| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.19019 |
| FMN1 | formin 1 | 0.11786 |
| FNDC3B | fibronectin type III domain containing 3B | 0.108857 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.108848 |
| SPAG9 | sperm associated antigen 9 | 0.0563889 |
| NAV2 | neuron navigator 2 | 0.0537651 |
| NRG3 | neuregulin 3 | 0.0515016 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0492269 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0468421 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0406231 |
| NDRG1 | N-myc downstream regulated 1 | 0.0382263 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0361186 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0357901 |
| MSN | moesin | 0.0349506 |
| CD44 | CD44 molecule (Indian blood group) | 0.0347977 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | 0.0333473 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0331033 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0321629 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0315786 |
| INPP5F | inositol polyphosphate-5-phosphatase F | 0.0306344 |
| FLNA | filamin A, alpha | 0.0300714 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0288395 |
| ANXA2 | annexin A2 | 0.0280694 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.02764 |
| HELZ | helicase with zinc finger | 0.0268456 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0266508 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0263508 |
| EP300 | E1A binding protein p300 | 0.0262376 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0258655 |
| SMAD3 | SMAD family member 3 | 0.0257654 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0254305 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0251764 |
| DST | dystonin | 0.0251606 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0250539 |
| LDHA | lactate dehydrogenase A | 0.0247518 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.024617 |
| PGK1 | phosphoglycerate kinase 1 | 0.0246075 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0243977 |
| OGA | O-GlcNAcase | 0.0237505 |
| ANLN | anillin, actin binding protein | 0.0237354 |
| TXNRD1 | thioredoxin reductase 1 | 0.0237076 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0236572 |
| FLNB | filamin B, beta | 0.0232935 |
| CLINT1 | clathrin interactor 1 | 0.0232577 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.023207 |
| FMNL2 | formin-like 2 | 0.0231949 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.023163 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0229684 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0226513 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0223144 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0222215 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0221811 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0221232 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0221138 |
| NOTCH2 | notch 2 | 0.0220899 |
| IL1RAP | interleukin 1 receptor accessory protein | 0.0220788 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0220772 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0219505 |
| ATP13A3 | ATPase type 13A3 | 0.0218421 |
| TRIM33 | tripartite motif containing 33 | 0.0216435 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0215525 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0215483 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0213893 |
| CANX | calnexin | 0.0213355 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0211625 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0210923 |
| TPM3 | tropomyosin 3 | 0.0210788 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0209808 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0208736 |
| SBF2 | SET binding factor 2 | 0.0206148 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0206147 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.020493 |
| COPA | coatomer protein complex, subunit alpha | 0.0203357 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.020022 |
| NCKAP1 | NCK-associated protein 1 | 0.0200189 |
| NGLY1 | N-glycanase 1 | 0.0200068 |
| RUNX1 | runt-related transcription factor 1 | 0.0199874 |
| CLTC | clathrin, heavy chain (Hc) | 0.019745 |
| SQSTM1 | sequestosome 1 | 0.019723 |
| CLIC4 | chloride intracellular channel 4 | 0.0196505 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0194582 |
| ANXA5 | annexin A5 | 0.0192129 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0191744 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0190141 |
| FNIP1 | folliculin interacting protein 1 | 0.0189959 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0188743 |
| ENO1 | enolase 1, (alpha) | 0.0188019 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0187879 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0186604 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0185678 |
| ARRDC3 | arrestin domain containing 3 | 0.01786 |
| PRKCSH | protein kinase C substrate 80K-H | 0.0178207 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0177909 |
| PRELID2 | PRELI domain containing 2 | 0.0176525 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0176481 |
| TFRC | transferrin receptor | 0.0176211 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0175735 |
| JMJD1C | jumonji domain containing 1C | 0.017536 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0174698 |
| MKI67 | marker of proliferation Ki-67 | 0.0171091 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS3 | ribosomal protein S3 | -0.0814925 |
| NLGN1 | neuroligin 1 | -0.0809037 |
| RPL35A | ribosomal protein L35a | -0.0558977 |
| RPL23 | ribosomal protein L23 | -0.0435504 |
| RPS6 | ribosomal protein S6 | -0.0426124 |
| RPS12 | ribosomal protein S12 | -0.0410171 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0402321 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0399359 |
| LSAMP | limbic system-associated membrane protein | -0.0365455 |
| FRMD4A | FERM domain containing 4A | -0.0364988 |
| PTMA | prothymosin, alpha | -0.0363496 |
| RPL37A | ribosomal protein L37a | -0.0361474 |
| RPL34 | ribosomal protein L34 | -0.0325665 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0313446 |
| RPS13 | ribosomal protein S13 | -0.0304947 |
| RPS8 | ribosomal protein S8 | -0.0294548 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0275785 |
| RPS21 | ribosomal protein S21 | -0.0253102 |
| FTL | ferritin, light polypeptide | -0.025098 |
| S100A9 | S100 calcium binding protein A9 | -0.0246681 |
| RPLP2 | ribosomal protein, large, P2 | -0.024541 |
| TMSB10 | thymosin beta 10 | -0.0238544 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0212045 |
| RPS29 | ribosomal protein S29 | -0.0211451 |
| RPS23 | ribosomal protein S23 | -0.0199765 |
| RPL38 | ribosomal protein L38 | -0.0199275 |
| MT2A | metallothionein 2A | -0.0198044 |
| RPS27A | ribosomal protein S27a | -0.0195368 |
| RPS14 | ribosomal protein S14 | -0.0193125 |
| RPLP1 | ribosomal protein, large, P1 | -0.0188576 |
| RPL36 | ribosomal protein L36 | -0.0187087 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0186041 |
| RPL9 | ribosomal protein L9 | -0.0185689 |
| RPS19 | ribosomal protein S19 | -0.0184665 |
| RACK1 | receptor for activated C kinase 1 | -0.0177084 |
| RPS15 | ribosomal protein S15 | -0.0175833 |
| RPL27 | ribosomal protein L27 | -0.0172478 |
| RPL11 | ribosomal protein L11 | -0.0171683 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0171463 |
| RPL37 | ribosomal protein L37 | -0.0170005 |
| RPL12 | ribosomal protein L12 | -0.0167952 |
| RPS16 | ribosomal protein S16 | -0.0166621 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0155154 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0154255 |
| PEX5L | peroxisomal biogenesis factor 5-like | -0.0151016 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0147388 |
| IFI44L | interferon-induced protein 44-like | -0.0146662 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0141265 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0140479 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0140198 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0139966 |
| RPL32 | ribosomal protein L32 | -0.0138872 |
| RAD51B | RAD51 paralog B | -0.0137867 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0135039 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.0134861 |
| RPS10 | ribosomal protein S10 | -0.0134699 |
| RPL18 | ribosomal protein L18 | -0.013456 |
| RPL13A | ribosomal protein L13a | -0.0133517 |
| B2M | beta-2-microglobulin | -0.0131803 |
| RPL31 | ribosomal protein L31 | -0.0129666 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0128928 |
| AUTS2 | autism susceptibility candidate 2 | -0.0127811 |
| RPL36A | ribosomal protein L36a | -0.0127274 |
| RPL30 | ribosomal protein L30 | -0.0126191 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0125268 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0124993 |
| RPL8 | ribosomal protein L8 | -0.012434 |
| ACTG1 | actin gamma 1 | -0.012259 |
| SEC61G | Sec61 gamma subunit | -0.0122408 |
| RPS17 | ribosomal protein S17 | -0.0122162 |
| RPS11 | ribosomal protein S11 | -0.0121839 |
| RPL27A | ribosomal protein L27a | -0.0120341 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0119763 |
| CNIH3 | cornichon family AMPA receptor auxiliary protein 3 | -0.0117168 |
| ATP5MK | ATP synthase membrane subunit k | -0.0116573 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0112766 |
| L3MBTL4 | l(3)mbt-like 4 (Drosophila) | -0.0109469 |
| RPS27 | ribosomal protein S27 | -0.0107781 |
| ATF4 | activating transcription factor 4 | -0.010536 |
| PFN1 | profilin 1 | -0.0105319 |
| RAN | RAN, member RAS oncogene family | -0.0104408 |
| ZNF704 | zinc finger protein 704 | -0.0104372 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0103703 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | -0.0103547 |
| DLGAP1 | discs, large (Drosophila) homolog-associated protein 1 | -0.0103411 |
| MFSD12 | major facilitator superfamily domain containing 12 | -0.0102697 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0102337 |
| FHIT | fragile histidine triad | -0.00999978 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0099859 |
| RPL26 | ribosomal protein L26 | -0.00988092 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00972241 |
| LINC02798 | long intergenic non-protein coding RNA 2798 | -0.00968556 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.00948458 |
| DDX18 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 | -0.00929641 |
| RPS5 | ribosomal protein S5 | -0.00924154 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.00917373 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.00899041 |
| SUMF1 | sulfatase modifying factor 1 | -0.00897793 |
| RPS20 | ribosomal protein S20 | -0.00895263 |
| C11ORF58 | chromosome 11 open reading frame 58 | -0.0089291 |
