Rucaparib (phosphate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.112914
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0930696
ZNF292 zinc finger protein 292 0.0892952
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0776112
RPL35A ribosomal protein L35a 0.074506
HDAC9 histone deacetylase 9 0.0725374
SSBP2 single-stranded DNA binding protein 2 0.0695355
EEF2 eukaryotic translation elongation factor 2 0.0682269
EML4 echinoderm microtubule associated protein like 4 0.0677789
RPS8 ribosomal protein S8 0.0653291
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0643533
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.061189
NAMPT nicotinamide phosphoribosyltransferase 0.0566427
QKI QKI, KH domain containing, RNA binding 0.0554846
B2M beta-2-microglobulin 0.0553593
FOXP1 forkhead box P1 0.0551108
RBM39 RNA binding motif protein 39 0.0542601
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0538948
PDGFC platelet derived growth factor C 0.0511236
TPT1 tumor protein, translationally-controlled 1 0.0510787
RPL11 ribosomal protein L11 0.050827
EIF4A2 eukaryotic translation initiation factor 4A2 0.0503305
RPS6 ribosomal protein S6 0.0496739
DSCAM Down syndrome cell adhesion molecule 0.0493897
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0493556
GOLGA4 golgin A4 0.0489739
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0488475
CCNL1 cyclin L1 0.048815
PCBP2 poly(rC) binding protein 2 0.0487006
PTK2 protein tyrosine kinase 2 0.0467999
PFN1 profilin 1 0.0467539
CPED1 cadherin-like and PC-esterase domain containing 1 0.0461893
NUP58 nucleoporin 58 0.0461323
WDR43 WD repeat domain 43 0.0459254
KMT2E lysine (K)-specific methyltransferase 2E 0.0458817
PNISR PNN-interacting serine/arginine-rich protein 0.0449395
RPS25 ribosomal protein S25 0.043977
NFIA nuclear factor I/A 0.043558
ECT2 epithelial cell transforming 2 0.0434435
ELOVL5 ELOVL fatty acid elongase 5 0.04309
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0425977
NAP1L1 nucleosome assembly protein 1-like 1 0.0422928
SETD5 SET domain containing 5 0.0420442
RPL37A ribosomal protein L37a 0.0417489
RPL13A ribosomal protein L13a 0.0415356
TFG TRK-fused gene 0.0413459
CALR calreticulin 0.0412595
RPS29 ribosomal protein S29 0.0405028
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0397703
NCKAP1 NCK-associated protein 1 0.0386848
ANKRD11 ankyrin repeat domain 11 0.0386155
FNDC3B fibronectin type III domain containing 3B 0.0385533
RPS19 ribosomal protein S19 0.0382898
RPS3 ribosomal protein S3 0.0377213
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0375022
CDC73 cell division cycle 73 0.037328
KDM3A lysine (K)-specific demethylase 3A 0.0373055
RPS13 ribosomal protein S13 0.036924
RPL36 ribosomal protein L36 0.0360968
RPL9 ribosomal protein L9 0.0359938
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0359657
WAC WW domain containing adaptor with coiled-coil 0.0359125
HELZ helicase with zinc finger 0.0355928
TJP1 tight junction protein 1 0.0355713
RPS12 ribosomal protein S12 0.0352835
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0352122
TOP1 topoisomerase (DNA) I 0.034082
TMSB4X thymosin beta 4, X-linked 0.0339641
RACK1 receptor for activated C kinase 1 0.0339576
RAB1A RAB1A, member RAS oncogene family 0.0337656
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0336176
RPLP0 ribosomal protein, large, P0 0.0335309
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0334888
USP3 ubiquitin specific peptidase 3 0.0332691
EVI5 ecotropic viral integration site 5 0.0330014
ZFAND3 zinc finger, AN1-type domain 3 0.0326993
TXNIP thioredoxin interacting protein 0.0326862
VIM vimentin 0.0326256
RAB7A RAB7A, member RAS oncogene family 0.0325286
KDM6A lysine (K)-specific demethylase 6A 0.0325102
KMT2C lysine (K)-specific methyltransferase 2C 0.0324706
RBM25 RNA binding motif protein 25 0.0321951
RPLP2 ribosomal protein, large, P2 0.0321633
NBAS neuroblastoma amplified sequence 0.0321151
POTEF POTE ankyrin domain family, member F 0.0321148
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0321016
RPL23 ribosomal protein L23 0.0319338
FBXO11 F-box protein 11 0.031848
ZNF148 zinc finger protein 148 0.0317881
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.031623
HLA-B major histocompatibility complex, class I, B 0.0312635
RNF145 ring finger protein 145 0.0311503
NCOR1 nuclear receptor corepressor 1 0.0311075
MSI2 musashi RNA-binding protein 2 0.0310583
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0310242
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0309623
RHEB Ras homolog enriched in brain 0.0307626
TGFBR3 transforming growth factor, beta receptor III 0.0303037
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0300515
GPBP1 GC-rich promoter binding protein 1 0.0299537

decreased expression

Symbol Name Standardized Value
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0710324
TXNRD1 thioredoxin reductase 1 -0.064423
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0617927
CCND1 cyclin D1 -0.0382195
EGFR epidermal growth factor receptor -0.0373476
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0348006
BMP2K BMP2 inducible kinase -0.0335334
ANXA1 annexin A1 -0.0305319
PDE4D phosphodiesterase 4D, cAMP-specific -0.0305314
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0304551
TM4SF1 transmembrane 4 L six family member 1 -0.0297522
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0296917
ATP9B ATPase, class II, type 9B -0.0282096
CLIP1 CAP-GLY domain containing linker protein 1 -0.0272407
AHNAK AHNAK nucleoprotein -0.0247889
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0246347
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0245158
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0235235
TMEM65 transmembrane protein 65 -0.0223051
EZR ezrin -0.0218814
MYOF myoferlin -0.0214111
ITSN1 intersectin 1 (SH3 domain protein) -0.0212505
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0201617
NCEH1 neutral cholesterol ester hydrolase 1 -0.0195793
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.019126
CLTC clathrin, heavy chain (Hc) -0.0182892
PLK2 polo-like kinase 2 -0.0178511
HSPA8 heat shock 70kDa protein 8 -0.017824
GCLM glutamate-cysteine ligase, modifier subunit -0.0177495
SOX6 SRY (sex determining region Y)-box 6 -0.017746
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0174262
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0173452
NSD3 nuclear receptor binding SET domain protein 3 -0.0171964
RPL4 ribosomal protein L4 -0.0170315
CAMKMT calmodulin-lysine N-methyltransferase -0.0162746
BMP10 bone morphogenetic protein 10 -0.0162585
CAVIN2 caveolae associated protein 2 -0.0160934
PHF20 PHD finger protein 20 -0.0158895
KLF2 Kruppel-like factor 2 -0.0157922
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0156695
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0152287
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0150638
ZNF106 zinc finger protein 106 -0.0150116
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0147624
SLC38A2 solute carrier family 38, member 2 -0.0143601
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0143597
DUSP4 dual specificity phosphatase 4 -0.0142117
TAS2R14 taste receptor, type 2, member 14 -0.0140882
ZNHIT6 zinc finger, HIT-type containing 6 -0.0140233
ANXA3 annexin A3 -0.0138551
ANLN anillin, actin binding protein -0.0137299
FAM91A1 family with sequence similarity 91, member A1 -0.0136287
STK4 serine/threonine kinase 4 -0.0135273
ZNF800 zinc finger protein 800 -0.0132947
ARMH4 armadillo like helical domain containing 4 -0.0128806
SORBS2 sorbin and SH3 domain containing 2 -0.0128389
PLCE1 phospholipase C, epsilon 1 -0.0127638
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0127291
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0126409
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -0.012604
RHOQ ras homolog family member Q -0.0125965
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 -0.0125211
EFNA5 ephrin-A5 -0.0123961
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0123368
ZBTB38 zinc finger and BTB domain containing 38 -0.0122923
ARHGAP5 Rho GTPase activating protein 5 -0.0122783
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.012216
PNRC1 proline-rich nuclear receptor coactivator 1 -0.012078
CPNE1 copine I -0.0120581
MKI67 marker of proliferation Ki-67 -0.0120409
CREB5 cAMP responsive element binding protein 5 -0.0120276
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0120203
R3HDM2 R3H domain containing 2 -0.0120147
ANKRD36C ankyrin repeat domain 36C -0.0119912
FRMD8 FERM domain containing 8 -0.0119362
GLI3 GLI family zinc finger 3 -0.0117733
TOR1AIP2 torsin A interacting protein 2 -0.0116303
TEAD4 TEA domain family member 4 -0.0115902
TBL1X transducin (beta)-like 1X-linked -0.0114279
MTA3 metastasis associated 1 family, member 3 -0.0114028
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0113823
CCNI cyclin I -0.0113738
PRH1 proline-rich protein HaeIII subfamily 1 -0.0113557
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0112506
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0111076
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.0108869
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 -0.0107687
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0107353
SPRY2 sprouty homolog 2 (Drosophila) -0.010567
DUSP16 dual specificity phosphatase 16 -0.0104982
H1-4 H1.4 linker histone, cluster member -0.010487
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.0104764
ATRN attractin -0.0102803
EBNA1BP2 EBNA1 binding protein 2 -0.0101724
PSAT1 phosphoserine aminotransferase 1 -0.0101177
S100A4 S100 calcium binding protein A4 -0.0100059
TPM4 tropomyosin 4 -0.0100005
TKT transketolase -0.00998585
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -0.00996357
MYO5A myosin VA (heavy chain 12, myoxin) -0.00993065