 0.0144019
RPL3 ribosomal protein L3 0.0143251
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0142411
ASPH aspartate beta-hydroxylase 0.0142068
CALU calumenin 0.0140819
UBC ubiquitin C 0.0138858
TMEM87A transmembrane protein 87A 0.0138543
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0138308
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0138198
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0137946
ZNF292 zinc finger protein 292 0.0137901
FAR1 fatty acyl CoA reductase 1 0.0137622
SNX9 sorting nexin 9 0.0136767
ADAM17 ADAM metallopeptidase domain 17 0.0136719
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0135865
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0134221
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.013409
EXT1 exostosin glycosyltransferase 1 0.0134015
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0133372
NUP58 nucleoporin 58 0.0133015
MAPK8 mitogen-activated protein kinase 8 0.0132094
IL6ST interleukin 6 signal transducer 0.0130313
PCBP2 poly(rC) binding protein 2 0.0130309
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0129799
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0129447
CAND1 cullin-associated and neddylation-dissociated 1 0.0128094
STK24 serine/threonine kinase 24 0.0127938
ZNF438 zinc finger protein 438 0.0127881
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.0127434
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0127274
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0127002
SFPQ splicing factor proline/glutamine-rich 0.0126833
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0126755
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0126455
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0126435
EFL1 elongation factor like GTPase 1 0.0126232
ANKRD17 ankyrin repeat domain 17 0.0125092
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0124816
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.01247
CAPRIN2 caprin family member 2 0.0123991
ATP13A3 ATPase type 13A3 0.0123033
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0122847
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0122829
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0121397
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0120669

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.123455
DLC1 DLC1 Rho GTPase activating protein -0.0873783
MT2A metallothionein 2A -0.0649314
RPL8 ribosomal protein L8 -0.0417425
RPLP1 ribosomal protein, large, P1 -0.0357486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0350749
FTL ferritin, light polypeptide -0.0350024
RPS6 ribosomal protein S6 -0.0323678
PTMA prothymosin, alpha -0.0312063
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0269588
HMGA1 high mobility group AT-hook 1 -0.0254577
RPL35A ribosomal protein L35a -0.0251409
RAD21 RAD21 homolog (S. pombe) -0.0242927
TPM4 tropomyosin 4 -0.0240626
S100A2 S100 calcium binding protein A2 -0.0240534
TPT1 tumor protein, translationally-controlled 1 -0.0239513
RPS24 ribosomal protein S24 -0.0236838
RPS8 ribosomal protein S8 -0.0235107
TMSB10 thymosin beta 10 -0.0230147
RPL7A ribosomal protein L7a -0.0224977
C2CD2 C2 calcium-dependent domain containing 2 -0.0223872
RPL12 ribosomal protein L12 -0.0222833
RPS20 ribosomal protein S20 -0.022261
INTS6 integrator complex subunit 6 -0.0221217
NAP1L1 nucleosome assembly protein 1-like 1 -0.0206077
RPL23 ribosomal protein L23 -0.0195688
ACTG1 actin gamma 1 -0.0191844
GNAS GNAS complex locus -0.0191618
KDM3A lysine (K)-specific demethylase 3A -0.0188601
RPL7 ribosomal protein L7 -0.01881
PGK1 phosphoglycerate kinase 1 -0.0187607
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0181877
RPL35 ribosomal protein L35 -0.018099
S100A9 S100 calcium binding protein A9 -0.0180768
LAMB3 laminin, beta 3 -0.0173938
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0169907
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -0.0166119
RPL37A ribosomal protein L37a -0.0165407
MTDH metadherin -0.0162373
RPS12 ribosomal protein S12 -0.0162172
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0161431
EGR1 early growth response 1 -0.016
IFI16 interferon, gamma-inducible protein 16 -0.015561
VDAC1 voltage-dependent anion channel 1 -0.0154805
EIF1 eukaryotic translation initiation factor 1 -0.0154728
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0154237
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0154193
LDHA lactate dehydrogenase A -0.0151721
BHLHE40 basic helix-loop-helix family, member e40 -0.0150284
AGO2 argonaute RISC catalytic component 2 -0.0146947
RPS27A ribosomal protein S27a -0.0145844
RPS27 ribosomal protein S27 -0.014308
FRMD6 FERM domain containing 6 -0.0143064
RUNX1 runt-related transcription factor 1 -0.0142819
RPL31 ribosomal protein L31 -0.0142611
RAB7A RAB7A, member RAS oncogene family -0.0142445
MATR3 matrin 3 -0.0142366
RPL30 ribosomal protein L30 -0.0138869
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0136755
RPS19 ribosomal protein S19 -0.0135731
RRBP1 ribosome binding protein 1 -0.0134323
CEP350 centrosomal protein 350kDa -0.0130497
RPS29 ribosomal protein S29 -0.0127801
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0127515
RPLP0 ribosomal protein, large, P0 -0.0127464
RPL32 ribosomal protein L32 -0.012695
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.012621
WNT2B wingless-type MMTV integration site family, member 2B -0.0125424
RPS5 ribosomal protein S5 -0.0124757
RPL18 ribosomal protein L18 -0.0124264
NABP1 nucleic acid binding protein 1 -0.0124233
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.01233
HMGB2 high mobility group box 2 -0.0122524
RPL11 ribosomal protein L11 -0.0120002
LOC102724023 ES1 protein homolog, mitochondrial -0.0118061
RPL34 ribosomal protein L34 -0.0117106
RPL26 ribosomal protein L26 -0.0115375
HMGA2 high mobility group AT-hook 2 -0.0114727
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0114465
RPL36A ribosomal protein L36a -0.0112578
RPS21 ribosomal protein S21 -0.0111585
CDK13 cyclin-dependent kinase 13 -0.0111326
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0111204
RPLP2 ribosomal protein, large, P2 -0.0111041
PHF3 PHD finger protein 3 -0.0110498
RGMB repulsive guidance molecule family member b -0.0109601
RPL39 ribosomal protein L39 -0.0108281
RPL9 ribosomal protein L9 -0.0108258
SQLE squalene epoxidase -0.0107893
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0106292
TBCA tubulin folding cofactor A -0.0104572
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.0104501
RPL13A ribosomal protein L13a -0.010448
RPS16 ribosomal protein S16 -0.0104394
PKM pyruvate kinase, muscle -0.0103929
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0103657
RPS25 ribosomal protein S25 -0.0103372
FRMD4A FERM domain containing 4A -0.01015
FBXO11 F-box protein 11 -0.0100907
GPATCH8 G patch domain containing 8 -0.00989906