| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Rucaparib (phosphate) perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Rucaparib (phosphate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.144227 |
| MT2A | metallothionein 2A | 0.130158 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0945677 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0919546 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0747637 |
| NDRG1 | N-myc downstream regulated 1 | 0.0703951 |
| B2M | beta-2-microglobulin | 0.0699037 |
| ANXA2 | annexin A2 | 0.0546905 |
| ARRDC3 | arrestin domain containing 3 | 0.0545053 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0534644 |
| HLA-A | major histocompatibility complex, class I, A | 0.0509985 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0505073 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0448074 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0445404 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0404487 |
| HLA-C | major histocompatibility complex, class I, C | 0.039862 |
| FAM13A | family with sequence similarity 13, member A | 0.0386287 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.038594 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0371368 |
| VEGFA | vascular endothelial growth factor A | 0.0358395 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0345985 |
| AHNAK | AHNAK nucleoprotein | 0.034593 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0344364 |
| CALR | calreticulin | 0.0338912 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0338142 |
| SDC4 | syndecan 4 | 0.0318899 |
| ADM | adrenomedullin | 0.0305924 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0304333 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0303505 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0301832 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.030025 |
| HLA-B | major histocompatibility complex, class I, B | 0.0294899 |
| ZNF292 | zinc finger protein 292 | 0.0291054 |
| SPAG9 | sperm associated antigen 9 | 0.0280734 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.028015 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0274993 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0272733 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.026957 |
| OGA | O-GlcNAcase | 0.0259743 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0259617 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0259311 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0257433 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0257084 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0256465 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0254919 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0247598 |
| TMEM263 | transmembrane protein 263 | 0.0246424 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0245918 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0244408 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0243836 |
| RPS8 | ribosomal protein S8 | 0.0243787 |
| PTMA | prothymosin, alpha | 0.024237 |
| RPL12 | ribosomal protein L12 | 0.0242268 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0232622 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0232037 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.023195 |
| CD44 | CD44 molecule (Indian blood group) | 0.0231271 |
| STC1 | stanniocalcin 1 | 0.0230114 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.022841 |
| PTGES2 | prostaglandin E synthase 2 | 0.022257 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | 0.022004 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0218614 |
| ANLN | anillin, actin binding protein | 0.0215966 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0215655 |
| GOLGB1 | golgin B1 | 0.0210714 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.020953 |
| COPA | coatomer protein complex, subunit alpha | 0.0208507 |
| FLNA | filamin A, alpha | 0.0205609 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0205493 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0197187 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.019682 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.0195041 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0192323 |
| TPM3 | tropomyosin 3 | 0.0190609 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0186977 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | 0.0185474 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0185287 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0183463 |
| WDR45B | WD repeat domain 45B | 0.0179551 |
| MT1X | metallothionein 1X | 0.0179318 |
| ANXA1 | annexin A1 | 0.0176319 |
| CCNI | cyclin I | 0.0176219 |
| COG5 | component of oligomeric golgi complex 5 | 0.017437 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.017424 |
| RPL37 | ribosomal protein L37 | 0.0173925 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0172786 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0171645 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.016975 |
| CALU | calumenin | 0.0169084 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0168807 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0168116 |
| ZNF395 | zinc finger protein 395 | 0.0166351 |
| LMO7 | LIM domain 7 | 0.0165778 |
| RPL23 | ribosomal protein L23 | 0.0164277 |
| FKBP10 | FK506 binding protein 10, 65 kDa | 0.0164149 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0164125 |
| ENO1 | enolase 1, (alpha) | 0.016352 |
| CD109 | CD109 molecule | 0.016331 |
| PCBP2 | poly(rC) binding protein 2 | 0.0162018 |
| RPL37A | ribosomal protein L37a | 0.0161639 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.0736362 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0733332 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0434764 |
| VCL | vinculin | -0.038313 |
| CALD1 | caldesmon 1 | -0.0374881 |
| VIM | vimentin | -0.0338627 |
| PRELID2 | PRELI domain containing 2 | -0.0324843 |
| GLIS3 | GLIS family zinc finger 3 | -0.0313192 |
| AUTS2 | autism susceptibility candidate 2 | -0.0288852 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0281187 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0266777 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0263392 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0251907 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.024207 |
| COL1A2 | collagen, type I, alpha 2 | -0.0233081 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0230031 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0226548 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.022201 |
| NAV1 | neuron navigator 1 | -0.0217647 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0217265 |
| ATP13A3 | ATPase type 13A3 | -0.0213666 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0210348 |
| DST | dystonin | -0.020731 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0203909 |
| FBXO11 | F-box protein 11 | -0.0198172 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0182507 |
| TPM4 | tropomyosin 4 | -0.017737 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0173202 |
| FAM20C | family with sequence similarity 20, member C | -0.0171014 |
| FRMD4A | FERM domain containing 4A | -0.0170272 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.017026 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0168759 |
| HMGA2 | high mobility group AT-hook 2 | -0.0168533 |
| KAZN | kazrin, periplakin interacting protein | -0.0168063 |
| LDHA | lactate dehydrogenase A | -0.0164707 |
| TPM1 | tropomyosin 1 (alpha) | -0.0164173 |
| RRBP1 | ribosome binding protein 1 | -0.0164023 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.016265 |
| FTL | ferritin, light polypeptide | -0.0162171 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0162045 |
| ARF4 | ADP-ribosylation factor 4 | -0.0160413 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | -0.0159322 |
| PCNX1 | pecanex 1 | -0.0155787 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0155421 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0153632 |
| PRKCA | protein kinase C, alpha | -0.0153567 |
| RASAL2 | RAS protein activator like 2 | -0.0152081 |
| CLIC4 | chloride intracellular channel 4 | -0.0148105 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0147339 |
| PALLD | palladin, cytoskeletal associated protein | -0.0147135 |
| EGR1 | early growth response 1 | -0.0143812 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0142846 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0142414 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0141833 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0140819 |
| JAG1 | jagged 1 | -0.0136935 |
| TNNC1 | troponin C type 1 (slow) | -0.0134151 |
| CEP350 | centrosomal protein 350kDa | -0.0132805 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0132142 |
| TXNDC11 | thioredoxin domain containing 11 | -0.0131545 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0130989 |
| NSD1 | nuclear receptor binding SET domain protein 1 | -0.0130573 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0130356 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0129914 |
| DNAH11 | dynein, axonemal, heavy chain 11 | -0.0127872 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0127568 |
| NRG1 | neuregulin 1 | -0.0126863 |
| MAP4 | microtubule-associated protein 4 | -0.0126172 |
| PCDH7 | protocadherin 7 | -0.0124966 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.012468 |
| VMP1 | vacuole membrane protein 1 | -0.0124088 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0123272 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | -0.0121819 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.0121021 |
| SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | -0.0120229 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0120146 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0119806 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0119466 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0119076 |
| TRAK2 | trafficking protein, kinesin binding 2 | -0.0117612 |
| NKTR | natural killer cell triggering receptor | -0.01169 |
| CPQ | carboxypeptidase Q | -0.0116768 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0116499 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0116421 |
| GOLGA8B | golgin A8 family, member B | -0.0116345 |
| TAPBP | TAP binding protein (tapasin) | -0.0115988 |
| CCDC6 | coiled-coil domain containing 6 | -0.0115727 |
| MAPK8 | mitogen-activated protein kinase 8 | -0.0115613 |
| NT5E | 5'-nucleotidase, ecto (CD73) | -0.0114603 |
| FLOT1 | flotillin 1 | -0.011418 |
| ATF6 | activating transcription factor 6 | -0.0114094 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0113578 |
| FOXN3 | forkhead box N3 | -0.0113001 |
| MAST2 | microtubule associated serine/threonine kinase 2 | -0.0112771 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0112617 |
| WDR1 | WD repeat domain 1 | -0.0112281 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0112048 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0112039 |
| RHOB | ras homolog family member B | -0.0110696 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0110672 |
