Rucaparib (phosphate)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 0.0855519
ARHGAP26 Rho GTPase activating protein 26 0.0838527
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0719099
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0696221
TRIO trio Rho guanine nucleotide exchange factor 0.0667537
PDE4D phosphodiesterase 4D, cAMP-specific 0.0630718
SINHCAF SIN3-HDAC complex associated factor 0.0598445
NAMPT nicotinamide phosphoribosyltransferase 0.0593088
SASH1 SAM and SH3 domain containing 1 0.0560982
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0557313
NDRG1 N-myc downstream regulated 1 0.0503265
NALF1 NALCN channel auxiliary factor 1 0.0463268
TPM3 tropomyosin 3 0.0449454
FAT1 FAT atypical cadherin 1 0.0434767
GRIK1 glutamate receptor, ionotropic, kainate 1 0.0417324
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0415135
MYH9 myosin, heavy chain 9, non-muscle 0.0408658
EEF2 eukaryotic translation elongation factor 2 0.0394753
LPP LIM domain containing preferred translocation partner in lipoma 0.0383526
TXNRD1 thioredoxin reductase 1 0.0370856
PABPC1 poly(A) binding protein, cytoplasmic 1 0.036587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0365076
CHGB chromogranin B 0.0359765
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0358615
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.035422
PSD3 pleckstrin and Sec7 domain containing 3 0.0353231
HDAC9 histone deacetylase 9 0.0349064
ENO1 enolase 1, (alpha) 0.0348202
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0344466
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0339567
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0330486
CKAP5 cytoskeleton associated protein 5 0.0329664
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0322916
TMSB4X thymosin beta 4, X-linked 0.0318422
PDIA6 protein disulfide isomerase family A, member 6 0.0308983
NCKAP5 NCK-associated protein 5 0.0307338
DNAH5 dynein, axonemal, heavy chain 5 0.0296952
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0294842
CENPF centromere protein F, 350/400kDa 0.029463
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0287954
SPIDR scaffolding protein involved in DNA repair 0.0278954
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0273249
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.027158
DST dystonin 0.0264608
ELL2 elongation factor, RNA polymerase II, 2 0.0262553
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase 0.0261876
NUP58 nucleoporin 58 0.0255241
GPC6 glypican 6 0.0252763
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.025155
XPO1 exportin 1 0.0250454
FTH1 ferritin, heavy polypeptide 1 0.0243325
JAZF1 JAZF zinc finger 1 0.0238728
FMN1 formin 1 0.0237889
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0235756
DENND1A DENN/MADD domain containing 1A 0.0232772
PEG10 paternally expressed 10 0.0232197
FAM13A family with sequence similarity 13, member A 0.0230793
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0226553
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0226253
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0225123
IRS2 insulin receptor substrate 2 0.0224746
NBAS neuroblastoma amplified sequence 0.0220447
HMGB3 high mobility group box 3 0.021975
CADM1 cell adhesion molecule 1 0.0217696
HSPA8 heat shock 70kDa protein 8 0.0216471
MACF1 microtubule-actin crosslinking factor 1 0.0214739
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0214527
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0214047
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0213418
TPK1 thiamin pyrophosphokinase 1 0.021256
UVRAG UV radiation resistance associated 0.0212355
TACC2 transforming, acidic coiled-coil containing protein 2 0.0211933
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 0.0209709
CCNL1 cyclin L1 0.0209325
APP amyloid beta (A4) precursor protein 0.0209308
ARHGAP24 Rho GTPase activating protein 24 0.0208517
FHIT fragile histidine triad 0.020731
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0206058
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0205853
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0204865
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0203154
ACACA acetyl-CoA carboxylase alpha 0.0203027
SCARB2 scavenger receptor class B, member 2 0.0202281
SET SET nuclear proto-oncogene 0.0202217
AFDN afadin, adherens junction formation factor 0.0201415
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0200353
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0199129
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0198736
JAM3 junctional adhesion molecule 3 0.0196797
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0196111
POTEF POTE ankyrin domain family, member F 0.0196081
DOCK5 dedicator of cytokinesis 5 0.0196005
LIFR leukemia inhibitory factor receptor alpha 0.0193952
F2RL3 coagulation factor II (thrombin) receptor-like 3 0.0190998
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0190091
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0190081
GRAMD4 GRAM domain containing 4 0.0189123
TSPYL2 TSPY-like 2 0.0186944
SFPQ splicing factor proline/glutamine-rich 0.0185579
EIF4A1 eukaryotic translation initiation factor 4A1 0.018419

decreased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa -0.0715909
SMOC1 SPARC related modular calcium binding 1 -0.053869
PTMA prothymosin, alpha -0.0516753
CNKSR3 CNKSR family member 3 -0.0494347
INHBA inhibin, beta A -0.048585
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0470511
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0456989
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0402477
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0373863
MT2A metallothionein 2A -0.0367077
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0347623
IGFBP5 insulin-like growth factor binding protein 5 -0.0344784
FNDC3A fibronectin type III domain containing 3A -0.0343764
SIK2 salt-inducible kinase 2 -0.0337593
ACTG1 actin gamma 1 -0.0336272
FTL ferritin, light polypeptide -0.0322984
EGR1 early growth response 1 -0.0319065
IFI6 interferon, alpha-inducible protein 6 -0.031715
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0305945
S100A9 S100 calcium binding protein A9 -0.0304939
EIF1 eukaryotic translation initiation factor 1 -0.0302947
RPS21 ribosomal protein S21 -0.0298504
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0285564
RPL26 ribosomal protein L26 -0.0285128
SMYD3 SET and MYND domain containing 3 -0.0271277
RPL31 ribosomal protein L31 -0.0262661
MAP7 microtubule-associated protein 7 -0.0257942
COL22A1 collagen, type XXII, alpha 1 -0.0256543
RPL37A ribosomal protein L37a -0.0253381
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0251894
RPLP1 ribosomal protein, large, P1 -0.0251875
ST18 suppression of tumorigenicity 18, zinc finger -0.0250992
RPS6 ribosomal protein S6 -0.024553
RPL23 ribosomal protein L23 -0.0239406
BCL2 B-cell CLL/lymphoma 2 -0.0235644
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.023548
GDAP1 ganglioside induced differentiation associated protein 1 -0.0232194
RPS16 ribosomal protein S16 -0.0230626
RPS19 ribosomal protein S19 -0.0229739
VMP1 vacuole membrane protein 1 -0.0227539
ESRRG estrogen-related receptor gamma -0.0226445
TENT5A terminal nucleotidyltransferase 5A -0.0224211
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0223722
ISG15 ISG15 ubiquitin-like modifier -0.0223366
TMSB10 thymosin beta 10 -0.0219597
GOLGB1 golgin B1 -0.0218507
NIPBL Nipped-B homolog (Drosophila) -0.020717
RPS29 ribosomal protein S29 -0.0205549
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0203219
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -0.0202098
RPS23 ribosomal protein S23 -0.0200808
RPS8 ribosomal protein S8 -0.0200659
CPE carboxypeptidase E -0.0199609
SOX4 SRY (sex determining region Y)-box 4 -0.0196872
RAB2A RAB2A, member RAS oncogene family -0.0196703
HOMER1 homer scaffolding protein 1 -0.0196516
RPL35A ribosomal protein L35a -0.0194098
ZFHX3 zinc finger homeobox 3 -0.0193901
PALLD palladin, cytoskeletal associated protein -0.0193317
WSB1 WD repeat and SOCS box containing 1 -0.0192557
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0188712
CDK13 cyclin-dependent kinase 13 -0.018847
RPL37 ribosomal protein L37 -0.0185868
SP100 SP100 nuclear antigen -0.0185726
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0185493
RPL34 ribosomal protein L34 -0.0185447
RPL38 ribosomal protein L38 -0.0184808
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.018412
RPS27 ribosomal protein S27 -0.0182447
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0178964
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0178149
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0176787
CHRM5 cholinergic receptor, muscarinic 5 -0.0176396
NRG1 neuregulin 1 -0.0173897
RIT2 Ras-like without CAAX 2 -0.0173091
TMEM165 transmembrane protein 165 -0.0172123
HM13 histocompatibility (minor) 13 -0.0170091
RPS27A ribosomal protein S27a -0.0168208
SETX senataxin -0.0167753
RPL32 ribosomal protein L32 -0.0167619
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0167514
GCC2 GRIP and coiled-coil domain containing 2 -0.0166902
ADGRL2 adhesion G protein-coupled receptor L2 -0.0164744
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.016363
GON4L gon-4-like (C. elegans) -0.0162789
GNG4 guanine nucleotide binding protein (G protein), gamma 4 -0.0162194
RPS5 ribosomal protein S5 -0.0161329
CEP350 centrosomal protein 350kDa -0.0160143
RABGAP1 RAB GTPase activating protein 1 -0.0159315
GPATCH8 G patch domain containing 8 -0.0158431
FBXO34 F-box protein 34 -0.0157951
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0157922
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0156728
RPL35 ribosomal protein L35 -0.0155627
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0155288
RPS25 ribosomal protein S25 -0.0155035
AOPEP aminopeptidase O (putative) -0.0153717
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.015101
KCTD8 potassium channel tetramerization domain containing 8 -0.0148347
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.014797