Rucaparib (phosphate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Rucaparib (phosphate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Rucaparib (phosphate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.146261
RPS6 ribosomal protein S6 0.0577201
HLA-A major histocompatibility complex, class I, A 0.0534668
RPL35A ribosomal protein L35a 0.0523916
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0440965
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0389286
RPS3 ribosomal protein S3 0.0388157
RPL37A ribosomal protein L37a 0.0376376
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0374853
RPL28 ribosomal protein L28 0.0360377
RPLP2 ribosomal protein, large, P2 0.0353231
RPS8 ribosomal protein S8 0.0351577
RPL13A ribosomal protein L13a 0.0347734
BHLHE40 basic helix-loop-helix family, member e40 0.0327263
RPS12 ribosomal protein S12 0.0322466
RPL18 ribosomal protein L18 0.0302988
RPL36 ribosomal protein L36 0.0294577
RPS19 ribosomal protein S19 0.0292563
RPL12 ribosomal protein L12 0.0279185
GSTP1 glutathione S-transferase pi 1 0.0278221
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0275708
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0266552
TMSB4X thymosin beta 4, X-linked 0.0259899
PTMA prothymosin, alpha 0.0257661
USP3 ubiquitin specific peptidase 3 0.0233553
FTL ferritin, light polypeptide 0.0232945
RPL8 ribosomal protein L8 0.0223904
RPS13 ribosomal protein S13 0.0222617
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0212829
NAMPT nicotinamide phosphoribosyltransferase 0.0208802
RPS2 ribosomal protein S2 0.0203442
RPS21 ribosomal protein S21 0.0201485
ACTG1 actin gamma 1 0.0198728
RPL19 ribosomal protein L19 0.0197014
FOSL1 FOS-like antigen 1 0.0194603
ATP5F1E ATP synthase F1 subunit epsilon 0.0193465
RPL38 ribosomal protein L38 0.0191774
DDIT4 DNA-damage-inducible transcript 4 0.0187913
RPL35 ribosomal protein L35 0.0185968
RPL30 ribosomal protein L30 0.018185
RPS29 ribosomal protein S29 0.0180312
RPS14 ribosomal protein S14 0.0179491
UBA6 ubiquitin-like modifier activating enzyme 6 0.0177842
LMTK2 lemur tyrosine kinase 2 0.0174373
ANXA2 annexin A2 0.0169972
RPL26 ribosomal protein L26 0.0168305
CST3 cystatin C 0.016664
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.015986
RACK1 receptor for activated C kinase 1 0.0159446
RPL37 ribosomal protein L37 0.015824
NAP1L4 nucleosome assembly protein 1-like 4 0.015684
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0155661
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 0.0152104
RAD23B RAD23 homolog B (S. cerevisiae) 0.0148532
KMT2E lysine (K)-specific methyltransferase 2E 0.0147674
KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 0.0146585
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0146276
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0145121
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0144439
RPL5 ribosomal protein L5 0.0142312
PFN1 profilin 1 0.0140888
RPS16 ribosomal protein S16 0.0140257
H1-0 H1.0 linker histone 0.0138403
GOLGA4 golgin A4 0.0138197
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0136375
RPL34 ribosomal protein L34 0.0133897
SF3A1 splicing factor 3a, subunit 1, 120kDa 0.0133005
MXD1 MAX dimerization protein 1 0.0131702
ROMO1 reactive oxygen species modulator 1 0.0129264
B2M beta-2-microglobulin 0.0128439
RPS10 ribosomal protein S10 0.0128092
H2AC6 H2A clustered histone 6 0.0127011
UBE2C ubiquitin-conjugating enzyme E2C 0.0126377
RPS11 ribosomal protein S11 0.0125976
RPL7A ribosomal protein L7a 0.0125503
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0124459
ZNF292 zinc finger protein 292 0.0120602
SQSTM1 sequestosome 1 0.0120052
RIOK3 RIO kinase 3 0.0119375
RPS15 ribosomal protein S15 0.0118274
NDRG1 N-myc downstream regulated 1 0.0117216
RPS25 ribosomal protein S25 0.0116961
RPL27 ribosomal protein L27 0.0116287
RPL11 ribosomal protein L11 0.0113456
RPS27 ribosomal protein S27 0.0112441
RPS23 ribosomal protein S23 0.0112021
HMGB1 high mobility group box 1 0.0109943
RPL27A ribosomal protein L27a 0.0107238
CLIC1 chloride intracellular channel 1 0.0105927
HSPA8 heat shock 70kDa protein 8 0.0103696
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0103305
S100A9 S100 calcium binding protein A9 0.0102197
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0101214
GPX4 glutathione peroxidase 4 0.0101147
UBE2B ubiquitin-conjugating enzyme E2B 0.010013
CLDN4 claudin 4 0.00994333
EIF1 eukaryotic translation initiation factor 1 0.00987554
TMED9 transmembrane emp24 protein transport domain containing 9 0.00978595
YBX1 Y box binding protein 1 0.00973295
COX6C cytochrome c oxidase subunit VIc 0.00971442

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.062665
UBC ubiquitin C -0.0625653
NCEH1 neutral cholesterol ester hydrolase 1 -0.0584401
BCL2L1 BCL2-like 1 -0.0574882
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0501943
MACC1 metastasis associated in colon cancer 1 -0.0469587
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0435403
EZR ezrin -0.0432384
VCL vinculin -0.0393218
MAML2 mastermind-like 2 (Drosophila) -0.0354257
ZMYND8 zinc finger, MYND-type containing 8 -0.0339413
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0334962
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0327314
MYO1E myosin IE -0.0326926
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0324492
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0322669
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0313626
NEBL nebulette -0.03026
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0301454
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0300398
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0299167
AHNAK AHNAK nucleoprotein -0.0296845
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0296718
ZBTB20 zinc finger and BTB domain containing 20 -0.0290549
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0276575
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0269424
PLSCR1 phospholipid scramblase 1 -0.0264646
ETV6 ets variant 6 -0.0263091
PCLO piccolo presynaptic cytomatrix protein -0.025757
ZNFX1 zinc finger, NFX1-type containing 1 -0.0247446
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0245496
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0241838
LOC102724023 ES1 protein homolog, mitochondrial -0.0241714
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0241199
PCBP2 poly(rC) binding protein 2 -0.0241032
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0240315
SP100 SP100 nuclear antigen -0.0236674
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0234071
LDHA lactate dehydrogenase A -0.0232478
EXOC4 exocyst complex component 4 -0.0231072
USP34 ubiquitin specific peptidase 34 -0.0224841
GOLGB1 golgin B1 -0.0223518
JMJD1C jumonji domain containing 1C -0.0216616
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0212711
OSBPL10 oxysterol binding protein-like 10 -0.0212367
RIGI RNA sensor RIG-I -0.0209444
PERP PERP, TP53 apoptosis effector -0.020889
MYOF myoferlin -0.0208459
RBM39 RNA binding motif protein 39 -0.0207163
VMP1 vacuole membrane protein 1 -0.0207157
PATJ PATJ crumbs cell polarity complex component -0.0206057
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0200737
TPM4 tropomyosin 4 -0.0200215
OXSR1 oxidative stress responsive 1 -0.0199552
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0199438
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0198528
SMYD3 SET and MYND domain containing 3 -0.0196241
RNF213 ring finger protein 213 -0.0194837
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0191622
CTBP2 C-terminal binding protein 2 -0.0191001
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0190083
EHBP1 EH domain binding protein 1 -0.0189524
CSNK1A1 casein kinase 1, alpha 1 -0.018786
MX2 MX dynamin-like GTPase 2 -0.0187745
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0180591
IFIH1 interferon induced with helicase C domain 1 -0.0180289
FNDC3B fibronectin type III domain containing 3B -0.0179671
ZBTB38 zinc finger and BTB domain containing 38 -0.0179421
PKM pyruvate kinase, muscle -0.0179245
JUN jun proto-oncogene -0.0178487
GMDS GDP-mannose 4,6-dehydratase -0.0178475
DLG1 discs, large homolog 1 (Drosophila) -0.0177443
PTPRK protein tyrosine phosphatase, receptor type, K -0.0177069
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0176663
MED13L mediator complex subunit 13-like -0.0176465
DIAPH1 diaphanous-related formin 1 -0.0176152
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0175205
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0174897
EGR1 early growth response 1 -0.0172116
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0172104
YAP1 Yes-associated protein 1 -0.0171535
TOP1 topoisomerase (DNA) I -0.0171095
USP9X ubiquitin specific peptidase 9, X-linked -0.0170818
PRELID2 PRELI domain containing 2 -0.0170647
IPO7 importin 7 -0.0168896
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0168494
ADNP activity-dependent neuroprotector homeobox -0.0168415
BPTF bromodomain PHD finger transcription factor -0.0167877
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0167025
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0165651
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0165543
SERINC3 serine incorporator 3 -0.0165172
CEMIP cell migration inducing protein, hyaluronan binding -0.0165158
CUX1 cut-like homeobox 1 -0.0164398
ARHGAP26 Rho GTPase activating protein 26 -0.0161548
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0159741
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0158967
TJP1 tight junction protein 1 -0.0158112
EXT1 exostosin glycosyltransferase 1 -0.0155817
NF1 neurofibromin 1 -0.0155631