Ruffle Gene Set

Dataset COMPARTMENTS Curated Protein Localization Evidence Scores 2025
Category structural or functional annotations
Type cellular component
Description Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. (Gene Ontology, GO_0001726)
External Link http://amigo.geneontology.org/amigo/term/GO:0001726
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Genes

120 proteins localized to the Ruffle cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores 2025 dataset.

Symbol Name Standardized Value
BCAR1 breast cancer anti-estrogen resistance 1 5.0
C2CD5 C2 calcium-dependent domain containing 5 5.0
PKN1 protein kinase N1 5.0
FERMT1 fermitin family member 1 5.0
S100A6 S100 calcium binding protein A6 5.0
WWC1 WW and C2 domain containing 1 5.0
PTK6 protein tyrosine kinase 6 5.0
MTMR14 myotubularin related protein 14 5.0
FBXL15 F-box and leucine-rich repeat protein 15 5.0
SNTG1 syntrophin, gamma 1 5.0
EPS8L2 EPS8-like 2 5.0
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 5.0
PSD4 pleckstrin and Sec7 domain containing 4 5.0
FAM107A family with sequence similarity 107, member A 5.0
CLASP2 cytoplasmic linker associated protein 2 5.0
TMEM87A transmembrane protein 87A 5.0
DLC1 DLC1 Rho GTPase activating protein 5.0
FSCN1 fascin actin-bundling protein 1 5.0
S100B S100 calcium binding protein B 5.0
EPS8L1 EPS8-like 1 5.0
PPP1R9B protein phosphatase 1, regulatory subunit 9B 5.0
SNX9 sorting nexin 9 5.0
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 5.0
ARF6 ADP-ribosylation factor 6 5.0
ARF4 ADP-ribosylation factor 4 5.0
LIMA1 LIM domain and actin binding 1 5.0
NF2 neurofibromin 2 (merlin) 5.0
NME1 NME/NM23 nucleoside diphosphate kinase 1 5.0
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 5.0
MACF1 microtubule-actin crosslinking factor 1 5.0
PODXL podocalyxin-like 5.0
SNX5 sorting nexin 5 5.0
MYO6 myosin VI 5.0
MTSS1 metastasis suppressor 1 5.0
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 5.0
SH3YL1 SH3 and SYLF domain containing 1 5.0
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 5.0
MYH9 myosin, heavy chain 9, non-muscle 5.0
S100A11 S100 calcium binding protein A11 5.0
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 5.0
RIGI RNA sensor RIG-I 5.0
MYADM myeloid-associated differentiation marker 5.0
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 5.0
MYO5A myosin VA (heavy chain 12, myoxin) 5.0
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 5.0
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 5.0
CARMIL2 capping protein regulator and myosin 1 linker 2 5.0
EZR ezrin 5.0
ACTN1 actinin, alpha 1 5.0
SPATA13 spermatogenesis associated 13 5.0
MTM1 myotubularin 1 5.0
MTSS2 MTSS I-BAR domain containing 2 5.0
ITGAV integrin, alpha V 5.0
VIL1 villin 1 5.0
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 5.0
GLMN glomulin, FKBP associated protein 5.0
IQGAP1 IQ motif containing GTPase activating protein 1 5.0
AMOT angiomotin 5.0
INPP5J inositol polyphosphate-5-phosphatase J 5.0
INPP5K inositol polyphosphate-5-phosphatase K 5.0
KANK1 KN motif and ankyrin repeat domains 1 5.0
KIF18A kinesin family member 18A 5.0
RPS3 ribosomal protein S3 5.0
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 5.0
CD2AP CD2-associated protein 5.0
BAIAP2 BAI1-associated protein 2 5.0
PROC protein C (inactivator of coagulation factors Va and VIIIa) 5.0
BMX BMX non-receptor tyrosine kinase 5.0
TOX4 TOX high mobility group box family member 4 4.0
FGD3 FYVE, RhoGEF and PH domain containing 3 4.0
PLEK pleckstrin 4.0
FGD1 FYVE, RhoGEF and PH domain containing 1 4.0
FGD2 FYVE, RhoGEF and PH domain containing 2 4.0
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 4.0
JCAD junctional cadherin 5 associated 4.0
CDK6 cyclin-dependent kinase 6 4.0
ARFIP2 ADP-ribosylation factor interacting protein 2 4.0
HIP1R huntingtin interacting protein 1 related 4.0
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 4.0
ARHGAP18 Rho GTPase activating protein 18 4.0
FGD6 FYVE, RhoGEF and PH domain containing 6 4.0
FGD4 FYVE, RhoGEF and PH domain containing 4 4.0
FGD5 FYVE, RhoGEF and PH domain containing 5 4.0
TPM1 tropomyosin 1 (alpha) 4.0
DBNL drebrin-like 4.0
ITGB1BP1 integrin beta 1 binding protein 1 4.0
CTTN cortactin 4.0
PSD2 pleckstrin and Sec7 domain containing 2 4.0
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 4.0
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 4.0
RINL Ras and Rab interactor-like 4.0
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 4.0
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 4.0
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 4.0
PDPN podoplanin 4.0
CYFIP1 cytoplasmic FMR1 interacting protein 1 4.0
EPS8 epidermal growth factor receptor pathway substrate 8 4.0
KNSTRN kinetochore-localized astrin/SPAG5 binding protein 4.0
EGFR epidermal growth factor receptor 4.0
PLCG1 phospholipase C, gamma 1 4.0
PSD3 pleckstrin and Sec7 domain containing 3 4.0
TESC tescalcin 4.0
AKT2 v-akt murine thymoma viral oncogene homolog 2 4.0
NME2 NME/NM23 nucleoside diphosphate kinase 2 4.0
ALS2 amyotrophic lateral sclerosis 2 (juvenile) 4.0
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 4.0
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 4.0
TRPV4 transient receptor potential cation channel, subfamily V, member 4 3.0
FSCN3 fascin actin-bundling protein 3, testicular 3.0
AIF1 allograft inflammatory factor 1 3.0
COBL cordon-bleu WH2 repeat protein 3.0
EPS8L3 EPS8-like 3 3.0
LAYN layilin 3.0
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 3.0
PLEKHO1 pleckstrin homology domain containing, family O member 1 3.0
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 3.0
NCKAP1 NCK-associated protein 1 3.0
MYO9B myosin IXB 3.0
TLN1 talin 1 3.0
PLA2G4F phospholipase A2, group IVF 3.0