Rucaparib (phosphate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.1105
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0653529
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0648694
WAC WW domain containing adaptor with coiled-coil 0.0626858
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0625888
GOLGA4 golgin A4 0.0532248
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0528529
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0506189
ANLN anillin, actin binding protein 0.0484854
DIAPH3 diaphanous-related formin 3 0.0476433
NAMPT nicotinamide phosphoribosyltransferase 0.0462096
RBM39 RNA binding motif protein 39 0.0452174
ANXA2 annexin A2 0.0447979
SPAG9 sperm associated antigen 9 0.0432496
ZNF292 zinc finger protein 292 0.0427363
TXNRD1 thioredoxin reductase 1 0.0422374
NUP58 nucleoporin 58 0.0411964
SETD5 SET domain containing 5 0.0404957
TPX2 TPX2, microtubule-associated 0.0403336
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0400875
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0390968
NAP1L1 nucleosome assembly protein 1-like 1 0.0380287
CANX calnexin 0.0376341
SMC4 structural maintenance of chromosomes 4 0.0357912
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0355088
ANKRD28 ankyrin repeat domain 28 0.0350822
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0343109
CALU calumenin 0.0341477
TMEM263 transmembrane protein 263 0.0324554
ECT2 epithelial cell transforming 2 0.0319849
HELZ helicase with zinc finger 0.0314885
COPB1 coatomer protein complex, subunit beta 1 0.0305526
MARCHF6 membrane associated ring-CH-type finger 6 0.0302475
MIS18BP1 MIS18 binding protein 1 0.02992
COG5 component of oligomeric golgi complex 5 0.0297439
RSRC2 arginine/serine-rich coiled-coil 2 0.0294398
LCORL ligand dependent nuclear receptor corepressor-like 0.0294323
EEF2 eukaryotic translation elongation factor 2 0.028873
PTMA prothymosin, alpha 0.0287379
MKI67 marker of proliferation Ki-67 0.0287366
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0283156
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0277759
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0275224
PHIP pleckstrin homology domain interacting protein 0.0274443
WDR45B WD repeat domain 45B 0.0271571
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0262115
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.026145
ANXA1 annexin A1 0.0259232
DEK DEK proto-oncogene 0.0258937
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0257549
YBX3 Y box binding protein 3 0.0255709
XPO1 exportin 1 0.0254629
YBX1 Y box binding protein 1 0.0251053
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0248496
DSCAM Down syndrome cell adhesion molecule 0.0247167
FXR1 fragile X mental retardation, autosomal homolog 1 0.0246482
KIF5B kinesin family member 5B 0.0244754
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0244513
TENT2 terminal nucleotidyltransferase 2 0.0244195
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0244181
CKAP2 cytoskeleton associated protein 2 0.0244019
OLA1 Obg-like ATPase 1 0.0242248
MYH9 myosin, heavy chain 9, non-muscle 0.0239649
MT2A metallothionein 2A 0.0237466
SET SET nuclear proto-oncogene 0.0236597
BIRC6 baculoviral IAP repeat containing 6 0.0228172
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0228083
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.022628
CHD1 chromodomain helicase DNA binding protein 1 0.0225579
QKI QKI, KH domain containing, RNA binding 0.0225575
RPL23 ribosomal protein L23 0.0224652
CLTC clathrin, heavy chain (Hc) 0.0223083
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0220824
TBK1 TANK-binding kinase 1 0.0220756
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0219545
CENPF centromere protein F, 350/400kDa 0.0219298
TM4SF1 transmembrane 4 L six family member 1 0.0219211
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.021891
CXCL8 chemokine (C-X-C motif) ligand 8 0.0217413
TTK TTK protein kinase 0.0215125
TRA2A transformer 2 alpha homolog (Drosophila) 0.0212242
ARRDC3 arrestin domain containing 3 0.0212049
WDR43 WD repeat domain 43 0.0211845
KIF4A kinesin family member 4A 0.0210303
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0209034
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0208074
NUP153 nucleoporin 153kDa 0.0208072
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.020748
RPS3 ribosomal protein S3 0.0207252
HILPDA hypoxia inducible lipid droplet-associated 0.0206495
AHCTF1 AT hook containing transcription factor 1 0.0205829
CKAP5 cytoskeleton associated protein 5 0.0204147
ATP13A3 ATPase type 13A3 0.0203711
MATR3 matrin 3 0.0202722
TUBB tubulin, beta class I 0.0202564
SEC23A Sec23 homolog A (S. cerevisiae) 0.0201988
HSPA8 heat shock 70kDa protein 8 0.0201695
XRN2 5'-3' exoribonuclease 2 0.0200865
NBAS neuroblastoma amplified sequence 0.0200263
KIAA1958 KIAA1958 0.0200061

decreased expression

Symbol Name Standardized Value
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.068205
HMGA2 high mobility group AT-hook 2 -0.059711
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0588922
TMSB10 thymosin beta 10 -0.0572505
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0536487
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0514124
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0502411
ZBTB20 zinc finger and BTB domain containing 20 -0.0453386
IGFBP3 insulin-like growth factor binding protein 3 -0.0438445
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0382975
FNDC3B fibronectin type III domain containing 3B -0.0363781
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0356882
RIGI RNA sensor RIG-I -0.035059
DST dystonin -0.0343419
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0335045
RAI14 retinoic acid induced 14 -0.0334156
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0330233
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0324014
PRSS23 protease, serine, 23 -0.0323533
PRKCA protein kinase C, alpha -0.0308398
NALCN sodium leak channel, non selective -0.0295127
INTS6 integrator complex subunit 6 -0.0294791
SH3KBP1 SH3-domain kinase binding protein 1 -0.0284648
PCED1B PC-esterase domain containing 1B -0.0281604
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0280326
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0276776
PRR16 proline rich 16 -0.0273753
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0267226
ATM ATM serine/threonine kinase -0.0266789
EGFR epidermal growth factor receptor -0.0265461
SLC38A2 solute carrier family 38, member 2 -0.0264315
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0263732
SVIL supervillin -0.0262778
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0262446
EGR1 early growth response 1 -0.0260977
PRH1 proline-rich protein HaeIII subfamily 1 -0.0259683
PTPRK protein tyrosine phosphatase, receptor type, K -0.0255766
BICD1 bicaudal D homolog 1 (Drosophila) -0.0254904
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0253004
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0252356
RAD51B RAD51 paralog B -0.0248364
COL5A1 collagen, type V, alpha 1 -0.0241598
DPYD dihydropyrimidine dehydrogenase -0.0238392
ATG7 autophagy related 7 -0.0233183
AEBP2 AE binding protein 2 -0.0232625
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0225629
ATXN1 ataxin 1 -0.0223422
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0220162
PODXL podocalyxin-like -0.0216767
CD44 CD44 molecule (Indian blood group) -0.0216263
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0216198
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0212407
CMIP c-Maf inducing protein -0.0210231
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0208925
SMYD3 SET and MYND domain containing 3 -0.0208258
GPC5 glypican 5 -0.0207802
MAML2 mastermind-like 2 (Drosophila) -0.0200482
NT5E 5'-nucleotidase, ecto (CD73) -0.0198262
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0197449
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0195997
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.019585
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0195747
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0195253
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.019342
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0190309
BPTF bromodomain PHD finger transcription factor -0.018575
IGF2 insulin-like growth factor 2 -0.0185656
ENO2 enolase 2 (gamma, neuronal) -0.0183622
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0182981
ZNF638 zinc finger protein 638 -0.0182664
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0182332
WARS1 tryptophanyl-tRNA synthetase 1 -0.0182277
TRPC1 transient receptor potential cation channel, subfamily C, member 1 -0.0181805
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0181712
ITGB4 integrin, beta 4 -0.0181698
ABR active BCR-related -0.0178906
ANGPTL4 angiopoietin-like 4 -0.0176812
PTK2 protein tyrosine kinase 2 -0.0175752
VCL vinculin -0.0173744
NIBAN2 niban apoptosis regulator 2 -0.0170285
SASH1 SAM and SH3 domain containing 1 -0.0168358
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0168298
PKM pyruvate kinase, muscle -0.0167771
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0166784
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0166683
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0166215
BTG1 B-cell translocation gene 1, anti-proliferative -0.0164441
FMN1 formin 1 -0.0162973
SKIL SKI-like proto-oncogene -0.0162803
IL1RAP interleukin 1 receptor accessory protein -0.0162763
MYO10 myosin X -0.0162474
PALM2AKAP2 PALM2 and AKAP2 fusion -0.016114
FLNB filamin B, beta -0.0159713
MYO9A myosin IXA -0.0157602
DSE dermatan sulfate epimerase -0.0157333
ZC3H12C zinc finger CCCH-type containing 12C -0.0156106
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0153637
LRRC49 leucine rich repeat containing 49 -0.0153589
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0152043
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0150228