Rucaparib Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/9931954
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Genes

198 proteins with high or low expression in Rucaparib relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
PEX7 peroxisomal biogenesis factor 7 2.91
CDCA3 cell division cycle associated 3 0.89
TSPAN3 tetraspanin 3 0.84
SH3YL1 SH3 and SYLF domain containing 1 0.81
CCNB1 cyclin B1 0.76
NFE2L1 nuclear factor, erythroid 2-like 1 0.7
WDR81 WD repeat domain 81 0.69
ANLN anillin, actin binding protein 0.67
DDB2 damage-specific DNA binding protein 2, 48kDa 0.66
PIF1 PIF1 5'-to-3' DNA helicase 0.65
TACC3 transforming, acidic coiled-coil containing protein 3 0.64
SMTN smoothelin 0.63
CHSY3 chondroitin sulfate synthase 3 0.62
UBE2C ubiquitin-conjugating enzyme E2C 0.61
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7 0.61
GTSE1 G-2 and S-phase expressed 1 0.6
ZC4H2 zinc finger, C4H2 domain containing 0.6
CUEDC2 CUE domain containing 2 0.59
RABL2A RAB, member of RAS oncogene family-like 2A 0.59
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.59
SGO2 shugoshin 2 0.58
TPX2 TPX2, microtubule-associated 0.57
INCENP inner centromere protein antigens 135/155kDa 0.57
AURKA aurora kinase A 0.54
CKAP2L cytoskeleton associated protein 2-like 0.54
ASIC1 acid sensing (proton gated) ion channel 1 0.54
CDCA5 cell division cycle associated 5 0.53
TP73 tumor protein p73 0.53
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 0.52
HBA1 hemoglobin, alpha 1 0.52
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.52
KIF18A kinesin family member 18A 0.52
NRBP2 nuclear receptor binding protein 2 0.52
RGPD8 RANBP2-like and GRIP domain containing 8 0.51
CCND3 cyclin D3 0.51
NUSAP1 nucleolar and spindle associated protein 1 0.51
RPE ribulose-5-phosphate-3-epimerase 0.51
CASC3 cancer susceptibility candidate 3 0.51
AXIN1 axin 1 0.5
CKAP2 cytoskeleton associated protein 2 0.5
ATP5PF ATP synthase peripheral stalk subunit F6 0.5
PRC1 protein regulator of cytokinesis 1 0.5
BLZF1 basic leucine zipper nuclear factor 1 0.49
SGO1 shugoshin 1 0.48
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.48
CDC20 cell division cycle 20 0.48
NPDC1 neural proliferation, differentiation and control, 1 0.48
PARPBP PARP1 binding protein 0.47
TRAF3IP2 TRAF3 interacting protein 2 0.46
LTBP3 latent transforming growth factor beta binding protein 3 0.46
PRRC2B proline-rich coiled-coil 2B 0.46
TMOD2 tropomodulin 2 (neuronal) 0.46
YBX3 Y box binding protein 3 0.43
CENPF centromere protein F, 350/400kDa 0.43
NAV2 neuron navigator 2 0.43
FSTL3 follistatin-like 3 (secreted glycoprotein) 0.43
CLSTN3 calsyntenin 3 0.43
PSRC1 proline/serine-rich coiled-coil 1 0.43
RACGAP1 Rac GTPase activating protein 1 0.42
PIMREG PICALM interacting mitotic regulator 0.42
ELF4 E74-like factor 4 (ets domain transcription factor) 0.42
JPT1 Jupiter microtubule associated homolog 1 0.41
CCNA2 cyclin A2 0.41
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast) 0.41
KIFC1 kinesin family member C1 0.41
DEAF1 DEAF1 transcription factor 0.41
DNAL1 dynein, axonemal, light chain 1 0.4
SLC35A4 solute carrier family 35, member A4 0.4
SH3BP2 SH3-domain binding protein 2 0.4
GKAP1 G kinase anchoring protein 1 0.4
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 0.4
M1AP meiosis 1 associated protein 0.4
FDXR ferredoxin reductase 0.4
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.4
SASS6 spindle assembly 6 homolog (C. elegans) 0.4
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 0.39
AURKB aurora kinase B 0.39
CEP72 centrosomal protein 72kDa 0.39
HIKESHI heat shock protein nuclear import factor hikeshi 0.39
MARCKS myristoylated alanine-rich protein kinase C substrate 0.39
GALT galactose-1-phosphate uridylyltransferase 0.38
KIF20A kinesin family member 20A 0.38
ERCC6L2 excision repair cross-complementation group 6-like 2 0.38
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 0.38
LRR1 leucine rich repeat protein 1 0.38
ZNF428 zinc finger protein 428 0.37
EPS8L2 EPS8-like 2 0.37
PCLAF PCNA clamp associated factor 0.37
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 0.37
BIRC5 baculoviral IAP repeat containing 5 0.37
NEK2 NIMA-related kinase 2 0.37
STMN3 stathmin-like 3 0.37
GMNN geminin, DNA replication inhibitor 0.37
JARID2 jumonji, AT rich interactive domain 2 0.37
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli) 0.37
CEP104 centrosomal protein 104kDa 0.36
FBXL6 F-box and leucine-rich repeat protein 6 0.36
FAM124A family with sequence similarity 124A 0.36

low expression

Symbol Name Standardized Value
TRIM29 tripartite motif containing 29 -2.47
CCDC15 coiled-coil domain containing 15 -2.3
ANKRD18B ankyrin repeat domain 18B -2.15
DES desmin -1.87
KIAA1107 KIAA1107 -1.86
KMT2B lysine (K)-specific methyltransferase 2B -1.76
TTLL4 tubulin tyrosine ligase-like family member 4 -1.41
ENO1 enolase 1, (alpha) -1.37
TMEM173 transmembrane protein 173 -1.24
AKR1C3 aldo-keto reductase family 1, member C3 -1.21
BAHCC1 BAH domain and coiled-coil containing 1 -1.13
KSR2 kinase suppressor of ras 2 -0.96
GPN3 GPN-loop GTPase 3 -0.92
ZNF275 zinc finger protein 275 -0.88
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.83
RGN regucalcin -0.83
SERINC1 serine incorporator 1 -0.82
CTNND2 catenin (cadherin-associated protein), delta 2 -0.76
CCPG1 cell cycle progression 1 -0.76
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.75
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 -0.72
ZFAND6 zinc finger, AN1-type domain 6 -0.72
EPB41 erythrocyte membrane protein band 4.1 -0.7
INPP5J inositol polyphosphate-5-phosphatase J -0.67
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.65
SET SET nuclear proto-oncogene -0.65
COA3 cytochrome c oxidase assembly factor 3 -0.65
ARID5B AT rich interactive domain 5B (MRF1-like) -0.64
GJB3 gap junction protein, beta 3, 31kDa -0.63
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.62
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -0.61
GCSH glycine cleavage system protein H (aminomethyl carrier) -0.59
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.59
CTSL cathepsin L -0.59
TMEM97 transmembrane protein 97 -0.58
FAM171A1 family with sequence similarity 171, member A1 -0.57
ZNF460 zinc finger protein 460 -0.56
NOP10 NOP10 ribonucleoprotein -0.56
IFRD1 interferon-related developmental regulator 1 -0.55
IFITM3 interferon induced transmembrane protein 3 -0.55
PRSS8 protease, serine, 8 -0.55
DCHS1 dachsous cadherin-related 1 -0.54
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.53
PTBP1 polypyrimidine tract binding protein 1 -0.53
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 -0.53
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -0.52
ARL15 ADP-ribosylation factor-like 15 -0.51
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -0.51
POLR1D polymerase (RNA) I polypeptide D, 16kDa -0.5
PTPRD protein tyrosine phosphatase, receptor type, D -0.49
STC2 stanniocalcin 2 -0.48
CCDC91 coiled-coil domain containing 91 -0.48
C11ORF95 chromosome 11 open reading frame 95 -0.47
MTPAP mitochondrial poly(A) polymerase -0.46
BLOC1S1 biogenesis of lysosomal organelles complex-1, subunit 1 -0.45
PSPH phosphoserine phosphatase -0.45
TRIM68 tripartite motif containing 68 -0.44
PCLO piccolo presynaptic cytomatrix protein -0.44
SPC24 SPC24, NDC80 kinetochore complex component -0.44
L1RE1 LINE1 retrotransposable element 1 -0.43
CBLC Cbl proto-oncogene C, E3 ubiquitin protein ligase -0.43
SLC38A2 solute carrier family 38, member 2 -0.43
TRIML2 tripartite motif family-like 2 -0.42
MT2A metallothionein 2A -0.42
TPM4 tropomyosin 4 -0.42
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 -0.42
KLHL5 kelch-like family member 5 -0.42
BAIAP2 BAI1-associated protein 2 -0.41
SUCO SUN domain containing ossification factor -0.41
FZD1 frizzled class receptor 1 -0.41
UPP1 uridine phosphorylase 1 -0.41
SLC16A6 solute carrier family 16, member 6 -0.41
GCH1 GTP cyclohydrolase 1 -0.41
C12ORF60 chromosome 12 open reading frame 60 -0.41
DPYD dihydropyrimidine dehydrogenase -0.4
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.4
UBXN2B UBX domain protein 2B -0.4
DGKE diacylglycerol kinase, epsilon 64kDa -0.4
ZNF749 zinc finger protein 749 -0.39
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.39
FAAP24 FA core complex associated protein 24 -0.38
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.38
ABHD3 abhydrolase domain containing 3 -0.38
PYGM phosphorylase, glycogen, muscle -0.38
CA13 carbonic anhydrase XIII -0.38
MCTS2P malignant T cell amplified sequence 2, pseudogene -0.38
ZCCHC8 zinc finger, CCHC domain containing 8 -0.37
MT1F metallothionein 1F -0.37
RIOK3 RIO kinase 3 -0.37
FBXO33 F-box protein 33 -0.37
ADI1 acireductone dioxygenase 1 -0.37
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 -0.37
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.37
ALMS1 Alstrom syndrome protein 1 -0.37
PRKX protein kinase, X-linked -0.36
FBXL4 F-box and leucine-rich repeat protein 4 -0.36
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.36
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.36
TMPPE transmembrane protein with metallophosphoesterase domain -0.36
TMEM230 transmembrane protein 230 -0.36